Xuejiao Yang

Nanjing Tech University

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Jing‐Juan Xu

Nanjing University

Hong‐Yuan Chen

Nanjing University

Chi Xu

Nanjing University

Maosong Liu

Nanjing University

Xiang‐Ling Li

South China Agricultural University

Kai Zhang

Nanjing University of Information Science and Technology

Tingting Zhang

Chengdu University of Traditional Chinese Medicine

Huiyuan Lu

Shanghai Customs College

Shoulin Wang

Nanjing Medical University

Huiling Chen

Wenzhou University

Cooperative Institutions

Wind Power Engineering (Japan)

295

Energy Storage Systems (United States)

283

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Nanjing University

Peking University

Nanjing Medical University

Huazhong University of Science and Technology

Shenyang Institute of Automation

Shandong University

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Triple signal amplification strategy for ultrasensitive in situ imaging of intracellular telomerase RNA

Analytica Chimica Acta (2023)

Juan Song Shan Li Jie Zhou Qiao Yu Xuejiao Yang

Deoxyribozyme

Rolling circle replication

10.1016/j.aca.2023.341145

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Citations (3)

Reliable Förster Resonance Energy Transfer Probe Based on Structure-Switching DNA for Ratiometric Sensing of Telomerase in Living Cells

Analytical Chemistry (2017)

Xuejiao Yang Kai Zhang Tingting Zhang Jing‐Juan Xu Hong‐Yuan Chen

In situ detection and monitoring of telomerase is of great importance as it is a relatively specific cancer target. However, the complexity of the biological system makes it difficult for the nanoprobe to keep absolutely stable and have a low background in living cells. This study designs a probe termed Förster resonance energy transfer (FRET) nanoflare to achieve ratiometric fluorescent detection of intracellular telomerase with higher specificity, which can effectively resist the disturbance from DNase I and GSH, etc. The probe is composed of a gold nanoparticle (AuNP) which is functioned with telomerase primer sequences (TS) and flares fluorescently labeled donors and acceptors at two terminals. In the presence of telomerase, flares are displaced from the primer sequences and form hairpin structures, so that the donors and acceptors are brought into close proximity, resulting in high FRET efficiency. The probe exhibits good performance for efficiently distinguishing tumor cells from normal cells and monitoring the change of intracellular telomerase activity during treatment with telomerase-related drugs, showing great potential for cancer diagnosis and estimating therapeutic effect.

Nanoprobe

Primer (cosmetics)

10.1021/acs.analchem.7b00267

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Citations (84)

Temporal variation of characteristic scales in urban landscapes: an insight into the evolving internal structures of China’s two largest cities

Landscape Ecology (2012)

Chi Xu Maosong Liu Chao Hong Ting Chi Shuqing An

Variation (astronomy)

Temporal scales

10.1007/s10980-012-9764-x

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Citations (23)

Aziridine-Derived Polysulfide Elastomers for Self-Healable, Strong, and Reusable Adhesives

ACS Applied Polymer Materials (2024)

Qingyong Chen Leying Xu Lin-Lin Zhu Liang Gao Jiye Luo

Inverse vulcanization offers an efficient method for synthesizing high-sulfur content polymers. However, the resulting polysulfides often exhibit poor mechanical properties, particularly a lack of high ductility or elasticity. In this study, we present a straightforward one-pot tandem strategy for the synthesis of functionalized polysulfides with improved elastomeric properties. Initially, heterofunctional monomer alkene-substituted aziridine, specifically 2-(oct-7-en-1-yl)-1-tosylaziridine, was easily prepared by treating 1,9-decadiene with chloramine-T, a byproduct in saccharin production. Subsequently, sulfonamide and thioether-bifunctionalized polysulfides were synthesized through a tandem ring-opening reaction/thio-ene "click"/inverse vulcanization process. These reactions were conducted in a one-pot procedure without the need for solvents or metal catalysts. Various thiols can be employed in this approach, providing flexibility in altering the chemical composition of the polysulfide. The resulting polysulfides exhibit enhanced elasticity, demonstrating an elongation of up to 666% and a tensile strength of 0.39 MPa. Enhancement of the tensile strength to 1.94 MPa, with a 192% strain at break, is achievable. Furthermore, the functionalized polysulfides undergo rapid self-healing at 50 °C. They can be directly utilized as adhesives without requiring a tedious curing process, demonstrating exceptional adhesive properties on wood, iron, and aluminum substrates (up to 3.35, 1.83, and 1.56 MPa, respectively). Notably, these polysulfides can be recycled and reused 8 times while retaining robust adhesion. We anticipate that the simple construction process, potent adhesive capabilities, and recyclable/reusable features of this kind of polysulfide adhesive will contribute to the advancement of environmentally friendly adhesive technologies.

Polysulfide

10.1021/acsapm.4c00692

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Citations (1)

Application of nucleic acid-functionalized gold nanoprobes in live-cell fluorescence imaging

Scientia Sinica Chimica (2020)

Xuejiao Yang Jing‐Juan Xu Hong‐Yuan Chen

Combining nanomaterials and nucleic acid technology, fluorescent nucleic acid-functionalized gold nanoprobes possess many advantages, such as improved stability, good biocompatibility, unique optical properties and precise programmability, which open a new era for live-cell imaging. In particular, amplified nucleic acid-functionalized gold nanoprobes are ideal for in situ detecting powerful but low-abundance biomarkers. In this review, from the perspective of live-cell fluorescence imaging and analysis, the major properties, design principles and applications of nucleic acid-functionalized gold nanoprobes are introduced.

Live cell imaging

Fluorescence-lifetime imaging microscopy

10.1360/ssc-2019-0139

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Spidroin Composite Biomimetic Multifunctional Skin with Meta‐Structure

Advanced Materials Technologies (2022)

Haoxi Luo Yujing Shen Zhijun Liao Xuejiao Yang Bingbing Gao

Abstract Whether for organic life or intelligent machines (robots, Actuators), skin plays an important role as a barrier and sensor, and a lot of research is centered on making multifunctional skins. Here, the authors report an electronic skin with high stretchability, excellent mechanical sensing, and biochemical detection capabilities obtained by combining photonic crystals and sponge‐like filled liquid metal (LM)–polyurethane (PU)–spidroin (SP) composite materials. Inspired by geckos and mussels, a micropillar array is designed and coated with polydopamine to synergistically improve adhesion. P(MMA‐BA) elastic copolymer nanoparticles (are assembled into a photonic crystal pattern to endow electronic skin biochemical detection capabilities. The regionalization of the photonic crystal pattern allows the electronic skin to detect multiple target compounds simultaneously. The base material is an LM–PU–SP composite material with excellent stretchability and pressure sensitivity and is used for motion monitoring and tactile sensing. It is envisioned that this multifunctional electronic skin can be attached to animal skins for health monitoring to facilitate the diagnosis of metabolic diseases and wound inflammation. Alternatively, electronic skins can be attached to robots and soft robots for the collection of samples from heavily polluted areas, to obtain real‐time feedback information during the collection process.

Electronic Skin

Tactile sensor

Biomimetics

10.1002/admt.202101097

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Citations (8)

Developing a quantitative landscape regionalization framework integrating driving factors and response attributes of landscapes

Landscape and Ecological Engineering (2013)

Chi Xu Sheng Sheng Ting Chi Xuejiao Yang Shuqing An

Drainage density

Driving factors

10.1007/s11355-013-0225-8

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Citations (12)

Cytochrome P450 2A13 is an efficient enzyme in metabolic activation of aflatoxin G1 in human bronchial epithelial cells

Archives of Toxicology (2013)

Zhan Zhang Xuejiao Yang Yun Wang Xichen Wang Huiyuan Lu

10.1007/s00204-013-1108-3

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Population genetic analysis of the domestic Bactrian camel in China by RAD‐seq

Ecology and Evolution (2019)

Chenmiao Liu Huiling Chen Zhanjun Ren Chengdong Zhang Xuejiao Yang

Restriction site-associated DNA sequencing (RAD-seq) is one of the most effective high-throughput sequencing technologies for SNP development and utilization and has been applied to studying the origin and evolution of various species. The domestic Bactrian camels play an important role in economic trade and cultural construction. They are precious species resources and indispensable animals in China's agricultural production. Recently, the rapid development of modern transportation and agriculture, and the deterioration of the environment have led to a sharp decline in the number of camels. Although there have been some reports on the evolution history of the domestic Bactrian camel in China, the origin, evolutionary relationship, and genetic diversity of the camels are unclear due to the limitations of sample size and sequencing technology. Therefore, 47 samples of seven domestic Bactrian camel species from four regions (Inner Mongolia, Gansu, Qinghai, and Xinjiang) were prepared for RAD-seq analysis to study the evolutionary relationship and genetic diversity. In addition, seven domestic Bactrian camel species are located in different ecological zones, forming different characteristics and having potential development value. A total of 6,487,849 SNPs were genotyped. On the one hand, the filtered SNP information was used to conduct polymorphism mapping construction, LD attenuation analysis, and nucleotide diversity analysis. The results showed that the number of SNPs in Dongjiang camel was the highest, the LD coefficient decayed the fastest, and the nucleotide diversity was the highest. It indicates that Dongjiang camel has the highest genetic diversity. On the other hand, the filtered SNPs information was used to construct the phylogenetic tree, and FST analysis, inbreeding coefficient analysis, principal component analysis, and population structure analysis were carried out. The results showed that Nanjiang camel and Beijiang camels grouped together, and the other five Bactrian camel populations gathered into another branch. It may be because the mountains in the northern part of Xinjiang and the desert in the middle isolate the two groups from the other five groups.

Nucleotide diversity

10.1002/ece3.5624

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Citations (13)

NIR-Activated Spatiotemporally Controllable Nanoagent for Achieving Synergistic Gene-Chemo-Photothermal Therapy in Tumor Ablation

ACS Applied Bio Materials (2019)

Xuejiao Yang Xiang‐Ling Li Hong‐Yuan Chen Jing‐Juan Xu

A rational combination of different therapeutic modalities within one single nanostructure is promising to enhance the therapeutic response, especially to achieve a synergistic therapeutic efficacy for tumor treatment. Herein, a near-infrared (NIR) photothermally activated nanoagent, which could achieve a spatially controllable codelivery of different curative molecules and a temporally controlled responsive release, was designed to perform effective gene-chemo-photothermal therapy of malignant tumors. The nanoagent consisted of a gold nanorod (AuNR) functionalized with mPEG, DNA, and small interfering RNA (siRNA). With the aid of aptamer AS1411-mediated recognition and endocytosis, the nanoagents were selectively delivered into cancer cells; subsequently, the photothermal conversion of AuNRs happened while under NIR irradiation, which successfully achieved an effective photothermal therapy, induced dehybridization of DNA duplexes, and simultaneously released doxorubicin (DOX) and siRNA. Then, the released siRNA silenced the expression of the multidrug resistance associated protein 1 (MRP1), the primary cause of the undesirable expelling of DOX in PC-3 cells, yielding a remarkable improvement in the efficiency of gene-chemo therapy. All of the results of in vitro and in vivo studies revealed that our prepared nanoagents exhibited an excellent performance in synergistic gene-chemo-photothermal therapy and successfully inhibited tumor growth. This work provides an interesting concept of a nanoscale therapeutic agent in achieving a dramatically enhanced therapeutic ability for tumor ablation, which benefits from the spatiotemporally controllable properties and the synergistic combination of chemotherapy, gene therapy, and photothermal therapy in one single nanoagent.

Aptamer

10.1021/acsabm.9b00329

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Citations (16)