Huan Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

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Jianjun You

Plastic Surgery Hospital

Fei Fan

West China Medical Center of Sichuan University

Yihao Xu

Chinese Academy of Medical Sciences & Peking Union Medical College

Ruobing Zheng

Capital Medical University

Junsheng Guo

Chinese Academy of Medical Sciences & Peking Union Medical College

Lehao Wu

Chinese Academy of Medical Sciences & Peking Union Medical College

Le Tian

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhen Song

Institute of Hematology & Blood Diseases Hospital

Xiaona Lu

Yale University

Xicai Sun

Fudan University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

Peking Union Medical College Hospital

Huazhong University of Science and Technology

Sun Yat-sen University

Eye & ENT Hospital of Fudan University

Capital Medical University

Central South University

Peking University

Air Force Medical University

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Innovative application of internal carotid artery embolization in salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma: A case‐matched comparison

International Forum of Allergy & Rhinology (2021)

Wanpeng Li Qiang Liu Huan Wang Huangkang Zhang Quan Liu

The efficacy and safety of internal carotid artery (ICA) embolization as a treatment strategy in recurrent nasopharyngeal carcinoma (rNPC) patients with tumors invading the ICA remain unclear.We enrolled all rNPC patients with tumors invading the ICA, who underwent salvage endoscopic surgery. Using propensity scores to adjust for specific potential prognostic factors, a well-balanced cohort of 42 patients with limited rNPC was formed by matching each patient who underwent ICA embolization (study group) with one who did not (control group). The survival rates and common treatment-related complications were compared between the 2 groups.The cohort included patients with the following tumor stages: rT2 (n = 3), rT3 (n = 24), and rT4 (n = 15). During a median follow-up of 15 (range, 2-63) months, the 2-year overall survival and progression-free survival rates were significantly higher in the ICA embolization group than in the ICA nonembolization group (90.5% vs 53.3% and 71.3% vs 33.0%, respectively; and p = 0.022 and p = 0.006, respectively). In addition, the incidence of treatment-related complications, such as nasal obstruction, nasopharyngeal hemorrhage, and nasopharyngeal necrosis, was significantly lower in the ICA embolization group than in the nonembolization group (p = 0.001, p = 0.014, and p = 0.038, respectively).The innovative application of ICA embolization in endoscopic surgery in patients with rNPC invading the ICA significantly improved patient survival and reduced the risk of treatment-related complications. Therefore, this may be a safe and effective method with the potential to improve outcomes in rNPC patients.

External carotid artery

10.1002/alr.22927

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Citations (11)

Endoscopic Endonasal Surgery for Dermoid Cysts Arising From the Middle Cranial Fossa Floor: A Rare Case Series

Ear Nose & Throat Journal (2022)

Haoyuan Xu Wanpeng Li Huankang Zhang Huan Wang Li Hu

Objective Dermoid cysts (DCs) are congenital, slowly growing, and may cause nervous system symptoms. Related literature is limited and mainly includes case reports. We report a case series of DCs originating from the middle cranial fossa floor (MCFF) and investigate their demographic information, clinical characteristics, imaging findings, surgical procedures, and prognostic outcomes. Methods We reviewed the patients with DCs arising from the MCFF undergoing endoscopic endonasal surgery (EES) in our center between 2012 and 2022. Results A total of 5 patients with DCs were enrolled (2 males and 3 females), with a mean age of 46.2 years at the onset. All DCs originated from the MCFF with 1 case involving the middle cranial fossa bone and another 1 case affecting the dura mater. One (20.0%) patient had neurological involvement. After admission, all patients received EES with a total resection rate of 100.0% (5 of 5). After a median follow-up of 73.2 months, all patients achieved complete clinical and radiological improvements. No surgical-related complications or relapses were observed during the long-term follow-up. Conclusion Endoscopic endonasal surgery is considered a safe and effective approach for the treatment of DCs in the MCFF. A larger sample size and longer follow-up time are needed.

Middle cranial fossa

Anterior cranial fossa

Middle fossa

10.1177/01455613221138209

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Citations (2)

[Treatment of adult prostate sarcoma: a report of six cases with literature review].

PubMed (2005)

Zhuo Wei Liu Fang Jjian Zhou Zi Ke Qin Hui Han Shao Long Yu

Primary adult prostate sarcoma is rare. Most patients come to hospital with huge pelvic tumors. Treatment for this disease remains controversial. We reported our experience of treating 6 cases of adult prostate sarcoma, and explore reasonable therapy strategy with literature review.Six adult patients with prostate sarcoma were treated in our hospital, 5 underwent cystoprostatectomy combined with urinary diversion, 1 underwent total pelvic exenteration combined with urinary diversion and colostomy; 3 had preoperative intervention to embolize bilateral internal iliac artery, 4 received postoperative radiotherapy. The recent 11 reports published in China with a total of 62 cases were reviewed, 32 of them had radical surgery. The pertinent literatures from other countries were also reviewed.Of our 6 patients, 1 survived with no evidence of disease for 33 months; 1 survived with recurrent tumor for 18 months; 4 died of recurrent sarcoma 5-40 months after surgery. In the whole group of 62 patients, 1-, and 2-year survival rates were 59%, and 34%.Up to now, radical surgery is the most effective treatment for adult prostate sarcoma.

Cystoprostatectomy

Pelvic exenteration

Urinary diversion

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Follow‐up of extensive calcified costal cartilage‐based rhinoplasty in Chinese People

Journal of Cosmetic Dermatology (2022)

Xin Wang Wenfang Dong Huan Wang Jianjun You Ruobing Zheng

To the best of our knowledge, there is currently no such study in the area of extensive calcified costal cartilage rhinoplasty. The study evaluated patients' satisfaction with extensive calcified costal cartilage compared with no calcified costal cartilage.Thirty-five patients with extensive calcified costal cartilage underwent rhinoplasty at our institution between January 2018 and May 2020. We also used a control group of 35 patients with absent rib cartilage calcification to compare the outcomes. Satisfaction was evaluated by the photogrammetric measurements and Rhinoplasty Outcomes Evaluation (ROE) scale.We found no significant difference in the nose measurement between the two groups before and after the operation. Besides, both groups had a significant difference in comparison with preoperative after surgery except for the nasofrontal angle. The difference between preoperative and postoperative ROE scores was statistically significant in both groups. We also compared the satisfaction of preoperative and postoperative outcomes between the two groups, where no difference was found between them. Each group had a patient who occurred an infection after surgery.Autologous costal cartilage provides the most abundant source for graft fabrication. Patients with extensive calcified cartilage could undergo rhinoplasty and have satisfactory results instead of choosing an artificial implant.

Costal cartilage

10.1111/jocd.14727

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Citations (3)

Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model

Burns & Trauma (2020)

Jingzhu Duan Yang Yang Erlin Zhang Huan Wang

Abstract Background Co-Cr-Mo alloy has been widely used in clinical implants because of its excellent mechanical and anti-corrosion properties, but there is an urgent need to address its disadvantages, such as implant-related infections and implant loosening. We synthesized Co-Cr-Mo-Cu (Co-Cu) alloys with different Cu contents to modify implant performance to be suitable as a bone-compatible implant material. Methods Microstructure, phase content and mechanical properties of the Co-Cr-Mo alloy were characterized. Histological and immunohistochemical analyses were performed after implantation in rabbits. The experimental alloy was implanted on the lateral side of the lower tibial condyle and the tibial nodule. Results Phase content and mechanical properties revealed that the crystallographic structure and wear resistance were changed. Experimental implantation results demonstrated that osteogenic capability was markedly enhanced, ascribed to the excellent antibacterial and osseointegration capacities of Cu phases, and with the release of Cu ions. In particular, Co-Cu alloy containing 2 wt% Cu exhibited the best osteogenic performance among all samples. Conclusions The results indicated that osteogenic performance of the Co-Cr-Mo alloy could be enhanced by adding Cu. In particular, the Co-2Cu alloy exhibited the best properties according to both immunohistochemical and histological analyses. Our study not only provides deep insight into the osteogenic effect of Cu but presents a new Co-Cu alloy for clinical implants.

10.1093/burnst/tkaa036

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Citations (12)

[The anatomical structure similarity research on auricular cartilage and nasal alar cartilage].

PubMed (2015)

Changyong Chen Fei Fan Wenzhi Li Binbin Li Jianjun You

There are many scaffold materials of repairing nasal alar cartilage defects. Auricuiar cartilage was used extensively in terms of its abundant tissues, good elasticity, little donor-site malformation, good plasticity etc. The authors dissected auricular cartilage and nasal alar cartilage, measured cartilage's morphous data and found some similar territories with nasal alar cartilage in the structure of auricular cartilage.An anatomical study was performed using 10 adult cadavers acquired through Plastic Surgery Hospital, Peking Union Medical College, Beijing, China. Seven male and three female cadav-ers were included in the study. Harvest 20 auricular cartilage specimens and 20 nasal alar cartilage specimens. Then, Computed Tomography Scan on the auricular cartilage and nasal alar cartilage were performed. The datas were imported into mimics and three-dimensional reconstructions of the auricular cartilage and nasal alar cartilage were carried on.Parts of the auricular cartilage, such as conchal fossa, tragus, intertragic notch, and cymba of auricular concha, curs of helix and curs of helix, triangular fossa, are ana-tomically similar to nasal alar cartilage.This study reports the anatomy of auricular cartilage and nasal alar cartilage, found some territories in the auricular cartilage, such as conchal fossa, tragus, intertragic notch, and cymba of auricular concha, curs of helix and curs of helix, triangular fossa, are anatomically similar to nasal alar cartilage. This research provides the anatomical basis that auricular cartilage was used to repair the nasal cartilage defect.

Fossa

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Comparison of two methods in the treatment of finger flexion deformity of scar contracture

Zhonghua shouwaike zazhi (2019)

Wei Feng Danmou Xing Dong Ren Yan Chen Huan Wang

Objective To investigate the clinical efficacy, indications and precautions of dual intersecting trapezoid flaps and laterodigital flaps in the treatment of finger flexion deformity of scar contracture. Methods From February 2014 to October 2016, 14 patients (25 fingers) with finger flexion deformity of scar contracture were treated. According to the extension of scar contracture line, dual intersecting trapezoid flaps were used in 7 cases (12 fingers) (group A) and laterodigital flaps were used in 7 cases (13 fingers) (group B). The repair range, infection and necrosis rate, total active motion of inured finger (TAM), extension rate of scar contracture line and reoperation were compared between the two groups. Results All the flaps survived uneventfully. The repair range of group A reached the level of DIP and group B reached the level of PIP. There was no reoperation due to recurrence of scar contracture in both groups, but the satisfaction of group B was lower than that of group A. Conclusion The dual intersecting trapezoid flaps have reliable blood supply and the operation is simple, the repair range of which can reach the level of DIP. They can allow early joint movement. It is a more ideal method for the treatment of finger flexion deformity of trans-articular scar contracture. Key words: Surgical flaps; Finger injuries; Cicatrix; Contracture

Z-plasty

10.3760/cma.j.issn.1005-054x.2019.01.011

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Clinical application of Reading man flap for repair of the wound of donor site at the dorsum of the finger

Wei Feng Danmou Xing Dong Ren Yan Chen Huan Wang

Objective To introduce the surgical technique and clinical efficacy of Reading man flap for repair of the wound of donor site at the dorsum of the finger. Methods From February 2016 to August 2018, 9 cases (9 fingers) of fingertip defects were treated with reverse dorsal digital island flap of the same finger. The donor site of dorsal digital flaps was repaired with Reading man flap. After repair of fingertip defects, the defect area of dorsal digital donor site ranged from 2.0 cm×1.3 cm to 2.5 cm×1.6 cm. Results All the flaps survived uneventfully. The average hospitalization time was 10 days. The follow-up time was 3 to 9 months. The texture, color, plumpness and elasticity of the dorsal digital donor site were good. No tendon adhesion, interphalangeal joint and metacarpophalangeal joint stiffness occurred. All the patients were satisfied with the appearance and function of the injured fingers. Conclusion The repair of the dorsal digital donor site with Reading man flap takes into account both appearance and durability, which is beneficial to the early rehabilitation of injured finger and less damage to donor site. The method of operation is safe and simple. It is an improvement on the repair of the donor site of the reverse dorsal digital island flap of the same finger. Key words: Finger injuries; Surgical flaps; Reading man flap; Flap donor site

Interphalangeal Joint

Distal interphalangeal joint

Metacarpophalangeal joint

10.3760/cma.j.issn.1005-054x.2019.04.002

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Subacute spinal subdural hematoma after spontaneous resolution of cranial subdural hematoma: causal relationship or coincidence?

Journal of Neurosurgery Spine (2004)

Carlo Bortolotti Huan Wang Kenneth Fraser Giuseppe Lanzino

✓ The etiopathogenesis of traumatic spinal subdural hematoma (SSH) is uncertain. Unlike the supratentorial subdural space, no bridging veins traverse the spinal subdural space. The authors describe a case of subacute SSH that occurred after spontaneous resolution of traumatic intracranial SDH and suggest a causal relationship between the two. A 23-year-old woman suffered an acute intracranial SDH after a snowboarding accident. There was no clinical or radiological evidence of spine injury. Conservative management of the supratentorial SDH resulted in spontaneous radiologically documented resolution with redistribution of blood in the subdural space. Four days after the injury, the patient started noticing new onset of mild low-back pain. The pain progressively worsened. Magnetic resonance imaging of the lumbosacral spine 10 days after the original injury revealed a large L4—S2 SDH. Ten days after the original injury, bilateral L5—S1 laminotomy and drainage of the subacute spinal SDH were performed. The patient experienced immediate pain relief. The authors hypothesize that in some cases spinal SDH may be related to redistribution of blood from the supratentorial subdural space.

Subdural space

Laminotomy

Subdural hemorrhage

10.3171/spi.2004.100.4.0372

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Citations (97)

A NOVEL NITRIC OXIDE-RELEASING GEL FOR DIABETIC WOUNDS

PLASTIC RECONSTRUCTIVE & REGENERATIVE SURGERY (2022)

Yukun Liu Songxue Guo Shuyi Wei Huan Wang Yong Liu

Background. Diabetic foot ulcers (DFUs) are a serious health problem. Nitric Oxide (NO) has been found to be an effective modulator in wound healing if administered externally. While NO is a promising therapy for DFUs, the current delivery of gaseous NO is cumbersome. The present work explores a novel gel that releases NO when in contact with wound exudates. Material and methods. Efficacy of the gel was assessed using a 1 cm2 full-thickness dorsal wound model on diabetic type 2 mice (Lepr db/db). The wounds were treated with NO-releasing gel at two concentrations: 100 μM (Gel 100) and 1000 μM (Gel 1000). A Gel-control group and an untreated group were included for comparison. Planimetry was employed for wound size dynamics up to day seven. H&E and IHC staining were used to quantify granulation tissue, CD31, and α-SMA expressions. Results. While the current experiment found no difference in wound healing kinetics between the groups, histological evaluation showed a significant increase in granulation tissue thickness in both Gel 100 and Gel-control groups compared to the other two groups (p < 0.05). Furthermore, Gel 100 significantly impacted the expression of angiogenesis marker CD31 and α-SMA compared to the other groups (p < 0.05). Conclusions. This preliminary study showed that the NO gel used has a dose-dependent effect on CD31, α-SMA resulting in regulation of granulation tissue formation during wound healing in diabetic murine models. While these preliminary studies show the potential of this treatment, further studies to optimize these compounds are needed.

Granulation tissue

CD31

Granulation

10.57604/prrs-004

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Citations (13)