A.A. Jordão

Universidade de São Paulo

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Hélio Vannucchi

Universidade de São Paulo

Rafael Deminice

Universidade Estadual de Londrina

Guilherme Vannucchi Portari

Universidade Federal do Triângulo Mineiro

Hélio Vannucchi

Universidade de São Paulo

Paula Andrea Navarro

Universidade de São Paulo

Paula Garcia Chiarello

Universidade de São Paulo

L.A. Dib

University of Oxford

J F C Figueiredo

Universidade Federal de Santa Maria

Fernando Salvador Moreno

Brigham and Women's Hospital

Helena Siqueira Vassimon

Prefeitura Municipal de Esteio

Cooperative Institutions

Universidade de São Paulo

148

Universidade de Ribeirão Preto

Clinics Hospital of Ribeirão Preto

Universidade Brasil

Cambridge University Press

New York University Press

Universidade Estadual Paulista (Unesp)

Fundação Faculdade de Medicina

Hospital Universitário da Universidade de São Paulo

National Council for Scientific and Technological Development

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PP351 BIOELETRICAL IMPEDANCE AS A TOOL TO ASSESS BODY COMPOSITION IN HIV INFECTED MEN WITH LIPODYSTROPHY SYNDROME

Clinical Nutrition Supplements (2010)

Helena Siqueira Vassimon Alcyone Artioli Machado Francisco José Albuquerque de Paula Jacqueline Pontes Monteiro A.A. Jordão

Lipodystrophy

Bioelectrical Impedance Analysis

10.1016/s1744-1161(10)70426-9

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Citations (1)

Lipoperoxidação em fígado de ratos induzida pela deficiência da vitamina

Resumos (1996)

M F Morandi A.A. Jordão Antonio Iglesias Paula Garcia Chiarello M R Arantes

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Cytogenetic study of chronic ethanol consumption in rats

Birth Defects Research (2001)

Denise Crispim Tavares A.O. Cecchi A.A. Jordão Hélio Vannucchi Catarina Satie Takahashi

Abstract Ethanol was supplied in the drinking water of Wistar rats at a concentration of 20% v/v for up to 30 days. The animals treated with ethanol demonstrated a nonsignificant increase in chromosomal aberration frequency when compared with control animals. The mitotic index values obtained indicated no significant differences between ethanol treatment and control groups. The final weights of control rats were significantly greater than those of the ethanol‐treated group. Chronic administration of ethanol showed no clastogenic or cytotoxic effect. After chronic ethanol consumption, the cytochromes P450 activity increases, thus possibly preventing the ethanol that has entered the circulation from reaching excessive levels, leading to metabolic adaptation and/or tolerance. Teratogenesis Carcinog. Mutagen. 21:361–368, 2001. © 2001 Wiley‐Liss, Inc.

Clastogen

Mitotic index

Chronic toxicity

10.1002/tcm.1024

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Citations (6)

Systemic and follicular oxidative stress in infertile women with endometriosis undergoing controlled ovarian stimulation for ICSI: is there a role in the etiopathogenesis of infertility?

Fertility and Sterility (2014)

Michele Gomes Da Broi Felipe Oliveira de Albuquerque Aline Zyman de Andrade Rafaela L. Cardoso A.A. Jordão

Follicular fluid

Malondialdehyde

10.1016/j.fertnstert.2014.07.267

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Assessment of indicators of vitamin A status in non-cirrhotic chronic hepatitis C patients

Figshare (2019)

Rodrigo de Carvalho Santana Alessandra Aparecida Vieira Machado Adriano Martinelli A.A. Jordão Leandra Naíra Zambelli Ramalho

Subjects with chronic liver disease are susceptible to hypovitaminosis A due to several factors. Therefore, identifying patients with vitamin deficiency and a requirement for vitamin supplementation is important. Most studies assessing vitamin A in the context of hepatic disorders are conducted using cirrhotic patients. A cross-sectional study was conducted in 43 non-cirrhotic patients with chronic hepatitis C to evaluate markers of vitamin A status represented by serum retinol, liver retinol, and serum retinol-binding protein levels. We also performed the relative dose-response test, which provides an indirect estimate of hepatic vitamin A reserves. These vitamin A indicators were assessed according to the stage of liver fibrosis using the METAVIR score and the body mass index. The sample study was predominantly composed of male subjects (63%) with mild liver fibrosis (F1). The relative dose-response test was <20% in all subjects, indicating vitamin A sufficiency. Overweight or obese patients had higher serum retinol levels than those with a normal body mass index (2.6 and 1.9 µmol/L, respectively; P<0.01). Subjects with moderate liver fibrosis (F2) showed lower levels of serum retinol (1.9 vs 2.5 µmol/L, P=0.01) and retinol-binding protein levels compared with those with mild fibrosis (F1) (46.3 vs 67.7 µg/mL, P<0.01). These results suggested an effect of being overweight on serum retinol levels. Furthermore, more advanced stages of liver fibrosis were related to a decrease in serum vitamin A levels.

10.6084/m9.figshare.7942193

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Water extracts of cabbage and kale inhibit ex vivo H2O2-induced DNA damage but not rat hepatocarcinogenesis

Brazilian Journal of Medical and Biological Research (2010)

Maria Aderuza Horst Thomas Prates Ong A.A. Jordão Hélio Vannucchi Fernando Salvador Moreno

The chemopreventive potential of water extracts of the Brassica vegetables cabbage and kale was evaluated by administering their aqueous extracts in drinking water ad libitum to Wistar rats submitted to Ito's hepatocarcinogenesis model (CB group and K group, respectively - 14 rats per group). Animals submitted to this same model and treated with water were used as controls (W group - 15 rats). Treatment with the vegetable extracts did not inhibit (P > 0.05) placental glutathione S-transferase-positive preneoplastic lesions (PNL). The number of apoptotic bodies did not differ (P > 0.05) among the experimental groups. Ex vivo hydrogen peroxide treatment of rat livers resulted in lower (P < 0.05) DNA strand breakage in cabbage- (107.6 +/- 7.8 microm) and kale- (110.8 +/- 10.0 microm) treated animals compared with control (120.9 +/- 12.7 microm), as evaluated by the single cell gel (comet) assay. Treatment with cabbage (2 +/- 0.3 microg/g) or kale (4 +/- 0.2 microg/g) resulted in increased (P < 0.05) hepatic lutein concentration compared with control (0.5 +/- 0.07 microg/g). Despite the absence of inhibitory effects of cabbage and kale aqueous extracts on PNL, these Brassica vegetables presented protection against DNA damage, an effect possibly related to increased hepatic lutein concentrations. However, it must be pointed out that the cause-effect relationship between lutein levels and protection is hypothetical and remains to be demonstrated.

Comet Assay

Ex vivo

10.1590/s0100-879x2009007500038

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Citations (9)

Evaluation of Oxidative Stress in the Late Postoperative Stage of Liver Transplantation

Transplantation Proceedings (2014)

Viviane S. Augusto Alfredo José Rodrigues Gisienne Reis Ana Paula Cassiano Silveira Orlando de Castro e Silva

10.1016/j.transproceed.2013.12.058

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Determination of energy value of hamburgers and meatballs by direct calorimetry and food analysis composition. Comparison with nutrition information displayed on packages.

Bioscience Journal (2009)

Daphne Santoro Leonardi Maria Beatriz de Camargo Feres Guilherme Vannucchi Portari A.A. Jordão

Food composition data

Value (mathematics)

Nutrition information

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Effect of vitamin supplementation on lipid peroxidation caused by methotrexate in rats

Animal Nutrition and Feed Technology (2007)

A.A. Jordão A.B. Teixeira-Oliveira Osvaldo de Freitas Clarice Izumi Hélio Vannucchi

The methotrexate (MTX) is an antitumoral agent, acting like an antagonist of the folic acid and the administration of the MTX increases free radical production and induces hepatorenal oxidative injury in rats. The aim of the present study was to assess the value of adding a high dose of vitamin mixture to rats in lipid peroxidation provoked by methotrexate, and the role of vitamin E against the free radical production. The study utilized 40 rats subdivided in 4 groups: Group A received a diet with 3 times the recommendation of vitamin mixture according to American Institute of Nutrition diets for rodents, published in 1993 (AIN93); Group B, the same diet with normal, one time, vitamin mixture according to AIN93; rats in Group C received a diet with 3 times vitamin mixture according to American Institute of Nutrition diets for rodents, published in 1976 (AIN76); Group D, the same diet with normal, one time, vitamin mixture according to AIN76. The increase in hepatic vitamin E and glutathione and decrease of lipid peroxidation levels with suplemmentation of 3 times vitamin mixture can be able to protect for the possible adverse effects of the MTX administration in the oxidative stress in rats.

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Frequency and Duration Modulate Anticarcinogenic Effects of a Physical Training in the Colon

International Journal of Sports Medicine (2015)

Cleverson Rodrigues Fernandes T. Marini Fernando Tadeu Trevisan Frajacomo A.A. Jordão Sérgio Britto Garcia

Physical exercise has proven protective against colon carcinogenesis. We sought to clarify whether the frequency and duration of physical training were key factors for its anticarcinogenic effects on the colon. Either sedentary or physically trained male Wistar rats (n=82) were either exposed or not to the carcinogen dimethylhidrazine (DMH). The first protocol investigated whether swimming for 60 min in different frequencies modulates antipreneoplastic effects of physical training. Another protocol then explored whether the duration for training 5 times a week impacts on the development of colon preneoplastic lesions. After 8 weeks, serum and colon samples were collected and analyzed afterwards. Swimming once a week for 60 min did not promote those anticarcinogenic effects found in rats trained 5 times weekly. Such weekly sustained physical training not only decreased the development of colon preneoplastic, but also epithelial proliferation, and subepithelial cyclooxygenase 2 (COX-2) expression. Interestingly, a 5 time per week training for less than 60 min was not as protective against colon carcinogenesis as swimming for 90 min. This 90 min training indeed reduced serum cholesterol and triglycerides levels, as well as colonic lipid peroxidation in carcinogen-exposed rats. Our collective data suggest anticarcinogenic effects of physical exercises are potentially promoted when training 5 times a week for at least 60 min.

Physical exercise

10.1055/s-0034-1398624

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Citations (3)