Musab Jilani

California Institute of Technology

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Oliver Plettenburg

Helmholtz Zentrum München

Christin Ahlbrecht

Helmholtz Zentrum München

Dvin Adalian

California Institute of Technology

Abhinav Agarwal

California Institute of Technology

Samson Chen

California Institute of Technology

Richard D. Smith

California Institute of Technology

S.-J. Li

California Institute of Technology

Axel Scherer

California Institute of Technology

Xiomi Madero

California Institute of Technology

Peter A. Petillo

ZIN Technologies (United States)

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California Institute of Technology

Helmholtz Zentrum München

Target (Germany)

Leibniz University Hannover

Heinrich Heine University Düsseldorf

Deutsches Diabetes-Zentrum e.V.

German Center for Diabetes Research

Kavli Energy NanoScience Institute

Howard Hughes Medical Institute

University of Giessen

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Patterned thin film enzyme electrodes via spincoating and glutaraldehyde vapor crosslinking: towards scalable fabrication of integrated sensor-on-CMOS devices

Lab on a Chip (2024)

Dvin Adalian Xiomi Madero Samson Chen Musab Jilani Richard D. Smith

Effective continuous glucose monitoring solutions require consistent sensor performance over the lifetime of the device, a manageable variance between devices, and the capability of high volume, low cost production. Here we present a novel and microfabrication-compatible method of depositing and stabilizing enzyme layers on top of planar electrodes that can aid in the mass production of sensors while also improving their consistency. This work is focused on the fragile biorecognition layer as that has been a critical difficulty in the development of microfabricated sensors. We test this approach with glucose oxidase (GOx) and evaluate the sensor performance with amperometric measurements of

Glutaraldehyde

10.1039/d4lc00206g

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