Ye Li

China Pharmaceutical University

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Co-Authors

Jian Zhou

North Sichuan Medical University

Zixiang Zhang

Soochow University

Dechun Li

Xuzhou Central Hospital

Dongming Zhu

Soochow University

Jian Yang

Soochow University

Ruo-Yun Chen

Chinese Academy of Medical Sciences & Peking Union Medical College

Bin Yi

Zhengzhou University

Luyu Yan

China National Environmental Monitoring Center

Dong-Hong Min

Northwest A&F University

Yi Zhang

Zhengzhou University

Cooperative Institutions

University of Adelaide

3,421

European Organization for Nuclear Research

1,189

A. Alikhanyan National Laboratory

741

Ludwig-Maximilians-Universität München

729

Universitatea Națională de Știință și Tehnologie Politehnica București

683

University of California, Santa Cruz

646

SR Research (Canada)

639

Federación Española de Enfermedades Raras

616

Centre National de la Recherche Scientifique

615

Atlas Scientific (United States)

594

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MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

Cold Spring Harbor Perspectives in Medicine (2014)

M. Gabay Ye Li Dean W. Felsher

Meital Gabay, Yulin Li and Dean W. Felsher Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, California 94305 Correspondence: dfelsher{at}stanford.edu

Senescence

10.1101/cshperspect.a014241

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Citations (732)

Determination of nine triterpenoid acids from Ganoderma lucidum of different producting areas by HPLC

China Journal of Chinese Materia Medica (2012)

Baoming Li Haifeng Gu Ye Li Chao Liu Hongqing Wang

To establish an HPLC method for determining nine triterpenes contained in Ganoderma lucidum.Chromatography conditions: Alltima C18 (4.6 mm x 150 mm, 5 microm) was adopted as the chromatographic column, with acetonitrile-0.04% formic acid solution as the mobile phase. The detective wavelength was set at 254 nm, and the column temperature was 15 degrees C.The linearities of ganoderic acid C2, ganoderic acid G, ganoderenic acid B, ganoderic acid B, ganoderenic acid A, ganoderic acid A, lucideric acid A, ganoderenic acid D, and ganoderic acid C1 ranged between 6.81-40.88, 6.38-38.25, 6.75-40.50, 6.38-38.25, 5.95-35.65, 5.90-35.25, 7.00-42.00, 6.20-37.15 and 6.05-36.4 mg x L(-1) (r = 0.999 4, 0.999 2, 0.999 4, 0.999 2, 0.999 2, 0.994 5, 0.999 0, 0.999 2 and 0.998 4). Their recoveries were 102.1%, 102.3%, 100.6%, 103.3%, 104.1%, 103.2%, 96.42%, 102.5% and 101.5%, with RSD being 1.5%, 0.96%, 1.9%, 1.3%, 1.7%, 2.5%, 0.62%, 2.9% and 1.3%. The content of triterpenes contained in G. lucidum samples from 31 different areas and under different cultivation conditions.The method is so feasible and highly reproducible that it can be used for quantitatie determination of the content of triterpenoid acid contained in G. lucidum.

Terpene

10.4268/cjcmm20122320

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A Novel Whole-Cell Biosensor for Bioavailable Antimonite in Water and Sediments

Applied and Environmental Microbiology (2023)

Lixin Zhang Ye Li Chuanyong Jing

Antimony (Sb) is a redox-sensitive pollutant ubiquitous in the environment. Sb(III) is dominant in the subsurface and is readily oxidized to less toxic Sb(V) upon exposure to air, and therefore, on-site Sb speciation analysis is essential to evaluate its bioavailability and toxicity.

Genetic algorithm

10.1128/aem.01817-22

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Citations (6)

Clinical analysis of 366 cases of upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs

China Practical Medicine (2010)

Ye Li

Objective To study the clinico-epidemiological features of the upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs.Methods 366 cases of upper gastrointestinal bleeding from Jan.2002 to Jan.2009 in The Sun Yat-sen Hospital of Sun Yat-sen University were investigated.Patients were divided into treated group(103 cases)and untreated group(263 cases)according to whether they had had NSAIDs in one week before admission.And the clinical data of the two groups of patients were analyzed.Results The treated group was older than the untreated group.Hemoglobin was significantly decreased in the treated group(P0.01).There were more gastric ulcer,complex ulcer and multiple ulcers in the treated group.The rate of Helicobacter Pylori(HP)Infection in treated group was obviously different from that in untreated group,which was 65.05%and 26.24%(P0.05).Conclusion The clinical characteristics of the upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs should be emphasized and we should reduce the adverse reactions to NSAIDs.

Upper Gastrointestinal Bleeding

Gastrointestinal bleeding

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Discussion about Cooperation Between Doctor and Nurse in Holistic Nursing

Ye Li

In holistic nursing, through strengthening the cooperation between doctor and nurse, establishing better doctor - nurse and nurse - patient relationship, we can transform functional nursing into patient - centred holistic nursing . We can improve the quality of nursing and nurses' vocational quality so that we can serve patients better.

Holistic nursing

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The combination of baseline neutrophil to lymphocyte ratio and dynamic changes during treatment can better predict the survival of osteosarcoma patients

Frontiers in Oncology (2023)

Longqing Li Ye Li Minxun Lu Yitian Wang Zhuangzhuang Li

Background Osteosarcoma is a primary malignant bone tumor with a high metastatic potential that accounts for a significant proportion of all bone tumors. The prognosis for patients with metastatic or recurrence disease remains poor. The neutrophil-to-lymphocyte ratio (NLR) has become a potential prognostic biomarker for cancer. Recent evidence suggests that the dynamic changes in neutrophil-to-lymphocyte ratio (NLR) during treatment may be more informative in predicting patient prognosis, but the value of dynamic NLR in osteosarcoma has not yet been determined. Methods This retrospective study retrospectively analyzed the clinical information of 251 osteosarcoma patients diagnosed and treated in West China Hospital of Sichuan University, explored the impact of baseline NLR and changes in NLR during treatment on the prognosis of osteosarcoma patients, and further combined baseline NLR with Delta NLR to build an NLR staging system. Results The results showed that both baseline NLR and delta NLR had some predictive ability for the prognosis of osteosarcoma patients (P = 6.90e-4, P = 0.022). Patients with high baseline NLR were more likely to have a decrease in delta NLR (P = 1.24e-10). The NLR stage had a better predictive ability than baseline NLR and delta NLR, and was an independent prognostic factor for overall survival in osteosarcoma patients HR: 2.456 (1.625-3.710) (P = 1.97e-05). Conclusion NLR has value in continuous monitoring, and continuous monitoring of NLR can better predict the survival of osteosarcoma patients compared to baseline NLR.

Baseline (sea)

10.3389/fonc.2023.1235158

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Diagnostic value of serum tumor biomarkers for endometrial cancer in elderly women with intrauterine abnormalities on transvaginal ultrasound

Zhonghua laonian yixue zazhi (2019)

Mingchun Zhi Liang Sun Wei Li Zhenai Li Chuanbao Li

Objective To investigate age-related changes in serum tumor markers carbohydrate antigen 125(CA125), CA153 and CA199, and the clinical significance of separate and combined detection of these markers for screening endometrial carcinoma(EC)in elderly women with intrauterine abnormalities on transvaginal ultrasound(TVS). Methods Cross-sectional data of 420 elderly women suspected of having an intrauterine abnormality by TVS and undergone hysteroscopy with dilation and curettage from January 2010 to December 2017 were retrospectively analyzed.Patients were divided into a 60-64 years-old group and a 65-83 years-old group.Aging-related changes in positive rates of CA125, CA153 and CA199 were compared between the two groups.Differences in positive rates of tumor markers were compared between different pathological types.Using postoperative pathological diagnosis as the gold standard for EC, the diagnostic sensitivity, specificity and accuracy of serum CA125, CA153 and CA199 alone or in combination for EC were calculated. Results The positive rates of CA125, CA153 and CA199 were 3.9%(16/412), 0%(0/172)and 5.0%(20/404), respectively.The positive rate of CA125 was higher in the 65-83 years-old group(6.5%, 16/246)than in the 60-64 years-old group(0.0%, 0/166)(P=0.001). The positive rates of CA125 and CA199 in patients with EC were 14.3%(4/28)and 42.9%(12/28), which were higher than those in patients with other pathological types.However, the sensitivity of single and combined detection of CA125 and CA199 was too low for the diagnosis of EC(14%、43%). Conclusions The single and combined detection of CA125, CA153 and CA199 for screening EC is of limited value in elderly women.New tumor markers need to be identified and used in combination with TVS for screening EC in elderly women. Key words: Endometrial neoplasms; Transvaginal sonography; Tumor biomarker

Dilation and curettage

10.3760/cma.j.issn.0254-9026.2019.01.011

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Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal Ischemia/Reperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

Oxidative Medicine and Cellular Longevity (2020)

Meng Chen Xue-Tao Yan Ye Li Jun-Jiao Tang Zongze Zhang

Intestinal ischemia/reperfusion (I/R) is a clinical emergency, which often causes lung injury with high morbidity and mortality. Although dexmedetomidine has been identified to have a protective effect on lung injury caused by intestinal I/R, its specific mechanism is still elucidated. In recent years, the cannabinoid (CB 2 ) receptor pathway has been found to be involved in I/R injury of some organs. In the current study, we investigated whether the CB 2 receptor pathway contributes to the protective effect of dexmedetomidine on the intestinal I/R-induced lung injury in rats. Dexmedetomidine treatment upregulated the expression of CB 2 receptor and suppressed the I/R-induced increases in lung injury scores, inflammatory cell infiltration, lung wet/dry ratio, MPO activity, MDA level, inflammatory cytokines, and caspase-3 expression while augmenting SOD activity and Bcl-2 expression, indicating attenuation of lung injury. Dexmedetomidine treatment also increased the expression of Akt. The protective effects of dexmedetomidine treatment were reversed by the CB 2 receptor antagonist AM630 or the PI3K inhibitor wortmannin. And the CB 2 receptor antagonist AM630 also downregulated the expression of Akt. Thus, our findings suggest that treatment with dexmedetomidine provides a protective role against lung injury caused by intestinal I/R in rats, possibly due to the upregulation of the CB 2 receptor, followed by the activation of the PI3K/Akt pathway.

Dexmedetomidine

Wortmannin

10.1155/2020/6120194

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Citations (25)

Observation of the clinical efficacy of treating recurrent aphthous ulcer with He-Ne laser and traditional Chinese medicine (TCM)

Jiguang zazhi (2007)

Ye Li

Objective: To observe the clinical efficacy of treating recurrent aphthous ulcer with He-Ne laser for local irradiation,Method:84 patients with recurrent aphthous ulcer were randomly divided into two groups.The treatment group(42 cases) was treated with He-Ne laser for local irradiation and TCM for oral administration.The control group(42 cases) was treated only with TCM for oral administration.Result: Apparent effectiveness: the combined group was 83.4%,the routine was 66.7%.The combined group and the routine both had obvious difference(PO.05).Conclusion: The treatment of aphthous ulcer with He-Ne laser for local irradiation could improve the curative effect in evidence;even consolidated.

Clinical efficacy

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Performance comparisons of different single-channel coils using different materials

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024)

Chunhu Song Qiaoyan Chen Shao Che Haining Wang Xiaoliang Zhang

The ultra-flexible RF coil can fit the image subjects well and thus improve signal-to-noise ratio (SNR). In this study, four types of single-channel receiver coils using different materials with the same size were constructed. Phantom studies were performed on a 3T MRI system. As a result, the liquid metal coil can achieve a most similar performance as the conventional copper coil, while the liquid metal coil is more flexible. This demonstrates that the liquid metal coil has a good application potential in imaging curved anatomical structures.

Radiofrequency coil

SIGNAL (programming language)

Voice coil

10.58530/2023/3903

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