Hao Li

Shandong Tumor Hospital

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i-10 index

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Jiangang Liu

Xiyuan Hospital

Lina Ma

Chinese Academy of Medical Sciences & Peking Union Medical College

Nanyang Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Hui Pei

Xiyuan Hospital

Yu Cao

Chinese Academy of Medical Sciences & Peking Union Medical College

Wensheng Qi

Chinese Academy of Medical Sciences & Peking Union Medical College

Luqi Huang

Chinese Academy of Medical Sciences & Peking Union Medical College

Yun Wei

Xiyuan Hospital

Meixia Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhixu Yang

Purdue University West Lafayette

Cooperative Institutions

University of California, Los Angeles

267

Chinese Academy of Medical Sciences & Peking Union Medical College

255

Chinese Academy of Sciences

180

Capital Medical University

157

Shanghai Jiao Tong University

122

Sun Yat-sen University

112

Huazhong University of Science and Technology

101

Sichuan University

Peking University

University of Chinese Academy of Sciences

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Effect of Huannao Yicong Prescription (还脑益聪方) extract on β-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse

Chinese Journal of Integrative Medicine (2012)

Hao Li Mingfang Liu Jiangang Liu Longtao Liu Jie Guan

10.1007/s11655-012-1204-x

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Citations (6)

Safety and Effectiveness of Nustim System Implantation in Dogs

Bladder (2022)

Xing Li Han Deng Zhaoxia Wang Hao Li Limin Liao

Objectives: To verify the safety and effectiveness of a novel micro-implantable wireless nerve stimulation device in healthy adult beagles and evaluate the feasibility of using the device in clinical practice. Methods: The stimulator was experimentally implanted into the quadriceps femoris of three adult beagles. The animals were subjected to training on daily basis for 14 days, and the threshold test was administered once a week. At the end, we analyzed the images of light microscopy and electron microscopy. Results: The implantation was easy to perform and the whole stimulation system worked stably and reliably. The stim-ulation threshold was stable. During the process, the stimulator did not move or cause damage to adjacent tissues. The whole system showed a good biocompatibility with recipient animals. The stimulator could induce muscular contraction and enhance the motor function of muscles. Conclusions: The preliminary results showed that the stimulator could be safely implanted into animal body, with good tissue compatibility, stability and reliability. In addition, it also worked well in eliciting muscle contraction. It promises to be used for the treatment of stress urinary incontinence in future.

10.14440/bladder.2022.844

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Citations (1)

Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells

Stem Cell Reports (2022)

Yanling Zhu Zhishuai Zhang Nana Fan Ke Huang Hao Li

Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extremely low efficiency. Here, we show that hPSCs failed to differentiate and contribute teratoma in the presence of mouse PSCs (mPSCs), while MYCN, a pro-growth factor, dramatically promotes hPSC contributions in teratoma co-formation by hPSCs/mPSCs. MYCN combined with BCL2 (M/B) greatly enhanced conventional hPSCs to integrate into pre-implantation embryos of different species, such as mice, rabbits, and pigs, and substantially contributed to mouse post-implantation chimera in embryonic and extra-embryonic tissues. Strikingly, M/B-hPSCs injected into pre-implantation Flk-1+/- mouse embryos show further enhanced chimerism that allows for obtaining live human CD34+ blood progenitor cells from chimeras through cell sorting. The chimera-derived human CD34+ cells further gave rise to various subtype blood cells in a typical colony-forming unit (CFU) assay. Thus, we provide proof of concept to obtain functional human cells through enhanced interspecies chimerism with hPSCs.

Chimera (genetics)

KOSR

10.1016/j.stemcr.2022.03.009

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Citations (8)

Role of alpha-fetoprotein in prognostic evaluation of patients with liver failure

临床肝胆病杂志 (2021)

Hong Wu Hao Li Shanhong Tang

China is a big country with liver diseases, and various hepatitis viruses, drug poisons, and alcohol can cause liver injury and even liver failure. The key to the prognosis of patients with liver failure is liver self-repair and regeneration. Alpha-fetoprotein (AFP) has been extensively studied as a tumor marker in liver cancer, but its role in liver regeneration in patients with liver failure awaits further studies. This article summarizes the basic research on AFP in liver regeneration and the clinical research on AFP in acute liver failure and acute-on-chronic liver failure (ACLF), as well as the previous research findings of our group that AFP is an important prognostic index and regeneration factor for liver regeneration after hepatitis B virus-related ACLF. The analysis shows that further studies on the role of AFP in the prognosis of various types of liver failure and the mechanism of liver regeneration will help deepen our understanding of AFP and liver regeneration, thereby providing new ideas and methods for the clinical diagnosis, treatment, and prognostic evaluation of patients with various types of liver failure.

Liver Regeneration

Liver Cancer

10.3969/j.issn.1001-5256.2021.11.048

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Capsaicin-Induced Activation of ERK1/2 and Its Involvement in GAP-43 Expression and CGRP Depletion in Organotypically Cultured DRG Neurons

Cellular and Molecular Neurobiology (2013)

Yunfeng Li Guixiang Liu Hao Li Youzheng Xu Hong Zhang

Dorsal root ganglion

Gap-43 protein

Capsaicin

10.1007/s10571-013-9909-8

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Citations (6)

Tanshinone IIA Delivery Silk Fibroin Scaffolds Significantly Enhance Articular Cartilage Defect Repairing via Promoting Cartilage Regeneration

ACS Applied Materials & Interfaces (2020)

Wei Chen Yong Xu Hao Li Yao Dai Guangdong Zhou

Cartilage tissue engineering is a promising approach for repairing articular cartilage defects and requires proper scaffolds and necessary growth factors. Herein, tanshinone IIA (TAN) delivery silk fibroin scaffolds were prepared for efficient cartilage defect repair by bioactivities of TAN. By incubating with the TAN delivery silk fibroin scaffold, the transcription of the chondrocytic activity-related genes was enhanced in chondrocytes, and it also can inhibit cell apoptosis and reduce the oxidative stress by regulating the transcription of related genes, indicating that these scaffolds may promote cartilage regeneration. TAN10 delivery silk fibroin scaffolds, in which the concentration of TAN is 10 μg/mL, significantly promotes chondrocytes to generate the cartilage-specific extracellular matrix and tissue both in vitro and in vivo, compared with silk fibroin scaffolds. By treating rabbit articular cartilage defects with TAN10 delivery silk fibroin scaffolds, cartilage defects were filled with hyaline-cartilage-like tissue that integrated with the surrounding cartilage perfectly and displayed strong mechanical properties and higher extracellular matrix content. Hence, TAN facilitates cartilage regeneration, and TAN delivery silk fibroin scaffolds can be potentially applied in the clinics treating cartilage defects in the future.

Fibroin

Hyaline cartilage

10.1021/acsami.0c03822

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Citations (47)

Liver X Receptor Activation Enhances Cholesterol Loss from the Brain, Decreases Neuroinflammation, and Increases Survival of the NPC1 Mouse

Journal of Neuroscience (2007)

Joyce J. Repa Hao Li Tamy C. Frank-Cannon Mark A. Valasek Stephen D. Turley

Although cholesterol is a major component of the CNS, there is little information on how or whether a change in sterol flux across the blood–brain barrier might alter neurodegeneration. In Niemann-Pick type C (NPC) disease, a mutation in NPC1 protein causes unesterified cholesterol to accumulate in the lysosomal compartment of every cell, including neurons and glia. Using the murine model of this disease, we used genetic and pharmacologic approaches in an attempt to alter cholesterol homeostasis across the CNS. Genetic deletion of the sterol transporters ATP-binding cassette transporter A1 (ABCA1) and low-density lipoprotein receptor in the NPC1 mouse did not affect sterol balance or longevity. However, deletion of the nuclear receptor, liver X receptor β (LXRβ), had an adverse effect on progression of the disease. We therefore tested the effects of increasing LXR activity by oral administration of a synthetic ligand for this transcription factor. Treatment with this LXR agonist increased cholesterol excretion out of brain from 17 to 49 μg per day, slowed neurodegeneration, and prolonged life. This agonist did not alter synthesis of cholesterol or expression of genes associated with the formation of 24( S )-hydroxycholesterol or neurosteroids such as CYP46A1, 3αHSD, and CYP11A1. However, levels of the sterol transporters ABCA1 and ATP-binding cassette transporter G1 were increased. Concomitantly, markers of neuroinflammation, CD14, MAC1, CD11c, and inducible nitric oxide synthase, were reduced, and microglia reverted from their amoeboid, active form to a ramified, resting configuration. Thus, LXR activation resulted in increased cholesterol excretion from the brain, decreased neuroinflammation, and deactivation of microglia to slow neurodegeneration and extend the lifespan of the NPC1 mouse.

Liver X receptor

NPC1

Reverse cholesterol transport

10.1523/jneurosci.4823-07.2007

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Citations (142)

Polymorphisms in the MTHRF, VDR, MMP-9 and IL-β Genes and the Risk of Premature Rupture of Membranes

Gynecologic and Obstetric Investigation (2010)

Xueqiang Fang Hao Li Yutao Diao Ruiqin Shan Juan Dong

Background: Premature rupture of membranes (PROM) occurs 2.5–3 times more often in premature births than in births that are full term, is accompanied by many complications for both the mother and fetus and can cause serious adverse consequences. Little is known about the genetic susceptibility of PROM. Objective: The purpose of this study was to evaluate the association between several genotypes and PROM in a high-risk hospital-based population. Methods: The cases were 206 pregnant women who had PROM in labor, and the controls were 287 pregnant women who did not have PROM in labor. All subjects were selected between July 2006 and July 2007 from the Maternal and Child Health Hospital in Jinan City. We genotyped the following genes: the MTHFR C677T, MMP-9 C1562T, VDR C352T and IL-1β C3593T genotypes. The associations between the genotypes and risk of PROM were analyzed. Results: The CC genotype at MTHFR C677T, combined with bacterial vaginosis, was associated with a significantly increased risk of PROM (odds ratio, OR: 3.55; 95% confidence interval, CI: 1.05–12.02). Compared to those in the stratum of 40 or more weeks of gestation, those in the stratum of 37 or less weeks of gestation had an increased risk of PROM (OR: 5.11, 95% CI: 2.0–13.05 for the TT/TC genotype of MTHFR C677T; OR: 5.31, 95% CI: 1.07–26.44 for the TC/TT genotype of MMP-9 C1562T, and OR: 6.08, 95% CI: 1.39–26.60 for the TT genotype of VDR C352T). Conclusion: The results indicated that an interaction exists between genetic and environmental factors that are related to the occurrence of PROM.

10.1159/000318867

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Citations (14)

Live combined bifidobacterium, lactobacillus and enterococcus capsules/powder in the treatment of ulcerative colitis: a metaanalysis

Zhongguo Shiyong Neike Zazhi (2016)

Hao Li Yongzhi Yang Yaozong Yuan Yang Yunsheng Huanlong Qin

Actinomycetaceae

Enterococcus faecalis

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Citations (3)

One-Year Objective and Functional Outcomes of De Novo Three-Level Reconstruction of Pelvic Organ Prolapse

SSRN Electronic Journal (2019)

Zhengchao Shen Caifen Guo Haiyuan Li Yin Chen Peng Gu

Background: The purpose of this study was to show 1-year outcomes of de novo three-level reconstruction of pelvic organ prolapse. Methods: Women with stage≧3 prolapse were assigned to de novo three-level reconstruction of pelvic organ prolapse. The primary outcome was prolapse stage ≤1 at 3, 6 months, and 1 year postoperatively. Secondary outcomes included quality of life and complications. Findings: All 78 evaluable participants were followed up for 1 year. Mean blood loss was 54±12ml (20~100ml) and mean operative time was 91±13 mins (62~158mins). Mean hospital stay was 4±0.6 day (3~7d). Compared with preoperative POP-Q points, statistically significant improvements in Aa, Ba, C, Ap, Bp, Gh, Pb and TVL were seen at the 3, 6-month, and 1-year time points (p < 0.0001). Statistically significant improvements were seen across all time points in the quality of life. 12 patients (12/78 15.4%) experienced prolapse by symptoms. 2 patients (2/78 2.6%) experienced stage II and III recurrences respectively. 8 patients felt thigh or groin mild pain, 4 patients had OAB, 3 patients had urgent urinary incontinence at 3-month follow up, but above complications were gradually in remission at 1-year follow up. There was no intra- or postoperative complications of urethra, bladder or rectum. There was no mesh exposure or blood transfusion. Interpretation: Objective and subjective improvement is seen after threelevel reconstruction of pelvic organ prolapse. The de novo surgery in clinical practice should lead to future randomized trials to assess the true value of this surgical approach in patients with pelvic organ prolapse. Funding Statement: Scientific Research Fund Project of Department of Education of Yunnan Province (2018JS208) and National Natural Science Foundation of China (81802548, 81860451).Declaration of Interests: The authors declare that they have no competing interests. Ethics Approval Statement: The First Affiliated Hospital of Kunming Medical University institutional review board approval was obtained for the study protocol. All women provided written informed consent to participate.

10.2139/ssrn.3369766

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