Kui Wang

Qilu Hospital of Shandong University

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Feng Shen

Eastern Hepatobiliary Surgery Hospital

Yong Xia

Shanghai University

Zhenlin Yan

Eastern Hepatobiliary Surgery Hospital

Wan Yee Lau

Chinese University of Hong Kong

Mengchao Wu

Second Military Medical University

Xuying Wan

Second Military Medical University

Dong Wu

Fujian Medical University

Lehua Shi

Eastern Hepatobiliary Surgery Hospital

Jun Li

Sun Yat-sen University

Anfeng Si

Nanjing University

Cooperative Institutions

Second Military Medical University

147

Eastern Hepatobiliary Surgery Hospital

128

Sun Yat-sen University

Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Zhongshan Hospital

Nanjing Medical University

Fujian Medical University

Huazhong University of Science and Technology

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Risk factors and management for early and late intrahepatic recurrence of solitary hepatocellular carcinoma after curative resection

HPB (2014)

Zhangjun Cheng Pinghua Yang Shuping Qu Jiahua Zhou Jue Yang

10.1111/hpb.12367

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Citations (152)

Diagnosis and management of Barrett's oesophagus

BMJ (2010)

Janusz Jankowski Hugh Barr Kui Wang Brendan Delaney

#### Summary points Barrett’s oesophagus affects 2% of the adult population in the West, which makes it one of the most common premalignant lesions after colorectal polyps. Conversion to oesophageal adenocarcinoma is the most important complication of the condition, with a lifetime risk of 5% in men and 3% in women.1 2 3 4 Several large trials investigating surveillance (Barrett’s Oesophagus Surveillance Study (BOSS)), chemoprevention (the Aspirin Esomeprazole Chemoprevention Trial (AspECT)), genetic stratification (EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium), and endotherapy for high risk individuals are under way to determine the best way to prevent progression to adenocarcinoma. There are now several endoscopic alternatives to the long established technique of radical surgical oesophagectomy for treating high grade dysplasia and early mucosal cancer, which avoid the mortality and morbidity of surgery. Recently consensus on optimal management of the condition was reached after a National Institute of Health and Clinical Excellence (NICE) review. It …

Barrett's oesophagus

10.1136/bmj.c4551

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Citations (63)

Nomograms for survival prediction in patients undergoing liver resection for hepatitis B virus related early stage hepatocellular carcinoma

European Journal of Cancer (2016)

Jun Li Jian Zhou Pinghua Yang Yong Xia Ying‐Hong Shi

Nomogram

10.1016/j.ejca.2016.04.011

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Citations (46)

A wide-margin liver resection improves long-term outcomes for patients with HBV-related hepatocellular carcinoma with microvascular invasion

Surgery (2018)

Pinghua Yang Anfeng Si Jue Yang Zhangjun Cheng Kui Wang

Margin (machine learning)

Resection margin

10.1016/j.surg.2018.09.016

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Citations (83)

Erratum to “Sorafenib down-regulates c-IAP expression post-transcriptionally in hepatic carcinoma cells to suppress apoptosis” [Biochem. Biophys. Res. Commun. 418 (2012) 531–536]

Biochemical and Biophysical Research Communications (2012)

Xifeng Li Renyan Gong Meng Wang Zhenlin Yan Bo Yuan

Hepatic carcinoma

10.1016/j.bbrc.2012.03.042

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Citations (0)

Axl Expression Stratifies Patients with Poor Prognosis after Hepatectomy for Hepatocellular Carcinoma

PLoS ONE (2016)

Jian Liu Kui Wang Zhenlin Yan Yong Xia Jun Li

Background Axl is a receptor tyrosine kinase which plays an important role in multiple human malignancies. Design The Axl expression was examined in several hepatocellular carcinoma(HCC) cell lines, paired tumor and nontumorous samples. Then, we examined cell growth curve, cell apoptosis and cell migration in SMMC-7721 cells over-expressed with Axl or siRNA against Axl, respectively. Finally, the prognostic value of Axl was investigated in a prospective cohort of 246 consecutive HCC patients undergoing curative hepatoectomy. Results We found Axl was positive in 22% of examined tumor tissues and all four cell lines. Over-expressing Axl in SMMC-7721 cells accelerated cell growth, cell migration and inhibited cell apoptosis, while knock-down of Axl exerted opposite effect. Axl expression was closely associated with serum AFP, multiple tumors, absence of encapsulation, microvascular invasion, and advanced BCLC or TNM stage. Patients with positive Axl staining had a higher 5-year recurrence rate (92% vs. 71%, P<0.001) and a lower 5-year survival rate (9% vs. 48%, P<0.001) than those with negative staining. The multivariate analyses showed that Axl expression was an independent factor for both tumor recurrence (HR: 1.725; 95% CI: 1.219–2.441) and survival (1.847; 1.291–2.642). Conclusion Axl expression suggests more aggressive tumor invasiveness and predicts worse prognosis for HCC patients undergoing resection.

10.1371/journal.pone.0154767

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Citations (48)

LBA9 Final overall survival (OS) results of befotertinib in patients with pretreated EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer (NSCLC)

Annals of Oncology (2023)

Shun Lu Y. Zhang Guoqiang Zhang Jianying Zhou Shundong Cang

T790M

10.1016/j.annonc.2023.10.565

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Citations (0)

201P Perioperative pembrolizumab and lenvatinib for resectable hepatocellular carcinoma: Updated efficacy and safety results from the phase II NeoLEAP-HCC study

Annals of Oncology (2024)