Samar Mansour

Ain Shams University

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Ahmed S. Geneidi

Ain Shams University

Rania M. Hathout

Ain Shams University

Salma N. Tammam

German University in Cairo

Nahed D. Mortada

Ain Shams University

Mohammad Abdel‐Halim

German University in Cairo

Gehanne A.S. Awad

Ain Shams University

Maha Nasr

Ain Shams University

Rania A.H. Ishak

Ain Shams University

Ulrike Breitinger

German University in Cairo

Mahmoud E. Soliman

Ain Shams University

Cooperative Institutions

German University in Cairo

Ain Shams University

Agricultural Research Center

Mansoura University

Saarland University

Helmholtz Institute for Pharmaceutical Research Saarland

Cairo University

University of Bonn

Helmholtz Centre for Infection Research

Suez Canal University

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Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats

Carbohydrate Polymers (2013)

Hamza Bshara Rihab Osman Samar Mansour Abd El-Hameed A. El-Shamy

Microemulsion

10.1016/j.carbpol.2013.08.027

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Citations (104)

Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis

European Journal of Pharmaceutics and Biopharmaceutics (2018)

Raghda Hassan Salma N. Tammam Sara El Safy Mohammad Abdel‐Halim Anastasia Asimakopoulou

Hepatic stellate cell

CCL4

Hepatic fibrosis

10.1016/j.ejpb.2018.11.018

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Citations (53)

Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; a potential approach for the treatment of channelopathies

International Journal of Biological Macromolecules (2019)

Shahenda Ramadan Salma N. Tammam Maryam A. Shetab Boushehri Hans‐Georg Breitinger Ulrike Breitinger

HEK 293 cells

Cell membrane

Transmembrane channels

10.1016/j.ijbiomac.2019.10.238

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Citations (10)

A liposomal platform for the delivery of ion channel proteins for treatment of channelopathies — Application in therapy of cystic fibrosis

International Journal of Biological Macromolecules (2023)

Noha T. ElNashar Ulrike Breitinger Hans‐Georg Breitinger Samar Mansour Salma N. Tammam

Cell membrane

10.1016/j.ijbiomac.2023.126652

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Citations (1)

Novel technique of insulin loading into porous carriers for oral delivery

Asian Journal of Pharmaceutical Sciences (2018)

Sarah Y. Eilleia Mahmoud E. Soliman Samar Mansour Ahmed S. Geneidi

The increasing demand for oral macromolecule delivery encouraged the development of microencapsulation technologies to protect such drugs against gastric and enzymatic degradation. However, microencapsulation often requires harsh conditions that may jeopardize their biological activity. Accordingly, many trials attempted to load macromolecules into porous drug carriers to bypass any formulation induced instability. In this study, we prepared chitosan coated porous poly (d, l-lactide-co-glycolide) (PLGA) microparticles (MPs) loaded with insulin using a novel loading technique; double freeze-drying. The results showed a significant increase in drug loading using only 5 mg/ml initial insulin concentration and conveyed a sustained drug release over uncoated MPs. Furthermore, SEM and confocal microscopy confirmed pore blocking and insulin accumulation within the MPs respectively. The oral pharmacodynamic data on rats also proved the preservation of insulin bioactivity after formulation. Finally, the new coating technique proved to be efficient in producing robust layer of chitosan with higher insulin loading while maintaining insulin activity.

PLGA

Pharmacodynamics

10.1016/j.ajps.2018.03.003

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Citations (13)

ISOLATION OF AEROMONAS SPECIES FROM DIARRHEAL PATIENTS IN ISMAILIA GOVERNORATE

Bulletin of Pharmaceutical Sciences Assiut (2006)

Samar Mansour Salah Abdalla Mohamed Ali Alaa Zeitoun

In order to know the prevalence of Aeromonas species as a causative agent of diarrhea in Ismailia, Three hundreds and fifty stool samples and rectal swabs were collected from infants and children under the age of 5 years visiting El Kilo11Clinic suffering from acute diarrhea in the period from May 2004 to September 2004.A stool samples were collected from control group of fifty healthy infants and children of matched age and sex.It was found that 29 diarrheal samples were positive for Aeromonas species with prevalence of 8.28%.None of control samples were positive for Aeromonas.In most cases it was found that the infection is water or food borne.Aeromonas strains show high degree of antibiotic susceptibility.

Isolation

Diarrheal diseases

10.21608/bfsa.2006.65180

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Citations (1)

Exploring gelatin nanoparticles as novel nanocarriers for Timolol Maleate: Augmented in-vivo efficacy and safe histological profile

International Journal of Pharmaceutics (2018)

Miral Shokry Rania M. Hathout Samar Mansour

Gelatin

Nanocarriers

Glutaraldehyde

10.1016/j.ijpharm.2018.04.059

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Citations (69)

Surface functionalization of methotrexate-loaded chitosan nanoparticles with hyaluronic acid/human serum albumin: Comparative characterization and in vitro cytotoxicity

International Journal of Pharmaceutics (2017)

Rania A. Hashad Rania A.H. Ishak Ahmed S. Geneidi Samar Mansour

Human serum albumin

Surface Modification

Gelatin

Surface charge

MTT assay

10.1016/j.ijpharm.2017.03.008

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Citations (37)

The skin delivery of tofacitinib citrate using transethosomes and hybridized ethosomes/nanostructured lipid carriers for vitiligo therapy: Dermatopharmacokinetics and in vivo assays

International Journal of Pharmaceutics (2022)

Heba Hesham Mai Rady Rania M. Hathout Mohammad Abdel‐Halim Samar Mansour

Vitiligo

10.1016/j.ijpharm.2022.122387

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Citations (22)

UTILIZATION EFFICIENCY OF DIFFERENT INDUSTRIAL BYPRODUCTS IN AMELIORATION OF SALINE-SODIC SOILS

Journal of Soil Sciences and Agricultural Engineering /Journal of Soil Sciences and Agricultural Engineering (2014)

Samar Mansour Mohamed Réda Mohamed Hamad E. E. E. Khafagy

A field experiment was conducted during two successive years (2011/2012 and 2012/2013) in a clay saline soil located at South of El-Hussynia plain, Research Station ,Port-Said Governorate, Egypt.This study aims to evaluate the utilization efficiency of some industrial byproducts i.e.Sugar lime, vinasse, by-pass, pyrite (FeS2) and aluminum sulfate (Al2 (SO4)318H2O) individual and interaction among them as a soil amendments and their effects on improving some chemical and physical properties of saline sodic soils, comparing with gypsum application, under Intermittent leaching technique was adopted using El-Salam canal water.The results showed that the chemical and physical properties of the studied soil were clearly improved due to amendments addition.The common parameters of saline sodic soil i.e., EC, pH, ESP, RSE, B.D, P.R, and WTD were clearly improved.The superior improvement of these parameters was resulted from T8, T9 andT7.The amendment can be arranged, ascending as follows: T1< T2< T10< T6< T3< T5< T4< T11< T13< T12< T7< T9< T8 for both surface and subsurface layers.The final aim is to displace Na from an exchange complex and replace it with Ca, leading to a decrease of exchangeable sodium percentage (ESP) or increased removal sodium efficiency (RSE) consequently improvement of soil structure.An additional advantage to this strategy is that any mixture is inexpensive and ready available in large quantities in contrast to gypsum in this study.

Sodic soil

10.21608/jssae.2014.49565

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Citations (2)