Lei Xu

Xinjiang Agricultural University

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Co-Authors

Keith D. Kaufman

Merck & Co., Inc., Rahway, NJ, USA (United States)

Samuel S. Engel

Merck & Co., Inc., Rahway, NJ, USA (United States)

Kevin Norwood

Allogene Therapeutics (United States)

Xiaowu Zhong

Affiliated Hospital of North Sichuan Medical College

Fan Jin

Merck & Co., Inc., Rahway, NJ, USA (United States)

Yang Liu

Jishou University

Sarina A. Piha‐Paul

The University of Texas MD Anderson Cancer Center

Hyun Cheol Chung

Yonsei University

Xiaolan Guo

Affiliated Hospital of North Sichuan Medical College

Edward A. O’Neill

Merck & Co., Inc., Rahway, NJ, USA (United States)

Cooperative Institutions

Peking University

179

The George Institute for Global Health

150

University of Sydney

135

Chinese Academy of Sciences

131

UNSW Sydney

130

Shanghai Jiao Tong University

119

Royal Prince Alfred Hospital

111

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Sichuan University

Author Statistics

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Research Field

Additional file 4 of Metagenomics reveals the habitat specificity of biosynthetic potential of secondary metabolites in global food fermentations

Figshare (2023)

Rubing Du Wu Xiong Lei Xu Yan Xu Qun Wu

Additional file 4: Supplementary Data 4. Two thousand three hundred thirty-four biosynthetic gene clusters (BGCs) and their distributions in gene cluster families (GCFs).

10.6084/m9.figshare.23001827

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Citations (0)

Are Young Adults Talking about Their Family Health History? - A Qualitative Pilot Study

2015 APHA Annual Meeting & Expo (Oct. 31 - Nov. 4, 2015) (2015)

Lei Xu

Source

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Citations (0)

Natural helper cells are associated with the exacerbated airway inflammation seen during RSV reinfection of neonatally primed mice

International Immunopharmacology (2017)

Jianqi Wu Haiyan Hu Lei Xu Feifei Qi Song Bai

Adoptive Cell Transfer

Infiltration (HVAC)

10.1016/j.intimp.2017.02.011

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Citations (1)

Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial

Diabetologia (2013)

B Charbonnel H. Steinberg E. Eymard Lei Xu Parin Thakkar

Glimepiride

Vildagliptin

10.1007/s00125-013-2905-1

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Citations (54)

Additional file 1 of Combined use of specific length amplified fragment sequencing (SLAF-seq) and bulked segregant analysis (BSA) for rapid identification of genes influencing fiber content of hemp (Cannabis sativa L.)

Figshare (2022)

Yue Zhao Yufeng Sun Kun Cao Xiaoyan Zhang Jing Bian

Additional file 1: Supplemental Table 1. Detailed information about the fresh fiber content of F1 bulk and mixed pool

Bulked segregant analysis

Identification

Cannabis sativa

10.6084/m9.figshare.19808042

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Citations (0)

The relationship between physical activity and Internet addiction among adolescents in western China: a chain mediating model of anxiety and inhibitory control

Psychology Health & Medicine (2024)

Yang Liu Ting Xiao Wei Zhang Lei Xu Tiancheng Zhang

This study aims to investigate the mediating effect of anxiety and inhibitory control in the relationship between physical activity and Internet addiction (IA) among adolescents. A total of 951 adolescents from western China completed a self-report survey assessing physical activity, anxiety, inhibitory control, and IA. Descriptive analysis, correlation analysis, and mediation analysis were conducted using SPSS software and the Process plug-in. Controlling for age, gender, and only child status, the findings revealed a negative association between physical activity and anxiety, inhibitory control, and IA. Moreover, anxiety were positively correlated with inhibitory control and IA. Additionally, anxiety exhibited a positive association with inhibitory control. Notably, physical activity directly and negatively predicted IA in adolescents, while also indirectly predicting it through anxiety and inhibitory control. This study contributes to a deeper understanding of the mechanisms that underlie the complex effects of physical activity on IA among adolescents.

Inhibitory control

Association (psychology)

10.1080/13548506.2024.2357694

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Citations (14)

Neoadjuvant chemotherapy combined with immunotherapy versus neoadjuvant chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma

Journal of Thoracic and Cardiovascular Surgery (2024)

Yongkui Yu Fanyu Meng Xiufeng Wei Xiankai Chen Haomiao Li

Neoadjuvant Therapy

Chemoradiotherapy

10.1016/j.jtcvs.2023.12.030

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Citations (14)

Targeting cellular senescence as a therapeutic vulnerability in gastric cancer

Life Sciences (2024)

Haigang Geng Chen Huang Lei Xu Yangyang Zhou Zhong‐Yi Dong

Senescence

Vulnerability

Cellular senescence

10.1016/j.lfs.2024.122631

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Citations (1)

Identification of a Gene Prognostic Model of Gastric Cancer Based on Analysis of Tumor Mutation Burden

Pathology & Oncology Research (2021)

Weijun Ma Weidong Li Lei Xu Lu Liu Yu Xia

Introduction: Gastric cancer is one of the most common cancers. Although some progress has been made in the treatment of gastric cancer with the improvement of surgical methods and the application of immunotherapy, the prognosis of gastric cancer patients is still unsatisfactory. In recent years, there has been increasing evidence that tumor mutational load (TMB) is strongly associated with survival outcomes and response to immunotherapy. Given the variable response of patients to immunotherapy, it is important to investigate clinical significance of TMB and explore appropriate biomarkers of prognosis in patients with gastric cancer (GC). Material and Methods: All data of patients with gastric cancer were obtained from the database of The Cancer Genome Atlas (TCGA). Samples were divided into two groups based on median TMB. Differently expressed genes (DEGs) between the high- and low-TMB groups were identified and further analyzed. We identified TMB-related genes using Lasso, univariate and multivariate Cox regression analysis and validated the survival result of 11 hub genes using Kaplan-Meier Plotter. In addition, “CIBERSORT” package was utilized to estimate the immune infiltration. Results: Single nucleotide polymorphism (SNP), C > T transition were the most common variant type and single nucleotide variant (SNV), respectively. Patients in the high-TMB group had better survival outcomes than those in the low-TMB group. Besides, eleven TMB-related DEGs were utilized to construct a prognostic model that could be an independent risk factor to predict the prognosis of patients with GC. What’s more, the infiltration levels of CD4 + memory-activated T cells, M0 and M1 macrophages were significantly increased in the high-TMB group compared with the low-TMB group. Conclusions: Herein, we found that patients with high TMB had better survival outcomes in GC. In addition, higher TMB might promote immune infiltration, which could provide new ideas for immunotherapy.

SNP

Univariate analysis

10.3389/pore.2021.1609852

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Citations (12)

The relationship between childhood psychological abuse and depression in college students: internet addiction as mediator, different dimensions of alexithymia as moderator

BMC Public Health (2024)

Yang Liu Liangfan Duan Qingxin Shen Lei Xu Tiancheng Zhang

Childhood psychological abuse (CPA) is highly associated with depression among college students. However, the underlying mechanisms between these variables need further exploration. This study aims to investigate internet addiction as a mediating factor and alexithymia and its different dimensions as moderating factors, to further complement the psychological mechanisms between CPA and depression among college students.

Moderation

Biostatistics

Mediator

Depression

10.1186/s12889-024-20232-2

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Citations (5)