Bin Liu

Harbin Engineering University

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Jun Lin

Changchun Institute of Applied Chemistry

Piaoping Yang

Harbin Engineering University

Shili Gai

Harbin Engineering University

Ping’an Ma

Changchun Institute of Applied Chemistry

Lili Feng

Harbin Engineering University

Fei He

Hainan Medical University

Meng Yuan

Changchun Institute of Applied Chemistry

Ruoxi Zhao

Harbin Engineering University

Shuming Dong

Harbin Engineering University

Dan Yang

Harbin Engineering University

Cooperative Institutions

Chinese Academy of Sciences

253

University of Chinese Academy of Sciences

132

University of Science and Technology of China

109

Harbin Engineering University

Changchun Institute of Applied Chemistry

Harbin University

Jilin University

Zhejiang University

Shanghai Jiao Tong University

Harbin Institute of Technology

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A novel spin trap for targeting sulfhydryl-containing polypeptides

Chemical Communications (2005)

Yang Ping Liu Yi Ji Yu Song Ke Jian Liu Bin Liu

A novel spin trap containing an iodoacetamide group has been synthesized and then used to target polypeptides, i.e. glutathione and bovine serum albumin, by which the resulting covalently bonded bioconjugates exhibit great potential for the application of spin trapping of transient radicals in biological systems.

Iodoacetamide

Spin trapping

Trap (plumbing)

Bovine serum albumin

10.1039/b509903j

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Citations (9)

Multifunctional Bi NSs@BSA Nanoplatform Guided by CT Imaging for Effective Photothermal Therapy

Langmuir (2022)

Xiaolei Zhang Bin Liu Yao Shu Zongming Liu Jinkai Li

Photothermal therapy (PTT) has attracted great attention as an anticancer treatment strategy. With the rapid development of nanomedicine, multifunctional inorganic nanophotothermal agents provide a new way to improve the effect of PTT. Herein, bovine serum albumin (BSA)-modified Bi nanosheets (Bi NSs) with good biocompatibility were synthesized by a facile redox and ball milling method and applied as a photothermal agent for the enhancement of PTT. Owing to the strong near-infrared absorption, Bi NSs exhibit high photothermal conversion efficiency (η = 36.17%) under 808 nm laser irradiation and can serve as a nanotherapeutic agent for cancer therapy. In addition, in vitro cell safety analysis also suggests that the toxicity of BSA-modified Bi NSs is negligible. Upon 808 nm irradiation, the uptake ability of tumor cells to Bi NSs@BSA has been improved. Moreover, Bi NSs@BSA also can be used as a good contrast agent for CT imaging and then to observe the distribution of materials in the tumor site. Finally, Bi NSs@BSA-mediated PTT results show a high ablation rate of A549 tumor cells both in vitro and in vivo. All results reveal that Bi NSs@BSA is a promising nanotherapeutic platform for PTT.

Bovine serum albumin

Biocompatibility

10.1021/acs.langmuir.2c02474

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Citations (3)

Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Advanced Materials (2021)

Shuang Liang Xiao Xiao Lixin Bai Bin Liu Meng Yuan

Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, a defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect is simply constructed and used for enhanced SDT. Compared with the commonly used sonosensitizer TiO 2 , D‐MOF(Ti) results in a superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves the US‐triggered electron–hole separation. Meanwhile, due to the existence of Ti 3+ ions, D‐MOF(Ti) also exhibits a high level of Fenton‐like activity to enable chemodynamic therapy. Particularly, US as the excitation source of SDT can simultaneously enhance the Fenton‐like reaction to achieve remarkably synergistic outcomes for oncotherapy. More importantly, D‐MOF(Ti) can be degraded and metabolized out of the body after completion of its therapeutic functions without off‐target toxicity. Overall, this work identifies a novel Ti‐familial sonosensitizer harboring great potential for synergistic sonodynamic and chemodynamic cancer therapy.

Sonodynamic therapy

Biocompatible material

Cancer Therapy

10.1002/adma.202100333

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Citations (260)

Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

ACS Nano (2023)

Yanlin Zhu Ruoxi Zhao Lili Feng Chen Wang Shuming Dong

Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains a significant challenge to fabricate highly efficient nanozymes acting in the tumor microenvironment. Herein, we develop a bimetallic nanozyme (Pt50Sn50) with the photothermal enhancement of dual enzymatic activities for tumor catalytic therapy. The structures and activities of PtSn bimetallic nanoclusters (BNCs) with different Sn content are explored and evaluated systematically. Experimental comparisons show that the Pt50Sn50 BNCs exhibit the highest activities among all those investigated, including enzymatic activity and photothermal property, due to the generation of SnO2–x with oxygen vacancy (Ovac) sites on the surface of Pt50Sn50 BNCs. Specifically, the Pt50Sn50 BNCs exhibit photothermal-enhanced peroxidase-like and catalase-like activities, as well as a significantly enhanced anticancer efficacy in both multicellular tumor spheroids and in vivo experiments. Due to the high X-ray attenuation coefficient and excellent light absorption property, the Pt50Sn50 BNCs also show dual-mode imaging capacity of computed tomography and photoacoustic imaging, which could achieve in vivo real-time monitoring of the therapeutic process. Therefore, this work will advance the development of noble-metal nanozymes with optimal composition for efficient tumor catalytic therapy.

Bimetallic strip

Nanoclusters

Bimetal

10.1021/acsnano.3c00423

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Citations (89)

Tumor microenvironment pH-responsive pentagonal gold prism-based nanoplatform for multimodal imaging and combined therapy of castration-resistant prostate cancer

Acta Biomaterialia (2022)

Haisong Tan Yanlei Liu Nan Hou Shengsheng Cui Bin Liu

Cancer Imaging

Multimodal therapy

Prism

10.1016/j.actbio.2022.01.012

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Citations (31)

Syntheses, structures and properties of three selenoarsenates templated by transition metal complexes

Inorganic Chemistry Communications (2004)

Ming‐Lai Fu Guo‐Cong Guo Xi Liu Bin Liu Li‐Zhen Cai

Solvothermal synthesis

10.1016/j.inoche.2004.10.021

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Citations (115)

Defect‐Engineered Tin Disulfide Nanocarriers as “Precision‐Guided Projectile” for Intensive Synergistic Therapy

Small Methods (2024)

Yanlin Zhu Ruoxi Zhao Lili Feng Wenzhuo Wang Ying Xie

Abstract Nanoformulations with endogenous/exogenous stimulus‐responsive characteristics show great potential in tumor cell elimination with minimal adverse effects and high precision. Herein, an intelligent nanotheranostic platform (denoted as TPZ@Cu‐SnS 2‐x /PLL) for tumor microenvironment (TME) and near‐infrared light (NIR) activated tumor‐specific therapy is constructed. Copper (Cu) doping and the resulting sulfur vacancies can not only improve the response range of visible light but also improve the separation efficiency of photogenerated carriers and increase the carrier density, resulting in the ideal photothermal and photodynamic performance. Density functional theory calculations revealed that the introduction of Cu and resulting sulfur vacancies can induce electron redistribution, achieving favorable photogenerated electrons. After entering cells through endocytosis, the TPZ@Cu‐SnS 2‐x /PLL nanocomposites show the pH responsivity property for the release of the TPZ selectively within the acidic TME, and the released Cu 2+ can first interact with local glutathione (GSH) to deplete GSH with the production of Cu + . Subsequently, the Cu + ‐mediated Fenton‐like reaction can decompose local hydrogen peroxide into hydroxyl radicals, which can also be promoted by hyperthermia derived from the photothermal effect for tumor cell apoptosis. The integration of photoacoustic/computed tomography imaging‐guided NIR phototherapy, TPZ‐induced chemotherapy, and GSH‐elimination/hyperthermia enhanced chemodynamic therapy results in synergistic therapeutic outcomes without obvious systemic toxicity in vivo.

Nanocarriers

10.1002/smtd.202400125

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Citations (9)

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

Nano Letters (2021)

Meng Yuan Shuang Liang Ying Zhou Xiao Xiao Bin Liu

The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice of sonodynamic therapy (SDT). In this work, hemoglobin (Hb) with natural metalloporphyrin was first shown to possess great potential as a sonosensitizer. Compared with traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four the porphyrin molecules were separated by four polypeptide chains. This effectively avoided the problem of low ROS quantum yield caused by the stacking of hydrophobic porphyrins. Meanwhile, Hb is an efficient and safe oxygen carrier that may release O2 at hypoxic tumors site, which improved tumor oxygenation and subsequently enhanced SDT efficacy. Therefore, Hb was integrated with zeolitic imidazolate framework 8 (ZIF-8) to form a nanoplatform that demonstrated a potent suppression effect on deep-seated tumors under ultrasound irradiation.

Sonodynamic therapy

Biocompatibility

Imidazolate

10.1021/acs.nanolett.1c01220

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Citations (119)

Charge convertibility and near infrared photon co-enhanced cisplatin chemotherapy based on upconversion nanoplatform

Biomaterials (2017)

Jiating Xu Ye Kuang Ruichan Lv Piaoping Yang Chunxia Li

Biocompatibility

Photon Upconversion

10.1016/j.biomaterials.2017.03.041

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Citations (82)

2D Piezoelectric Bi₂MoO₆ Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

Advanced Materials (2021)

Yushan Dong Shuming Dong Bin Liu Cheng‐Hao Yu Jing Liu

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals of developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) are designed as piezoelectric sonosensitizers for glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, and the GSH‐activated BMO NRs (GBMO) exhibit an oxygen‐deficient structure, which can promote the separation of electron–hole pairs, thereby enhancing the efficiency of ROS production in SDT. The ultrathin GBMO NRs are piezoelectric, in which ultrasonic waves introduce mechanical strain to the nanoribbons, resulting in piezoelectric polarization and band tilting, thus accelerating toxic ROS production. The as‐synthesized BMO NRs enable excellent computed tomography imaging of tumors and significant tumor suppression in vitro and in vivo. A piezoelectric Bi 2 MoO 6 sonosensitizer‐mediated two‐step enhancement SDT process, which is activated by endogenous GSH and amplified by exogenous ultrasound, is proposed. This process not only provides new options for improving SDT but also broadens the application of 2D piezoelectric materials as sonosensitizers in SDT.

Sonodynamic therapy

10.1002/adma.202106838

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Citations (254)