Wenxin Li

Shanghai Institute of Applied Physics

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Qingnuan Li

Shanghai Institute of Applied Physics

Chunhai Fan

Renji Hospital

Ying Zhu

China Pharmaceutical University

Xinqiang Wang

Xi'an Technological University

Bo Yu

Hong Kong Polytechnic University

Yuanfu Chen

National Engineering Research Center of Electromagnetic Radiation Control Materials

Yuguo Li

University of Hong Kong

Junxia Geng

Chinese Academy of Sciences

Dongxu Yang

Shanghai First Maternity and Infant Hospital

Jinxue Guo

Qingdao University of Science and Technology

Cooperative Institutions

Chinese Academy of Sciences

109

University of Chinese Academy of Sciences

Shanghai Institute of Applied Physics

University of Electronic Science and Technology of China

National Engineering Research Center of Electromagnetic Radiation Control Materials

Shanghai Jiao Tong University

Sichuan University

University of Science and Technology of China

Zhejiang University

Chengdu University

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The Different Bio-Effects of Functionalized Multi-Walled Carbon Nanotubes on tetrahymena pyriformis

Current Nanoscience (2008)

Jinxue Guo Xiao Zhang Shusheng Zhang Ying Zhu Wenxin Li

To promote the applications of namomaterials, the potential toxicity of multi-walled carbon nanotubes (MWCNTs) and their derivates to environment have been studied. With γ-ray irradiation, MWCNTs were modified chemically with glucosamine and decylamine to obtain glucosamine-MWCNTs (g-MWCNTs) and decylamine-MWCNTs (d-MWCNTs). Their toxicological experiments were carried out with Tetrahymena pyriformis. The results illustrate that d-MWCNTs show a dose-dependent growth inhibition to the cells, due to the increasing concentration of toxic decylamine. This was attributed to the biological function performed by the decylamine after it was carried into the cell interior by the tubes. The results have a certain reference value for the applications of MWCNTs used as drug delivery system. Both glucosamine and purified MWCNTs (p-MWCNTs) alone show little biological activity, but g-MWCNTs exhibit a dose-dependent growth stimulation. This is due to the fact that the increasing hydrophilicity of g-MWCNTs promotes the conjugation of nanotubes with soluble peptone in culture medium via noncovalent binding. Uptake of the g-MWCNTs-peptone conjugates with various concentration of peptone by the cells is responsible for the dose-dependent growth stimulation. Consequently we propose the effects of concentration of functional groups, hydrophilicity of functionalized nanotubes as well as sequential nonspecific interaction between nanotubes with some components in culture medium on living system should be taken into account in the study of cytotoxicity of carbon nanotubes. Keywords: Carbon nanotubes, chemical modification, bio-effects, tetrahymena pyriformi

Tetrahymena pyriformis

Growth inhibition

10.2174/157341308785161145

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Citations (8)

The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems

Theranostics (2012)

Ying Zhu Jing Li Wenxin Li Yu Zhang Xiafeng Yang

Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and more attention in biomedicine recently due to their excellent physical and chemical properties. This paper summarizes the main results from the in vitro and in vivo safety assessments of NDs and reports the application of NDs in the development of drug delivery systems. In view of the NDs' characteristics of easy formation of a porous cluster structure in solution, an adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging.

Biocompatibility

10.7150/thno.3627

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Citations (363)

Vertical V-Doped CoP Nanowall Arrays as a Highly Efficient and Stable Electrocatalyst for the Hydrogen Evolution Reaction at all pH Values

ACS Applied Energy Materials (2019)

Xinqiang Wang Yuanfu Chen Jiarui He Bo Yu Bin Wang

Developing low-cost and high-efficiency electrocatalysts toward hydrogen evolution reaction (HER) in a wide pH range is still challenging. Herein, a three-dimensional (3D) porous nanoarchitecture, constructed by vertical V-doped CoP nanowall arrays (V-CPNA), has been grown on carbon cloth (CC) via a simple liquid-reaction approach and subsequent phosphorization. As a binder-free electrocatalyst, the V-CPNA/CC exhibits outstanding HER activity in the entire pH range. Particularly, it shows ultralow overpotentials of 87, 93, and 98 mV at 10 mA cm–2 in alkaline, acidic, and neutral media, respectively. Moreover, it delivers outstanding electrochemical durability with no degradation up to 60 h at all pH values. Such excellent electrocatalytic performance is mainly attributed to the synergistic effect between V and Co atoms. In addition, the unique 3D nanostructure of V-doped CoP nanowall arrays can promote the diffusions of H2 gas and the access of electrolytes, thus boosting the HER performance. This work presents a facile strategy to synthesize 3D porous heteroatom-doped metal phosphides as highly effective and stable pH-universal catalysts for HER.

Heteroatom

10.1021/acsaem.9b02075

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Citations (46)

Exploring the Dual Characteristics of CH3OH Adsorption to Metal Atomic Structures on Si (111)-7 × 7 Surface

Molecules (2021)

Wenxin Li Jiawen Wang Wanyu Ding Youping Gong Huipeng Chen

Metal atoms were deposited on an Si (111)-7 × 7 surface, and they were adsorbed with alcohol gases (CH

10.3390/molecules26195824

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Citations (1)

Systematic Influence Induced by 3 nm Titanium Dioxide Following Intratracheal Instillation of Mice

Journal of Nanoscience and Nanotechnology (2010)

Yufeng Li Jungang Li Jilei Yin Wenxin Li Cheng Kang

This work reported the systematic influence of titanium dioxide nanoparticles (TiO2 NPs) with a diameter of 3 nm on mice. Mice were repeated intratracheally instilled with TiO2 NPs, once per-week for 4 consecutive weeks, at total dose of 13.2 mg/kg. At 28 days post-instillation, the biochemical parameters in broncboalveolar lavage fluid (BALF) and brain homogenate as well as histopathologic changes of tissues were examined to describe the subacute toxicity of instilled TiO2 NPs. The results showed that instilled TiO2 NPs could induce lung damage, and change the permeability of alveolar-capillary barrier. The TiO2 NPs were able to get access to blood circulation and reach extrapulmonary tissues, then lead to injury at the different level, such as liver and kidney. Our results also indicated that TiO2 NPs might pass through the blood-brain barrier (BBB), and induce the brain injury through oxidative stress response.

Titanium Dioxide

Intratracheal instillation

10.1166/jnn.2010.2690

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Citations (81)

Study of release kinetics and degradation thermodynamics of ferric citrate liposomes

Chemistry and Physics of Lipids (2019)

Shan Wang Wenxin Li Kaiyue Sun Ru Zhang Shuping Wang

Endothermic process

Zeta potential

10.1016/j.chemphyslip.2019.104811

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Citations (18)

Modification of water-soluble MWNTs after γ-irradiation

Journal of Radiation Research and Radiation Processing (2006)

Wenxin Li

Water-soluble multi-walled carbon nanotubes (MWNTs) were obtained by functionalizing MWNTs with glucosamine after γ-ray irradiation. Products after each chemical treatment were characterized by FTIR and RAMAN spectroscopy. Elemental and TGA analyses of the modified MWNTs indicated that the concentration of functional groups bound on MWNTs increased with irradiation dose, due to increased defects of the MWNTs induced by γ-irradiation. Water solubility of MWNTs modified with glucosamine after irradiation enhanced considerably. The results provide a novel access for functionalizations and applications of carbon nanotubes.

Chemical modification

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Study on microbiologically influenced corrosion of HSLA-65 steel

Journal of Materials Research and Technology (2024)

M. Saleem Khan Xianbo Shi Shengfu Yuan Fujian Guo Wenxin Li

In the current study, the corrosion behavior of HSLA-65 steel was investigated in a simulated marine environment inoculated with P. aeruginosa. In the electrochemical measurements, the negative shift in OCP, lower values of corrosion potential, pitting potential, and increased corrosion current density of the HSLA-65 steel in the biotic medium signified its low corrosion resistance in the presence of P. aeruginosa. The observation of the surface morphology revealed biofilm formation on the steel surface in the P. aeruginosa-inoculated culture medium, which significantly accelerated the pitting corrosion of the steel. The pit observed on the steel surface in the biotic medium was about 3.9 times deeper than in the sterile medium. In addition, the weight loss of the steel in the biotic medium was about 2.4 times higher compared to that in the sterile medium. These findings suggest that the P. aeruginosa biofilm significantly accelerated the corrosion of HSLA-65 steel in the simulated marine environment.

10.1016/j.jmrt.2024.08.064

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The radioprotection of fullerenols against the stylonychia mytilus exposed to γ-rays

Journal of Radiation Research and Radiation Processing (2004)

Wenxin Li

Groups of Stylonychia mytilus were exposed to Co γ?rays for 1.5h and irradiated to 100, 300, 500, 60 800, 1200 and 1500Gy, respectively. On the fifth day after the irradiation, surviving fractions of the irradiated groups were about 47%、18%、16%、8%、5% and 3%, respectively, with the increasing the doses. . Based on the observation, radioprotection of fullerenols to Stylonychia mytilus groups exposed to Co γ?rays was studied. The results showed 60 that the surviving fractions of the Stylonychia mytilus in fullerenols solutions increased significantly in either the high dose groups and the low dose groups, in comparison to the control group. It was also found that the radioprotection was related to concentration of the fullerenols. The study indicated that fullerenols, as a potential radioprotection medicine, could scavenge free radical and reduce damage of the cells from γ?ray radiation.

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The GMCPHD Filter for Irregular Group Target Spawning Based on Star-Convex RHMs

2022 IEEE Radar Conference (RadarConf22) (2023)

Yue Liu Wenxin Li Haiyi Mao Cong Peng Wei Yi

Target spawning and extended shape estimation are important problems in group target tracking. In this paper, we propose a Gaussian mixture cardinalized probability hypothesis density (GMCPHD) filter for group targets with spawning and irregular shape based on star-convex Random Hypersurface Model (RHM). In order to solve the problem of irregular group shape, we use star-convex RHM to describe the distribution of measurement sources. Besides, we use the distance division method to realize the division of measurement sets and the judgment of group splitting. On this basis, the real-time tracking of the motion state and extended shape is realized under the framework of GMCPHD. The performance of this algorithm is showcased by comparison with the elliptical RHM-based GMCPHD filter, and the results show that the proposed algorithm can improve the estimation accuracy of group shape and motion state effectively.

Tracking (education)

Star (game theory)

Basis (linear algebra)

10.1109/radarconf2351548.2023.10149561

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Citations (1)