Robert C. Stadalnik

University of California, Davis

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David R. Vera

University of California, San Diego

Nathaniel M. Matolo

Kenya Agricultural and Livestock Research Organization

Kenneth A. Krohn

University Radiology

Gerald L. DeNardo

University of California, San Francisco

Paul O. Scheibe

Arroyo Grande Community Hospital

Masatoshi Kudo

Kindai University

Walter L. Trudeau

University of California, Davis

E. Steve Woodle

University of Cincinnati

K. A. Krohn

University of Washington

John P. McGahan

University of California Davis Medical Center

Cooperative Institutions

University of California Davis Medical Center

University of California, Davis

Active Medicine (United Kingdom)

Stanford University

Imaging Center

Taichung Veterans General Hospital

University of California System

University of California, Los Angeles

University of California, Berkeley

Kobe Central Hospital

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Hepatic uptake of [99mTc]galactosyl-neoglycoalbumin is sensitive to receptor quantity

International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology (1991)

Masatoshi Kudo David R. Vera Walter L. Trudeau Robert C. Stadalnik

Radioligand

Radioligand Assay

10.1016/0883-2897(91)90003-4

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Citations (12)

In Vivo Measurement of Hepatic Binding Protein Using Galactosyl-Neoglycoalbumin: Clinical Application as a New Liver Function Test.:Clinical Application as a New Liver Function Test

Masatoshi Kudo David R. Vera Robert C. Stadalnik

Liver function

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Recovery of hepatic asialoglycoprotein receptors after major hepatic resection.

PubMed (1999)

Norihiro Kokudo David R. Vera Mitsuru Koizumi Makoto Seki Tadao Sato

Although morphological restoration of the hepatic mass after partial hepatectomy has been well studied, fewer reports have appeared on the change of functional hepatic capacity during liver regeneration. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoprotein. Kinetic modeling of 99mTc-labeled diethylenetriamine pentaacetic acid-galactosyl-human serum albumin (TcGSA) time-activity data yields estimates of ASGP-R concentration [R]o and amount R0, which are directly related to functional liver mass. We have investigated the changes in ASGP-R status as well as liver volume in regenerating human liver after major hepatic resection.Twenty-two patients (18 noncirrhotic, 4 cirrhotic) had a TcGSA study before and 3 wk after major hepatic resection, with a mean hepatic parenchymal resection rate of 36.0%.[R]0 was significantly decreased from 0.683+/-0.024 micromol/L to 0.565+/-0.032 micromol/L (P < 0.001) after resection. The decrease in [R]0 was more prominent in cirrhotic patients. Recovery of ASGP-R was observed as a significantly increased R0 3 wk after the operation. Subsequent (long-term) restoration of ASGP-R appeared to be slower when compared with the volume restoration.ASGP-R concentration of the liver significantly decreased after major hepatic resection. Subsequent recovery of ASGP-R amount was shown by TcGSA study. By estimating hepatic functional reserve expressed by ASGP-R amount and concentration, one may detect a delayed or impaired liver regeneration with higher sensitivity.

Asialoglycoprotein receptor

Liver Regeneration

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Citations (21)

TC-99M GALACTOSYL-NEOGLYCOALBUMIN (TC-NGA)

Clinical Nuclear Medicine (1983)

Robert C. Stadalnik David R. Vera Lois F. O Grady R. Quadro Paul O. Scheibe

Stadalnik, Robert C.; Vera, David R.; O'Grady, Lois F.; Quadro, Robert E.; Scheibe, Paul O.; Krohn, Kenneth A.; Hutak, Dusan P. Author Information

10.1097/00003072-198309001-00016

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A musculoskeletal radiologist's view of nuclear medicine

Seminars in Nuclear Medicine (1997)

Adam Greenspan Robert C. Stadalnik

Bone scintigraphy

Conventional radiography

Modality (human–computer interaction)

Projectional radiography

10.1016/s0001-2998(97)80010-4

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Citations (29)

Hepatic Scintiangiographic Patterns

Radiology (1974)

Gerald L. DeNardo Robert C. Stadalnik Sally J. DeNardo Antolin Raventos

Venous blood

10.1148/111.1.135

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Citations (27)

Experience with 99mTc diphosphonate in studying vascularity of the femoral head.

PubMed (1975)

Robert D’Ambrosia Richard S. Riggins Robert C. Stadalnik Gerald L. DeNardo

The most common complication of femoral neck fractures is avascular necrosis secondary to loss of blood supply; this condition occurs in one of every three patients incurring such an injury. A simple, accurate procedure for assessing the blood supply prior to definitive surgery would identify those patients in whom this complication could develop, thus avoiding secondary salvage operations. In previous studies, we found positron scintigraphy using radioactive fluorine (/sup 18/F) to be useful in the clinical management of patients with fractures of the femoral neck. /sup 99m/Tc diphosphonate is one of the newer, less-expensive bone scanning agents which have become more readily available, and we undertook a study to determine its usefulness.

Vascularity

Avascular Necrosis

Blood supply

Bone scintigraphy

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The “hot” spot in bone imaging

Seminars in Nuclear Medicine (1983)

Robert C. Stadalnik Tapan K. Chaudhuri Tuhin K. Chaudhuri

Bone imaging

Metabolic bone disease

Bone disease

10.1016/s0001-2998(83)80039-7

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Citations (7)

Solitary vertebral body uptake on bone scintigraphy: The “black ivory” vertebrae sign

Seminars in Nuclear Medicine (1985)

Robert C. Stadalnik Gary S. Greene Alan H. Maurer

Bone scintigraphy

10.1016/s0001-2998(85)80008-8

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Citations (2)

Increased Scrotai Activity

Robert C. Stadalnik Fred S. Mishkin

T HIS 14-yr-old youth was awakened at night by severe pain of his right scrotal contents. The pain persisted but decreased in intensity over the next 3 days when he finally sought medical help. The right scrotal sac was markedly swollen and tense with fluid. There was minimal tenderness over the spermatic cord and testis. The epididymis could not be separately defined. Urinalysis was normal. A scrotal study using 99mTc as pertechnetate was performed to exclude the possibility of torsion (Fig. 1). The images showed inflammatory disease. The patient was placed on Ampicillin with resolution of his symptoms and findings over the next 4 days. Causes of increased activity of the scrotal contents are listed below) -3 U n c o m m o n

Scrotal Pain

Spermatic cord

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