Lei Liu

Shandong University

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i-10 index

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Shutao Sun

Ministry of Agriculture and Rural Affairs

Hong‐Xiang Lou

Shandong University

Yao Fu

CAS Key Laboratory of Urban Pollutant Conversion

Xigong Liu

Shandong University

Paul E. Floreancig

University of Pittsburgh

Bin Xiao

University of Science and Technology of China

Zhilin Meng

Shandong University

Zhiyu Xie

Guangzhou University of Chinese Medicine

Rui Wang

Lanzhou University

Qing‐Xiang Guo

Sichuan Agricultural University

Cooperative Institutions

Shandong University

169

Chinese Academy of Sciences

126

Sichuan University

Robert Bosch (Germany)

University of Chinese Academy of Sciences

University of Science and Technology of China

Zhejiang University

Laboratoire de Chimie Moléculaire et Thioorganique

Sun Yat-sen University

Zhejiang University of Technology

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Highly Enantioselective Catalytic Cross-Dehydrogenative Coupling ofN-Carbamoyl Tetrahydroisoquinolines and Terminal Alkynes

Organic Letters (2015)

Shutao Sun Chengkun Li Paul E. Floreancig Hong‐Xiang Lou Lei Liu

The first catalytic asymmetric cross-dehydrogenative coupling of cyclic carbamates and terminal alkynes has been established. The reaction features high enantiocontrol and excellent functional group tolerance and displays a wide range of structurally and electronically diverse carbamates as well as terminal alkynes. N-Acyl hemiaminals were identified as the reactive intermediates through preliminary control experiments. Employing readily removable carbamates as substrates rather than traditionally adopted N-aryl amines allows applications in complex molecule synthesis and therefore advances the C–H functionalization strategy to a synthetically useful level.

Functional group

Surface Modification

10.1021/acs.orglett.5b00447

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Citations (143)

Structurally Diverse α-Substituted Benzopyran Synthesis through a Practical Metal-Free C(sp³)–H Functionalization

Organic Letters (2014)

Wenfang Chen Zhiyu Xie Hongbo Zheng Hong‐Xiang Lou Lei Liu

A trityl ion-mediated practical C–H functionalization of a variety of benzopyrans with a wide range of nucleophiles (organoboranes and C–H molecules) at ambient temperature has been disclosed. The metal-free reaction has an excellent functional group tolerance and high chemoselectivity and displays a broad scope with respect to both benzopyran and nucleophile partners, efficiently affording a collection of benzopyrans bearing diverse skeletons and α-functionalities in one step.

Surface Modification

Benzopyrans

10.1021/ol503004a

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Citations (78)

Cross-dehydrogenative coupling enables enantioselective access to CF₃-substituted all-carbon quaternary stereocenters

Chemical Science (2020)

Xiaoguang Pan Zehua Wang Linglong Kan Ying Mao Yasheng Zhu

A cross-dehydrogenative coupling strategy for enantioselective access to acyclic CF

Stereocenter

Quaternary carbon

Carbon fibers

10.1039/c9sc05894j

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Citations (42)

Copper‐Catalyzed[3 + 2 + 1] Cycloaddition of Alkenes with Benzoquinones and Dicarbonyl Compounds via Tandem Oxidative Dicarbofunctionalization/Cyclization Sequence

Chinese Journal of Chemistry (2022)

Tianxing Du Song Li Yunfei He Huan Long Xigong Liu

Comprehensive Summary Developed is an efficient three‐component [3 + 2 + 1] cycloaddition of simple alkenes with two C—H substrates via oxidative dicarbofunctionalization/cyclization sequence. The copper‐catalyzed reaction involves the formation of two C—C bonds and one C—O bond through the cleavage of three C—H bonds in a single operation. The method has an excellent functional group tolerance, and features a broad substrate scope, affording a variety of functionalized chromenes in good yields.

Tandem

Oxidative cleavage

Cleavage (geology)

Functional group

Bond cleavage

Sequence (biology)

10.1002/cjoc.202200113

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Citations (8)

ChemInform Abstract: Palladium‐Catalyzed Decarboxylative Coupling of Potassium Nitrophenyl Acetates with Aryl Halides.

ChemInform (2011)

Rui Shang Zheng Huang Ling Chu Yao Fu Lei Liu

Abstract A wide range of aryl and hetaryl halides is successfully converted to 1,1‐diarylmethane structures.

Decarboxylation

10.1002/chin.201151078

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Citations (0)

Catalytic Asymmetric Synthesis of β,γ-Alkynyl α-Amino Esters via Chemo- and Enantio-selective Transfer Hydrogenation

Chinese Journal of Organic Chemistry (2020)

Lu Zhang Aiqin Liu Huazheng Liu Renzhong Wan Shutao Sun

报道了一个通过β,γ-炔基α-亚胺酸酯的化学和对映选择性转移氢化反应来合成光学纯β,γ-炔基α-氨基酸酯的方法.该不对称还原反应所展示出的优秀的化学选择性是由手性磷酸作为催化剂以及苯并噻唑啉作为氢负供体实现的.反应展示出了良好的官能团兼容性,高对映选择性地合成了一系列光学活性的非天然氨基酸酯化合物.

Transfer hydrogenation

10.6023/cjoc202005037

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Citations (2)

Convergent and Stereospecific Synthesis of Highly Substituted Azepines

Organic Letters (2024)

Yi Tian Lei Liu Tu Zeng Xingcan Zhang Baosheng Li

This study reported a convergent pattern to stereospecifically synthesize 4,5-dihydrogen azepine from simple and readily available starting materials, addressing synthetic and stereoselective issues. Several synthetically important transformations, such as Simmon-Smith cyclopropanation, halogenation, and hydrogenation, demonstrated the utilities of this strategy. Particularly, the final azepine products could effectively contract into highly substituted pyridine derivatives through an intramolecular oxidation rearrangement.

Stereospecificity

10.1021/acs.orglett.4c03053

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Citations (2)

ChemInform Abstract: Practical and Highly Selective C—H Functionalization of Structurally Diverse Ethers.

ChemInform (2015)

Miao Wan Zhilin Meng Hong‐Xiang Lou Lei Liu

Abstract Alkynylations, arylations and alkenylations of a broad variety of substrates (including cyclic and acyclic ethers and various heterocyclic substrates) are achieved.

Surface Modification

10.1002/chin.201519066

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Citations (0)

Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo‐ and Enantioselective Oxidative 1,6‐Conjugate Addition

Angewandte Chemie International Edition (2021)

Xigong Liu Changyin Zhao Rongxiu Zhu Lei Liu

Abstract The asymmetric construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. We disclose a solution involving diastereo‐ and enantioselective oxidative 1,6‐conjugate addition. The practical asymmetric cross‐dehydrogenative coupling of 2,2‐diarylacetonitriles and diverse α‐substituted cyclic 1,3‐dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach is further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β‐ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo‐ and enantioselectivity.

Stereocenter

Vicinal

Conjugate

Moiety

Quaternary carbon

10.1002/anie.202105594

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Citations (39)

[3+2] Cycloaddition Reactions of Cyclopropyl Imines with Enones

Organic Letters (2007)

Lei Liu John Montgomery

A nickel-catalyzed [3+2] cycloaddition of cyclopropyl aldimines and enones has been developed. The process provides direct access to trisubstituted cyclopentanes, and the scope exceeds that of the corresponding reactions involving cyclopropyl ketones. A basis for the improved performance of cyclopropyl aldimines compared with cyclopropyl ketones is provided.

Aldimine

Cyclopentanes

10.1021/ol071376l

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Citations (61)