Jian‐Hu Li

Zhejiang University

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Bang‐Jing Li

Chengdu Institute of Biology

Qijuan Yuan

Xihua University

Zhenqiang Dong

Quzhou University

Sheng Zhang

Beijing University of Chemical Technology

Yi‐Fu Wang

National Cheng Kung University

Ya Cao

Sichuan University

Xueying Li

Chengdu University of Traditional Chinese Medicine

Yi‐Le Zhou

Xi’an Children’s Hospital

Hong‐Hu Zhu

Capital Medical University

Jiejing Qian

Zhejiang University

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First Affiliated Hospital Zhejiang University

Zhejiang University

Blood Center of Zhejiang Province

Sichuan University

Chinese Academy of Sciences

Zhejiang Cancer Hospital

Hangzhou Cancer Hospital

Chengdu University of Traditional Chinese Medicine

Sun Yat-sen University

Quzhou University

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Macromol. Rapid Commun. 10/2013

Macromolecular Rapid Communications (2013)

Zhenqiang Dong Ya Cao Qijuan Yuan Yi‐Fu Wang Jian‐Hu Li

Front Cover: A redox-induced shape-memory polymer is prepared by cross-linking β-cyclodextrin modified chitosan and ferrocene modified poly(ethylene imine). The reversible redox-sensitive β-CD/Fc inclusion complexes and covalent cross-links serve as reversible phases and fi xing phases, respectively. This material can be processed into a desired temporary shape upon reduction and recovers to its initial shape after oxidation. The shape memory behavior also occurs when glucose is introduced with glucose oxidase entrapped in the system. Further details can be found in the article by Z.-Q. Dong, Y. Cao, Q.-J. Yuan, Y.-F. Wang, J.-H. Li, B.-J. Li,* and S. Zhang- on page 867.

Imine

Glucose oxidase

10.1002/marc.201370032

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CDKN2A deletions are associated with poor outcomes in 101 adults with T‐cell acute lymphoblastic leukemia

American Journal of Hematology (2020)

Huanping Wang Yi‐Le Zhou Xin Huang Yi Zhang Jiejing Qian

The identification of genetic risk subgroups of T-cell acute lymphoblastic leukemia (T-ALL) may provide evidence for risk stratification and individualized treatment. We investigated the characteristics and prognostic value of tumor suppressor gene CDKN2A deletions in 101 patients with T-ALL. The CDKN2A deletion was present in 23% (23/101) of T-ALL by fluorescence in situ hybridization (FISH). The most common type of CDKN2A deletion was homozygous deletion (70%, 16/23). A lower frequency of CDKN2A deletion was found in patients with early T-cell precursor (ETP) ALL than in patients with non-ETP-ALL (10.4% vs 34.0%; P = .008). Deletion of CDKN2A was significantly associated with younger age (P = .001), higher white blood cell (WBC) count (P < .001) and higher lactate dehydrogenase (LDH) level (P = .002). Patients with CDKN2A deletion had lower 2-year overall survival (OS) and event-free survival (EFS) rates than patients without CDKN2A deletion (2-year OS: 18.6% ± 8.9% vs 47.4% ± 6.2%, P = .032; EFS: 16.4 ± 8.3 vs 38.6 ± 5.9%, P = .022). In multivariable analysis, CDKN2A deletion was an independent adverse prognostic factor for OS (P = .016). In conclusion, adult T-ALL patients with CDKN2A deletion had a poor prognosis, and these patients might benefit from intensive chemotherapy or allogeneic hematopoietic stem-cell transplantation.

10.1002/ajh.26069

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pH‐Switchable Macroscopic Assembly through Host–Guest Inclusion

Macromolecular Rapid Communications (2013)

Qijuan Yuan Yifu Wang Jian‐Hu Li Bang‐Jing Li Sheng Zhang

Abstract A novel pH‐switchable macroscopic assembly is reported using alginate‐based hydrogels functionalized with host (α‐cyclodextrin, αCD) and guest (diethylenetriamine, DETA) moieties. Since the interaction of αCD and DETA is pH sensitive, the host hydrogel and guest hydrogel could adhere together when the pH is 11.5 and separate when the pH is 7.0. Furthermore, this pH‐controlled adhesion and dissociation shows a good reversibility. The host and guest polymers have good biocompatibility; therefore, this pH‐sensitive macroscopic assembly shows great potential in biotechnological and biomedical applications. magnified image

Diethylenetriamine

Biocompatibility

10.1002/marc.201300289

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Redox‐ and Glucose‐Induced Shape‐Memory Polymers

Macromolecular Rapid Communications (2013)

Zhenqiang Dong Ya Cao Qijuan Yuan Yi‐Fu Wang Jian‐Hu Li

Abstract A novel redox‐induced shape‐memory polymer (SMP) is prepared by crosslinking β‐cyclodextrin modified chitosan (β‐CD‐CS) and ferrocene modified branched ethylene imine polymer (Fc‐PEI). The resulting β‐CD‐CS/Fc‐PEI contains two crosslinks: reversible redox‐sensitive β‐CD‐Fc inclusion complexes serving as reversible phases, and covalent crosslinks serving as fixing phases. It is shown that this material can be processed into temporary shapes as needed in the reduced state and recovers its initial shape after oxidation. The recovery ratio and the fixity ratio are both above 70%. Furthermore, after entrapping glucose oxidase (GOD) in the system, the material shows a shape memory effect in response to glucose. The recovery ratio and the fixity ratio are also above 70%. magnified image

Shape-memory polymer

10.1002/marc.201300084

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Citations (71)