Yasukatsu Oshima

Tohoku University

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Takeshi Yasumoto

Japan Food Research Laboratories

Masayuki Satake

The University of Tokyo

Yuko Cho

Hokkaido University Hospital

Mari Yotsu‐Yamashita

Tohoku University

Keiichi Konoki

Tohoku University

Yasushi Ohizumi

Tohoku Fukushi University

Shigeki Tsuchiya

Tohoku University

Takuo Omura

Tokyo University of Marine Science and Technology

Hideo Naoki

Sanyo (Japan)

Ryuichi Watanabe

Saitama Medical University

Cooperative Institutions

Tohoku University

The University of Tokyo

Osaka University

Kitasato University

Kyoto University

Hokkaido University

Japan Fisheries Research and Education Agency

Tokyo University of Agriculture

Tokyo University of Marine Science and Technology

Kyushu University

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Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

Organic & Biomolecular Chemistry (2014)

Shigeki Tsuchiya Yuko Cho Keiichi Konoki Kazuo Nagasawa Yasukatsu Oshima

Here, we describe the synthesis of the genetically predicted biosynthetic intermediates of the neurotoxin saxitoxin (STX) (1), 2, 6 and 7, and identification of 2 and 6 in toxin-producing microorganisms. This is the first chemical evidence supporting the genetically predicted biosynthetic route toward 1.

Saxitoxin

Dinoflagellate

Alexandrium tamarense

Identification

10.1039/c4ob00071d

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Citations (56)

Liquid chromatographic-fluorometric analysis of paralytic shellfish toxins.

Agricultural and Biological Chemistry (1984)

Yasukatsu Oshima Makoto Machida Kazuo Sasaki Yoko Tamaoki Takeshi Yasumoto

Alkaline oxidation of paralytic shellfish toxins with tert-butyl hydroperoxide yielded highly fluorescent derivatives. Even gonyautoxins I and IV and neosaxitoxin, which were nonfluorescing by previously proposed hydrogen peroxide oxidations, were successfully converted to fluorescent compounds. A continuous shellfish toxin analyzer was constructed by incorporating the reaction into a high pressure liquid chromatographic system. The limit of detection was within the range of 0.042.2 nmol for gonyautoxins I V, neosaxitoxin and saxitoxin.

Saxitoxin

Paralytic shellfish poisoning

Shellfish Poisoning

10.1271/bbb1961.48.1707

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Iridoids and Sesquiterpenoids with NGF-Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei

Chemical and Pharmaceutical Bulletin (2006)

Yuanqiang Guo Jing Xu Yushan Li Ryuichi Watanabe Yasukatsu Oshima

A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Neurite

10.1248/cpb.54.123

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Citations (26)

Yessotoxin analogues in several strains of Protoceratium reticulatum in Japan determined by liquid chromatography–hybrid triple quadrupole/linear ion trap mass spectrometry

Journal of Chromatography A (2006)

Toshiyuki Suzuki Yoshifumi Horie Kazuhiko Koike Masayuki Satake Yasukatsu Oshima

Quadrupole ion trap

Enone

10.1016/j.chroma.2006.12.048

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Citations (47)