Lei Chen

Nanjing University

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Ding Du

China Pharmaceutical University

Jie Feng

China Pharmaceutical University

Jian Gao

Chinese Research Academy of Environmental Sciences

Tao Lu

China Pharmaceutical University

Guang‐Ao Yu

Central China Normal University

Hongling Xie

Changzhou University

Fan Zhang

Jinan University

Yuebo Shao

China Pharmaceutical University

Hai Huang

Changzhou University

Jianwei Sun

University of Hong Kong

Cooperative Institutions

Chinese Academy of Sciences

Fudan University

Nanjing University

China Pharmaceutical University

University of Chinese Academy of Sciences

Sun Yat-sen University

Shanghai Jiao Tong University

Shandong University

Huazhong University of Science and Technology

Collaborative Innovation Center of Chemistry for Energy Materials

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CuI/PPh₃‐catalyzed Sonogashira coupling reaction of aryl iodides with terminal alkynes in water in the absence of palladium

Applied Organometallic Chemistry (2008)

Jin Tao Guan Guang‐Ao Yu Lei Chen Tan Qing Weng Jing Yuan

Abstract The Sonogashira cross‐coupling of aryl iodides with terminal alkynes catalyzed by a simple and inexpensive catalyst system of CuI/PPh 3 in water as the sole solvent has been reported. In the presence of CuI/PPh 3 , with KOH used as a base, a number of aryl iodides were treated with alkynes to afford the corresponding products in moderate to excellent yields. Copyright © 2008 John Wiley & Sons, Ltd.

Sonogashira coupling

Base (topology)

10.1002/aoc.1474

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Citations (52)

A Highly Efficient Bismuth Nitrate/Keto-ABNO Catalyst System for Aerobic Oxidation of Alcohols to Carbonyl Compounds under Mild Conditions

Molecules (2022)

Yongke Hu Lei Chen Gulou Shen Jin Li Shaozhong Li

An efficient and practical catalytic system for the oxidation of alcohols to aldehydes/ketones using catalytic amounts of Bi(NO3)3 and Keto-ABNO (9-azabicyclo [3.3.1]nonan-3-one N-oxyl) with air as the environmentally benign oxidant was developed. Various primary and secondary alcohols were smoothly oxidized to the corresponding products under mild conditions, and satisfactory yields were achieved. Moreover, this methodology avoids the use of a ligand and base. The gram-scale reaction was demonstrated for the oxidation of 1-phenyl ethanol, and the product of acetophenone was obtained at an isolated yield of about 94%.

Acetophenone

Alcohol Oxidation

Primary (astronomy)

Bismuth

Catalytic Oxidation

10.3390/molecules27123727

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Citations (8)

Bio- and Medicinally Compatible α-Amino-Acid Modification via Merging Photoredox and N-Heterocyclic Carbene Catalysis

Organic Letters (2020)

Ding Du Kuili Zhang Rui Ma Lei Chen Jian Gao

An N-heterocyclic carbene and photoredox cocatalyzed α-amino-acid decarboxylative carbonylation reaction is presented. This method displays good scope generality, providing a direct pathway to access various downstream α-amino ketones under bio- and medicinally compatible conditions. Moreover, this strategy is appealing to chemical biology because it has great potential for the chemical modification of peptides or the late-stage synthesis of keto-peptides.

Photoredox catalysis

Carbonylation

Chemical Biology

Generality

10.1021/acs.orglett.0c02202

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Citations (31)

The Influence of the Northbound Spread of Literary Ethos upon the Ruling Classes in the Sui and Early Tang Dynasties

Fudan Journal (2006)

Lei Chen

A large number of southern intellectuals were obliged to migrate to the north after the unification.During the period of the Sui and early Tang Dynasties,most of them became literary chamberlains as a result of their specialties as well as the repulsive tendency of the ruling classes out of some political and cultural dilemmas.Their experiences had helped to foster the ethos of the ruling classes.

Ethos

Unification

Source

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Citations (0)

Axially Chiral Biphenyl Compound‐Based Thermally Activated Delayed Fluorescent Materials for High‐Performance Circularly Polarized Organic Light‐Emitting Diodes

Advanced Science (2020)

Zhen‐Long Tu Zhi‐Ping Yan Xiao Liang Lei Chen Zheng‐Guang Wu

To boost intrinsic circularly polarized luminescence (CPL) properties of chiral emitters, an axially chiral biphenyl unit is inlaid in thermally activated delayed fluorescent (TADF) skeleton, urging the participation of chiral source in frontier molecular orbital distributions. A pair of enantiomers, (R)-BPPOACZ and (S)-BPPOACZ, containing the cyano as electron-withdrawing moieties and carbazole and phenoxazine as electron-donating units are synthesized and separated. The circularly polarized TADF enantiomers exhibit both high photoluminescence quantum yield of 86.10% and excellent CPL activities with maximum dissymmetry factor |gPL| values of almost 10-2 in solution and 1.8 × 10-2 in doped film, which are among the best values of previously reported small chiral organic materials. Moreover, the circularly polarized organic light-emitting diodes based on the TADF enantiomers achieve the maximum external quantum efficiency of 16.6% with extremely low efficiency roll-off. Obvious circularly polarized electroluminescence signals with |gEL| values of 4 × 10-3 are also recorded.

Carbazole

Quantum yield

Quantum Efficiency

Biphenyl

10.1002/advs.202000804

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Citations (93)

Direct air capture of CO2 using bi-amines-functionlized hierarchical mesoporous silica: Effects of organic amine loading, moisture and temperature

Separation and Purification Technology (2024)

Xiaolong Dong Shengjie Zhu Lei Chen Xiangping Li Yaqing Zhang

10.1016/j.seppur.2024.129647

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Citations (1)

Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn²⁺ Detection and Selective On-Demand Photodynamic Therapy

Analytical Chemistry (2017)

Ping Hu Rui Wang Lei Zhou Lei Chen Qingsheng Wu

As a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (1O2) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor-associated disruption of labile Zn2+ (denoted as Zn2+ hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+ in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes.

Nanoprobe

Photon Upconversion

10.1021/acs.analchem.6b04548

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Citations (47)

Combination of spontaneous regional brain activity and HTR1A/1B DNA methylation to predict early responses to antidepressant treatments in MDD

Journal of Affective Disorders (2022)

Chenjie Gao Zhi Xu Tingting Tan Zimu Chen Shen Tian

Lasso

Elastic net regularization

10.1016/j.jad.2022.01.098

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Citations (5)

ChemInform Abstract: Synthesis of Trisubstituted Isoxazoles by Palladium(II)‐Catalyzed Cascade Cyclization—Alkenylation of 2‐Alkyn‐1‐one O‐Methyl Oximes.

ChemInform (2012)

Zhigang She Dongyue Niu Lei Chen Maria A. Gunawan Xhesika Shanja

Abstract The method represents a new, convenient, and widely applicable approach to the target compounds.

10.1002/chin.201231130

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Citations (0)

Atroposelective Synthesis of Axially Chiral 4-Aryl α-Carbolines via N-Heterocyclic Carbene Catalysis

Organic Letters (2021)

Rui Ma Xiaoxue Wang Qiaoyu Zhang Lei Chen Jian Gao

The first catalytic asymmetric construction of axially chiral 4-aryl α-carboline skeletons has been accomplished through an N-heterocyclic carbene (NHC)-catalyzed atroposelective formal [3 + 3] annulation of 4-nitrophenyl 3-arylpropiolates with 2-sulfonamidoindolines. The synthetic utility of the title compounds has been demonstrated by the diverse late-stage structural modifications. Density functional theory calculations were also conducted to illuminate the key factors for controlling the origin of the enantioselectivity. This strategy not only provides an efficient pathway to access axially chiral α-carboline atropisomers but also offers a novel catalytic enantioselective mode for the construction of axially chiral heterobiaryls by using NHC-bound alkynyl acylazoliums.

Atropisomer

Annulation

Axial symmetry

Axial Chirality

10.1021/acs.orglett.1c01221

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Citations (53)