Large-scale selective synthesis of uniform microcrystals lead tungstate (PbWO4) with controlled morphologies has been achieved via a facile surfactant-assisted hydrothermal process. The formation of PbWO4 crystal is strongly dependent on its reaction parameters. The variation of different types of surfactants (such as P123, cetyltrimethyl ammonium bromide (CTAB), poly (vinyl pyrrolidone) (PVP), and dodecyl benzene sulfonic acid sodium salt (SDBS), respectively), reaction temperature, and reaction time are found to play a crucial role in controlling the particle size and morphology of the products. The growth process has been investigated by carefully following time-dependent experiments, and the oriented attachment process has been proposed for the possible formation mechanism. The optical properties, such as UV−vis spectra and PL spectra of PbWO4 crystals, were studied and the room-temperature photoluminescence of PbWO4 samples with different morphologies was investigated.
Au 25 nanoclusters as a self-therapeutic nanodrug significantly modulated macrophage polarization from M1 to M2 and could act as an inhibitor of thioredoxin reductase (TrxR), which induced ROS-mediated FLS apoptosis by breaking redox homeostasis.
We have described a turn-on near-infrared fluorescent probe Cy–NO2 based on nitro group reduction for intracellular H2S detection. The probe employs cyanine dye as a fluorophore, and is equipped with a nitro group as a fluorescent modulator. It is readily employed for assessing intracellular H2S level changes, and confocal imaging is achieved successfully.
Through the comparisons with the testing resultes of solidified resins, conceived and designed a new formula after repeated orthogonal experiment analysis. The film-forming materials are fluorine carbon resin and organic silicon modified acrylic resin.Same additives are added to improve it's physical and chemical characteristics. By experiment, the viscosity, solidifying time, adhesion, water resistant, hardness, abrasion resistance, thickness and contact angle were tested.
Introduction Gestational diabetes mellitus (GDM) is a condition characterized by glucose intolerance during pregnancy, estimated to affect approximately 20% of the whole pregnancies and is increasing in prevalence globally. However, there is still a big gap in knowledge about the association between gut microbiota associated metabolism alterations and GDM development. Methods All the participants accomplished the validated internet-based dietary questionnaire for Chinese and serum, fecal samples were collected. HFD, control diet or colesevelam intervention was fed to GDM mice models or Fxr-/- mice models, with or without antibiotics cocktail treatment. Fecal microbiota transplantation were used for further validation. Gut microbiota and metabolites were detected by metagenomic sequencing and high-performance liquid chromatography-mass spectrometry, respectively. Bile acids of serum, fecal samples from human and mice were analysised. Body weight, average feed intake, blood glucose, insulin levels and oral glucose tolerance test was performed among each groups. Expression levels of Fxr, Shp and Fgf15 mRNA and protein were detected by quantitative reverse transcription polymerase chain reaction and western blot, respectively. Results Our data indicated that high fat diet (HFD) was linked with higher prevalence of GDM, and HFD was positively associated with poor prognosis in GDM patients. Moreover, compared with normal diet (ND) group, GDM patients from HFD group performed a loss of gut microbiota diversity and enrichment of Alistipes onderdonkii , Lachnospiraceae bacterium 1_7_58FAA , and Clostridium aspaaragiforme while ruduction of Akkermansiaceae, Paraprevotell xylaniphila, and Prevotella copri . Additionally, HFD aggravated GDM in mice and gut microbiota depletion by antibiotics crippled the effect of excess fat intake. BAs profile altered in HFD GDM patients and mice models. Fecal microbiota transplantation (FMT) further confirmed that gut microbiota contributed to bile acids (BAs) metabolic dysfunction during HFD-associated GDM development. Mechanically, HFD-FMT administration activated Fxr, Shp, and Fgf15 activity, disturbed the glucose metabolism and aggravated insulin resistance but not in HFD-FMT Fxr−/− mice and ND-FMT Fxr−/− mice. Furthermore, colesevelam intervention alleviated HFD-associated GDM development, improved BAs metabolism, suppressed Fxr, Shp, and Fgf15 activity only in WT mice but not in the Fxr−/− HFD + Colesevelam group and Fxr−/− HFD group. HFD induced GDM and contributed to poor prognosis in GDM parturients through inducing gut microbial dysbiosis and metabolic alteration, especially appeared in BAs profile. Moreover, Fxr pathway participated in regulating HFD-associated gut microbiota disordered BAs metabolites and aggravating GDM in mice. Discussion Modulating gut microbiota and BAs metabolites could be a potential therapeutic strategy in the prevention and treatment of HFD-associated GDM.
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