Xiao Zhang

Gansu Agricultural University

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Zhanjun Gu

Institute of High Energy Physics

Wenyan Yin

Institute of High Energy Physics

Yuliang Zhao

National Center for Nanoscience and Technology

Gan Tian

Chinese Academy of Medical Sciences & Peking Union Medical College

Yi‐Xin Zeng

Sun Yat-sen University

Shanshan Zhang

WuXi AppTec (China)

Tong Xiang

Sichuan University

Liang Yan

National Center for Nanoscience and Technology

Wanlin Zhang

Chinese PLA General Hospital

Yanhong Chen

Zhejiang University of Finance and Economics

Cooperative Institutions

Chinese Academy of Sciences

296

University of Chinese Academy of Sciences

165

Technology Applications (United States)

163

Sun Yat-sen University

134

Chinese Academy of Medical Sciences & Peking Union Medical College

130

Army Medical University

117

Shanghai Jiao Tong University

102

Peking University

Zhejiang University

Huazhong University of Science and Technology

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A MOF-Based Potent Ferroptosis Inducer for Enhanced Radiotherapy of Triple Negative Breast Cancer

ACS Nano (2023)

Lijuan Zeng Shuaishuai Ding Yuhua Cao Chenglong Li Bin Zhao

Radiotherapy (RT) is one of the important clinical treatments for local control of triple-negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been recognized as a natural barrier for cancer progression and represents a significant role of RT-mediated anticancer effects, while the simultaneous activation of ferroptosis defensive system during RT limits the synergistic effect between RT and ferroptosis. Herein, we engineered a tumor microenvironment (TME) degradable nanohybrid with a dual radiosensitization manner to combine ferroptosis induction and high-Z effect based on metal-organic frameworks for ferroptosis-augmented RT of TNBC. The encapsulated l-buthionine-sulfoximine (BSO) could inhibit glutathione (GSH) biosynthesis for glutathione peroxidase 4 (GPX4) inactivation to break down the ferroptosis defensive system, and the delivered ferrous ions could act as a powerful ferroptosis executor via triggering the Fenton reaction; the combination of them induces potent ferroptosis, which could synergize with the surface decorated Gold (Au) NPs-mediated radiosensitization to improve RT efficacy. In vivo antitumor results revealed that the nanohybrid could significantly improve the therapeutic efficacy and antimetastasis efficiency based on the combinational mechanism between ferroptosis and RT. This work thus demonstrated that combining RT with efficient ferroptosis induction through nanotechnology was a feasible and promising strategy for TNBC treatment.

GPX4

Triple-negative breast cancer

Radioresistance

10.1021/acsnano.3c00048

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Citations (74)

Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive Activity

Frontiers in Endocrinology (2022)

Xiaoling Zheng Yongquan Zheng Dongxu Qin Yao Yao Xiao Zhang

Growth differentiation factor-8 (GDF-8) is a member of the transforming growth factor-beta superfamily. Studies in vitro and in vivo have shown GDF-8 to be involved in the physiology and pathology of ovarian reproductive functions. In vitro experiments using a granulosa-cell model have demonstrated steroidogenesis, gonadotrophin responsiveness, glucose metabolism, cell proliferation as well as expression of lysyl oxidase and pentraxin 3 to be regulated by GDF-8 via the mothers against decapentaplegic homolog signaling pathway. Clinical data have shown that GDF-8 is expressed widely in the human ovary and has high expression in serum of obese women with polycystic ovary syndrome. GDF-8 expression in serum changes dynamically in patients undergoing controlled ovarian hyperstimulation. GDF-8 expression in serum and follicular fluid is correlated with the ovarian response and pregnancy outcome during in vitro fertilization. Blocking the GDF-8 signaling pathway is a potential therapeutic for ovarian hyperstimulation syndrome and ovulation disorders in polycystic ovary syndrome. GDF-8 has a regulatory role and potential importance in ovarian reproductive activity and may be involved in folliculogenesis, ovulation, and early embryo implantation.

Growth differentiation factor-9

Follicular fluid

Ovarian Reserve

Lysyl Oxidase

Ovarian hyperstimulation syndrome

10.3389/fendo.2022.878069

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Citations (7)

Volume‐Enhanced Raman Scattering Detection of Viruses

Small (2019)

Xingang Zhang Xiao Zhang Changliang Luo Zhengqi Liu Yiyun Chen

Abstract Virus detection and analysis are of critical importance in biological fields and medicine. Surface‐enhanced Raman scattering (SERS) has shown great promise in small molecule and even single molecule detection, and can provide fingerprint signals of molecules. Despite the powerful detection capabilities of SERS, the size discrepancy between the SERS “hot spots” (generally, <10 nm) and viruses (usually, sub‐100 nm) yields poor detection reliability of viruses. Inspired by the concept of molecular imprinting, a volume‐enhanced Raman scattering (VERS) substrate composed of hollow nanocones at the bottom of microbowls (HNCMB) is developed. The hollow nanocones of the resulting VERS substrates serve a twofold purpose: 1) extending the region of Raman signal enhancement from the nanocone surface (e.g., surface “hot spots”) to the hollow area within the cone (e.g., volume “hot spots”)—a novel method of Raman signal enhancement, and 2) directing analyte such as viruses of a wide range of sizes to those VERS “hot spots” while simultaneously increasing the surface area contributing to SERS. Using HNCMB VERS substrates, greatly improved Raman signals of single viruses are demonstrated, an achievement with important implications in disease diagnostics and monitoring, biomedical fields, as well as in clinical treatment.

10.1002/smll.201805516

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Citations (191)

Enhancing chemotherapy for pancreatic cancer through efficient and sustained tumor microenvironment remodeling with a fibroblast-targeted nanosystem

Journal of Controlled Release (2023)

Xinyuan Zhou Pan Zhang Nan Liu Xiao Zhang Hui Lv

Cancer-Associated Fibroblasts

10.1016/j.jconrel.2023.07.061

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Citations (11)

Recent Advances in Upconversion Nanoparticles‐Based Multifunctional Nanocomposites for Combined Cancer Therapy

Advanced Materials (2015)

Gan Tian Xiao Zhang Zhanjun Gu Yuliang Zhao

Lanthanide‐doped upconversion nanoparticles (UCNPs) have the ability to generate ultraviolet or visible emissions under continuous‐wave near‐infrared (NIR) excitation. Utilizing this special luminescence property, UCNPs are approved as a new generation of contrast agents in optical imaging with deep tissue‐penetration ability and high signal‐to‐noise ratio. The integration of UCNPs with other functional moieties can endow them with highly enriched functionalities for imaging‐guided cancer therapy, which makes composites based on UCNPs emerge as a new class of theranostic agents in biomedicine. Here, recent progress in combined cancer therapy using functional nanocomposites based on UCNPs is reviewed. Combined therapy referring to the co‐delivery of two or more therapeutic agents or a combination of different treatments is becoming more popular in clinical treatment of cancer because it generates synergistic anti‐cancer effects, reduces individual drug‐related toxicity and suppresses multi‐drug resistance through different mechanisms of action. Here, the recent advances of combined therapy contributed by UCNPs‐based nanocomposites on two main branches are reviewed: i) photodynamic therapy and ii) chemotherapy, which are the two most widely adopted therapies of UCNPs‐based composites. The future prospects and challenges in this emerging field will be also discussed.

Cancer Therapy

Photon Upconversion

Cancer Treatment

10.1002/adma.201503280

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Citations (260)

Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis

Cellular and Molecular Immunology (2022)

Jinfeng Chen Ziqi Jin Shuqing Zhang Xiao Zhang Peipei Li

Immunogenic cell death

Immunosurveillance

Arsenic Trioxide

10.1038/s41423-022-00956-0

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Citations (41)

A two-step gas/liquid strategy for the production of N-doped defect-rich transition metal dichalcogenide nanosheets and their antibacterial applications

Nanoscale (2020)

Tao Wang Xiao Zhang Linqiang Mei Dongqing Ma You Liao

A simple two-step strategy based on gas expansion combined liquid exfoliation to synthesize defect-rich N-doped MoS₂ and N-doped WS₂ nanosheets (NSs) was proposed. The NSs with improved peroxidase-like catalytic activity can be applied as effective nanoantimicrobials.

Exfoliation joint

10.1039/d0nr00192a

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Citations (51)

Supplementary Data from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation

Xiaobing Duan Haiwen Chen Xiang Zhou Pingjuan Liu Xiao Zhang

Supplementary Data from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation

10.1158/0008-5472.22431012

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Citations (0)

Intelligent MoS₂ Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging

ACS Applied Materials & Interfaces (2018)

Xinghua Dong Wenyan Yin Xiao Zhang Shuang Zhu Xiao He

Chemotherapy resistance remains a major hurdle for cancer therapy in clinic because of the poor cellular uptake and insufficient intracellular release of drugs. Herein, an intelligent, multifunctional MoS2 nanotheranostic (MoS2-PEI-HA) ingeniously decorated with biodegradable hyaluronic acid (HA) assisted by polyethyleneimine (PEI) is reported to combat drug-resistant breast cancer (MCF-7-ADR) after loading with the chemotherapy drug doxorubicin (DOX). HA can not only target CD44-overexpressing MCF-7-ADR but also be degraded by hyaluronidase (HAase) that is concentrated in the tumor microenvironment, thus accelerating DOX release. Furthermore, MoS2 with strong near-infrared (NIR) photothermal conversion ability can also promote the release of DOX in the acidic tumor environment at a mild 808 nm laser irradiation, achieving a superior antitumor activity based on the programmed response to HAase and NIR laser actuator. Most importantly, HA targeting combined with mild NIR laser stimuli, rather than using hyperthermia, can potently downregulate the expression of drug-resistance-related P-glycoprotein (P-gp), resulting in greatly enhanced intracellular drug accumulation, thus achieving drug resistance reversal. After labeled with 64Cu by a simple chelation strategy, MoS2 was employed for real-time positron emission tomography (PET) imaging of MCF-7-ADR tumor in vivo. This multifunctional nanoplatform paves a new avenue for PET imaging-guided spatial-temporal-controlled accurate therapy of drug-resistant cancer.

10.1021/acsami.7b17506

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Citations (146)

Catalytic MnWO₄ Nanorods for Chemodynamic Therapy Synergized Radiotherapy of Triple Negative Breast Cancer

Advanced Functional Materials (2023)

Bin Zhao Zhili Ma Shuaishuai Ding Yuhua Cao Jiangfeng Du

Abstract Nanomedicine‐based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid tumor ablation, which holds great hope for the refractory and recurrent cancers, such as triple negative breast cancer (TNBC). The clinical translation of hafnium oxide (HfO 2 ), commercially named as NBTXR3, has aroused new research focus on single‐component inorganic nanomedicines as clinical candidates. Herein, the single‐component MnWO 4 is first reported as a new kind of Fenton‐like agent yet radiosensitizer for TNBC treatment undergoing the synergistic CDT/RT mechanism. MnWO 4 nanorods are synthesized via a simple one‐pot hydrothermal method and then undergo a layer‐by‐layer PEGylation to obtain bioavailable MnWO 4 ‐PEG (MWP). MWP‐based Fenton‐like reaction efficacy depends on reaction time, temperatures, pH values, and MWP concentrations. Mn‐triggered chemodynamic effect delays RT‐induced DNA damage repair and sorts cell cycles distribution toward radiosensitive phases, while W‐mediated radiosensitization improves the tumoral H 2 O 2 overexpression to enhance CDT, remarkably amplifying of the intracellular oxidative stress to boost 4T1 cell apoptosis. In vitro and in vivo evaluations further demonstrate the effectiveness and biosafety of MWP‐based synergistic therapy. Considering the potential magnetic resonance and computed tomography imaging capabilities, MWP can be expected as an intelligent cancer theranostics for imaging‐guided cancer therapy in clinic in the future.

Triple-negative breast cancer

Radiosensitizer

Nanorod

10.1002/adfm.202306328

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Citations (14)