Xiaobo Li

Harbin Medical University

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Shenshen Wu

Capital Medical University

Rui Chen

Zhejiang University

Tianzhen Wang

Shanghai Maritime University

Mingjiao Weng

Harbin Medical University

Yan He

First Affiliated Hospital of Jiangxi Medical College

Hongbao Yang

China Pharmaceutical University

Qingtao Meng

Capital Medical University

Guangyu Wang

Houston Methodist

Xiaoming Jin

Guangdong Hydropower Planning & Design Institute

Jing Tang

Harbin Medical University

Cooperative Institutions

Harbin Medical University

204

Chinese Academy of Sciences

175

Shanghai Jiao Tong University

149

Chinese Academy of Medical Sciences & Peking Union Medical College

140

Sun Yat-sen University

130

Capital Medical University

108

Zhejiang University

102

Fudan University

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

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RNA processing genes characterize RNA splicing and further stratify colorectal cancer

Cell Proliferation (2020)

Xiaofan Lu Yujie Zhou Jialin Meng Liyun Jiang Jun Gao

Due to the limited evaluation of the prognostic value of RNA processing genes (RPGs), which are regulators of alternative splicing events (ASEs) that have been shown to be associated with tumour progression, this study sought to determine whether colorectal cancer (CRC) could be further stratified based on the expression pattern of RPGs.The gene expression profiles of CRCs were collected from TCGA (training set) and three external validation cohorts, representing 1060 cases totally. Cox regression with least absolute shrinkage and selection operator (LASSO) penalty was used to develop an RNA processing gene index (RPGI) risk score. Kaplan-Meier curves, multivariate Cox regression and restricted mean survival (RMS) analyses were harnessed to evaluate the prognostic value of the RPGI.A 22-gene RPGI signature was developed, and its risk score served as a strong independent prognostic factor across all data sets when adjusted for major clinical variables. Moreover, ASEs for certain genes, such as FGFR1 and the RAS oncogene family, were significantly correlated with RPGI. Expression levels of genes involved in splicing- and tumour-associated pathways were significantly correlated with RPGI score. Furthermore, a combination of RPGI with age and tumour stage resulted in significantly improved prognostic accuracy.Our findings highlighted the prognostic value of RPGs for risk stratification of CRC patients and provide insights into specific ASEs associated with the development of CRC.

Lasso

10.1111/cpr.12861

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Citations (4)

Noncoding RNAs in the development, diagnosis, and prognosis of colorectal cancer

Translational research (2016)

Mingjiao Weng Di Wu Chao Yang Haisheng Peng Guangyu Wang

Pseudogene

Circular RNA

Small nucleolar RNA

Intergenic region

10.1016/j.trsl.2016.10.001

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Citations (81)

Plasma Gelsolin Promotes Proliferation of Mesangial Cell in IgA Nephropathy

Cellular Physiology and Biochemistry (2016)

Lei Zhang Dan Kong Hongxue Meng Changsong Han Jiang Zhu

Plasma gelsolin (pGSN) is an actin-binding protein that plays a critical role in the pathogenesis of rheumatoid arthritis. However, whether pGSN is involved in other immunological diseases remains unknown. This study focused on the relationship between pGSN and immunoglobulin A (IgA) nephropathy (IgAN).Two hundred patients with IgAN, 200 patients each with several other types of nephropathy and healthy controls (HCs) who underwent kidney biopsies between 2000 and 2014 were enrolled in the study. The Oxford classification system was used to predict the risk of disease progression. Serum and renal tissue were used to detect pGSN, and the correlations between pGSN and IgA, galactose-deficient IgA1 (Gd-IgA1), transforming growth factor beta1 (TGF-β1), fibronectin (FN) content, clinical symptoms, and kidney function were analyzed.We found that the pGSN levels were significantly decreased in sera from IgAN patients compared to sera from patients with other forms of glomerular nephritis and HCs. Furthermore, the serum pGSN levels were negatively correlated with the serum IgA1, FN, and TGF-β1 levels, and positively correlated with the estimated glomerular filtration rate. Conversely, the glomerular pGSN content was significantly elevated in the IgAN patients and was positively correlated with TGF-β1 and FN levels. In renal tissue, the pGSN levels were significantly higher in IgAN patients with M1 and S1 compared to patients with M0 and S0 (p < 0.05). Meanwhile, pGSN promoted human mesangial cell (HMC) proliferation by facilitating cell mitosis in vitro. pGSN also promoted integrin α2β1 expression in HMCs and enhanced the integrin α2β1-pGSN interaction.Our study suggested that pGSN may play an important role in the development of IgAN by promoting the proliferation of mesangial cells and that serum and glomerular pGSN levels may be new markers for predicting IgAN progression and prognosis.

Gelsolin

Mesangial cell

10.1159/000453199

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Citations (10)

Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics simulation

Molecular Simulation (2012)

Wenming Li Xiaobo Li Su‐Xia Sun Jing Liang Run‐Ling Wang

Oestrogen receptor (ER) is a ligand-activated transcription factor which plays an important role in many physiological processes. The aim of this study was to explore the difference between agonist and antagonist recognition mode. Molecular dynamics simulation of ER/diethylstilbestrol and ER/4-hydroxytamoxifen complexes was carried out. Our research results indicate that Glu353 participates in both agonist and antagonist recognition; His524 is the key residue in agonist recognition; Met343, Leu346, Thr347 and Asp351 are the key residues in the antagonist recognition.

10.1080/08927022.2012.717281

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Application of magnifying chromoendoscopy in endoscopic mucosal resection of colorectal neoplasms

Zhonghua xiaohua zazhi (2010)

Xiaobo Li Huimin Chen Yun‐Jie Gao Lei Shen Hanbing Xue

Objective To evaluate the clinical efficacy and safety of endoscopic mucosal resection (EMR) assisted with magnifying chromoendoscopy in treatment of colorectal neoplasms. Methods Patients who met criteria for EMR including appropriate flat or depressed type and sessile lesions were enrolled. The association of morphology of colorectal lesions with histopathology was observed and the accuracy of estimation of invasive depth by magnifying chromoendoscopy was evaluated. Results Ninety lesions of 81 patients were reseeted by EMR (25 being sessile and 65 being flat or depressed). The histological results revealed low-grade dysplasia (LGD) in 58 lesions, high-grade dysplasia (HGD) in 20 lesions, and adenocarcinoma in 12 lesions. The average size of lesions was (1.4±0.5) cm in HGD, (1.6±0.5) cm in cancer and (1.0±0.4) cm in LGD with no significant difference (P> 0.05). It was shown that the flat and depressed lesions were more likely to be HGD or cancer as compared to sessile lesions, but with no statistical difference [41.5 % (27/65)vs. 20.0% (5/25), P= 0.084]. Moreover, the lesion with central depression was more likely to be HGD or cancer as compared to those without depressed surface [51.0% (25/49) vs. 17.1 % (7/41), P<0.01)]. The accuracy of estimating invasive depth by magnifying chromoendoscopy was 97.8% (86/90). Complete resection was confirmed histologically in 95.8% (88/90) of all lesions. Conclusions Colorectal lesions of depressed and flat types with central depression are more likely to be malignant. Estimation of invasive depth of colorectal neoplasia by magnifying chromoendoscopy in EMR treatment makes it more effective and safer. Key words: Colorectal neoplasms; Endoscopic mucosal resection; Magnifying chromoendoscopy

Chromoendoscopy

Endoscopic mucosal resection

Histopathology

10.3760/cma.j.issn.0254-1432.2010.01.003

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Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer

Molecular Cancer (2015)

Tianzhen Wang Guangyu Wang Dapeng Hao Xi Liu Dong Wang

RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of human malignancies. Let-7, one of the most well-known tumor suppressors, is frequently down-regulated in a variety of human cancers. The RBP LIN28A/LIN28B, a direct target of the let-7 family of miRNAs, is an inhibitor of let-7 biogenesis and is frequently up-regulated in cancers. Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors is reportedly involved in cancer development, contributing to cellular proliferation, cell death resistance, angiogenesis, metastasis, metabolism reprogramming, tumor-associated inflammation, genome instability, acquiring immortality and evading immune destruction. In this review, we summarized the mechanisms of LIN28A/LIN28B and let-7 loop aberrant regulation in human cancer and discussed the roles and potential mechanisms of the LIN28A/LIN28B and let-7 loop in regulating the hallmarks of cancer. The crosstalk between LIN28A/LIN28B and let-7 loop and certain oncogenes (such as MYC, RAS, PI3K/AKT, NF-κB and β-catenin) in regulating hallmarks of cancer has also been discussed.

Reprogramming

10.1186/s12943-015-0402-5

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Citations (177)

Supplementary Data from Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p

Jie Xu Qingtao Meng Xiaobo Li Hongbao Yang Jin Xu

<p>This file contains supplemental materials and methods, supplemental tables: ST1 Demographic characteristics of CRC patients recruited for microarray assay, ST2: Distributions of demographic and clinicopathologic characteristics of patients recruited for TMA; ST3: Demographic information of colorectal adenoma (ADE) patients for PCR analysis; ST4:Demographic information of colorectal cancer (CRC) patients for PCR analysis; supplemental figures SF1:Construction of an immunity-associated network involved in CRC progression; SF2:Roles of RELA and MIR17HG in murine AOM-DSS models and CRC cohorts; SF3:miR-17-5p promotes CRC tumorigenesis; SF4: MIR17HG promotes CRC tumorigenesis through suppressing BLNK; SF5: MIR17HG promotes CRC tumorigenesis through binding to miR-17-3p in vitro and in vivo; SF6: Regulation of MALT1, NFKBIE, PPP3R1 and MAP3K7 by miR-17-3p in CRC; SF7: Expression levels of PD-L1 mRNA in cells; SF8: Expression levels of PD-L1 protein in tumor tissues</p>

10.1158/0008-5472.22420728

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ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system

Figshare (2015)

Deng Wu Yan Huang Juanjuan Kang Kongning Li Xiaoman Bi

Programmed cell death (PCD) is a critical biological process involved in many important processes, and defects in PCD have been linked with numerous human diseases. In recent years, the protein architecture in different PCD subroutines has been explored, but our understanding of the global network organization of the noncoding RNA (ncRNA)-mediated cell death system is limited and ambiguous. Hence, we developed the comprehensive bioinformatics resource (ncRDeathDB, www.rna-society.org/ncrdeathdb) to archive ncRNA-associated cell death interactions. The current version of ncRDeathDB documents a total of more than 4600 ncRNA-mediated PCD entries in 12 species. ncRDeathDB provides a user-friendly interface to query, browse and manipulate these ncRNA-associated cell death interactions. Furthermore, this resource will help to visualize and navigate current knowledge of the noncoding RNA component of cell death and autophagy, to uncover the generic organizing principles of ncRNA-associated cell death systems, and to generate valuable biological hypotheses.

10.6084/m9.figshare.1568373

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CD11b Activation Suppresses Pro-Inflammatory suPAR in Myeloid Cells and Reduces Lupus Nephritis in Mice

Journal of the American Society of Nephrology (2020)

Veronica Villanueva Xiaobo Li Samia Q. Khan Sanja Sever Jochen Reiser

SuPAR

Nephritis

10.1681/asn.20203110s1526b

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Hypoxia-regulated microRNAs in human cancer

Acta Pharmacologica Sinica (2013)

Guomin Shen Xiaobo Li Yongfeng Jia Gary A. Piazza Yaguang Xi

Hypoxia plays an important role in the tumor microenvironment by allowing the development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 (HIF1) regulates a panel of microRNAs, whereas some of microRNAs target HIF1. The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis, such as angiogenesis, metabolism, apoptosis, cell cycle regulation, proliferation, metastasis, and resistance to anticancer therapy. This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells. It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvironments and thus benefit the development of new anticancer drugs.

Hypoxia

10.1038/aps.2012.195

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Citations (146)