P Pedraza

Universidad Autónoma de Madrid

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Gabriella Morreale de Escobar

King Faisal Specialist Hospital & Research Centre

Juan R. Martinez-Galán

University of Castilla-La Mancha

Antonio Ruiz‐Marcos

Instituto Cajal

Marı́a Santacana

Hospital Universitari Arnau de Vilanova

Francisco Escobar del Rey

Consejo Superior de Investigaciones Científicas

Björn Vennström

Karolinska Institutet

Douglas Forrest

National Institutes of Health

Lily Ng

National Institute of Diabetes and Digestive and Kidney Diseases

Rosa Calvo

Universitat de Barcelona

Marı́a Jesús Obregón

Instituto de Investigaciones Biomédicas Sols-Morreale

Cooperative Institutions

Consejo Superior de Investigaciones Científicas

Universidad Autónoma de Madrid

Instituto de Investigaciones Biomédicas Sols-Morreale

National Institutes of Health

Instituto de Salud Carlos III

Instituto Cajal

Unidades Centrales Científico-Técnicas

National Institute of Diabetes and Digestive and Kidney Diseases

Centro de Investigaciones Biológicas Margarita Salas

Karolinska Institutet

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Myelin basic protein immunoreactivity in the internal capsule of neonates from rats on a low iodine intake or on methylmercaptoimidazole (MMI)

Developmental Brain Research (1997)

Juan R. Martinez-Galán P Pedraza Marı́a Santacana Francisco Escobar del Rey Gabriella Morreale de Escobar

Capsule

10.1016/s0165-3806(97)00071-0

Cite

Citations (14)

Audiogenic seizure susceptibility in thyroid hormone receptor β-deficient mice

Neuroreport (2001)

Lily Ng P Pedraza Jonathan S. Faris Björn Vennström Tom Curran

As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TRα1 and TRβ thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TRβ (Thrbtm1/tm1) and is marked by early onset and persistence, thereby differing from mouse strains where AGS is age-restricted. Thrbtm1/tm1 mice display AGS whether on a mixed 129/Sv × C57BL/6J or congenic C57BL/6J background. 27% of wild-type mice on the mixed and 0% on the congenic background exhibited AGS. The inability of Thrbtm1/tm1 mice to downregulate the response to sustained acoustic stimulation may reside in the brain or in the auditory system itself as Thrbtm1/tm1 mice also display auditory deficits. The AGS phenotype identifies a novel neurological role for TRβ.

Congenic

Thyroid hormone receptor

10.1097/00001756-200108080-00015

Cite

Citations (28)

Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism.

Journal of Clinical Investigation (1997)

Juan R. Martinez-Galán P Pedraza Marı́a Santacana F Escobar del Ray Gabriella Morreale de Escobar

The most severe brain damage associated with thyroid dysfunction during development is observed in neurological cretins from areas with marked iodine deficiency. The damage is irreversible by birth and related to maternal hypothyroxinemia before mid gestation. However, direct evidence of this etiopathogenic mechanism is lacking. Rats were fed diets with a very low iodine content (LID), or LID supplemented with KI. Other rats were fed the breeding diet with a normal iodine content plus a goitrogen, methimazole (MMI). The concentrations of -thyroxine (T4) and 3,5,3'triiodo--thyronine (T3) were determined in the brain of 21-d-old fetuses. The proportion of radial glial cell fibers expressing nestin and glial fibrillary acidic protein was determined in the CA1 region of the hippocampus. T4 and T3 were decreased in the brain of the LID and MMI fetuses, as compared to their respective controls. The number of immature glial cell fibers, expressing nestin, was not affected, but the proportion of mature glial cell fibers, expressing glial fibrillary acidic protein, was significantly decreased by both LID and MMI treatment of the dams. These results show impaired maturation of cells involved in neuronal migration in the hippocampus, a region known to be affected in cretinism, at a stage of development equivalent to mid gestation in humans. The impairment is related to fetal cerebral thyroid hormone deficiency during a period of development when maternal thyroxinemia is believed to play an important role.

Cretinism

10.1172/jci119459

Cite

Citations (111)

Displacement of T4 from transthyretin by the synthetic flavonoid EMD 21388 results in increased production of T3 from T4 in rat dams and fetuses.

Endocrinology (1996)

P Pedraza Rosa Calvo Marı́a Jesús Obregón M. Asunción Francisco Escobar del Rey

EMD 21388 displaces T, from circulating transthyretin, is a potent in vitro inhibitor of outer-ring deiodination (5'D) of T, and affects thyroid hormone secretion.

10.1210/endo.137.11.8895363

Cite

Citations (15)