The proto‐oncogene protein DEK has been implicated in the t(6;9) chromosomal translocation associated with a subtype of acute myelogenous leukemia (AML), which results in the formation of a DEK‐CAN fusion protein. Histone acetylation is an important post‐translational modification which is involved in transcriptional regulation. In this study, we report that the acidic domain containing protein DEK interacts with histones and exerts a potent inhibitory effect on both p300 and PCAF‐mediated histone acetyltransferase activity and transcription. Using chromatin immunoprecipitation assays, we have demonstrated that the recruitment of DEK to the appropriate promoter induces the histone H3 and H4 hypoacetylation of chromatin. Collectively, our data illustrate the important regulatory role played by protein DEK in transcriptional regulation, and suggest that transcription‐regulating acidic domain regions may play a role in leukemogenesis.
A new design approach to clustered stud shear connection in composite bridges with precast decks is required to accommodate highly concentrated shear force in small area. Shear connection of the prefabricated slab consists of stud connectors, mortar in a shear pocket and reinforcement around the pocket. More general design approach for the shear connection is provided by relative strength between shear strength of shear connectors, bearing strength of mortar in shear pockets, and the shear strength of precast deck. Considering the relatively high strength mortar in the bearing zone of the shear connection this paper deals with structural performance of stud clusters to simplify the connection details. In a shear pocket, closer stud spacing than the current pitch requirement was considered. Push-out tests were conducted to evaluate the ultimate strength according to expected failure modes. The main parameters of the test were stud spacing and confining details. In order to use group arrangement of stud connectors, it is necessary to prevent premature failure of bearing zone by strengthening the shear connection using confining reinforcements. An empirical equation of ultimate shear strength of the shear connection was proposed to consider the effect of stud spacing when the spacing is less than five times stud diameter. Fatigue tests showed that the fatigue endurance of clustered stud connectors with spacing of more than three times stud diameter can be evaluated using current design codes.
4차 산업혁명의 핵심 분야 중 하나인 증강현실(AR) 관련 기술이 발전함에 따라 이러한 기술을 다양한 분야에 적용하려는 시도가 점차 증가하고 있다. 특히 군은 훈련장 부족 문제 해결 및 훈련 간 안전을 보장하기 위해 교육훈련 분야에 증강현실(AR) 기술을 접목하려는 연구를 활발히 진행 중이다. 또한 2019년 여름부터 국내에서 본격적으로 상용화되고 있는 5G 기술이 증강현실 등과 같은 4차 산업혁명 핵심기술들과 융합되면서 매우 높은 시너지 효과를 낼 것으로 기대된다. 이 논문에서는 5G 네트워크가 제공하는 초고속, 초저지연, 대용량 데이터 전송 특성과 증강현실(AR) 기술이 제공하는 생생한 현실감(reality)을 결합해 다양한 상황에서 다목적으로 활용할 수 있는 5G 기반 증강현실 통합 지휘통제플랫폼 구축 방안을 제시하고자 한다. 제안된 통합 지휘통제플랫폼을 활용하면 현장과 지휘소의 인원들 모두가 동일하고 정확한 상황인식(Situational Awareness, SA) 하에서 효율적이고 성공적인 작전을 수행할 수 있다. 나아가 이 논문에서는 제안된 통합 지휘통제플랫폼의 활용방안에 대해 살펴보고자 한다.
The effect of parasitic components such as equivalent series resistance, equivalent series inductance, and parasitic inductance of the load, on the dynamic response is presented. The analysis is useful in minimizing the output capacitor while meeting the voltage regulation of a buck converter. The proposed analysis quantifies the parasitic effects by an equivalent circuit model of the output stage. The effectiveness and preciseness of the analysis were verified by comparing estimation, simulation, and experimental results which is obtained by a 400-kHz 15 V-3.3 V prototype buck converter.
An in-depth analysis on the load transient operation of a buck converter with auxiliary current control is presented in this article. The analysis quantifies the effects of nonideal characteristics, such as the equivalent series resistance, inductor current and output voltage ripples, time delay, and slew rate of the load current, on the fluctuation of the output voltage in a practical implementation. The analysis results reveals that some of the non-idealities may cancel each other out and become negligible in the implementation. A design considering the nonidealities can achieve the transient-wise capacitor charge balance of the output capacitor and minimize the output voltage deviation during the load transient. The agreement between the simulation and experimental results validates the effectiveness and precision of the proposed analysis and design.
When a single-phase full bridge inverter with an LC filter is operated at no load through the proportional resonance controller, the proportional resonance controller becomes unstable when the influence of resonance is not considered. This paper propose a design method of PR controller that can be controlled stably at no load through design method of PR controller based on output impedance considering active damping of single phase full bridge inverter. The transfer function of the open-loop model and the controller model of the inverter is composed of the closed-loop transfer function. The validity of the proposed method is verified through simulation and experiment.
A control method for the auxiliary buck/boost converter is proposed to improve the load transient of the buck converter. The proposed technique maximizes the efficiency of the auxiliary converter by enabling the soft switching operation. The proposed control is free form complicated arithmetic operation, digital sampling, and load prediction, and is realized by simple analog components only. The design guidelines for achieving capacitor charge balance of the output capacitor during the transient are also presented. The simulation results revealed that the output voltage overshoot and settling time during the load step-down transient were 62 mV and 29.4 μs, respectively; however, in the case of conventional time-optimal control, these values were 666 mV and 57.2 μs, respectively, under the same condition. The prototype buck converter of which is input is 15 V, output is 3.3 V, switching frequency is 200 kHz had been built to prove the performance and effectiveness of the proposed technique.
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