Rongrong Liu

First Affiliated Hospital of GuangXi Medical University

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Yongrong Lai

First Affiliated Hospital of GuangXi Medical University

Gaohui Yang

First Affiliated Hospital of GuangXi Medical University

Xingan Wu

Air Force Medical University

Shijuan Shan

Shandong Normal University

Shiyuan Hou

Air Force Medical University

Guiwen Yang

Shandong Normal University

Zhenbin Wei

Guangxi Medical University

Lianjin Liu

Shaanxi Normal University

Mingwei Han

People's Liberation Army 401 Hospital

Xuemei Zhou

Guangxi Medical University

Cooperative Institutions

Air Force Medical University

134

Guangxi Medical University

Chinese Academy of Sciences

First Affiliated Hospital of GuangXi Medical University

Peking University

Soochow University

Central South University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

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Nomogram to identify severe Coronavirus Disease 2019 (COVID-19) based on initial clinical and CT characteristics: a multi-center study

Research Square (Research Square) (2020)

Yixing Yu Ximing Wang Min Li Lan Gu Zongyu Xie

Abstract Background: To develop and validate a nomogram for early identification of severe coronavirus disease 2019 (COVID-19) based on initial clinical and CT characteristics. Methods: The initial clinical and CT imaging data of 217 patients with COVID-19 were analyzed retrospectively from January to March 2020. 217 patients with 146 mild cases and 71 severe cases were randomly divided into training and validation cohorts. Independent risk factors were selected to construct the nomogram for predicting severe COVID-19. Nomogram performance in terms of discrimination and calibration ability was evaluated using the area under the curve (AUC), calibration curve, decision curve, clinical impact curve and risk chart. Results: In the training cohort, the severity score of lung in the severe group (7, interquartile range [IQR]:5-9) was significantly higher than that of the mild group (4, IQR:2-5) ( P < 0.001). Age, density, mosaic perfusion sign and severity score of lung were independent risk factors for severe COVID-19. The nomogram had a AUC of 0.929 (95% CI, 0.889-0.969), sensitivity of 84.0% and specificity of 86.3%, in the training cohort, and a AUC of 0.936 (95% CI, 0.867-1.000), sensitivity of 90.5% and specificity of 88.6% in the validation cohort. The calibration curve, decision curve, clinical impact curve and risk chart showed that nomogram had high accuracy and superior net benefit in predicting severe COVID-19. Conclusion: The nomogram incorporating initial clinical and CT characteristics may help to identify the severe patients with COVID-19 in the early stage.

Nomogram

Interquartile range

10.21203/rs.3.rs-41684/v1

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Multiple Tissue Sample Collection Device for MRI Guided Transrectal Prostate Biopsy: Optimization and MRI Compatibility Tests

IEEE Access (2023)

Farrukh Anique Rongrong Liu Muhammad Umar Farooq Sung Suk Oh Jung Ki Jo

Biopsies are one of the most common ways to diagnose and prognose prostate cancer. Transrectal and Transperineal approaches are used to access the prostate for biopsy. Advancements in Magnet Resonance Imaging (MRI) offer a clear visualization of soft tissues and improved volumetric clarity. Real time MRI guidance can significantly change the paradigm of soft tissue biopsy. Proposed is a device with the ability to collect the tissue samples taken by a biopsy needle during an MRI guided Prostate biopsy and store them temporarily. This could help avoid interruption during the process and make the entire process teleoperated. The proposed design consists of a double layer of papers, rolling over a set of pulleys. Paper collects and stores the core tissue sample. Experiments have been performed to optimize paper tension, speed, and size. Tissue collection performance improvement is noticed with optimum paper tension, speed, and size. A test has also been performed in an MRI environment to check MR compatibility of the device. The device is MRI conditional and demonstrates a maximum of 13.1% SNR reduction in MR images. The proposed device exhibits the potential to be integrated with an MRI safe or conditional robotic manipulator for real time MRI guided Prostate biopsy.

Prostate biopsy

10.1109/access.2023.3293735

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Citations (3)

HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

Communications Biology (2021)

Rongrong Liu Ruixue Ma Ziyu Liu Haifeng Hu Jiayi Shu

Hantaan viruses (HTNVs) are zoonotic pathogens transmitted mainly by rodents and capable of infecting humans. Increasing knowledge of the human response to HTNV infection can guide the development of new preventative vaccines and therapeutic strategies. Here, we show that HTNV can infect CD8+ T cells in vivo in patients diagnosed with hemorrhagic fever with renal syndrome (HFRS). Electron microscopy-mediated tracking of the life cycle and ultrastructure of HTNV-infected CD8+ T cells in vitro showed an association between notable increases in cytoplasmic multivesicular bodies and virus production. Notably, based on a clinical cohort of 280 patients, we found that circulating HTNV-infected CD8+ T cell numbers in blood were proportional to disease severity. These results demonstrate that viral infected CD8+ T cells may be used as an adjunct marker for monitoring HFRS disease progression and that modulating T cell functions may be explored for new treatment strategies.

Hantaan virus

10.1038/s42003-021-02182-2

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Citations (19)

Gut microbiota induced epigenetic modifications in the non‐alcoholic fatty liver disease pathogenesis

Engineering in Life Sciences (2023)

Ruiqi Tang Rongrong Liu Hua Zha Yiwen Cheng Zongxin Ling

Abstract Non‐alcoholic fatty liver disease (NAFLD) represents a growing global health concern that can lead to liver disease and cancer. It is characterized by an excessive accumulation of fat in the liver, unrelated to excessive alcohol consumption. Studies indicate that the gut microbiota‐host crosstalk may play a causal role in NAFLD pathogenesis, with epigenetic modification serving as a key mechanism for regulating this interaction. In this review, we explore how the interplay between gut microbiota and the host epigenome impacts the development of NAFLD. Specifically, we discuss how gut microbiota‐derived factors, such as lipopolysaccharides (LPS) and short‐chain fatty acids (SCFAs), can modulate the DNA methylation and histone acetylation of genes associated with NAFLD, subsequently affecting lipid metabolism and immune homeostasis. Although the current literature suggests a link between gut microbiota and NAFLD development, our understanding of the molecular mechanisms and signaling pathways underlying this crosstalk remains limited. Therefore, more comprehensive epigenomic and multi‐omic studies, including broader clinical and animal experiments, are needed to further explore the mechanisms linking the gut microbiota to NAFLD‐associated genes. These studies are anticipated to improve microbial markers based on epigenetic strategies and provide novel insights into the pathogenesis of NAFLD, ultimately addressing a significant unmet clinical need.

Epigenome

Crosstalk

Epigenomics

Steatohepatitis

Pathogenesis

10.1002/elsc.202300016

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Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis

BioMed Research International (2019)

Yumei Huang Rongrong Liu Xiaoyun Wei Jiaodi Liu Lingyuan Pan

Extramedullary hematopoiesis (EMH) is common in non-transfusion-dependent thalassemia (NTDT) patients. Clinical presentations of EMH vary as MRI screening is not feasible. Hence, serum biomarkers are used to predict the risk of EMH.52 NTDT patients, including 26 EMH (+) and 26 EMH (-), together with 26 healthy controls, were enrolled in this case-control study from 2013 to 2016. EMH was confirmed by computed tomography or MRI. Demographic, transfusion, genetic, laboratory, and liver iron concentration (LIC) data, as well as clinical complications, were analyzed.EMH (+) patients had significantly higher serum ferritin (SF), growth differentiation factor 15 (GDF15), and erythropoietin (EPO) levels compared with EMH (-) patients and controls. The levels of erythroferrone (ERFE), hepcidin, and sTfR did not differ significantly between EMH (+) and EMH (-) patients (p>0.05). In NTDT patients, serum ERFE was not related to SF, LIC, hepcidin, sTfR, EPO, GDF15, and Hb levels. GDF15, EPO concentrations, and GDF15 to sTfR and GDF15 to EPO ratios are able to determine the presence of EMH with considerable sensitivity and specificity.GDF15, EPO, and GDF15 to EPO and GDF15 to sTfR ratios are potential biomarkers for the early prediction of NTDT in patients who are at risk for EMH.

GDF15

Extramedullary hematopoiesis

Ineffective erythropoiesis

10.1155/2019/4504302

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Citations (17)

Negative regulation of interferon regulatory factor 6 (IRF6) in interferon and NF-κB signalling pathways of common carp (Cyprinus carpio L.)

BMC Veterinary Research (2022)

Yaxin Liang Rongrong Liu Jiahui Zhang Yixin Chen Shijuan Shan

Abstract Background Interferon (IFN) regulatory factors (IRFs) is a kind of transcription factors, which play an important role in regulating the expression of type I IFN and related genes. In mammals, IRF6 is not relevant with IFN expression, while zebrafish IRF6 was reported to be a positive regulator of IFN expression and could be phosphorylated by both MyD88 and TBK1. However, the role of IRF6 in the immune response and IFN transcription of common carp is unknown. Results In the present study, the cDNA of IRF6 gene ( Cc IRF6) was cloned from common carp using RACE technique, with a total length of 1905 bp, encoding 471 amino acid residues, which possesses two functional domains of DBD and IAD. Similarity analysis showed that Cc IRF6 had more than 50% similarity with IRFs of other vertebrates, and had the highest similarity with grass carp and zebrafish, among which the DBD domain was much more conserved. The phylogenetic analysis showed that Cc IRF6 is in the branch of Osteichthyes and has the closest relationship with grass carp. In healthy common carp, the Cc IRF6 was expressed in all the examined tissues, with the highest level in the oral epithelium, and the lowest level in the head kidney. After intraperitoneal injection of poly(I:C) or Aeromonas hydrophila , the expression of Cc IRF6 increased in spleen, head kidney, foregut and hindgut of common carp. Moreover, poly(I:C), LPS, PGN and flagellin induced the expression of Cc IRF6 in peripheral leukocytes and head kidney leukocytes of common carp in vitro. In EPC cells, Cc IRF6 inhibited the expression of some IFN-related genes and pro-inflammatory cytokines, and dual luciferase reporter assay showed that Cc IRF6 reduced the activity of IFN and NF-κB reporter genes. Conclusions The present study suggests that Cc IRF6 is involved in the antiviral and antibacterial immune response of common carp, and negatively regulate the expression of IFN and NF-κB signalling pathways, which provides a theoretical basis for the study and prevention of fish disease pathogenesis.

Common carp

Grass carp

Hindgut

IRF7

IRF1

10.1186/s12917-022-03538-4

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Citations (3)

Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic performance of colposcopy among women with oncogenic HPV

BMC Women s Health (2023)

Xiaoxiao Li Fenfen Xiang Yunzhi Zhao Qian Li Qing Gu

Abstract Background HPV screening tests may improve cervical cancer risk stratification and better guide decisions about follow-up with colposcopy/biopsy. This study aimed to estimate the risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) among women with oncogenic HPV types and evaluate the performance of colposcopy in the diagnosis of histologic CIN2 + at Putuo Hospital, Shanghai, China. Methods This cross-sectional survey was conducted from February 2020 to December 2022 among women who were referred to colposcopy. Women with high-risk (HR) HPV-positive, cytology testing and colposcopy-directed biopsy were included. Results Univariate and multivariate analysis indicated that high-grade colposcopic impression ((OR, 17.61%, 95%CI: 11.54–26.85%) was associated with the highest risk for detecting CIN2+, followed by HSIL + cytology (OR, 6.90%, 95%CI: 3.56–13.37%) and HPV16/18 positive (OR, 2.91%, 95%CI: 2.12–3.99%). Overall, CIN2 + was detected in 14.6% of 2007 women. HPV16/18 had higher CIN2 + risks than other HR-HPV genotypes (30.1% vs. 10.2%, P <0.001). Among women with low-grade cytology, 24.1% had CIN2+, and the risks for HPV16/18 (58.2%) were higher than for other HR-HPV(16.8%). For those with high-grade cytology, there was no significant difference between HPV groups ( 75.0% vs. 72.9%, P > 0.05). The diagnostic performance of colposcopy in diagnosis of CIN2 + by senior and junior colposcopists was comparable. Conclusions The results indicated that referral to colposcopy is recommended in managing women with HR-HPV positive, and colposcopic impressions provide key clues for identification CIN2+.

10.1186/s12905-023-02538-2

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Citations (4)

Advances in the evasion of innate immunity by fish viruses: A glance at RLRs and cGAS-STING signaling pathways

Aquaculture (2023)

Rongrong Liu Shijuan Shan

Sting

10.1016/j.aquaculture.2023.740197

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Citations (2)

Comparison of fresh and frozen-thawed embryo transfer cycles in patients with low oocyte retrieval

Pakistan Journal of Medical Sciences (2024)