Kexin Li

Fudan University

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Pingping Zheng

Jilin University

Yan Yao

Jilin University

Tianyu Feng

Jilin University

Pan Pan

Jinan Central Hospital

Lina Jin

Jilin University

Yaogai Lv

Jilin University

Mengzi Sun

First Affiliated Hospital of Xi'an Jiaotong University

Chunli Bi

China Academy of Information and Communications Technology

Yingshuang Wang

Chengdu University of Traditional Chinese Medicine

Zhiqiang Xue

Xidian University

Cooperative Institutions

Jilin University

Chinese Academy of Sciences

Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhongshan Hospital

Peking University

Harbin Medical University

Huazhong University of Science and Technology

Central South University

First Affiliated Hospital of Zhengzhou University

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Myocardial infarction-induced hippocampal microtubule damage by cardiac originating microRNA-1 in mice

Journal of Molecular and Cellular Cardiology (2018)

Linlin Sun Ming-Jing Duan Jichao Ma Ling Xu Meng Mao

10.1016/j.yjmcc.2018.05.009

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Citations (36)

Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism

Cell Research (2025)

Wei Fu Yunfeng Lai Kexin Li Yue Yang Xiao Guo

Abstract Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2. In the current study, we found that the depletion of Ntsr2 in white adipocytes upregulated food intake, while the local treatment of NTS suppressed food intake. Our mechanistic study revealed that suppression of NTS-NTSR2 signaling enhanced the phosphorylation of ceramide synthetase 2, increased the abundance of its products ceramides C20–C24, and downregulated the production of GDF15 in white adipose tissues, which was responsible for the elevation of food intake. We discovered a potential causal and positive correlation between serum C20–C24 ceramide levels and human food intake in four populations with different ages and ethnic backgrounds. Together, our study shows that NTS-NTSR2 signaling in white adipocytes can regulate food intake via its direct control of lipid metabolism and production of GDF15. The ceramides C20–C24 are key factors regulating food intake in mammals.

Thermogenin

10.1038/s41422-024-01038-8

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Citations (1)

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

Frontiers in Pharmacology (2019)

Ruizheng Sun Ranran Wang Siyuan Chang Kexin Li Rongsi Sun

Lung cancer is one of main causes of cancer mortality and 83% of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Patients with NSCLC usually have a poor prognosis and one of the leading causes is drug resistance. With the progress of drug therapy, the emergence and development of drug resistance affected the prognosis of patients severely. Accumulating evidence reveals that long non-coding RNAs (lncRNAs), as "dark matters" of the human genome, is of great significance to drug resistance in NSCLC. Herein, we review the role of lncRNAs in drug resistance in NSCLC.

10.3389/fphar.2019.01457

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Citations (26)

2型糖尿病におけるlncRNA-circRNA-miRNA-mRNAネットワークのハイスループット配列決定と探索【JST・京大機械翻訳】

BioMed Research International (Web) (2020)

Fang Yang Chen Yang Zhiqiang Xue Yaogai Lv Li Shen

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Identification of The Critical Genes and miRNAs in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis

Research Square (Research Square) (2021)

Jun Wang Chuyan Wang Liuqing Yang Kexin Li

Abstract Hepatocellular carcinoma (HCC) is a global health problem with a complex etiology and pathogenesis. Microarray data is increasingly being used as a novel and effective method for cancer pathogenesis analysis. To unravel the potential prognosis of HCC, an integrative study of mRNA and miRNA for HCC was conducted. Two microarray datasets (GSE89377 and GSE101685) and two miRNAs expression profiles (GSE112264 and GSE113740) were obtained from Gene Expression Omnibus (GEO) database. A total of 177 DEGs and 80 DEMs were screened out. Functional enrichment of DEGs was proceeded by Clue GO, including GO and KEGG pathway analysis. These genes were significantly enriched in chemical carcinogenesis. PPI network was then established on the STRING platform, and ten hub genes (CDC20, TOP2A, ASPM, NCAPG, AURKA, CYP2E1, HMMR, PRC1, TYMS, and CYP4A11) were visualized via Cytoscape software. Then, a miRNA-target network was established to identify the dysregulated miRNA. A key miRNA (hsa-miR-124-3p) was filtered. Finally, the miRNA-target- transcription factor networks were constructed for hsa-miR-124-3p. The network for hsa-miR-124-3p included two transcription factors (TFs) and five targets. These identified DEGs and DEMs, TFs, targets, and regulatory networks may help advance our understanding the underlying pathogenesis of HCC.

KEGG

Gene regulatory network

10.21203/rs.3.rs-1042663/v1

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miR‑1299/NOTCH3/TUG1 feedback loop contributes to the malignant proliferation of ovarian cancer

Oncology Reports (2020)

Yuqing Pei Kexin Li Xiaoying Lou Yue Wu Xin Dong

Recent studies have revealed the oncogenic role of notch reporter 3 (NOTCH3) in ovarian cancer (OC). However, the possible regulators and mechanisms underlying notch receptor 3 (NOTCH3)‑mediated behaviors in OC remain to be completely investigated. In the present study, we aimed to identify regulators of NOTCH3 and their interactions underlying the pathogenesis of OC. Bioinformatics analysis and luciferase reporter assay were used to identify potential regulatory miRNAs and lncRNAs of NOTCH3 in OC. Several in vivo and in vitro assays were performed to evaluate their effects on the proliferative ability mediated by NOTCH3. We identified microRNA‑1299 (miR‑1299) as a novel negative regulator of NOTCH3. miR‑1299 was downregulated in OC and was found to be considerably correlated with tumor differentiation. Upregulation of miR‑1299 inhibited cell proliferation, colony formation, and 5‑ethynyl‑2'‑deoxyuridine (EdU) incorporation, as well as induced cell cycle arrest in the G0G1 phase in OC cells. Overexpression of miR‑1299 in xenograft mouse models suppressed tumor growth in vivo. The lncRNA taurine upregulated gene 1 (TUG1), acting as a sponge of miR‑1299, was found to upregulate NOTCH3 expression and promote cell proliferation in OC through the competing endogenous RNA mechanism. In addition, TUG1 was found to be a potential downstream target of NOTCH3, forming a miR‑1299/NOTCH3/TUG1 feedback loop in the development of OC. Collectively, our findings improve the understanding of NOTCH3‑mediated regulation in OC pathogenesis and facilitate the development of miRNA‑ and lncRNA‑directed diagnostics and therapeutics against this disease.

Competing Endogenous RNA

Pathogenesis

10.3892/or.2020.7623

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Citations (24)

LncRNA MIR155HG Overexpression Promotes Proliferation, Migration, and Chemoresistance in Gastric Cancer Cells

International Journal of Medical Sciences (2023)

Hong Lin Ruoxuan Ni Dongdong Li Mei Zhao Yan Li

Long non-coding RNAs are thought to play a vital role in a variety of human malignancies.Studies have shown that MIR155 host gene (MIR155HG) acts as an oncogene in several cancers, but the function and its mechanism of MIR155HG in gastric cancer (GC) is still poorly understood.In this study, we determined the biological functions and underlying mechanisms of MIR155HG in GC cells.We found that expression levels of MIR155HG was increased markedly in GC patients' serum.In vitro and in vivo studies demonstrated that MIR155HG modulated the malignant phenotype of GC cells, such as cell proliferation, colony forming ability, cell migration ability, and tumor growth in nude mice.Next, our results revealed that NF-κB and STAT3 signaling pathways could be involved in regulating the malignant behavior of GC cells.Our rescue experiments showed that inhibiting NF-κB and STAT3 signaling pathways attenuated the phenotypes caused by MIR155HG overexpression.Moreover, cytotoxicity and apoptosis assays revealed overexpression of MIR155HG reduced the apotosis of GC cells induced by cisplatin and 5-FU.Together, our studies suggested that MIR155HG overexpression promoted proliferation, migration, and chemoresistance of GC cells.These results might provide a lncRNA-based target for GC treatment in future.

10.7150/ijms.82216

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Citations (8)

Identification of the critical genes and miRNAs in hepatocellular carcinoma by integrated bioinformatics analysis

Medical Oncology (2022)

Jun Wang Chuyan Wang Liuqing Yang Kexin Li

Gene regulatory network

Interaction network

10.1007/s12032-021-01622-7

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Citations (7)

Natural Small Molecule Compounds Targeting Wnt Signaling Pathway Inhibit HPV Infection