Jerry I. Hirsch

Virginia Commonwealth University

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James L. Tatum

National Cancer Institute

Harvey J. Sugerman

Virginia Commonwealth University

A.M. Strash

Virginia Commonwealth University Medical Center

Melvin J. Fratkin

Virginia Commonwealth University

Jamal Zweit

Virginia Commonwealth University

Gobalakrishnan Sundaresan

Virginia Commonwealth University

C Bass

Virginia Commonwealth University

Marian Axente

Emory University

Andrei Pugachev

Oregon Health & Science University

Lazar J. Greenfield

University of Connecticut

Cooperative Institutions

Virginia Commonwealth University

Virginia Commonwealth University Medical Center

National Institutes of Health

Johannes Gutenberg University Mainz

Columbia University

University of Richmond

Children's Hospital of Richmond at VCU

Virginia Tech

University of California, Los Angeles

Hunter Holmes McGuire VA Medical Center

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Scintigraphy for Pulmonary Capillary Protein Leak

Harvey J. Sugerman James L. Tatum Jerry I. Hirsch A.M. Strash

Abstract : Pulmonary gamma scintigraphy is a rapid, non-invasive technique for measuring a pulmonary capillary protein leak in ARDS. In these studies, the method demonstrated that the acute anesthetized lung lymph fistula sheep model was associated with a significant pulmonary capillary protein leak. No leak was demonstrated in dogs following either large doses of Intralipid, sodium morrhuate or endotoxin. The protein leak following oleic acid could not be prevented with methylprednisolone (30 mg/kg), ibuprofen (12.5 mg/kg), MK-447 (4 mg/kg), or calcium gluconate (140 mg/kg). A significant and persistent leak followed the instillation of 0.1 hydrochloric acid into the trachea of dogs. This was not altered with pre-treatment with 30 mg/kg methylprednisolone or 12.5 mg/kg ibuprofen. Prostacyclin (PGI sub2) infusion at 0.3 mcg/kg/min increased the rate of leak, as measured by the SI, by 50%. A significant SI was noted in pigs following the intravenous infusion of Pseudomonas (1,000,000,000 orgs/kg/ min). Studies will be undertaken to investigate the ability of various agents (methylprednisolene, ibuprofen, PGI sub2) to alter the SI following Pseudmonas infusions in the pig. Atelectasis was produced in 5 dogs by inflation of a balloon in the right main bronchus and repeat SI's were obtained. Altelectasis did not produce an increased SI. These studies will be compared to a group of dogs in which a right lobar pneumococcal pneumonia will be produced..

Lipiodol

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Evidence that bile salts are important for iron absorption

AJP Gastrointestinal and Liver Physiology (1994)

Arun J. Sanyal Jerry I. Hirsch Edward W. Moore

The role of bile salts in intestinal Fe absorption has not previously been defined. We have recently shown that bile salts having cholanic ring 7 alpha-OH and/or 12 alpha-OH groups bind Fe2+ with high affinity at premicellar concentrations and also produce a two-to threefold enhancement in Fe2+ uptake from perfused intestinal segments in vivo. However, the physiological relevance of these observations for Fe2+ absorption was not known. To study this, we examined the effects of a single dose of taurocholate (TC) administered with 59Fe-FeSO4 in reversing iron malabsorption induced by bile duct ligation. Fe absorption from three 0.5-mg doses of 59Fe-FeSO4 was measured from five groups of six adult Sprague-Dawley rats each: group 1, before and after bile duct ligation and subsequent administration of 59Fe-FeSO4 + TC test dose; group 2, before and after bile duct ligation followed by a third dose of Fe alone; group 3, before and after bile duct ligation followed by a third dose of Fe+taurodehydrocholate (TDHC); group 4, sham laparotomy; and group 5, nonoperated controls where Fe absorption was measured from three doses of 59Fe-FeSO4 at the same time intervals as group 1. Absorption was measured, using whole body counting, after achievement of steady-state counts after each Fe dose. Mean percentage absorption from dose 1 (baseline) was 35.33 +/- 4.6% (SE). No significant differences between any groups were noted. In nonoperated controls (group 4), Fe absorption was virtually identical after all three doses. Also, hematocrit did not change in any of the 30 animals.(ABSTRACT TRUNCATED AT 250 WORDS)

10.1152/ajpgi.1994.266.2.g318

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SU-F-BRA-01: Object-Based Analysis of Spatial Concordance Between Coregistered Images of Intratumoral Uptake of [18F]FLT and Distribution of Cell Proliferation Markers

Medical Physics (2011)

Marian Axente Jian He C Bass Gobalakrishnan Sundaresan Jerry I. Hirsch

Purpose: To propose a new objective method for deformable coregistration of multimodality images acquired with digital autoradiography (DAR) and microscopy in the context of PET tracer histopathological validation. To analyze the spatial concordance between the uptake pattern of 18F-fluorothymidine (FLT) as imaged with DAR and the distribution of cell proliferation as revealed by immunofluorescence microscopy imaging.Methods: Tumor-bearing mice were injected with FLT and other markers including bromodeoxyuridine (cell proliferation). After sacrifice, tumors were excised, frozen and sectioned. Multiple stacks of sequential 8μm sections were collected from each tumor. Selected sections were used for DAR to image FLT uptake distribution. Adjacent sections were used to acquire histopathological data. To correct for imperfections of the tissue cutting and collection, all images were deformably coregistered to the FLT DAR image based on biological images of tumor blood flow (Hoechst) that was acquired from each tissue section used. For each FLT DAR — cell proliferation microscopy image pair, object-based analysis was conducted, including overlap and relative operating characteristics (ROC) analysis. Results: Total registration error of proposed coregistration method was 44.86μm. This supersedes current rigid registration methods with reported errors of 100–200μm. In tumors with well-compartmentalized functional aspects, area under the ROC curve (AUCroc= 0.7) indicated FLT DAR image thresholding as an accurate method of detecting cell proliferation. For these tumors, Dice overlap index indicated maximum detection rates at thresholds between 20% and 40% of the maximum DAR intensity. For the tumors characterized by more heterogeneous distribution of cell proliferation across the tumor section, FLT DAR image thresholding could not predict cell proliferation beyond random chance. Conclusions: We developed a comprehensive method of obtaining and analyzing coregistered images of cell proliferation markers and intratumoral uptake of FLT. Tumor microenvironment heterogeneity is a significant factor affecting the utility of FLT for imaging cell proliferation.

Image registration

Concordance

10.1118/1.3612868

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Tumour microenvironment heterogeneity affects the perceived spatial concordance between the intratumoural patterns of cell proliferation and 18F-fluorothymidine uptake

Radiotherapy and Oncology (2012)

Marian Axente Jun He C Bass Jerry I. Hirsch Gobalakrishnan Sundaresan

Concordance

Spatial heterogeneity

Tumour heterogeneity

10.1016/j.radonc.2012.02.011

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Citations (5)

Effects of ibuprofen on a pig Pseudomonas ARDS model

Journal of Surgical Research (1986)

C.Chin Lee Harvey J. Sugerman James L. Tatum Thomas P. Wright Paul D. Hirsh

Thromboxane B2

Arterial blood

Ibuprofen

Pulmonary wedge pressure

10.1016/0022-4804(86)90212-x

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Citations (26)

Reperfused-viable and reperfused-infarcted myocardium: differentiation with in vivo P-31 MR spectroscopy.

Radiology (1989)

Roger B. Rehr James L. Tatum Jerry I. Hirsch R Quint G Clarke

The ability of in vivo phosphorus-31 magnetic resonance (MR) spectroscopy to permit accurate distinction between reperfused-viable and reperfused-infarcted myocardium was examined in a canine model of acute coronary occlusion. In vivo myocardial pH and phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were measured at baseline and for the first 90 minutes after reperfusion of a total coronary artery occlusion producing either predominantly viable (nine animals) or infarcted (nine animals) myocardium in the region of metabolic study. Myocardial viability was assessed in each animal by means of postmortem triphenyltetrazolium chloride staining. Tissue was characterized from the in vivo P-31 MR data by means of logistic regression analysis. The accuracy of using the P-31 MR data for distinguishing reperfused-viable from reperfused-infarcted myocardium was 100% (69 of 69 data points, 18 of 18 animals). Results of the logistic regression procedure indicated that phosphocreatine was the metabolic variable enabling most effective separation of reperfused-viable and reperfused-infarcted myocardium. Thus, metabolic data obtained with P-31 MR spectroscopy permit effective separation of reperfused-viable from reperfused-infarcted myocardium.

Coronary occlusion

10.1148/radiology.172.1.2740521

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Citations (30)

Effects of pulmonary vascular recruitment on gamma scintigraphy and pulmonary capillary protein leak.

PubMed (1981)

H J Sugerman James L. Tatum A.M. Strash Jerry I. Hirsch L. J. Greenfield

Pulmonary wedge pressure

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A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80

Applied Sciences (2012)

Jianqiao Luo John D. Wilson Jianyuan Zhang Jerry I. Hirsch Harry C. Dorn

The current report describes the development of a dual modality tomographic agent for both positron emission tomography and magnetic resonance imaging (PET/MRI). The dual-modality agent in this study was based on a 124I (PET) radiolabeled tri-gadolinium endohedral metallofullerene Gd3N@C80 (MRI) nanoprobe platform. The outer surface of the fullerene cage of the Gd3N@C80 metallofullerenes was surface functionalized with carboxyl and hydroxyl groups (f-Gd3N@C80) using previously developed procedures and subsequently iodinated with 124I to produce 124I-f-Gd3N@C80 nanoprobe. Orthotopic tumor-bearing rats were infused intratumorally by convection-enhanced delivery (CED) with the 124I-f-Gd3N@C80 agent and imaged by MRI or micro PET. The anatomical positioning and distribution of the 124I-f-Gd3N@C80 agent were comparable between the MRI and PET scans. The 124I-f-Gd3N@C80 dual-agent distribution and infusion site within the tumor was clearly evident in both T1- and T2-weighted MR images. The results demonstrate the successful preparation of a dual-modality imaging agent, 124I-f-Gd3N@C80, which could ultimately be used for simultaneous PET/MR imaging.

Nanoprobe

PET Imaging

10.3390/app2020465

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Citations (29)

[Contribution to the true non-African Burkitt's lymphoma (author's transl)].

PubMed (1982)

W Wöckel Rüdiger Kd K Wutke J Wilke P Wutzler

It is reported on a 6-year-old Middle European boy suffering from a nasopharynx tumor with involvement of a submandibular lymph node. The tumor was classified by morphologic, serologic and virologic data as a true or Epstein-Barr virus-associated Burkitt's lymphoma, resp., which has been, up to now, seldom seen outside Africa. The patient died 3 months after diagnosis. Autopsy has shown tumor involvement of nasopharynx and soft tissues in the left neck region, several lymph nodes, kidneys, liver, spleen, and bone marrow. Cytologic, light and electron microscopic data are reported and the structural change of the tumor is referred to.

Lymphoepithelioma

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P.6.b.008 Modulation of gabaergic transmission in alcoholic subjects and sons of alcoholics

European Neuropsychopharmacology (2006)

Thomas F. Dielentheis M. Schreckenberger Christian Landvogt K. Hobusch Jerry I. Hirsch

Semiconductor detector

Crystal (programming language)

10.1016/s0924-977x(06)70679-4

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