The present work shows a new contribution to the design of superhydrophobic surfaces with the additional function of active corrosion protection, through the encapsulation of inhibiting agents.
LED surface defect detection is a vital procedure of quality control in the mass production of LEDs. Traditional methods rely on artificial vision, which requires experienced workers and is extremely low on efficiency. In this paper, we develop a new LED chip surface defect detection by the modified Faster R-CNN. The model is pre-trained on the dataset of COCO and then is fine-tuned on our collected LED surface dataset. The dataset consists of 1556 images which are labeled with 5 types of surface defects. Based on the experimental results on the collected dataset from the production line, the model can achieve over 79% mAP on our dataset.
Abstract Glycosylation profoundly influences the interactions between cancer cells and microenvironmental stromal cells during the peritoneal disseminated metastasis of ovarian carcinoma (OC), which is the major cause of cancer-related death. Although the characteristic cancer glycoconjugates are widely used as biomarkers for cancer diagnosis, our knowledge about cancer glycome remains quite fragmented due to the technique limitations in analyzing glycan chains with tremendous structural and functional heterogeneity. Given the dysregulated cancer glycome is defined by the altered glycosylation machinery, here we performed a systematic loss-of-function screen on 498 genes involved in glycosylation for key regulators of OC dissemination. We identified neuraminidase 4 (NEU4), an enzyme capable of hydrolyzing terminal sialic acid from glycoconjugates, as a vital peritoneal dissemination-promoting modifier of OC glycome. In human patients with high-grade serous OC (HGSOC), increased NEU4 was detected in the disseminated OC cells when compared with that in the primary tumor cells, which significantly correlated with the worse survival. Among three alternative splice-generated isoforms of human NEU4, we revealed that only the plasma membrane-localized NEU4 isoform 2 (NEU4-iso2) and intracellular isoform 3 promoted the peritoneal dissemination of OC by enhancing the cell motility and epithelial-mesenchymal transition. We also identified NEU4-iso2-regulated cell surface glycoproteome and found that NEU4-iso2 desialylated the epithelial growth factor receptor (EGFR), in particular at N196 residue, for the hyperactivation of EGFR and its downstream tumor-promoting signaling cascades. Our results provide new insights into how the OC glycome is dysregulated during OC progression and reveals a functionally important glycosite on EGFR for its abnormal activation in cancer.
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