Fan Chen

Qinghai University Affiliated Hospital

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Qiuzi Zhong

Chinese Academy of Medical Sciences & Peking Union Medical College

Ye‐Xiong Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Lin Yin

Qinghai University Affiliated Hospital

Hua Wang

The University of Texas MD Anderson Cancer Center

Zemin Li

The First Affiliated Hospital, Sun Yat-sen University

Zhaomin Zheng

Sun Yat-sen University

Yong Yang

Shanghai Jiao Tong University

Hao Jing

Chinese Academy of Medical Sciences & Peking Union Medical College

Shulian Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Jianru Wang

The First Affiliated Hospital, Sun Yat-sen University

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Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

The First Affiliated Hospital, Sun Yat-sen University

Sichuan University

Chinese Academy of Sciences

Peking Union Medical College Hospital

Peking University

Central South University

Fujian Medical University

Shanghai Jiao Tong University

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Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma

Aging (2020)

Qifeng Ou Ning Ma Zheng Yu Rongchang Wang Yucheng Hou

We investigated the prognostic significance of Nudix hydrolase 1 (NUDT1) in hepatocellular carcinoma (HCC).NUDT1 mRNA and protein levels were significantly higher in HCC tissues than normal liver tissues.The level of NUDT1 expression correlated with tumor grade, stage, size, differentiation, degree of vascular invasion, overall survival (OS), and disease-free survival (DFS) in HCC patients.Multivariate analysis showed that NUDT1 expression was an independent prognostic factor for OS and DFS in HCC patients.We constructed a prognostic nomogram with NUDT1 expression, AFP levels, vascular invasion, Child-Pugh classification, age, sex, AJCC staging, and tumor differentiation as variables.This nomogram was highly accurate in predicting the 5-year OS of HCC patients (c-index= 0.709; AUC= 0.740).NUDT1 silencing in HCC cells significantly reduced their survival, colony formation, migration, and invasiveness.Gene set enrichment analysis showed that biological pathways related to cell cycle, fatty acid metabolism, bile acid and bile salt metabolism, and PLK1 signaling were associated with NUDT1, as were the gene ontology terms "DNA binding transcription activator activity," "RNA polymerase II," "nuclear division," and "transmembrane transporter activity."Our study thus demonstrates that NUDT1 is a prognostic biomarker with therapeutic potential in HCC patients.

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10.18632/aging.103083

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Citations (12)

Efficacy of three internal fixation methods for type C distal humeral fractures: a comparative study

Zhonghua chuangshang zazhi (2013)

Guo Yong-zhi He‐ling Dai Jianwen Zhao Shaoguang Li Cheng Peng

Objective To compare effects of three internal fixation techniques in treatment of type C distal humeral fractures.Methods The study involved 75 patients with type C distal humeral fractures undergone double tension band fixation (Group A,n =22),vertical dual-plate fixation (Group B,n =27),or parallel dual-plate fixation (Group C,n =26) between January 2003 and October 2010.According to AO classification of fractures,there were five patients with type C1,11 with type C2 and six with type C3 in Group A; four with type C1,13 with type C2 and 10 with type C3 in Group B; seven with type C1,10 with type C2 and nine with type C3 in Group C.Bilateral approach through triceps brachii or olecranon osteotomy following median incision over posterior elbow was undertaken for all the patients.An analysis was made on indices like fixation modes,elbow range of extension and flexion,and complications.In addition,elbow function was assessed according to the modified Cassebaum scoring system.Results All patients were followed up for average 18 months,which showed bone union without wound infection.At the last follow-up,extension and flexion of the elbow was (122.06 ± 13.13)° in Group A,(118.70 ± 12.37)° in Group B,and (119.90 ± 11.79)° in Group C respectively,with no significant differences among groups(P ＞ 0.05).Overall excellence rate was 82％ in Group A,85％ in Group B and 85％ in Group C,respectively (P ＞ 0.05).Conclusion All three internal fixation techniques can attain a good clinical outcome in treatment of type C distal humeral fracture and satisfy the biomechanical requests of distal humerus. Key words: Humeral fractures; Internal fixators; Plates

10.3760/cma.j.issn.1001-8050.2013.05.003

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Deletion of protein kinase B2 preserves cardiac function by blocking interleukin-6-mediated injury and restores blood pressure during angiotensin II/high-salt-diet-induced hypertension

Journal of Hypertension (2017)

Shuai Yang Dandan Chen Fan Chen Xinmei Zhao Yubin Zhang

Protein kinase B2 (AKT2) is implicated in cardiomyocyte survival during various stress conditions. However, the role of AKT2 in heart function, cardiac hypertrophy and blood pressure (BP) control during hypertension is not fully understood. Therefore, we sought to determine whether the deletion of AKT2 protects cardiac function during angiotensin II/high-salt-diet (AngII/HSD) treatment and find out the signaling pathway.Male C57BL/6J (wild type), AKT2 knockout and interleukin (IL)-6 knockout mice were fed a 4% NaCl diet for 5 weeks. In the last week, mice were split in two groups and infused subcutaneously with either vehicle or AngII (1.5 μg/h per mouse) for 1 week. Then, BP and cardiac function were assessed. Immunohistology of IL-6 and monocyte chemoattractant protein 1 was performed to detect inflammation in the heart. Masson's trichrome staining was performed to evaluate cardiac fibrosis. Heart tissue homogenates and neonatal mice cardiomyocytes were collected to analyze oxidative stress.Compared with wild-type mice, AKT2 knockout mice maintained BP and showed better left ventricle ejection fraction, lower level of fibrosis, reduced oxidative stress, reduced IL-6 expression and less macrophage infiltration, when treated with AngII/HSD. IL-6 knockout mice treated with AngII/HSD also showed alleviated left ventricular function, fibrosis, oxidative stress and macrophage infiltration compared with wild type.AKT2 deficiency prevents the development of AngII/HSD-induced hypertension, cardiac dysfunction and myocardial injury including oxidative stress, fibrosis and inflammation by suppressing IL-6 expression. These data reveal an important role of the AKT2-IL-6 pathway in mediating AngII/HSD-induced hypertension and cardiomyopathy.

Knockout mouse

Cardiac Fibrosis

10.1097/hjh.0000000000001613

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Citations (10)

Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas

Modern Pathology (2009)

Khush Mittal Fan Chen Jian Wei Kiran Rijhvani Rohini Kurvathi

Uterine Leiomyoma

Smooth Muscle Tumor

Ki-67

10.1038/modpathol.2009.96

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Citations (117)

Supplementary Tables 1-2 from Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis

Guanghui Wang Fuquan Jiang Yinghui Duan Zhi-Ping Zeng Fan Chen

<p>PDF file - 44K, S1. The predicted truncated merlin protein was not detected in Ben-Men-1 cells. S2. IC50 determination of AR-42 in normal meningeal cells. S3. AR-42 treatment increased protein acetylation and decreased p-AKT. S4. Normal meningeal cells proliferate with a doubling time of about three days. S5. Ben-Men-1-LucB and parental Ben-Men-1 cells exhibit similar sensitivities to AR-42. S6. Intracranial NF2-deficient KT21-MG1 xenograft tumors demonstrated features of malignant meningiomas. S7. Ben-Men-1-LucB xenografts strongly expressed vimentin, amesenchymal marker for meningiomas. S8. AR-42 treatment caused tumor regression, whereas AR-12 treatment slowed tumor growth over time. S9. MRI detected a small tumor in a Ben-Men-1-LucB tumorbearing mouse treated with AR-42 for three months. S10. MRI did not detect the residual tumor in an AR-42-treated mouse after removal from AR-42 diet for six months.</p>

10.1158/0008-5472.22396940.v1

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RNA interference against interleukin-5 attenuates airway inflammation and hyperresponsiveness in an asthma model

Journal of Zhejiang University SCIENCE B (2009)

Shaoxing Chen Feng‐Ying Huang Guang‐Hong Tan Cai‐Chun Wang Yonghao Huang

10.1631/jzus.b0820226

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Citations (6)

Influence of Age on Long-term Net Survival Benefit for Early-stage MALT Lymphomas Treated With Radiotherapy: a SEER Database Analysis (2000-2015)

Research Square (Research Square) (2022)

Yunpeng Wu Xin Liu Brandon S. Imber Qiuzi Zhong Yong Yang

Abstract BACKGROUND Given the lower incidence of lymphoma-related death but higher background mortality in patients with early-stage mucosa-associated lymphoid tissue (MALT) lymphoma, it is critically important to examine how age affects a treatment’s survival benefit. METHODS 9,467 patients with early-stage MALT lymphoma in the Surveillance, Epidemiology, and End Results (SEER) database treated between 2000-2015 were extracted and analyzed. Primary therapy was classified as radiotherapy (n = 3,407), chemotherapy (n = 1,294), and other/unknown treatments including observation (n = 4,766). Inverse probability of treatment weighting (IPTW) was conducted to balance baseline characteristics between groups. Relative survival (RS), standardized mortality ratio (SMR), and transformed Cox regression were conducted to compare survival differences between treatment modalities by controlling for the background mortality. Radiotherapy–age interaction was examined. RESULTS Across age-groups, early-stage MALT lymphoma patients were at lower risk of lymphoma-related death than death due to other causes. The 10-year overall survival (OS, 73.8%) and RS (96.6%) rates were significantly higher, and the SMR (1.14) significantly lower, with radiotherapy than with chemotherapy (OS, 61.7%; RS, 86.4%; SMR, 1.54; P < 0.001) or other/unknown treatments (OS, 61.1%; RS, 87.2%; SMR, 1.41; P < 0.001). By multivariable analysis and IPTW, radiotherapy remained an independent predictor of better RS (HR 0.81, 95%CI, 0.73-0.89; P < 0.001). A significant interaction between age and radiotherapy was identified for both RS ( P interaction = 0.016) and OS ( P interaction = 0.024), indicating greater benefit in young adults. CONCLUSION Radiotherapy can provide significant survival benefit in early-stage MALT lymphoma, especially in young adults.

10.21203/rs.3.rs-1417451/v1

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Clinical observation of 532nm laser photocoagulation for pre-retinal hemorrhage

Fan Chen

Objective To explore the clinical efficacy of 532 nm laser photocoagulation for pre-retinal hemorrhage. Methods T hirteen patients( 1 3 eyes) with pre-retinal hemorrhage in our hospital from January 2 0 1 0 to O cto ber 2 0 1 3 were collected and the clinical data were retrospectively analyzed. All 1 3 eyes were treated by 5 3 2 nm laser photo co agulation,in which 8 eyes underwent the laser photo co agulation treatment of pre-retinal hemorrhage after the laser incision and drainage of the posterior vitreous cortex had failed,5 eyes with the treatment duration of over 2 weeks directly underwent the laser photo co agulation treatment. All the patients went through the retinal laser photo co-agulation once or tw ice,the follow-up time was 1 month,the visions,fundus photo-graphs and com plications were o bserved. Results O f all the 1 3 eyestreated by laser,6eyes( 4 6. 2 %) undergone the retinal laser photo co agulation once and 7 eyes( 5 3. 8 %)tw ice. After the treatment the pre-retinal hemorrhage significantly absorbed and the average time of absorbing was 1 8. 9 2 days. The vision of all cases im proved tovarying de-grees,the average vision at postoperative 1 month im proved by 6. 0 lines. N ophoto co agulation spots were left and nopigment proliferation appeared on the laser mark after pre-retinal hemorrhage absorbing. N o o bvious laser com plication was o bserved in all cases. Conclusion 5 3 2 nm laser photo co agulation for pre-retinal hemorrhage is sim ple,practical,safe and effective,and can be operated repeatedly. It can be used as an effective metho d after the failure of the laser incision and drainage of the posterior vitreous cortex or in the context of arelatively long duration.

Vitreous hemorrhage

Fundus (uterus)

Laser Treatment

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Prediction of 5‐year overall survival of diffuse large B‐cell lymphoma on the pola‐R‐CHP regimen based on 2‐year event‐free survival and progression‐free survival

Cancer Medicine (2024)

Wan‐Ru Zhang Xin Liu Qiuzi Zhong Tao Wu Yong Yang

Abstract This study aimed to predict the 5‐year overall survival (OS) benefit of pola‐R‐CHP versus R‐CHOP in the POLARIX trial based on the 2‐year event‐free survival (EFS) and progression‐free survival (PFS) rates in diffuse large B‐cell lymphoma (DLBCL). We identified randomized controlled trials (RCT) published before 31 May 2023. The correlation between the logarithmic (log) hazard ratio (HR) for EFS (HR EFS ) or PFS (HR PFS ) and the HR for OS (HR OS ) was estimated at the trial‐level. Correlation analysis was performed between 2‐year PFS or EFS and 5‐year OS rates at the treatment arm‐level. Linear regression models were used to calculate the 5‐year OS of pola‐R‐CHP and R‐CHOP. In the included 20 RCTs, a linear correlation between HR EFS ( r = 0.765) or HR PFS ( r = 0.534) and HR OS was observed at the trial‐ level. Two‐year EFS ( r = 0.918) or 2‐year PFS ( r = 0.865) correlated linearly with 5‐year OS. Linear regression analysis between 2‐year EFS/PFS and 5‐year OS gave estimated 5‐year OS rates between pola‐R‐CHP and R‐CHOP of 6.4% and 6.3%, respectively. Two‐year EFS and PFS are feasible early endpoints in patients with DLBCL treated primarily with immunochemotherapy. The pola‐R‐CHP regimen is expected to improve 5‐year OS.

Regimen

Progression-free survival

10.1002/cam4.6899

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Citations (3)

Artificial Cycle with or without a Depot Gonadotropin-releasing Hormone Agonist for Frozen-thawed Embryo Transfer: An Assessment of Infertility Type that Is Most Suitable

Current Medical Science (2018)

Di Xie Fan Chen Xie Shou-zhen Zhilan Chen Ping Tuo

Live birth

Assisted Reproductive Technology

Unexplained infertility

Gonadotropin-releasing hormone agonist

10.1007/s11596-018-1923-0

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Citations (10)