Aim To investigate the correlation of changes of levles of blood suger(BS)and lipase(LPS)in hemorrhagic fever with renal syndrome(HFRS) patients with severity of HFRS.Methods A total of 66 patients with HFRS were recruited from the Shenyang Sixth People's Hospital from May 2005 to May 2006.Thehe levels of LPS and BS were determined.The peak value and the results were analyzed using statistical methods.Results The levels of BS and LPS in HFRS patients were increasingly elevated in HFRS patients of mild,medium and severe types.Conclusion The degree of pancreatic damage is paralleled with the severity of the disease.
<p>Table S2. Second generation sequencing data (whole exome sequencing, including Copy Number Variation,Insert deletion, Singal Nucleotide Variation and gene fusion)</p>
Objective:To evaluate the effect of argatroban in induced hemodialysis patients with central venous catheter.Methods:One hundred and four patients at CKD stage 5 were randomly divided into 2 groups:Unfractional Heparin(UFH group)and argatroban group(ARG group).All the patients received twice induced hemodialysis at the 2nd and 3rd hour.The blood analysis,blood chemical analysis,activated partial thromboplastin time(APTT)and activated clotting time(ACT)was measured before and during hemodialysis.In ARG group,arterial and venous APTT and ACT were measured simultaneously.Results:There is no difference in clotting condition between the two groups while less hemorrhage occurred in ARG group.Both APTT and ACT were significantly shorter in the ARG group compared with those in UFH group.In ARG group the APTT and ACT were shorter in arteria compared with those in veins.Conclusion:To obtain the same anticoagulation effect in induced hemodialysis,the APTT and ACT are shorter with argartroban than unfractional heparin.Argatroban might be a new alternative anticoagulation agent in hemodialysis.
Cysteine-rich 61 (CYR61) is implicated in many pulmonary diseases. However, the relationship between CYR61 and community-acquired pneumonia (CAP) patients was unknown. This research aimed to estimate the correlations of serum CYR61 with severity and prognosis in CAP patients through a prospective cohort study.All 541 CAP patients were enrolled in this study. Fasting venous blood was collected. Clinical characteristics and demographic information were obtained. CYR61 and inflammatory cytokines were detected in serum using ELISA.Serum CYR61 was gradually increased in parallel with severity scores in CAP patients. Correlative analysis indicated that serum CYR61 was strongly associated with many clinical parameters in CAP patients. Moreover, mixed logistic and linear regression models found that there were positive correlations between serum CYR61 and CAP severity scores after adjusted for age, BMI, and respiratory rate. Stratified analyses suggested that age affected the associations between serum CYR61 and severity scores. On admission, higher serum CYR61 levels elevated the risks of mechanical ventilation, vasoactive agent, ICU admission, death, and longer hospital stays during hospitalization. Moreover, serum CYR61 in combination with severity scores upregulated the predictive capacities for severity and death than single serum CYR61 or severity scores in CAP patients.There are significantly positive dose-response associations of serum CYR61 on admission with the severity and adverse prognostic outcomes, demonstrating that CYR61 is involved in the pathophysiology of CAP. Serum CYR61 may be used as a potential biomarker for the diagnosis and prognosis in CAP patients.
Currently, endoscopic transsphenoidal surgery (ETS) and microscopic transsphenoidal surgery (MTS) are commonly applied treatments for patients with pituitary adenomas. This meta-analysis was conducted to evaluate the efficacy and safety of ETS and MTS for these patients.A computer search of Pubmed, Embase, Cochrane library, Web of Science, and Google Scholar databases was conducted for studies investigating ETS and MTS for patients with pituitary adenomas. The deadline is March 01, 2021. RevMan5.1 software was used to complete this meta-analysis after literature screening, data extraction, and literature quality evaluation.A total of 37 studies including 5,591 patients were included. There was no significant difference in gross tumor removal (GTR) and hormone-excess secretion remission (HES remission) between two groups [RR = 1.10, 95% CI (0.99-1.22), P = 0.07; RR = 1.09, 95% CI (1.00-1.20), P = 0.05]. ETS was associated with lower incidence of diabetes insipidus (DI) [RR = 0.71, 95% CI (0.58-0.87), P = 0.0008], hypothyroidism [RR = 0.64, 95% CI (0.47-0.89), P = 0.007], and septal perforation [RR = 0.32, 95% CI (0.13-0.79), P = 0.01] than those with MTS.This meta-analysis indicated that ETS cannot significantly improve GTR and HES remission. However, ETS could reduce the incidence of DI, hypothyroidism, and septal perforation without increasing the rate of other complications.https://www.crd.york.ac.uk/prospero/#myprospero, identifier: CRD42021241217.
Recent studies have indicated that endocannabinoids are novel mediators for liver diseases and that blockade of cannabinoid receptors may prevent liver cirrhosis. The present study was designed to test whether this cannabinoid mechanism is involved in the development of liver cirrhosis induced by infection of schistosoma mansoni. Mice were infected with schistosoma mansoni by transfer of the cercaria to the abdominal space. Nine weeks later, mouse livers were harvested, and morphological examinations showed typical pathological changes in liver cirrhosis with worm tubercles of schistosoma deposited in the liver tissue, fibrosis around the worm tubercles and infiltration or soakage of inflammatory cells. By real time RT-PCR and Western blot analysis, it was found that both mRNA and protein expression levels of cannabinoid receptor 1 (CB1) were significantly increased in livers from schistosoma infected mice compared with normal mouse. By immunohistochemical analysis, we found that in the liver from normal mice CB1 receptors were primarily expressed in the enchylema of hepatocytes and around the portal vein. In schistosoma infected mouse livers, although the expression pattern of CB1 receptors was not changed, the level of this receptor was significantly increased. The results suggest that endocannabinoids may importantly participate in the development of liver cirrhosis associated with schistosoma via overexpressed CB1 receptors (supported by National Nature Science Foundation of China 30571627).
OBJECTIVE To study the immunomodulatory effect of Part III of Cynomorium songaricum Rupr. on the immunosuppressive mice. METHODS The immunity-deficiency model was induced by intraperitoneal injection of cyclophosphamide (CTX) at the dose of 100 mg/kg in mice; all the animals were divided into normal control group, immunity-deficiency model group, Part III treated group (300 mg/kg) and positive control group (TSPG, 300 mg/kg). The hemogram of peripheral blood, the index of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin were measured. RESULTS The index of organs, the phagocytosis activity of macrophage and the content of serum hemolysin in the model group increased after administrated of Part III. CONCLUSION Part III from Cynomorium songaricum Rupr. has protective effect on the immunosuppressive mice, which may be related to the increasing of humoral immunity and nonspecific immunity.
To assess the efficacy and safety of cinacalcet on secondary hyperparathyroidism in patients with chronic kidney disease, Pubmed, Embase, and the Cochrane Central Register of Controlled Trials were searched until March 2016. Trial sequential analysis (TSA) was conducted to control the risks of type I and II errors and calculate required information size (RIS). A total of 25 articles with 8481 participants were included. Compared with controls, cinacalcet administration did not reduce all-cause mortality (RR = 0.97, 95% CI = 0.89-1.05, P = 0.41, TSA-adjusted 95% CI = 0.86-1.08, RIS = 5260, n = 8386) or cardiovascular mortality (RR = 0.95, 95% CI = 0.83-1.07, P = 0.39, TSA-adjusted 95% CI = 0.70-1.26, RIS = 3780 n = 5418), but it reduced the incidence of parathyroidectomy (RR = 0.48, 95% CI = 0.40-0.50, P < 0.001, TSA-adjusted 95% CI = 0.39-0.60, RIS = 5787 n = 5488). Cinacalcet increased the risk of hypocalcemia (RR = 8.48, 95% CI = 6.37-11.29, P < 0.001, TSA-adjusted 95% CI = 5.25-13.70, RIS = 6522, n = 7785), nausea (RR = 2.12, 95% CI = 1.62-2.77, P < 0.001, TSA-adjusted 95% CI = 1.45-3.04, RIS = 4684, n = 7512), vomiting (RR = 2.00, 95% CI = 1.79-2.24, P < 0.001, TSA-adjusted 95% CI = 1.77-2.26, RIS = 1374, n = 7331) and diarrhea (RR = 1.17, 95% CI = 1.05-1.32, P = 0.006, TSA-adjusted 95% CI = 1.02-1.36, RIS = 8388, n = 6116). Cinacalcet did not significantly reduce the incidence of fractures (RR = 0.58, 95% CI = 0.21-1.59, P = 0.29, TSA-adjusted 95% CI = 0.01-35.11, RIS = 76376, n = 4053). Cinacalcet reduced the incidence of parathyroidectomy, however, it did not reduce all-cause and cardiovascular mortality, and increased the risk of adverse events including hypocalcemia and gastrointestinal disorders.
Objective: To observe the expression of IGF-1during pollen pini preventing parotid tissues from getting senescent.Method: Made rat models with subacute senility by means of continuous intraperitoneal injection with D-galactosum and then observed the effects of pollen pini of different dosage on the expression of IGF-1 in senescent parotid tissues by in situ hybridization method.Result: IGF-1 was expressed extensively in parotid tissues,with the expression of IGF-1 in the rat model group with subacute senility caused by D-galactosum fallen remarkably and shown a remarkable difference compared with the normal control group(P0.01);but after pollen pini was given into the senescent parotid tissues,the expression of IGF-1 especially that in the preventing group,rose remarkably.Conclusion: Pollen pini had the effect of relieving the disorder of parotid tissues in senescent male rats and preventing their parotid tissues from getting senescent.
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