Xiangyu Chen

Tianjin Medical University General Hospital

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Enhua Xiao

Second Xiangya Hospital of Central South University

Juan Chen

Chongqing Medical University

Ya Li

First Affiliated Hospital of Henan University

Tianlong Huang

Second Xiangya Hospital of Central South University

Qihua Wang

Tianjin Medical University General Hospital

Xuexue Hao

Tianjin Medical University General Hospital

Cong Ma

Huazhong University of Science and Technology

Xingsheng Hu

Chinese Academy of Medical Sciences & Peking Union Medical College

Congzhe Ren

Tianjin Medical University General Hospital

Quanliang Shang

Second Xiangya Hospital of Central South University

Cooperative Institutions

Central South University

Second Xiangya Hospital of Central South University

Xiangya Hospital Central South University

Tianjin Medical University General Hospital

Chongqing Medical University

Huazhong University of Science and Technology

First Affiliated Hospital of Chongqing Medical University

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Fujian Medical University

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Calibration of 24-Hour Urinary Sodium Excretion Estimates from Fasting Morning Urine in Chinese Populations: A Comparative Analysis of Two Calibration Models and A Locally Developed Model

American Journal of Clinical Nutrition (2024)

Xiaofu Du Jìng Guo Xiangyu Chen Jie Zhang Feng Lu

Spot urine collection offers a convenient alternative to the more cumbersome 24-h urine collection. However, the widely recognized estimation models, such as Tanaka and International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT), have not been adequately adapted for widespread use in the general Chinese population.

10.1016/j.ajcnut.2024.08.007

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Value for combination of T

PubMed (2023)

Junjiao Hu Meitao Liu Wei Zhao Ziyan Ding Fang Wu

With the increasing detection rate of lung nodules, the qualitative problem of lung nodules has become one of the key clinical issues. This study aims to evaluate the value of combining dynamic contrast-enhanced (DCE) MRI based on time-resolved imaging with interleaved stochastic trajectories-volume interpolated breath hold examination (TWIST-VIBE) with T

Dynamic contrast

Dynamic Contrast-Enhanced MRI

10.11817/j.issn.1672-7347.2023.220588

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Risk factors associated with acute respiratory distress syndrome in COVID-19 patients outside Wuhan: A double-center retrospective cohort study of 197 cases in Hunan, China

World Journal of Clinical Cases (2021)

Xingsheng Hu Chunhong Hu Ping Zhong Yajing Wen Xiangyu Chen

Risk factors associated with acute respiratory distress syndrome in COVID-19 patients outside Wuhan: A double-center retrospective cohort study of 197 cases in Hunan, China

2019-20 coronavirus outbreak

10.12998/wjcc.v9.i2.344

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Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature

Oncology Letters (2014)

Jing Ma Yongfang Jiang Xiangyu Chen Guozhong Gong

Langerhans cell histiocytosis (LCH) is a rare proliferative disorder in which pathological Langerhans cells accumulate in a variety of organs. LCH usually affects the bone, skin and lymph nodes of children; however, LCH occasionally affects vital organs, including the liver, spleen and pituitary gland. The present study reports a case of an adult LCH patient with marked liver damage, splenomegaly and pituitary damage treated using a new therapeutic strategy. This case was misdiagnosed as liver cancer and pituitary tumor on the basis of abdominal ultrasound, abdominal magnetic resonance imaging (MRI) and head MRI. The final diagnosis was established by identifying the proliferation of cluster of differentiation 1a-positive LCs in liver tissues. A new regimen of combined 12-week therapy of prednisolone/desmopressin/vincristine and 10 months of maintenance therapy of prednisolone/vinblastine/6-mercaptopurine improved symptoms, liver function and blood cell tests.

Langerhans Cell Histiocytosis

Prednisolone

10.3892/ol.2014.1928

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Citations (19)

Disturbances of phosphatidylcholines metabolism in major depressive disorder

CNS Spectrums (2023)

Yue Wang Xiangyu Chen Zhi Chen Heming Yu Yu Tian

Major depressive disorder (MDD) is a common neuropsychiatry disorder with high prevalence and recurrence rate, but the misdiagnosis rate is inevitable due to the shortage of objective laboratory-based diagnostic criteria. This study is focused on the disturbance of lipid metabolism, providing potential biomarkers for diagnosing.Lipid metabolism-related molecules in plasma of 42 drug-naïve MDD patients and 49 healthy people were measured by liquid chromatography-mass spectrometry. Further to evaluate the diagnostic values of changed metabolites, these molecules were evaluated by the receiver operating characteristic curve. Based on the significant role of phosphatidylcholine (PC) disturbance in depression, oxidization of PCs, oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC), IL-8 and caspase-3 in hippocampus, and serum of chronic lipopolysaccharide (cLPS) depression mice were detected by ELISA.Compared with healthy control, MDD patients expressed higher 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (16:0-16:0 PC, DPPC), 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (16:0-20:4 PC, PAPC), 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine (16:0-18:0 PC), glycocholic acid, taurocholic acid, glycoursodeoxycholic acid, and chenodeoxycholic acid glycine conjugate, and lower 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC 20:0). The 16:0-20:4 PC showed the great diagnostic value for MDD with an area under the curve (AUC) of 0.9519, and combination of 16:0 PC, 16:0-18:0 PC, and 16:0-20:4 PC exhibited the highest diagnostic value with AUC of 0.9602. OxPAPC was certified increase in hippocampus and serum of cLPS depression mice, which further supported PCs disorder participated in depression.This research offers 16:0-20:4 PC as the latent diagnostic indicator for MDD and hints the important role of PCs in depression.

Phosphocholine

Chenodeoxycholic acid

Glycocholic acid

Taurocholic acid

10.1017/s1092852923000020

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Multi-Feature Fusion Method Combining Brain Functional Connectivity and Graph Theory for Schizophrenia Classification and Neuroimaging Markers Screening

Journal of Psychiatric Research (2025)

Chang Wang Yaning Ren Rui Zhang Jiyuan Zhang Li Xiao

Dempster–Shafer theory

10.1016/j.jpsychires.2025.02.025

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Comparative efficacy of olaparib in combination with or without novel antiandrogens for treating metastatic castration-resistant prostate cancer

Frontiers in Endocrinology (2023)

Xiangyu Chen Yang Pan Qihua Wang Congzhe Ren Muwei Li

Background Studies using novel antiandrogens (NAA) in patients with metastatic castration-resistant prostate cancer (mCRPC) have shown overall survival benefit. As patients develop resistance to NAA therapy, the poly(ADP-ribose) polymerase inhibitor (PARPi) olaparib in combination with NAA may become a promising therapy. However the overall benefit of olaparib monotherapy or combination therapy still needs to be evaluated. Therefore, we performed a network meta-analysis to assess the efficacy and toxicity between olaparib, olaparib combined with abiraterone and NAA. Methods We searched PubMed, EMBASE, the Cochrane Library and American Society of Clinical Oncology (ASCO) University Meeting abstracts for randomized controlled trials reporting olaparib and NAA from 2010 up to March, 2023. Network meta-analysis using Stata 16.0 and R 4.4.2, hazard ratios (HR) with 95% confidence intervals (CI) were used to assess the results. Results Four trials reported olaparib, olaparib plus abiraterone and apalutamide plus abiraterone. radiographic progression-free survival (rPFS) was significantly lower in patients on apalutamide plus abiraterone compared to olaparib (HR, 1.43; 95% CI, 1.06-1.93). rPFS was similar for olaparib plus abiraterone and olaparib (HR, 1.35; 95% CI, 0.99-1.84); likewise, olaparib plus abiraterone and apalutamide plus abiraterone were similar (HR, 1.06; 95% CI, 0.83-1.35). In addition, there was no significant difference between the three interventions for OS. But olaparib has the highest probability of being a preferred treatment for improving rPFS and OS. Conclusion rPFS was in favor of olaparib compared with apalutamide plus abiraterone. But there were no difference between olaparib plus abiraterone and either olaparib or apalutamide plus abiraterone. Apalutamide plus abiraterone might be the most preferred intervention in cases where AEs are involved. Systematic review registration https://inplasy.com , identifier INPLASY2023100072.

Olaparib

Antiandrogens

PARP inhibitor

Enzalutamide

10.3389/fendo.2023.1225033

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Citations (2)

Alterations of neurotransmitters and related metabolites in the habenula from CUMS-susceptible and -resilient rats

Biochemical and Biophysical Research Communications (2020)

Yu Tian Zhonghao Wu Yue Wang Chong Chen Yong He

Pathogenesis

10.1016/j.bbrc.2020.11.065

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Association of serum 25-hydroxyvitamin D with urinary incontinence in elderly men: evidence based on NHANES 2007-2014

Frontiers in Endocrinology (2023)

Li Liu Mingming Xu Hang Zhou Xuexue Hao Xiangyu Chen

The correlation between serum 25-hydroxyvitamin D (25(OH)D) and different sub-types of urinary incontinence in elderly men continues to be uncertain. Hence, we performed this research to evaluate whether serum 25(OH)D levels are correlated with urinary incontinence among elderly men.The present study incorporated the male population aged 50 years and above from four cycles of the NHANES database spanning from 2007 to 2014, for the purpose of analysis. The assessment of urinary incontinence was carried out through a correlation questionnaire, while standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) was adopted to quantify serum 25(OH)D. A weighted multi-factorial logistic regression analysis was carried out to ascertain and investigate any potential correlation that may exist between serum 25(OH)D and urinary incontinence in senior males.Ultimately, a sum of 4663 elderly men were involved in our analysis. The outcomes of the univariable analysis illustrated that the group with vitamin D deficiency exhibited augmented odds of all three urinary incontinence types in comparison to the vitamin D-sufficient group. After accounting for age, race, and BMI, no appreciable variations in the outcomes were noticed. However, after accounting for all covariates, only SUI (OR = 1.677; 95% confidence interval (CI) = 1.074-2.618) and MUI (OR = 1.815; 95% confidence interval (CI) = 1.010-3.260) demonstrated statistical significance.Decreased serum 25(OH)D levels were connected with stress urinary incontinence and mixed urinary incontinence in elderly men.

10.3389/fendo.2023.1215666

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Citations (3)

The differences of clinical characteristics and outcomes between imported and local patients of COVID-19 in Hunan: A two-center retrospective study

Research Square (Research Square) (2020)

Chang Wang Lizhi Zhou Juan Chen Yong Yang Tianlong Huang

Abstract Background: The clinical characteristics and outcomes of 2019 novel coronavirus (COVID-19) pneumonia are different in Hubei and out of Hubei in China. But there are few comparative studies on the imported and local patients. Methods: We investigated 169 patients of COVID-19 pneumonia in two centers in Hunan Province, and divided into two groups according to epidemiology history, aiming to analyze the difference of clinical characteristics and outcomes in the two groups. All the epidemiological, clinical, imaging, and laboratory data were analyzed and contrasted. Results: The incidence of fever on admission in imported patients was significantly higher than local patients. The proportion of abnormal pulmonary signs was also significantly higher in imported patients. There was a significantly higher proportion of hypokelamia, hyponatremia in imported patients than that in local patients. Compared with local patients, the imported patients using antibiotics, glucocorticoids and gamma globulin were significantly higher. The moderate type was more common in local patients, and the severe type are more frequent in imported patients. In addition, the median duration of viral clearance was longer in imported patients. Conclusions: In summary, we found that imported patients more likely developed into severe patients than local patients and required more powerful treatments. Trial registration : We registered 21 March, 2020, and this study has been approved by the Medical Ethics Committee (Approved Number. 2020017).

10.21203/rs.3.rs-23247/v1

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