M Brouard

Hospital Universitario de Canarias

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i-10 index

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J Iribarren

Hospital Universitario de Canarias

R Pérez

Hospital Universitario Ramón y Cajal

Leonardo Lorente

Hospital Universitario de Canarias

R Martinez

Hospital Universitario de Canarias

M Mora

Hospital Universitario Fundación Jiménez Díaz

JJ Jiménez

Hospital Universitario de Canarias

JL Iribarren

Hospital Universitario de Canarias

L Lorenzo

University of Verona

S Palmero

Hospital Universitario de Canarias

Carolina García

Icesi University

Cooperative Institutions

Hospital Universitario de Canarias

Universidad de La Laguna

Observatorio de la Inmigración de Tenerife

Instituto de Salud Carlos III

Hospital General Universitario Gregorio Marañón

Universidad Autónoma de Madrid

Universidad Europea de Canarias

Hospital Universitario Ramón y Cajal

Inserm

MedStar Washington Hospital Center

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TNF +250 polymorphism and hyperdynamic state in cardiac surgery with extracorporeal circulation

Interactive Cardiovascular and Thoracic Surgery (2008)

J Iribarren Fernando Martínez‐Sagasti Juan José Jiménez M Brouard Eduardo Salido

We have investigated genetic and clinical factors associated with hyperdynamic state (HS) after heart surgery with extracorporeal circulation (ECC). We performed a prospective cohort study of consecutive patients who underwent elective heart surgery with ECC. HS was defined as hyperthermia (>38 °C), cardiac index (CI) >3.5 l/min/m2 and systemic vascular resistance index (SVRI) <1600 dynes·s/cm5·m2. The study included demographic variables, gene polymorphisms A/G of tumor necrosis factor-beta (TNFβ+250), G/A-1082 of interleukin-10 (IL-10), polymorphism of interleukin-1 receptor antagonist (IL-1ra), comorbidity, type of surgery, serum levels of interleukin-6 (IL-6), and postoperative course. We used Pearson χ2 or Fisher exact test, and Student t-test for univariate analysis, with forward stepwise logistic regression for multivariate adjustment. Eighty patients were studied, of whom 22 (27.5%) developed HS. The presence of allele G of TNFβ+250 polymorphism was associated with an increased incidence of HS (68% vs. 37%; P=0.011). In the multivariate analysis, a longer duration of ECC, and the presence of the G allele, were associated with the development of HS. The G allele of TNFβ+250 polymorphism, and prolonged extracorporeal circuit times, may favor the development of a hyperdynamic state after heart surgery with ECC.

Extracorporeal circulation

Cardiac index

Univariate analysis

10.1510/icvts.2008.177501

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Citations (4)

Prognostic value of the echocardiographic-derived calcium index in coronary artery disease

Critical Care (2012)

J Jiménez J Iribarren Juan Lacalzada‐Almeida Alejandro de la Rosa Rocío Juárez

Calcification of different cardiac structures is associated with atherosclerotic risk factors. The aim of this study is to determine whether the echocardiography-derived calcium index (ECI) assessed by transthoracic echocardiography (TTE) predicts cardiovascular events, besides determining the coronary artery calcium score (CACS), the presence of obstructive coronary artery disease (CAD) and the composition of plaques, all of which determined by multidetector computed tomography (MDCT).

Multidetector computed tomography

10.1186/cc10798

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Global longitudinal strain value for predicting left ventricular remodeling after primary percutaneous reperfusion therapy in acute myocardial infarction

Critical Care (2015)

JJ Jiménez JL Iribarren Juan Lacalzada‐Almeida Alejandro de la Rosa M Brouard

After an acute myocardial infarction with ST-segment elevation (STEMI) treated with percutaneous coronary intervention (PCI), the left ventricle (LV) can undergo negative remodeling (R-). We aimed to investigate whether global longitudinal strain (SGL) of the left ventricle (LV) predicts remodeling.

Ventricular remodeling

Reperfusion Therapy

10.1186/cc14242

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Lower incidence of catheter-related bloodstream infection in cubital than in femoral artery access

Scandinavian Journal of Infectious Diseases (2011)

Leonardo Lorente Alejandro Jiménez María M. Martín M Brouard J Iribarren

Data on catheter-related bloodstream infection (CRBSI) in cubital artery access are scarce. Thus, the objective of this study was to compare the incidence of CRBSI in a large series of patients with femoral or cubital artery catheters. We found 11 events of CRBSI in 1085 femoral artery catheters during 6497 days and none in 449 cubital artery catheters during 2709 days. Poisson regression analysis showed a higher incidence of CRBSI in femoral than in cubital artery site access (1.69 vs 0 CRBSI events per 1000 catheter-days; odds ratio 6.41, 95% confidence interval 1.05-infinite; p = 0.02). In conclusion, according to the results of our observational study, cubital artery access could have a lower risk of CRBSI than femoral artery access. However the development of randomized controlled trials is necessary before this conclusion can be definitively established. In addition, it is necessary to consider other potential mechanical complications when decision-making.

Bloodstream infection

Bacteremia

10.3109/00365548.2011.588608

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Citations (4)

Coronary artery disease and differential analysis of a valve calcium score by transthoracic echocardiography

Critical Care (2011)

JL Iribarren JJ Jiménez Juan Lacalzada‐Almeida Antonio Barragán M Brouard

Valvular calcification represents a form of atherosclerosis similar to that produced in the wall of the coronary arteries, so that the presence of mitral annular calcification (MAC), aortic valvular sclerosis and aortic root (AVRS) detected by transthoracic echocardiography (TTE) is associated with an increased risk for developing coronary artery disease (CAD). Coronary calcification and intracoronary lesions can be assessed by non-invasive coronary multidetector computed tomography (MDCT). The aim of this study was to determine whether a global valvular calcium score (GVCS) and/or partial (MAC and AVRS) assessed by TTE can predict critical values of calcium at the level of the coronary wall, the Agatston score (AS) and/or the presence of significant coronary lesions detected using MDCT.

Agatston score

Coronary arteries

valvular heart disease

Coronary anatomy

10.1186/cc9451

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Citations (1)

Critical Care (2006)

J.J. Jiménez Rivera J Iribarren Sarrias Ibrahim Nassar B Alarcó M Diaz

10.1186/cc4570

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Citations (2)

Influence of tracheostomy on the incidence of central venous catheter-related bacteremia

European Journal of Clinical Microbiology & Infectious Diseases (2009)

Leonardo Lorente Alejandro Jiménez María M. Martín J Castedo R Galván

Bacteremia

Central venous catheter

Medical microbiology

10.1007/s10096-009-0742-4

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Citations (39)

Levosimendan preconditioning in patients undergoing elective cardiac surgery with poor ejection fraction. preliminary results.

Journal of Cardiothoracic Surgery (2015)

R Ávalos Rafael Martínez‐Sanz JJ Jiménez JL Iribarren J. L. Montoto

Background and Aims Left ventricular systolic dysfunction (LVSD) represents a risk factor for the development of low cardiac output syndrome (LCOS) resulting in a high mortality in patients undergoing cardiac surgery, Levosimendan is a drug with inotropic, vasodilatory and organ-protective properties, often used in heart failure and low cardiac output patients. We study the effects of preoperative levosimendan administration (PLA) in patients with LVSD undergoing elective cardiac surgery on LCOS development and other secondary post-surgery outcomes

Levosimendan

Cardiothoracic surgery

Vascular surgery

10.1186/1749-8090-10-s1-a310

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Citations (3)

Lesser incidence of accidental catheter removal with femoral versus radial arterial access

Medicina Intensiva (2012)

Leonardo Lorente M Brouard Isabel Bielsa Alejandro Jiménez Eduardo Pastor

Arterial catheter

Arterial line

10.1016/j.medin.2012.05.014

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Citations (10)

Left ventricular TEI index: comparison between flow and tissue Doppler analyses and its association with postoperative atrial fibrillation in cardiopulmonary bypass surgery

Critical Care (2008)

J Iribarren Cayetano Naranjo M. Mora R Galván R Pérez

The TEI index (myocardial performance index), an indicator of combined ventricular systolic and diastolic function, is defined as the ratio of the sum of the isovolumic relaxation time and the isovolumic contraction time. The TEI index is independent of ventricular geometry, and is not significantly affected by heart rate or blood pressure. We sought to determine whether there was association with postoperative atrial fibrillation (AF) after cardiopulmonary bypass surgery.

10.1186/cc6467

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