Lili Wang

Zhoushan Hospital

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Chuanxin Wang

Shanghai Clinical Research Center

Lutao Du

Qilu Hospital of Shandong University

Yongmei Yang

Qilu Hospital of Shandong University

Hua Yang

Chinese Institute for Brain Research

Yang Zhao

Third Affiliated Hospital of Guangzhou Medical University

Guixi Zheng

Qilu Hospital of Shandong University

Haitao Wang

Tianjin Medical University

Xin Zhang

Capital Medical University

Shuo Chen

Third Affiliated Hospital of Guangzhou Medical University

Zhi‐Hong Zong

Xi'an University of Architecture and Technology

Cooperative Institutions

Shandong University

171

Chinese Academy of Medical Sciences & Peking Union Medical College

141

Chinese Academy of Sciences

132

Capital Medical University

131

Shanghai Jiao Tong University

123

Nanjing Medical University

121

Sun Yat-sen University

Huazhong University of Science and Technology

Peking University

Sichuan University

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Targeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression

Cancer Biology & Therapy (2022)

Zhang Li Ming Li Pengcheng Xia Lili Wang Zhiming Lu

Glioma is a primary intracranial malignant tumor with poor prognosis, and its pathogenesis is unclear. This study discussed the impact of p53/lncRNA plasmacytoma variant translocation 1 (lncRNA PVT1)/transforming growth factor beta (TGF-β)/Smad axis on the biological characteristics of glioma. Glioma and normal tissues were collected, in which relative lncRNA PVT1 and p53 expression was assessed. Pearson's analysis was adopted for the correlation analysis between lncRNA PVT1 and p53. Short interfering RNA (siRNA) against lncRNA PVT1 (siRNA-PVT1), siRNA-p53 or both was transfected into the glioma cells to evaluate effects of lncRNA PVT1 and p53 on cell proliferation, migration, invasion, and apoptosis. Mouse xenograft model of glioma was established to verify function of lncRNA PVT1 and p53 in vivo. Relationship among p53, lncRNA PVT1 and TGF-β/Smad was predicted and confirmed. Glioma tissues and cells showed downregulated p53 expression and increased lncRNA PVT1 expression. An adverse relationship was noted between p53 expression and lncRNA PVT1 expression. p53 was shown to be enriched in the lncRNA PVT1 promoter region and resulted in its suppression. p53 inhibited glioma cell proliferation, migration, and invasion, and induced apoptosis as well as arrested tumor growth by downregulating lncRNA PVT1. LncRNA PVT1was found to bind to TGF-β and activate TGF-β/Smad pathway, promoting progression of glioma. Consequently, p53 exerts anti-oncogenic function on glioma development by suppressing lncRNA PVT1 and subsequently inactivating TGF-β/Smad pathway.

PVT1

10.1080/15384047.2022.2042160

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Citations (17)

Self-Assembled Supramolecular Films Derived from Marine Deoxyribonucleic Acid (DNA)−Cationic Surfactant Complexes: Large-Scale Preparation and Optical and Thermal Properties

Chemistry of Materials (2001)

Lili Wang Jonichi Yoshida Naoya Ogata Sono Sasaki Tisato Kajiyama

Series of polyelectrolyte−surfactant complexes, DNA−cationic surfactant complexes (cetyltrimethylammonium, cetylpyridinium, and cetylbenzyldimethylammonium), and their self-assembled bulk film materials were prepared on a large scale. Circular dichroism (CD) analysis indicated that the right-handed double helix structure of DNA was retained in these bulk film materials. TGA analysis suggested that 4 molecules of water were required to retain the B-type conformation of the DNA helix in the self-assembled bulk film materials. In addition, it revealed that DNA and the DNA−surfactant complex film materials were thermostable up to as high as 180 °C. Thermodynamical analysis indicated that these film materials were thermo-extensive over a temperature range from 100 to 148 °C. The DNA conformation in the supramolecular complex films can be reversibly tuned by changing the environmental humidity. Film formation was found to occur by self-assembly and self-organization with evaporation of solvent molecules. Various functional dyes such as laser dye, NLO dye, and photochromic dye could easily be incorporated in the self-assembled supramolecular complex films as adducts. Studies of the induced CD spectra demonstrated that 4[4-(dimethylamino)styryl]-1-dococylpyridinium (DMASDPB) could orient on the chiral nanotemplates of DNA in the self-assembled films. UV−vis analysis indicated that these film materials have high transparency from 300 to about 1000 nm. These self-assembled functional-dye-containing DNA−surfactant complex materials, with good processability for multilayer integration into large-area devices, will have promising applications in molecular optical and molecular optoelectronic fields.

Cationic polymerization

Helix (gastropod)

10.1021/cm000869g

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Citations (339)

Au nanocages/SiO₂ as saturable absorbers for passively Q-switched all-solid-state laser

Materials Research Express (2018)

Lili Wang Xiaohan Chen Jinxi Bai Binghai Liu Qiongyu Hu

Based on Au nanocages/SiO2 (Au-NCs/SiO2) as saturable absorber (SA), passively Q-switched Nd:YVO4 lasers with the output couplers (OCs) with the transmittance (T) of 4% and 10.8% were demonstrated, respectively. Q-switched pulse with the shortest pulse duration of 154.2 ns was achieved at T = 4% under the pump power of 2.11 W with the corresponding repetition rate of 280.0 kHz and average output power of 140.6 mW. While the maximum average output power of 150.2 mW was obtained at T = 10.8% under the pump power of 2.42 W, corresponding to the pulse width and repetition rate of 222.0 ns and 279.1 kHz.

Nanocages

Saturable absorption

Q-switching

Pulse duration

Output coupler

10.1088/2053-1591/aabe11

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Citations (1)

Effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants

Tropical Journal of Pharmaceutical Research (2024)

Lili Zhang Lili Wang Mei You Zi-xuan Wei Yuan Ding

Purpose: To investigate the effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants. Methods: A total of 151 preterm infants admitted to the Neonatology Department, First Affiliated Hospital of Anhui Medical University, Hefei, China, from November 2020 to June 2021 were selected. Preterm infants were randomly divided into control and study groups. Control group received 2 % povidone-iodine and 75 % ethanol application, followed by gentle pressure with a cotton swab while the study group received amoxicillin-clavulanate potassium applied to the umbilical cord while shaking. The management interventions were stopped after umbilical cord separation in preterm infants, and the difference in umbilical cord separation time between the two groups was compared. Factors associated with preterm birth conditions, hospitalization, and maternal health were identified by univariate and multivariate logistic regression analyses. Results: The number of cases with umbilical cord separation time > 14 days was significantly higher in the study group compared to control group (p < 0.05). The average umbilical cord separation time in the study group was significantly lower compared to control group (p < 0.05). Univariate analysis revealed that incubator residence time significantly affects umbilical cord separation time in preterm infants (p < 0.05). Logistic multivariate regression analysis identified incubator residence time as the main factor influencing umbilical cord separation time in preterm infants. Conclusion: The use of amoxicillin-clavulanate potassium shortens umbilical cord separation time, and incubator residence time is the major factor influencing umbilical cord separation in preterm infants. Further studies should expand the study scale and increase the number of samples used.

Neonatology

10.4314/tjpr.v23i7.18

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DNA‐repair status should be assessed in treatment‐emergent neuroendocrine prostate cancer before platinum‐based therapy

The Prostate (2022)

Shimiao Zhu Zheng Zhang Hui Zhang Zihao Liu Min Liu

Abstract Objectives This study sought to provide contemporary data from a multi‐institution with respect to DNA‐repair genes (DRGs) status and its impact on effects of platinum‐based chemotherapy in treatment‐emergent neuroendocrine prostate cancer (t‐NEPC), for which little data exist. Patients and Methods All patients were retrospectively collected with eligible biopsied tissues for targeted next generation sequencing (NGS). The main outcomes were radiologic progression‐free survival and overall survival according to Response Evaluation Criteria in Solid Tumors, version 1.1. Results Among the 43 NEPC patients, 13/43 (30%) harbored homozygous deletions, deleterious mutations, or both in DRGs. Eleven patients (11/13, 85%) with DRGs aberrations had effective response, including 7 patients with BRCA1/2 defects and 2 with mismatch repair‐deficient caused by MSH2 alterations. While significantly fewer responders (30%) were detected in patients without DRGs aberrations (odds ratio = 12.83, p = 0.003). Compared with patients without genomic DRGs aberrations, the hazard ratio (HR) for radiologic progression in those with DRGs defects was 0.42 (95% confidence interval [CI]: 0.19–0.93), and the HR for death was 0.65 (95% CI: 0.24–1.72). The most common adverse event of Grade 3 or 4 was anemia, as noted in 7 patients (16%). Conclusion The DRGs status is therapeutically meaningful in t‐NEPC. Given the potential responses to platinum‐based chemotherapy, our findings support the clinical use of NGS in t‐NEPC patients to identify DRGs aberrations.

Carboplatin

10.1002/pros.24292

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Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer

Technology in Cancer Research & Treatment (2023)

Limeng Yu Ruilin Wang Yuhua Zhao Yingxi Wu Lili Wang

Epidermal growth factor receptor (EGFR) mutations are common driver genes in nonsmall-cell lung cancer and have different sensitivities to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). EGFR is divided into classic mutations and rare mutations. Classic mutations are well known, but the understanding of rare mutations is not sufficient. In this article, we summarize the clinical research and treatment progress of rare mutations for different EGFR-TKIs and provide a basis for clinical treatment decisions.

10.1177/15330338231168466

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Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice

Frontiers in Microbiology (2022)

Yu Feng Yanbo Yu Zheng Chen Lili Wang Jingyu Ma

As a chronic metabolic disease caused by disorders of purine metabolism, gout has shown increasing incidence rate worldwide. Considering that gout is not easily treated and cured, further studies are explored to prevent gout development through diet modification. Both β-carotin and green tea powder are rich in dietary fiber, which helps maintain the balance of gut microbiota in humans. The aim of this study was to investigate the effects of β-carotin and green tea powder diet on the prevention of gouty arthritis in relation to the bacterial structure of gut microbiota in mice. We successfully induced gouty arthritis in C57BL/6 mice by injecting monosodium urate (MSU) crystals and feeding high-fat diet (HFD), and further investigated the effects of additional β-carotin and green tea powder in the diets of mice on the prevention of gouty arthritis in mice. Our results showed that diet of β-carotin and green tea powder reduced the joint swelling and pain in mice with gout, reduced the levels of serum uric acid (UA) and three types of pro-inflammatory cytokines, i.e., interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), improved the gut microbiota profile, and reduced the metabolic levels of purines and pyrimidines. In conclusion, our study provided evidence to support the application of β-carotin and green tea powder diet as a dietary adjustment method to prevent and treat gouty arthritis.

Gouty arthritis

Purine metabolism

10.3389/fmicb.2022.837182

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MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2

Cancer Letters (2012)

Juan Li Lutao Du Yongmei Yang Chuanxin Wang Hui Liu

10.1016/j.canlet.2012.10.019

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Citations (120)

Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability

Therapeutics and Clinical Risk Management (2021)

Xiangli Xu Hua Yang Beibei Liu Fubo Zhou Lili Wang

To investigate the relationship between calcification characteristics of carotid atherosclerotic plaque and lipid rich necrotic core (LRNC) and intraplaque hemorrhage (IPH).Patients with severe carotid stenosis undergoing carotid endarterectomy (CEA) were selected. Ultrasound and CT angiography (CTA) were performed to evaluate the calcification characteristics of the plaque before the surgery.A total of 142 patients were included and 142 pathological specimens of postoperative plaque were obtained accordingly. There were 78 plaques (54.9%) with LRNC and 41 (28.9%) with IPH. The plaque with LRNC had higher calcification rate (93.6%) compared with the plaque with IPH (87.8%). LRNC was often found in multiple calcification (P = 0.003) and mixed type calcification (P = 0.001). Multiple calcification was more likely to combine with IPH (P = 0.008), while simple basal calcification was not likely to combine IPH (P = 0.002). Smaller granular calcification was more likely to be associated with IPH (P < 0.05). In multivariate regression analysis of IPH and calcification characteristics, simple basal calcification was still a protective factor for IPH (OR, 0.25; 95% CI, 0.09-0.66; P = 0.005), while multiple calcification was closely related to the occurrence of IPH (OR, 3.58; 95% CI, 1.49-8.61; P = 0.004).Calcification characteristics of carotid atherosclerotic plaques are closely related to the vulnerability of plaques, especially multiple calcification and mixed type calcification.

Fibrous cap

10.2147/tcrm.s303485

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Citations (13)

Interventional Therapy for Transplant Renal Artery Stenosis Is Safe and Effective in Preserving Allograft Function and Improving Hypertension

Vascular and Endovascular Surgery (2016)

Lili Wang Bin Liu Jieke Yan Yongzheng Wang Wujie Wang

Purpose: To evaluate the outcomes of percutaneous intervention (PI) for transplant renal artery stenosis (TRAS). Materials and Methods: Doppler ultrasonography was used as the screening tool, and angiography was the diagnostic method for TRAS. The indications for PI were (1) a reduction in lumen diameter of >50% or (2) a mean pressure gradient of >15 mm Hg. Technical success was assessed immediately after the procedure. The short-term results of stenosis were evaluated by serum creatinine (Scr) levels and blood pressure (BP). The long-term results were assessed by graft survival and renal function. Results: From October 2009 to July 2015, a total of 660 patients had kidney transplantation and 22 cases underwent PI. The technical success was 100%. The mean Scr level preintervention was 321.6 ± 167.2 (range, 171.3-862.0) μmol/L, and it decreased to 145.3 ± 44.7 (range, 74.3-260.8) μmol/L 1 month postintervention ( P < .001). Blood pressure was also improved at 1 month postintervention, as assessed by systolic (157.0 ± 13.0 vs 131.0 ± 11.0 mm Hg, P < .001), diastolic (95.0 ± 5.0 vs 77.0 ± 9.0 mm Hg, P < .001), and mean arterial pressure (116.0 ± 7.0 vs 95.0 ± 9.0 mm Hg, P < .001). The patency rate was 100%, 91.7%, and 85.7% at 1, 3, and 12 months, respectively. The secondary patency rate was 100%. Graft survival was 100% during follow-up. There was no significant deterioration in graft function or BP ( P > .05) postintervention when compared to posttransplantation. Conclusions: Percutaneous intervention for TRAS is safe and results in significant improvement both in allograft function and in BP.

10.1177/1538574416682157

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Citations (12)