AM

Akira Matsuno

International University of Health and Welfare

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Tadashi Nagashima

Institute of Electrical and Electronics Engineers

R. Yoshiyuki Osamura

Tokai University

Mineko Murakami

Teikyo University Chiba Medical Center

Tatsuya Tanaka

International University of Health and Welfare

Keisuke Onoda

International University of Health and Welfare

Eiichi Suehiro

International University of Health and Welfare

Fumitaka Yamane

International University of Health and Welfare

Hiroshi Nakaguchi

Mitsui Memorial Hospital

Susumu Takekoshi

Tokai University

Yuhei Michiwaki

International University of Health and Welfare

Cooperative Institutions

The University of Tokyo

Teikyo University

International University of Health and Welfare

Kyoto University

Osaka University

Neurological Surgery

Tohoku University

Tokai University

Nippon Medical School

Queen Mary University of London

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Stichopin-containing nerves and secretory cells specific to connective tissues of the sea cucumber

Proceedings of the Royal Society B Biological Sciences (2007)

Masaki Tamori Apurba Kumar Saha Akira Matsuno Sukumar Chandra Noskor Osamu Koizumi

Stichopin, a 17-amino acid peptide isolated from a sea cucumber, affects the stiffness change of the body-wall catch connective tissues and the contraction of the body-wall muscles. The localization of stichopin in sea cucumbers was studied by indirect immunohistochemistry using antiserum against stichopin. Double staining was performed with both stichopin antiserum and 1E11, the monoclonal antibody specific to echinoderm nerves. A stichopin-like immunoreactivity (stichopin-LI) was exclusively found in the connective tissues of various organs. Many fibres and cells with processes were stained by both the anti-stichopin antibody and 1E11. They were found in the body-wall dermis and the connective tissue layer of the cloacae and were suggested to be connective tissue-specific nerves. Oval cells with stichopin-LI (OCS) without processes were found in the body-wall dermis, the connective tissue sheath of the longitudinal body-wall muscles, the connective tissue layer of the tube feet and tentacles, and the connective tissue in the radial nerves separating the ectoneural part from the hyponeural part. Electron microscopic observations of the OCSs in the radial nerves showed that they were secretory cells. The OCSs were located either near the well-defined neural structures or near the water-filled cavities, such as the epineural sinus and the canals of the tube feet. The location near the water-filled cavities might suggest that stichopin was secreted into these cavities to function as a hormone.

Immunoperoxidase

Dense connective tissue

10.1098/rspb.2007.0583

Cite

Citations (10)

Expression of Pit-1 mRNA and Activin/Inhibin Subunits in Clinically Nonfunctioning Pituitary Adenomas

Hormone Research in Paediatrics (1998)

Naoko Sanno Akira Teramoto Makoto Sugiyama Akira Matsuno Ichiro Takumi

The pituitary-specific transcriptional factor Pit-1 is known to play a role in the development and differentiation of pituitary cells. Recent investigations have suggested a role for this transcriptional factor in pituitary adenomas, especially growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas. In this study we analyzed the expression of Pit-1 mRNA and its protein in 24 clinically nonfunctioning pituitary adenomas in comparison with normal pituitary glands using in situ hybridization (ISH) and immunohistochemistry (IHC). The interaction between inhibin/activin, a member of the transforming growth factor-beta family, and Pit-1 was also studied. Immunohistochemically, Pit-1 protein was detected in 9 of 24 adenomas (37.5 %), and 8 of these 9 were also positive for the alpha subunit of glycoprotein (alphaSU). The expression of Pit-1 mRNA was detected in 14 of 24 (58.3%) clinically nonfunctioning adenomas, and it was found in all cases which expressed the Pit-1 protein. By the combined ISH and IHC method, Pit-1 mRNA was frequently observed in alphaSU-immunopositive cells in adenomas. The inhibin/activin alpha subunit was detected in all 24 adenomas and the betaA subunit was detected in 13 of 24 adenomas. The inhibin/activin betaA subunit was detected frequently with Pit-1 mRNA. From our observations, the inhibin/activin betaA subunit in nonfunctioning adenomas may have related the expression of Pit- mRNA in these adenomas.

10.1159/000023194

Cite

Citations (29)

Rare Complications of Lumboperitoneal Shunts: Abdominal Cerebrospinal Fluid Pseudocysts in Adults

Tatsuya Tanaka Tomoyuki Naito Takahiro Kumono Eiichi Suehiro Takashi Agari

Abdominal cerebrospinal fluid (CSF) pseudocysts are rare complications of shunt surgery, predominantly reported in pediatric patients undergoing a ventriculoperitoneal (VP) shunt. In contrast, their occurrence following lumboperitoneal (LP) shunt is exceptionally uncommon. We report the case of a 76-year-old woman who presented with recurrent symptoms, including gait disturbance and cognitive decline, approximately three years after undergoing LP shunt placement for idiopathic normal pressure hydrocephalus. Diagnostic imaging, including shuntography and abdominal computed tomography (CT), revealed an abdominal CSF pseudocyst, likely due to peritoneal adhesions from prior abdominal surgery. Reoperation with catheter repositioning successfully relieved her symptoms. This case highlights the necessity of considering abdominal CSF pseudocysts as a differential diagnosis for shunt malfunction, particularly in patients with a history of abdominal surgery. Early diagnostic procedures, such as shuntography and abdominal CT, are critical for timely intervention and symptom resolution.

10.7759/cureus.78225

Cite

Citations (0)

Symptomatic pituitary metastasis of malignant thymoma

Journal of Clinical Neuroscience (2005)

Seisaku Kanayama Akira Matsuno Tadashi Nagashima Yasuo Ishida

Pituitary Tumors

10.1016/j.jocn.2004.11.020

Cite

Citations (16)

[Pediatric craniopharyngioma].

Yudo Ishii Akira Matsuno

Craniopharyngioma

Cite

Citations (1)

A Case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone ? an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture

Acta Neurochirurgica (1996)

Akira Matsuno Tadashi Sasaki T. Mochizuki Takamitsu Fujimaki N Sanno

Prolactin cell

Corticotropic cell

10.1007/bf01411291

Cite

Citations (22)

Confocal Laser Scanning Microscopic Imaging of Subcellular Organelles, mRNA, Protein Products, and the Microvessel Environment.

ACTA HISTOCHEMICA ET CYTOCHEMICA (2001)

Johbu Itoh Akira Matsuno Yukito Yamamoto Kenji Kawai Akihiko Serizawa

The confocal laser scanning microscope (CLSM) was employed to visualize highly contrasted images of histochemically stained subcellular organelles. In early studies, only fluorescent signals were detectable by CLSM, however, recent innovations have enabled the visualization of non-fluorescent probes such as horseradish peroxidase (HRP)-diaminobenzidine (DAB). The non-fluorescent signals are permanently preserved and allow repeated or retrospective examinations. We applied CLSM to specimens prepared for light microscopy, and visualized subcellular organelles and pituitary hormone mRNA. The images were comparable to those obtained by electron microscopy (EM). We also applied this technique to the observation of tumor angiogenesis and the microvessel environment of hormone-secreting cells. Both the visualization of subcellular organelles, mRNA and protein products, and 3D images of the microvessel environment of hormone-secreting cells are discussed in this review.

Organelle

Microvessel

Horseradish peroxidase

10.1267/ahc.34.285

Cite

Citations (14)

ACTA HISTOCHEMICA ET CYTOCHEMICA (1998)

Hiroshi Hirano Ken‐ichi Kasai Hayato Kawakami H. Hirano Daisuke Aoki

Glycoconjugates constituting cells and tissues are known to play important roles in a variety of indispensable functions of living organisms such as cellular recognition and others.Recent progress in histo-and cytochemistry enables to determine and locate glycoconjugates in situ.Cytochemical aspects of glycoconjugates can be visualized under the microscope employing appropriate probes.At present, lectins, specific antibodies, and cationized ferritin are the most commonly used probes for the detection of sugar residues of cells and tissues.Usually binding specificity of probes is cautiously examined using blotting techniques in parallel with the conventional immunostaining procedures.Nowadays, not only glycoproteins but also glycolipids are included within the scope of histo-and cytochemisty.Accessibility of labeled probes to intra-and intercellular target structures is facilitated with the combined use of the

10.1267/ahc.31.123

Cite

Citations (0)

Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors

The Journal of Clinical Endocrinology & Metabolism (2020)

Pedro Marques Francisca Caimari Laura C. Hernández‐Ramírez David Collier Donato Iacovazzo

Abstract Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course.

10.1210/clinem/dgaa040

Cite

Citations (56)

ZnS:Mn Electroluminescent Thin Films Prepared by Multisource Deposition under Controlled Sulfur Vapor Pressure

Japanese Journal of Applied Physics (1994)

Takashi Nire Akira Matsuno A. Miyakoshi Koutoku Ohmi Koutoku Ohmi

ZnS:Mn thin-film electroluminescent (TFEL) devices have been prepared by using a multisource deposition (MSD) method. A new technique of sulfur vapor pressure control has been developed for the thin-film growth at a high sulfur vapor pressure. Growth kinetics of ZnS:Mn thin films on the sulfur vapor pressure have been studied. It has been found that at sulfur vapor pressure higher than 0.1 Pa, the growth rate is limited by the effective amount of the Zn flux. The ZnS:Mn film grown at the sulfur vapor pressure of 0.85 Pa shows a smooth surface and has a uniform grain size of about 200 nm. The ZnS:Mn TFEL device shows the luminance of 300 cd/m 2 and the efficiency of 3.5 lm/W at 30 V above the threshold voltage of 180 V with 60 Hz drive.

Deposition

10.1143/jjap.33.2605

Cite

Citations (16)