This paper seeks to find out customers' preference towards Web stores. To serve the purpose, a Fishbein's multi-attribute attitude model was employed to empirically investigate the customers' attitudes toward different product categories at the Web stores. We view the consumer's intention of shopping from the Web stores as a function of beliefs about the attributes possessed by the Web stores weighted by the importance of each attribute. Web-based as well as paper-based surveys are conducted to support the analysis, and we find out products are less acceptable at the Web stores than at the traditional stores t different product categories do have different customers' indices of the Web stores. We also find that non-student shoppers appear to be more positive toward online shopping. Nevertheless, the results from our survey indicate that the gender effect and the experience effect on the acceptance index of the Web stores are not statistically significant.
Peer-to-peer insurance models combine insurer's underwriting with peers' risk sharing. This paper presents a mathematical formulation of two emerging peer-to-peer insurance models: the individual-covered model and the group-covered model, and establishes their equivalence for a homogeneous participant pool. Both models involve a two-layered risk allocation approach: the first layer covers losses below the deductible and is distributed among the participants, while the second layer addresses losses that surpass the risk-bearing capacity of the pool and are assumed by an insurer. Furthermore, we provide a theoretical analysis of the optimal level of risk pooling in terms of the deductible in peer-to-peer insurance, exploring its existence, closed-form expression, and associated properties.
Inflammation is linked to coronavirus disease 2019 (COVID-19)-related heart failure (HF), but the specific mechanisms are unclear. This study aimed to assess the relationship between specific inflammatory factors, such as interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, interferon (IFN)-α, and IFN-γ, and COVID-19-related HF. We retrospectively identified 212 adult patients with COVID-19 who were hospitalized at Shanghai Public Health Center from March 1 to May 30, 2022 (including 80 patients with HF and 132 without HF). High-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and inflammatory factors, including IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IFN-α, and IFN-γ, were compared between patients with COVID-19 with and without HF. Patients with COVID-19 having and not having HF differed with regard to sex, age, hs-CRP, PCT, and IL-6 levels (p < 0.05). Logistic regression analysis indicated a significant positive association between IL and 6 and HF (odds ratio = 1.055; 95 % confidence interval: 1.019–1.093, p < 0.005). Sex, age, and hs-CRP were also associated with HF. Women had a greater risk of HF than men. Older age, higher levels of hs-CRP, and IL-6 were associated with a greater risk of HF. In patients with COVID-19, increased IL-6 levels are significantly associated with COVID-19-related HF.
Objective:To establish the animal model of skeletal fluorosis caused by coal-burning.Methods:SD rats taken as the experimental objects were randomly assorted into 5 groups(the number either female or male was the same in each group):control group,high-dose fluorine group,high-dose fluorine supplemented with low calcium diet group,low-dose fluorine group,low-dose fluorine supplemented with low calcium diet group.All rats were fed with corn dried by burning coal,which came from disease borough with high fluorine,to establish the animal model of skeletal fluorosis.All rats were killed by femoral arterial exsanguination,followed by examinations of dental fluorosis,fluorine in urine,bone and dental,bone mineral density(BMD).The tibia slices of chronic fluorosis rats were stained with HE.Results:Compared with control group,the BMD increased except that in high-dose fluorine supplemented with low calcium diet group,which was statistically significant(P0.05).The enhanced osteoblastic activity was found from the tibia slices.The BMD in high-dose fluorine supplemented with low calcium diet group was lower than that in control group(P0.05).The compact bone of the cortex in high-dose fluorine supplemented with low calcium diet group became intenerate while it become porosity in low-dose fluoride supplemented with low calcium diet group.Conclusion:Excessive fluorine can induce accelerative bone turnover by stimulatinging the activity both osteoblasts and osteoclasts,Low calcium diet can promote bone absorption of skeletal fluorosis.
Two heptad repeat regions (HR1, HR2) from F clone of the virulent and avirulent NDV were cloned, expressed with vector pGEX-6p-1 in E. coli BL21 (DE3), and purified the fusion protein by Glutathiones Sepharose 4B Column. After cleaved by precission protease, the desired protein was purified by Glutathione Sepharose 4B Column and high temperature. Purified HR1 and HR2 were analyzed by Mass spectrum, the results shows that the Molecular Weights of HR1 and HR2 of virulent NDV are 7103 and 6301, and the Molecular Weights of HR1 and HR2 of avirulent NDV is 7107 and 6309.
46,XY sex reversal 11 (SRXY11) [OMIM#273250] is characterized by genital ambiguity that may range from mild male genital defects to gonadal sex reversal in severe cases. DHX37 is an RNA helicase that has recently been reported as a cause of SRXY11. So far, a total of 21 variants in DHX37 have been reported in 58 cases with 46,XY disorders of sex development (DSD).
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)