Bao Wei

Chongqing Medical University

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Chenghua Yang

State Key Laboratory of Remote Sensing Science

Yangbo Sun

University of Tennessee Health Science Center

Gaozhen Jia

Shanghai First People's Hospital

Haolan Yu

Shanghai Institute of Nutrition and Health

Chenxia Sun

Hebei Agricultural University

Fuping Wen

Shanghai Tenth People's Hospital

Xiaochen Sun

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhenyang Dong

Changhai Hospital

Chengcheng Du

First Affiliated Hospital of Chongqing Medical University

Junyi Liao

First Affiliated Hospital of Chongqing Medical University

Cooperative Institutions

Pacific Environment

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Chinese Academy of Sciences

Huazhong University of Science and Technology

Chongqing Medical University

Shanghai Jiao Tong University

Central South University

Sun Yat-sen University

First Affiliated Hospital of Chongqing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

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Data from TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells

Fuping Wen Xiaochen Sun Chenxia Sun Zhenyang Dong Gaozhen Jia

<div>AbstractTransgelin (TAGLN, also named SM22) is an actin-associated protein and affects dynamics of actin filaments. Deregulation of TAGLN contributes to the development of different cancers, and it is commonly considered to be a tumor suppressor. TAGLN is usually downregulated in prostate cancer; however, the detailed functions of TAGLN in prostate cancer and how TAGLN is regulated remains unclear. In this study, we confirmed that TAGLN is downregulated in prostate cancer tissues and demonstrated that the downregulation of TAGLN occurs through proteasomal degradation. Next, we found that the expression level of TAGLN is inversely correlated with TRAF6. We screened more than 20 E2–E3 pairs by in vitro ubiquitination assay and found that the E2A–TRAF6 pair catalyzed mono ubiquitination of TAGLN. We then identified the ubiquitination sites of TAGLN to be on K89 or K108 residues and demonstrated that ubiquitination of TAGLN on K89/K108 are important for TRAF6-mediated proteasomal degradation. Furthermore, we investigated the function of TAGLN in prostate cancer cells. We found that ablation of TAGLN promoted prostate cancer cell proliferation and suppressed their migration via activation of NF-κB and Myc signaling pathways. Overall, our study provided new insights into the mechanisms underlying TAGLN expression and activity in prostate cancer.Implications:E3 ligase TRAF6 mediate mono-ubiquitination and degradation of TAGLN, which leads to activation of NF-κB and Myc signaling pathways in prostate cancer cells.</div>

Degradation

10.1158/1541-7786.c.6545055

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Body Fat Distribution, Cardiometabolic Traits, and Risk of Major Lower-Extremity Arterial Disease in Postmenopausal Women

Guo‐Chong Chen Rhonda Arthur Victor Kamensky Jin Choul Chai Bing Yu

OBJECTIVE To assess the relationship between body fat distribution and incident lower-extremity arterial disease (LEAD). RESEARCH DESIGN AND METHODS We included 155,925 postmenopausal women with anthropometric measures from the Women’s Health Initiative who had no known LEAD at recruitment. A subset of 10,894 participants had body composition data quantified by dual energy X-ray absorptiometry (DXA). Incident cases of symptomatic LEAD were ascertained and adjudicated via medical record review. RESULTS We identified 1152 incident LEAD cases during a median 18.8 years follow-up. After multivariable adjustment and mutual adjustment, waist and hip circumference was positively and inversely associated with risk of LEAD, respectively (both P-trend values <0.0001). In a subset (n = 22,561) where various cardiometabolic biomarkers were quantified, a similar positive association of waist circumference with risk of LEAD was eliminated after adjustment for diabetes and HOMA-IR (P-trend = 0.89), whereas hip circumference remained inversely associated with the risk after adjustment for major cardiometabolic traits (P-trend = 0.0031). In the DXA subset, higher trunk fat (P-trend = 0.0081) and higher leg fat (P-trend <0.0001) was associated with higher and lower risk of LEAD, respectively. Further adjustment for diabetes, dyslipidemia, and blood pressure diminished the association for trunk fat (P-trend = 0.49), yet the inverse association for leg fat persisted (P-trend = 0.0082). CONCLUSIONS Among US postmenopausal women, a positive association of upper-body fat with risk of LEAD appeared to be attributable to traditional risk factors especially insulin resistance. Lower-body fat was inversely associated with risk of LEAD beyond known risk factors.

Dyslipidemia

Circumference

10.2337/figshare.16775866

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Effect of interferon a-2b on HLA-DR and CD_(la) molecules of hypertrophic scars

Jiepouxue zazhi (2002)

Chen Dong Bao Wei

Objective:To investigate the change in HLA-DR and CD1a molecules of hypertrophic scars after treated with injection of Interferon a-2b. Methods: Hypertrophic scars were treated by injection of Interferon a-2b and the content of HLA-DR and CD1a molecules were determined by Streptavidin/Peroxidase (SP) method. Results: (1) The number of HLA-DR molecules positive LC in HS were 806.67± 101.72/mm2,which was significantly higher than normal skin 510. 01 ± 45.17/mm2(P0. 05). The number of CD,, molecules positive LC in HS were 700. 00 ± 97. 23/mm2.which was significantly higher than normal skin 521.24 ± 57.87/mm2(P0. 05). (2) HLA-DR molecules revealed anomalous expression on Kerationcytes and fibroblasts besides the increase in LC. (3) The number of HLA-DR molecules positive LC were 283.34 ± 73.12/mm2 and 516 ± 49. 67/mm2 (P 0. 05), HLA-DR positive kerationcytes and fibroblasts of hypertrophic scar after 3 d and 7 d. The number of CD1a molecules positive DC were 220.00 ± 83.92/mm2 and 589.10 ± 108. 82/mm2(P0.05) in epidermis of hypertrophic scar after 3 d and 7 d. Conclusion; (1) The increase in density of HLA-DR and CD1a molecules suggest HS is in a higher state of immunoreaction. (2) Through inhibition of HLA-DR and CD1a molecules Interferon a-2b lowers higher state of immune reaction in HS.

Hypertrophic scars

HLA-DR

Epidermis (zoology)

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Association of maternal pre-pregnancy diabetes and gestational diabetes with congenital anomalies of the newborn

Yuxiao Wu Buyun Liu Yangbo Sun Yang Du Mark K. Santillan

<a>Objective: To examine the association of maternal pre-pregnancy diabetes, gestational diabetes mellitus (GDM), and 12 subtypes of congenital anomalies of the newborn.</a> Methods: We included 29,211,974 live births with maternal age ranged from 18 to 49 years old documented in the National Vital Statistics System in the United States, 2011-2018. Information on pre-pregnancy diabetes, GDM, and congenital anomalies was retrieved from birth certificates. Log-binomial regression was used to estimate risk ratios (RRs) and 95% confidence intervals (CIs) for congenital anomalies overall and by subtypes. Results: Of the 29,211,974 births, there were 90,061 infants who had congenital anomalies identified at birth. The adjusted RRs of congenital anomalies at birth were 2.44 (95% CI, 2.33-2.55) for pre-pregnancy diabetes and 1.28 (95% CI, 1.24-1.31) for GDM. The association were generally consistent across subgroups by maternal age, race/ethnicity, pre-pregnancy obesity status, and infant sex. For specific subtypes of congenital anomalies, maternal pre-pregnancy diabetes or GDM was associated with an increased risk of most subtypes. For example, the adjusted RRs of cyanotic congenital heart disease were 4.61 (95% CI, 4.28-4.96) for pre-pregnancy diabetes and 1.50 (95% CI, 1.43-1.58) for GDM; the adjusted RRs of hypospadias were 1.88 (95% CI, 1.67-2.12) for pre-pregnancy diabetes and 1.29 (95% CI, 1.21-1.36) for GDM. Conclusion: Pre-pregnancy diabetes and, to a lesser extent, GDM were associated with several subtypes of congenital anomalies of the newborn. These findings suggest potential benefits of preconception counseling in women with pre-existing diabetes or at risk of GDM for the prevention of congenital anomalies.

10.2337/figshare.13017422

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ラット尿中のアクリルアミドの毒性に対するケルセチンのメタボノミクス解析【Powered by NICT】

Food & Function (2017)

Bao Wei Cao Can Siqi Li Bo Lü Zhang Meiyan

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Studies on the Anatomical Structure of Leaves in Four Mosses

Acta Botanica Yunnanica (2004)

Li Gao Bao Wei

In the present paper,the anatomical structures of Bryoerythrophyllum inaequalifolium (Tayl.) Zand., Polytrichum formosum (Hedw.) G.Sm., Bartramia pomiformis and Grimmia macrotheca Mitt.from Rangtang,Sichuan were observed and analysed by means of paraffin section.Though leaves of the four mosses exist similar structure in both blades with one cell-layer and costae with several cell-layers,the thickness and cell density in the both aspects are evidently different.In addition,costae of B.pomiformis have cell differentiation and more complex construction than that of G.macrotheca ,of which cells scarcely differentiated.The ventral surface of leaves of P.formosum is covered with lamellae,the surface of leaf cells of B.inaequalifolium has fine papillae,the leaf cell walls of G.macrotheca are thickened.

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Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy

Advanced Healthcare Materials (2024)

Junyi Liao Zhenglin Zhu Jing Zou Senrui Liu Xuefeng Luo

Abstract Osteoarthritis (OA) is an inflammatory and progressive joint disease characterized by angiogenesis‐mediated sustained, chronic, and low‐grade synovitis. Anti‐angiogenesis is emerging as a strategy for attenuating OA progression, but is often compromised by poor targeted drug delivery and immune clearance. Recent studies have identified macrophages formed a “protective barrier” in the lining layer (LL) of synovium, which blocked the communication of joint cavity and sublining layer (SL) of synovium. Inspired by natural mimicry, macrophage membrane‐camouflaged drug delivery is explored to avoid immune clearance. Based on the single cell RNA sequencing, the CD34 + synovial cells are identified as “sentinel cells” for synovium angiogenesis. Consequently, CD34 antibody‐modified macrophage membrane is constructed to target new angiogenesis. Hence, a biomimetic multi‐layered nanoparticle (NP) is developed that incorporates axitinib‐loaded poly(lactic‐co‐glycolic) acid (PLGA) with CD34 antibody modified macrophage membrane (Atb@NP@Raw@CD34) to specifically deliver axitinib (Atb) to the SL and sustain inhibiting angiogenesis without immune elimination. It is found that the Atb@NP@Raw@CD34 can pass through macrophage “barrier”, specifically targeting CD34 + cells, continuously releasing Atb and anti‐angiogenesis in OA synovitis. Furthermore, in vivo data demonstrated that Atb@NP@Raw@CD34 can attenuate joint degeneration by inhibiting synovium angiogenesis‐mediated synovitis. In conclusion, local injection of Atb@NP@Raw@CD34 presents a promising approach for clinically impeding OA progression.

10.1002/adhm.202401985

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Supplementary Figure S1, Figure S2, Figure S3 from TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells

Fuping Wen Xiaochen Sun Chenxia Sun Zhenyang Dong Gaozhen Jia

Figure S1:Plot of Fraction Genome Altered versus Cancer Type. Figure S2: Cellular localization of TAGLN and TRAF6. Figure S3: GO annotation of differentially expressed mRNA in shTAGLN BPH1 cells.

10.1158/1541-7786.22526334

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Association of maternal pre-pregnancy diabetes and gestational diabetes with congenital anomalies of the newborn

Yuxiao Wu Buyun Liu Yangbo Sun Yang Du Mark K. Santillan

10.2337/figshare.13017422.v1

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染色廃水処理への強化嫌気性バイオテクノロジーの応用【JST・京大機械翻訳】

Huagong Huanbao (2016)

Bao Wei Huang Yong Zhang Ningbo Fei Wang

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