Yangyang Wang

Harbin Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Qiang Zhao

Huazhong University of Science and Technology

Long Li

Jining First People's Hospital

Jie Yan

Second Affiliated Hospital of Guangzhou Medical University

Yudong Su

Qinghai University

Jun Xiao

Zhejiang University

Jian Zheng

China Three Gorges University

Zhenyi Xue

Incyte (United States)

Peng Chen

Qingdao University

Jie Yin

Shanghai Jiao Tong University

Daowei Wang

University of Alberta

Cooperative Institutions

Chinese Academy of Sciences

Sun Yat-sen University

Zhengzhou University

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

University of Chinese Academy of Sciences

First Affiliated Hospital of Zhengzhou University

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer′s disease mice

Neural Regeneration Research (2016)

Peng Zhao Gaoshang Chai Yangyang Wang Amina Yasheng

Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β2-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β2-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease. To test this hypothesis, we investigated the effects and mechanisms of action of β2-adrenoceptor activation on neurogenesis and memory in amyloid precursor protein/presenilin 1 (APP/PS1) mice using the agonist clenbuterol (intraperitoneal injection, 2 mg/kg). We found that β2-adrenoceptor activation enhanced hippocampal neurogenesis, ameliorated memory deficits, and increased dendritic branching and the density of dendritic spines. These effects were associated with the upregulation of postsynaptic density 95, synapsin 1 and synaptophysin in APP/PS1 mice. Furthermore, β2-adrenoceptor activation decreased cerebral amyloid plaques by decreasing APP phosphorylation at Thr668. These findings suggest that β2-adrenoceptor activation enhances neurogenesis and ameliorates memory deficits in APP/PS1 mice.

Synaptophysin

Amyloid beta

10.4103/1673-5374.193241

Cite

Citations (48)

Supplementary Table from Anlotinib Induces a T Cell–Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD-1 Checkpoint Blockade in Neuroblastoma

Yudong Su Bingying Luo Yao Lü Daowei Wang Jie Yan

Supplementary Table from Anlotinib Induces a T Cell–Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD-1 Checkpoint Blockade in Neuroblastoma

Normalization

10.1158/1078-0432.22483731.v1

Cite

Citations (0)

Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation

Cell Reports (2023)

Eric Lowet Daniel J. Sheehan Ulises Chialva Rodrigo F. O. Pena Rebecca A. Mount

Hippocampal CA1 neurons generate single spikes and stereotyped bursts of spikes. However, it is unclear how individual neurons dynamically switch between these output modes and whether these two spiking outputs relay distinct information. We performed extracellular recordings in spatially navigating rats and cellular voltage imaging and optogenetics in awake mice. We found that spike bursts are preferentially linked to cellular and network theta rhythms (3-12 Hz) and encode an animal's position via theta phase precession, particularly as animals are entering a place field. In contrast, single spikes exhibit additional coupling to gamma rhythms (30-100 Hz), particularly as animals leave a place field. Biophysical modeling suggests that intracellular properties alone are sufficient to explain the observed input frequency-dependent spike coding. Thus, hippocampal neurons regulate the generation of bursts and single spikes according to frequency-specific network and intracellular dynamics, suggesting that these spiking modes perform distinct computations to support spatial behavior.

10.1016/j.celrep.2023.112906

Cite

Citations (10)

The Role of Oligodendrocyte Progenitor Cells Depolarization in the Activation of Na+-Ca2+ Exchanger in the Effect of Sevoflurane on Myelination

SSRN Electronic Journal (2022)

Ningning Li Ruilou Zhu Shuang Zeng Yangyang Wang Yi Yang

Aims: This study has been designed to investigated the role of oligodendrocyte progenitor cells (OPC) depolarization in the activation of Na+-Ca2+ exchanger (NCX) in the effect of sevoflurane on myelination.Main methods: Seven-day-old mice were exposed to 3% sevoflurane for 2-h per day on postnatal days 7,8,9. The proliferation, differentiation and myelin sheath of OPC were observed by Immunofluorescence, Quantitative real-time polymerase chain reaction (QRT-PCR) and Transmission electron microscopy (TEM) at different time points. Open field test, Y-maze test and New object recognition test were used to detect spatial learning and memory. Using siRNA knockdown NCX1 in human OPC (HOPC) before sevoflurane exposure, Transwell migration assay was used to detect cell migration ability, and Fluo 4-AM was used to detect intracellular calcium concentration.Key findings: Pretreatment with NCX inhibitor attenuated the proliferation and differentiation of OPC induced by sevoflurane, also ,showed a remarkable increase in platelet-derived growth factor receptor-alpha(PDGFRα)、Mast Cell Chymase(CC1)、2, 3-cyclic nucleotide 3-phosphodiesterase(CNPase)、oligodendrocyte transcription factor 1(Olig1)、oligodendrocyte transcription factor 2(Olig2) and homeodomain protein NK2 homeobox 2(NKX2.2) level. Pretreatment with NCX inhibitor alleviated sevoflurane-induced myelination disorder and cognitive impairment. Sevoflurane plus siRNA-NCX1 group could reverse the decrease of cell migration and increase of intracellular Ca2+ concentration in sevoflurane plus siRNA-NC group.Significance: This study suggests that repeated sevoflurane exposure in newborn mice leads to depolarization of OPC, which leads to Ca2+ influx through NCX and affects OPC proliferation, migration, differentiation and myelination, ultimately leading to cognitive impairment.

Progenitor

10.2139/ssrn.4184298

Cite

Citations (0)

Electrical stimulation alters cellular signaling in addition to membrane voltage in the mammalian brain

Brain stimulation (2025)

Hua-an Tseng Yangyang Wang Sheng Xiao Emma P. Bortz Yuxin Zhou

10.1016/j.brs.2024.12.755

Cite

Citations (0)

Intelligent Voltage Control Method in Active Distribution Networks Based on Averaged Weighted Double Deep Q-network Algorithm

Journal of Modern Power Systems and Clean Energy (2023)

Yangyang Wang Meiqin Mao Liuchen Chang Nikos Hatziargyriou

High penetration of distributed renewable energy sources and electric vehicles (EVs) makes future active distribution network (ADN) highly variable. These characteristics put great challenges to traditional voltage control methods. Voltage control based on the deep Q-network (DQN) algorithm offers a potential solution to this problem because it possesses human-level control performance. However, the traditional DQN methods may produce overestimation of action reward values, resulting in degradation of obtained solutions. In this paper, an intelligent voltage control method based on averaged weighted double deep Q-network (AWDDQN) algorithm is proposed to overcome the shortcomings of overestimation of action reward values in DQN algorithm and underestimation of action reward values in double deep Q-network (DDQN) algorithm. Using the proposed method, the voltage control objective is incorporated into the designed action reward values and normalized to form a Markov decision process (MDP) model which is solved by the AWDDQN algorithm. The designed AWDDQN-based intelligent voltage control agent is trained offline and used as online intelligent dynamic voltage regulator for the ADN. The proposed voltage control method is validated using the IEEE 33-bus and 123-bus systems containing renewable energy sources and EVs, and compared with the DQN and DDQN algorithms based methods, and traditional mixed-integer nonlinear program based methods. The simulation results show that the proposed method has better convergence and less voltage volatility than the other ones.

10.35833/mpce.2022.000146

Cite

Citations (16)

Peripheral cutaneous synucleinopathy characteristics in genetic Parkinson’s disease

Frontiers in Neurology (2024)

Yanpeng Yuan Yangyang Wang Minglei Liu Haiyang Luo Xiaojing Liu

Background Cutaneous phosphorylated alpha-synuclein (p-α-syn) deposition is an important biomarker of idiopathic Parkinson’s disease (iPD). Recent studies have reported synucleinopathies in patients with common genetic forms of PD. Objective This study aimed to detect p-α-syn deposition characteristic in rare genetic PD patients with CHCHD2 or RAB39B mutations. Moreover, this study also aimed to describe peripheral alpha-synuclein prion-like activity in genetic PD patients, and acquire whether the cutaneous synucleinopathy characteristics of genetic PD are consistent with central neuropathologies. Methods We performed four skin biopsy samples from the distal leg (DL) and proximal neck (C7) of 161 participants, including four patients with CHCHD2 mutations, two patients with RAB39B mutations, 16 patients with PRKN mutations, 14 patients with LRRK2 mutations, five patients with GBA mutations, 100 iPD patients, and 20 healthy controls. We detected cutaneous synucleinopathies using immunofluorescence staining and a seeding amplification assay (SAA). A systematic literature review was also conducted, involving 64 skin biopsies and 205 autopsies of genetic PD patients with synucleinopathy. Results P-α-syn was deposited in the peripheral cutaneous nerves of PD patients with CHCHD2 , LRRK2 , or GBA mutations but not in those with RAB39B or PRKN mutations. There were no significant differences in the location or rate of α-syn-positive deposits between genetic PD and iPD patients. Peripheral cutaneous synucleinopathy appears to well represent brain synucleinopathy of genetic PD, especially autosomal dominant PD (AD-PD). Cutaneous α-synuclein SAA analysis of iPD and LRRK2 and GBA mutation patients revealed prion-like activity. Conclusion P-α-syn deposition in peripheral cutaneous nerves, detected using SAA and immunofluorescence staining, may serve as an accurate biomarker for genetic PD and iPD in the future.

Synucleinopathies

Skin biopsy

10.3389/fneur.2024.1404492

Cite

Citations (1)

Plasmonic biosensing based on non-noble-metal materials

Chinese Chemical Letters (2017)

Jianhua Zhou Yangyang Wang Li Zhang Xuemeng Li

Noble metal

10.1016/j.cclet.2017.09.003

Cite

Citations (23)

Is the threat of malignant melanoma in the UK still increasing? A comprehensive analysis of 30 years of historical data and Bayesian age-period-cohort model projections for 2030

European Journal of Cancer Prevention (2024)

Hao Chen Yangyang Wang

Malignant melanoma, a highly aggressive skin cancer, though less common, significantly contributes to cancer-related mortality. In the UK, it is of growing concern with an aging population, making it crucial to analyze historical trends and forecast future burdens. We used Joinpoint regression and age-period-cohort models to analyze trends in incidence, prevalence, and mortality of malignant melanoma in the UK from 1990 to 2021. Bayesian age-period-cohort model was applied to predict the disease burden for different age groups by 2030. From 1991 to 2021, melanoma incidence and prevalence in the UK exhibited distinct temporal patterns: a significant upward trend until 2015, particularly pronounced in individuals aged 60 and older, followed by a downward trend after 2015. By 2030, incidence and prevalence are projected to decrease, particularly in younger and middle-aged populations, with incidence expected to fall from 20.78/100 000 in 2020 to 11.90/100 000, and prevalence from 167.80/100 000 to 80.13/100 000. Mortality is also expected to decrease. However, high-risk groups, especially those aged 85 and above, are predicted to maintain higher incidence and prevalence rates. Despite a historical rise, melanoma incidence, prevalence, and mortality have declined since 2015 and are projected to continue declining through 2030. However, the elderly population remains at higher risk, underscoring the need for targeted public health interventions.

Cohort effect

10.1097/cej.0000000000000947

Cite

Citations (0)

Indirect co-culture of osteoblasts and endothelial cells in vitro based on a biomimetic 3D composite hydrogel scaffold to promote the proliferation and differentiation of osteoblasts

PLoS ONE (2024)

Cheng Li Guanghui Chen Yangyang Wang Wenwu Xu Minghui Hu

The field of orthopedics has long struggled with the challenge of repairing and regenerating bone defects, which involves a complex process of osteogenesis requiring coordinated interactions among different types of cells. The crucial role of endothelial cells and osteoblasts in bone vascularization and osteogenesis underscores the importance of their intimate interaction. However, efforts to bioengineer bone tissue have been impeded by the difficulty in establishing proper angiogenesis and osteogenesis in tissue structures. This study presents a novel approach to bone tissue engineering, involving a three-dimensional composite hydrogel scaffold composed of sodium alginate microspheres encapsulated in type I collagen. Using this scaffold, a three-dimensional indirect co-culture system was established for osteoblasts and endothelial cells to evaluate the osteogenic differentiation potential of osteoblasts. Results demonstrate that the non-contact co-culture system of endothelial cells and osteoblasts constructed by the composite hydrogel scaffold loaded with microspheres holds promise for bone tissue engineering. The innovative concept of an indirect co-culture system presents exciting prospects for conducting intercellular communication studies and offers a valuable in vitro tissue platform to investigate tissue regeneration.

Bone tissue

10.1371/journal.pone.0298689

Cite

Citations (3)