S. Campana

Azienda Ospedaliero-Universitaria Careggi

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Co-Authors

Giovanni Taccetti

Meyer Children's Hospital

N. Ravenni

Meyer Children's Hospital

C. Braggion

Cystic Fibrosis Research Foundation

Daniela Dolce

Meyer Children's Hospital

Filippo Festini

Meyer Children's Hospital

P. Cocchi

Hospital Universitario 12 De Octubre

A.S. Neri

Meyer Children's Hospital

Gianfranco Mergni

Meyer Children's Hospital

Lisa Cariani

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Valeria Galici

Meyer Children's Hospital

Cooperative Institutions

University of Florence

Meyer Children's Hospital

Istituti di Ricovero e Cura a Carattere Scientifico

Azienda Ospedaliero-Universitaria Careggi

National Agency for New Technologies, Energy and Sustainable Economic Development

ENEA Casaccia Research Centre

Cystic Fibrosis Research Foundation

Istituto Giannina Gaslini

Bambino Gesù Children's Hospital

University of Genoa

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73 Impact of community-acquired MRSA and hospital-acquired MRSA on pulmonary function of CF patients

Journal of Cystic Fibrosis (2015)

S. Campana N. Ravenni Lisa Cariani Carla Colombo Ersilia Fiscarelli

10.1016/s1569-1993(15)30250-2

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Citations (0)

Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis

Giovanni Taccetti S. Campana Filippo Festini Matteo Mascherini

In cystic fibrosis (CF) patients early antibiotic treatment of lung infection has been shown to lead to Pseudomonas aeruginosa eradication. The present study determined: 1) the time period from eradication to new P. aeruginosa acquisition; 2) P. aeruginosa re-growth and new acquisition; and 3) the impact of eradication therapy on lung function, antimicrobial resistance, emergence of other pathogens and treatment costs. Ciprofloxacin and colistin were used to eradicate P. aeruginosa in 47 CF patients. Bacterial pathogens, lung function decline, P. aeruginosa antimicrobial resistance and anti-pseudomonal serum antibodies were assessed quarterly and compared with an age-matched CF control group. Additionally, costs of antibiotic therapy in both groups were assessed. Early antibiotic therapy leads to a P. aeruginosa free-period of a median (range) of 18 (4-80) months. New acquisition with different P. aeruginosa genotypes occurs in 73% of episodes. It also delays the decline of lung function compared with chronically infected patients, prevents the occurrence of antibiotic resistant P. aeruginosa strains, does not lead to emergence of other pathogens, and significantly reduces treatment costs. The treatment substantially lowers P. aeruginosa prevalence in CF. In conclusion, early antibiotic therapy exerts beneficial effects on the patient's clinical status and is cost-effective compared with conventional antibiotic therapy for chronically infected cystic fibrosis patients.

Colistin

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Citations (7)

156 Chronic airway colonization by Aspergillus fumigatus (Af) in patients with cystic fibrosis (CF): Does it contribute to lung function decline?

Journal of Cystic Fibrosis (2013)

C. Braggion R. Pasotto Gianfranco Mergni Giovanni Taccetti Daniela Dolce

Allergic bronchopulmonary aspergillosis

10.1016/s1569-1993(13)60298-2

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Chromogenic versus cetrimide-based media for Pseudomonas aeruginosa isolation

Journal of Cystic Fibrosis (2010)

N. Ravenni Daniela Dolce P. Cocchi C. Braggion S. Campana

Cetrimide

Isolation

Chromogenic

10.1016/s1569-1993(10)60108-7

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128 Isolation and identification of “difficult” pathogens from CF airways: molecular analysis results

Journal of Cystic Fibrosis (2006)

P. Cocchi N. Ravenni Giovanni Taccetti S. Campana

Isolation

Identification

10.1016/s1569-1993(06)80112-8

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71 Pseudomonas aeruginosa in paranasal sinuses and in lower airways in cystic fibrosis patients

Journal of Cystic Fibrosis (2015)

Daniela Dolce Silvia Bresci Eleonora Masi S. Campana C. Braggion

10.1016/s1569-1993(15)30248-4

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Citations (1)

Early Pseudomonas aeruginosa infection: is susceptibility testing justified?

Journal of Cystic Fibrosis (2010)

Daniel W. MacDonald J. R. W. Govan Leah Cuthbertson C. Doherty S. Campana

10.1016/s1569-1993(10)60154-3

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Epidemiology of first/new Pseudomonas aeruginosa infection in cystic fibrosis patients

Journal of Cystic Fibrosis (2010)

L. Zavataro Giovanni Taccetti Lisa Cariani N. Ravenni Giulia Braccini

10.1016/s1569-1993(10)60111-7

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Citations (6)

Transmission of Burkholderia cepacia Complex: Evidence for New Epidemic Clones Infecting Cystic Fibrosis Patients in Italy

Journal of Clinical Microbiology (2005)

S. Campana Giovanni Taccetti N. Ravenni F. Favari Lisa Cariani

To analyze national prevalence, genomovar distribution, and epidemiology of the Burkholderia cepacia complex in Italy, 225 putative B. cepacia complex isolates were obtained from 225 cystic fibrosis (CF) patients attending 18 CF centers. The genomovar status of these isolates was determined by a polyphasic approach, which included whole-cell protein electrophoresis and recA restriction fragment length polymorphism (RFLP) analysis. Two approaches were used to genotype B. cepacia complex isolates: BOX-PCR fingerprinting and pulsed-field gel electrophoresis (PFGE) of genomic macrorestriction fragments. A total of 208 (92%) of 225 isolates belonged to the B. cepacia complex, with Burkholderia cenocepacia as the most prevalent species (61.1%). Clones delineated by PFGE were predominantly linked to a single center; in contrast, BOX-PCR clones were composed of isolates collected either from the same center or from different CF centers and comprised multiple PFGE clusters. Three BOX-PCR clones appeared of special interest. One clone was composed of 17 B. cenocepacia isolates belonging to recA RFLP type H. These isolates were collected from six centers and represented three PFGE clusters. The presence of insertion sequence IS 1363 in all isolates and the comparison with PHDC reference isolates identified this clone as PHDC, an epidemic clone prominent in North American CF patients. The second clone included 22 isolates from eight centers and belonged to recA RFLP type AT. The genomovar status of strains with the latter RFLP type is not known. Most of these isolates belonged to four different PFGE clusters. Finally, a third clone comprised nine B. pyrrocinia isolates belonging to recA RFLP type Se 13. They represented three PFGE clusters and were collected in three CF centers.

Burkholderia cepacia complex

Burkholderia cenocepacia

Molecular Epidemiology

clone (Java method)

Multilocus sequence typing

10.1128/jcm.43.10.5136-5142.2005

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Citations (51)

Training Executive Functions Within the Mathematical Domain: A Pilot Study with an Integrated Digital‐Paper Procedure in Primary Second‐Grade

Mind Brain and Education (2024)

Costanza Ruffini Camilla Chini Giulia Lombardi Silvia Della Rocca Annarita Monaco

Abstract Interventions targeting cognitive control processes, such as Executive Functions (EF) have recently been experimented to enhance early math skills. This pilot study explored the feasibility and effectiveness of an intervention integrating EF activities into the mathematical domain among second‐grade students. One hundred and four typically‐developing‐children were assigned to either a group that underwent the intervention (Trained Group; n = 58) or a group that continued with daily didactic activities (Control Group; n = 46). The training lasted for 8 weeks and included both home‐based digital and school‐based paper activities. According to teachers' feedback, the intervention was highly appreciated by children and compatible with classical school curricula. The Trained Group improved in behavioral self‐regulation, math abilities and problem‐solving in comparison to the Control Group. Notably, within the Trained Group, benefits of the training were higher in children with high working memory. This training offers a model to support math learning in primary school, considering inter‐individual differences in EF.

Primary (astronomy)

10.1111/mbe.12404

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Citations (3)