According to social cognitive theory, this study explored the relationship between intrapreneurship and opportunity recognition. We developed a moderated mediation model of creative self-efficacy as a mediator and support for innovation as a moderator linking intrapreneurship with opportunity recognition. Using a sample of 206 college students from Chinese universities, we found that intrapreneurship is positively related to opportunity recognition, and this relationship was mediated by creative self-efficacy. Our research further found that the effect of intrapreneurship on opportunity recognition was conditional on support for innovation. Finally, the theoretical and practical implications are discussed.
Background Obstructive sleep apnea syndrome (OSAS) is a major public health concern, which can predispose people to metabolic and cardiovascular diseases. It is an urgent problem in need of a reasonable biomarker in screening OSAS patients. The aim of this study is to determine the association between serum sphingosine-1-phosphate (S1P) concentrations with the presence and severity of OSAS. Methods The study included 111 obese subjects, who underwent nocturnal polysomnography (PSG) to assess eligibility for obesity surgery. Among them, 86 patients were diagnosed with OSAS, and the remaining 25 were enrolled as control cases. Serum S1P levels were detected with enzyme linked immunosorbent assay (ELISA). Demographic and clinical Information were collected and analyzed.Results There was a significant increase in serum S1P in OSAS patients compared with control subjects. Among OSAS patients, serum S1P level progressively decreased with severity of OSAS. Linear regression analyses revealed the strong negative association between serum S1P level with apnea-hypopnea index (AHI), and positive association between S1P level with lowest saturation oxygen (LSaO2). Furthermore, Receiver operating characteristic (ROC) curve test demonstrated that serum S1P showed a better predictive capacity for OSAS compared to Epworth Sleepiness Scale (ESS) and STOP scores in OSAS screening.Conclusion Serum S1P was significantly lower in OSAS patients when compared with control subjects and was negatively correlated with the severity of OSAS. Furthermore, Serum S1P also has a reasonable specificity, sensitivity and positive predictive value in the diagnosis of OSAS. Thus, serum S1P can be a potential diagnostic biomarker for OSAS.
Abstract It has been reported that hepatitis B virus (HBV) core protein (HBc) can inhibit the transcription of human interferon-induced MxA gene. In this study, we investigated whether HBc protein mutations at hot spots (L60V, S87G and I97L) could still inhibit MxA transcription and the potential significance of this inhibition in virus replication in vitro. Our data indicated that the IFN-induced MxA mRNA expression level and MxA promoter activity was significantly down-regulated by mutant protein of HBc(I97L), compared to WT and the other two mutated HBc proteins(L60V or S87G). However, in Huh7 cells stably expressing WT or the mutated HBc proteins (L60V, S87G or I97L), IFN-α could inhibit the extra- and intracellular HBV DNA level and HBsAg secretion to a similar level compared to that in cells transfected with control plasmids. In conclusion, HBc protein with I97L mutation may play an especial role in suppressing the transcription of MxA gene. Moreover, the inhibitory effect on MxA gene transcription by the WT or mutated HBc proteins (L60V, S87G and I97L) has no impact on inhibition of HBV replication by IFN-α in Huh7 cells. The clinical significance of the inhibitory effect of MxA gene transcription by HBc protein requires further study.
Cordyceps sinensis is a well-known traditional Chinese herb commonly used as a tonic drug for hundreds of years.It is mainly distributed in Asian high-altitude grasslands,growing parasitically on buried larvae of Lepidoptera.Hirsutella sinensis is the only anamorph of C.sinensis that has been supported by several reports especially at rDNA-ITS level.However,the rDNA-ITS sequences of C.sinensis available from the NCBI database are still significantly divergent,except for the apparently erroneous-accessioned sequences.Based on the GenBank sequences,a hypothesis of three cryptic species involved in C.sinensis species complex was proposed before.In order to examine this hypothesis,we carried out the experiment by designing specific primers for targeted rDNA-ITS sequences using the DNA sample from individual C.sinensis fruiting body.Specimens of C.sinensis were collected from Sichuan and Qinghai of China,respectively.Our results suggested that only the C.sinensis-group A is the authentic C.sinensis.The so-called C.sinensis-group B and C.sinensis-group C are most likely different fungal species rather than the cryptic species of C.sinensis.
Abstract Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic analysis reveal that IRE1α-XBP1s pathway activity is required for c-MYC signaling, one of the most highly activated oncogenic pathways in PCa. XBP1s is necessary for optimal c-MYC mRNA and protein expression, establishing, for the first time, a direct link between UPR and oncogene activation. In addition, an XBP1-specific gene expression signature is strongly associated with PCa prognosis. Our data establish IRE1α-XBP1s signaling as a central pathway in PCa and indicate that its targeting may offer novel treatment strategies.
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