In the absence of an effective vaccine or treatment, the current best defence against COVID-19 is social distancing—staying at home as much as possible, keeping distance from others, and avoiding large gatherings. Although social distancing maximizes physical health, we know little about its psychological consequences. In this research (N = 374), we investigated the effect of social distancing duration on negative moods and memory. The relation between social distancing duration and both negative mood and memory errors followed the same U-shaped function: negative moods and memory errors initially decreased steadily as social distancing duration increased, at which point (~ 30 days) they began to steadily increase. Subsequent analyses indicated that memory errors were mediated by lonely mood in particular. Thus, short-term social distancing might benefit psychological well-being and memory performance, but extended social distancing has the expected negative impact on mood and memory.
Inflammatory responses induced by chronic cerebral hypoperfusion (CCH) play a critical role in the progression of vascular dementia. Stimulator of interferon genes (STING) signaling function as a key mediator of inflammation and immunological responses in the central nervous system (CNS), and resveratrol (RES) exerts potent anti-inflammatory effects. However, the role of STING signaling and the relationship between RES and STING signaling in persistent hypoperfusion-induced cerebral inflammation remain unclear. In this study, Sprague-Dawley rats were subjected to either Sham or bilateral common carotid artery occlusion (2VO) surgery and received RES or vehicle daily by intraperitoneal injection for 4 or 8 weeks. Morris's water maze was used for the analysis of cognitive function. The neuroinflammatory responses in white matter and hippocampus of the rat brain were assessed by Western blot, Immunofluorescence staining, and qRT-PCR analyses. Myelin integrity, neutrophil infiltration, and microglia proliferation were assessed by Immunohistochemistry and histologic analysis. We demonstrated that after CCH, neurons, microglia, and astrocyte under endoplasmic reticulum (ER) stress upregulated the expression of STING, TANK-binding kinase 1 (TBK1), and the transcription factor interferon regulatory factor 3 (IRF3), as well as translocation of IRF3 into the nucleus. These were accompanied by infiltration of neutrophils, activation of microglia, and overproduction of proinflammatory mediators. Improvements in cognitive deficits were related to reduced hippocampal neuronal cell death and increased myelin integrity in RES-treated rats. The neuroprotective effects of RES were associated with suppression of the expression of tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecule 1 (ICAM-1), VCAM-1, interferon-β (IFN-β), and IL-1β, likely through mitigation of the STING/TBK1/IRF3 pathway. These inhibitory effects exerted by RES also inhibited the levels of myeloperoxidase, reduced excess expression of reactive astrocytes, and activated microglia. In conclusion, the STING/TBK1/IRF3 axis may be critical for proinflammatory responses in cerebral tissue with persistent hypoperfusion, and RES exerts its anti-inflammatory effects by suppressing STING/TBK1/IRF3 signaling.
Objective To explore the relationship between job burnout and occupational stress among nurses for the improvements of the nurses' mental and physical health and life quality.Methods The study population was comprised of 515 nurses working more than 6 months from six hospitals in Liaoning province.Job burnout was measured with Maslach Burnout Inventory-General Survey(MBI-GS).Occupational stress was measured with Job Content Questionnaire(JCQ) and Effort-Reward Imbalance Questionnaire(ERI).Results The mean MBI-GS scores were 13.45±7.18 for emotional exhaustion,7.21±5.27 for cynicism,and 26.04±10.19 for professional efficacy.Univariate analyses showed that MBI-GS scores of the nurses of younger(≤30 years),single,being a head nurse,working on shift,and with serious dissatisfaction to nurse-patient relationship were higher than those of other groups(P0.05).The influencing factors,in the sequence of standardized coefficients of multivariate regression,were extrinsic effort(β=0.383),intrinsic effort(β=0.226) and decision authority(β=-0.115) for emotional exhaustion,extrinsic effort(β=0.253),overcommitment(β=0.159),supervisor support(β=-0.112) and skill discretion(β=-0.098) for cynicism,and psychological job demand(β=-0.159) and skill discretion(β=0.130) for professional efficacy.Conclusion Occupational stress has significant effect on job burnout among nurses.
The intention to leave among intensive care unit (ICU) healthcare professionals in China has become a concerning issue. Therefore, understanding the factors influencing the intention to leave and implementing appropriate measures have become urgent needs for maintaining a stable healthcare workforce.This study aims to investigate the current status of intention to leave among ICU healthcare professionals in China, explore the relevant factors affecting this intention, and provide targeted recommendations to reduce the intention to leave among healthcare professionals.A cross-sectional survey was conducted, involving ICU healthcare professionals from 3-A hospitals of the 34 provinces in China. The survey encompassed 22 indicators, including demographic information (marital status, children, income), work-related factors (weekly working hours, night shift frequency, hospital environment), and psychological assessment (using Symptom Checklist-90 (SCL-90)). The data from a sample population of 3653 individuals were analyzed using the extreme gradient boosting (XGBoost) method to predict intention to leave.The survey results revealed that 62.09% (2268 individuals) of the surveyed ICU healthcare professionals expressed an intention to leave. The XGBoost model achieved a predictive accuracy of 75.38% and an Area Under the Curve (AUC) of 0.77.Satisfaction with income was found to be the strongest predictor of intention to leave among ICU healthcare professionals. Additionally, factors such as years of experience, night shift frequency, and pride in hospital work were found to play significant roles in influencing the intention to leave.
Backgrounds: Nursing is the key group to provide healthcare services, and it is easy for nursing staff to develop mental health problems. Aims: The study aimed to evaluate prevalence of psychological symptoms in nurses working in an intensive care unit (ICU) and the inter-relationship of associations of psychological symptoms using network analysis. Methods: This study is a cross-sectional design study. The Chinese version of the Symptom Check List-90 (SCL-90) was used to measure the psychological status of ICU nurses. The network structure of psychological symptoms was characterised, and indices of ‘Expected influence’ were used to identify symptoms central to the network. Network stability was examined using a case-dropping bootstrap procedure. Results: Multiple logistic regression analysis found those who had worked more than 15 years were less likely to experience positive psychological symptoms, whereas nurses working in emergency ICU and other ICUs, nurses working in departments with over 16 beds were more likely to develop psychological symptoms. In addition, ‘Anxiety’, ‘Mental degeneration’ and ‘Depression’ were central symptoms in the network. Conclusions: ICU nurses reported a high level of psychological symptoms, which may affect the quality of their work and worsen public health problems.
E-2-6 Titre : Journees EMOIS Nancy 2013 : Disparites des trajectoires de recours aux soins des femmes enceintes au regard de leur environnement socio- economique.
Auteur (s) :
Nolwenn LE MEUR (EHESP - INSERM UMR 936, Modelisation Conceptuelle des Connaissances Biomedicales, Rennes, France)
Fei GAO (EHESP, Rennes, France)
Gaspar MASSIOT (ENSAI, Bruz, France)
Sahar BAYAT (EHESP - INSERM UMR 936, Modelisation Conceptuelle des Connaissances Biomedicales, Rennes, France)
Clelia GASQUET (EHESP - UMR 6590, ESO, Espaces et Societes, Rennes, France)
Severine DEGUEN (EHESP - INSERM UMR 1085, IRSET, Rennes, France)
Resume :
Introduction : Ce projet vise a etudier les disparites de trajectoires de recours aux soins des femmes enceintes au regard du parcours preconise par la securite sociale et en relation avec leur environnement socio-economique.
Methodes : Les donnees de recours aux soins sont issues de l’Echantillon Generaliste des Beneficiaires (EGB) du SNIIRAM et du PMSI-MCO pour les annees de 2008 a 2009. Les donnees de contexte socio-economique sont issues de l’INSEE. Ces donnees sont analysees et integrees par des methodes d’analyses statistiques multidimensionnelles de fouilles de donnees (ex : K-moyennes, Analyses en composante principales).
Resultats : A partir des trajectoires de recours aux soins, nous avons identifie trois groupes de patientes. Par rapport au parcours preconise par la securite sociale, le premier groupe se caracterise par une plus forte consommation de soins uniquement au debut de la grossesse, le second par une plus forte consommation tout au long de la grossesse et le troisieme une sous-consommation globale. Au regard du contexte socio-economique, les femmes consommant beaucoup de soins resident dans des communes au niveau socio-economique plutot favorable (ex : niveau d’education eleve, nombreux actifs) tandis que les femmes consommant peu de soins resident dans des communes aux conditions materielles plutot defavorables (ex : logement HLM, nombre important de personnes par piece). Nous observons egalement des disparites departementales : certains departements comptant un nombre de femmes accedant tardivement aux soins prenataux statistiquement superieur a d’autres departements. Toutefois ces resultats sont a analyser avec precautions du fait du faible nombre de femmes enceintes dans certains departements (limite intrinseque a l’EGB).
Discussion/conclusion : Nous remplacerons les donnees de l’EGB par une extraction specifique du SNIIRAM pour etendre notre analyse a l’ensemble des femmes enceintes. En complement des determinants socio-economiques, nous etudierons le role de la cooperation des acteurs de sante dans la trajectoire de soins des femmes enceintes.
Mots-cles : Maternite
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