Based on pluronic lecithin, P.L.O. gels were established in the present research as a topical carrier for the regulated delivery of Meloxicam. Every P.L.O. gel composition was discovered to have pH values between 5.57 and 5.62, which falls within the pH range that skin. The spreadability of organogels from F1 to F4 (25.09-23.41 g.cm/s) decreased due to lecithin. The F5 through F8 saw an increase in the percentage of pluronic (22.45-21.44 g.cm/s). The range of the viscosity of gel formulations was determined to be between 1825 and 3732 cps (F1-F4) and 2136-3663 cps (F5–F8). Eight different organized formulations' gel transition temperatures were measured among such ranges of 32.3oC and 33.2oC (F1-F4) and 27.4 - 33.6oC (F5 – F8). The formulations of F2 and F3 have been chosen for kinetic tests and stability studies because they had the most significant percentage of drug content and the highest drug release during eight hours, and all physical parameters were found to be within acceptable limits. It was discovered that the order of release of drug through different formulations was F1 – F8. A drug is released from the improved formulation F2 regulated according to zero order rate kinetics. The optimized Meloxicam organogel in-vivo anti-inflammatory effectiveness against a commonly used commercial product (ZCLO-CM gel) was satisfactory but also significant.
Background Aggressive periodontitis is a specific type of periodontitis with clearly identifiable clinical characteristics such as “rapid attachment loss, bone destruction” and “familial aggregation”. Regeneration of mineralized tissues affected by aggressive periodontitis comprises a major scientific and clinical challenge. In recent years some evidence has been provided that bioactive glass is also capable of supporting the regenerative healing of periodontal lesions. Objective The aim of this clinical and radiological prospective study was to evaluate the efficacy of bioactive glass in the treatment of intra-bony defects in patients with localized aggressive periodontitis. Methods Twelve localized aggressive periodontitis patients with bilaterally located three-walled intra-bony defect depth ? 2 mm, preoperative probing depths ? 5 mm were randomly treated either with the bioactive glass or without the bioactive glass. The clinical parameters plaque index, gingival index, probing depth, gingival recession, clinical attachment level, and mobility were recorded prior to surgery as well as 12 months after surgery. Intraoral radiographs were digitized to evaluate the bone defect depth at baseline and 12 months after the surgery. Results After 12 months, a reduction in probing depth of 3.92 + 0.313 mm (P <0.001) and a gain in clinical attachment level of 4.42+0358mm (P <0.001) were registered in the test group. In the control group, a reduction in probing depth of 2.5 +0.230mm (P <0.001) and a gain in clinical attachment level of 2.58 + 0.149 mm (P<0.001) was recorded. Radiographically, the defects were found to be filled by 2.587 + 0.218 mm (P <0.001) in the test group and by 0.1792 + 0.031mm (P <0.001) in the control group. Changes in gingival recession showed no significant differences. . Conclusion Highly significant improvements in the parameters Probing depth, Clinical attachment level, and Bone defect depth were recorded after 12 months, with regenerative material. KATHMANDU UNIVERSITY MEDICAL JOURNAL VOL.10 | NO. 1 | ISSUE 37 | JAN - MAR 2012 | 11-15 DOI: http://dx.doi.org/10.3126/kumj.v10i1.6906
Mandibular parasymphysis fracture is very commonly observed especially in old age when there is resorptions of the alveolar ridges. In cervical dystonia, there is centrally mediated disease in which there is uncontrolled and spasmodic contraction of the facial and the masticatory muscles. Due to the application of this sudden and uncontrolled force, there is a tendency of the bone to unfavourably remodel and weaken. The case presented here is of a geriatric patient who presented to us with a fracture at the right parasymphysis and left dentoalveolar region of the mandible and was suffering from cervical dystonia. Management of this case posed a challenge in every step, and it needed a resurgery where the fracture was managed by the placement of reconstruction plate. Not many cases in the literature have been reported where dystonic movements have resulted in the fracture of the mandible.
The aim of the paper is to present a novel method for solving radial electrical distribution networks. The proposed method involves only the evaluation of simple algebraic voltage expressions without any trigonometric functions. Thus, computationally, the proposed method is very efficient and requires less computer memory storage as all data is stored in vector form. In this paper, the proposed method is tested in IEEE 12-bus system and IEEE 33-bus system. The main objective of the proposed work is to solve a distribution network through novel approach.
The orocutaneous fistulous tract of odontogenic origin is often a diagnostic challenge, due to its rare manifestation and absence of dental signs and symptoms. The odontogenic cutaneous fistula is often misdiagnosed as a superficial skin lesion of non-odontogenic origin delaying the treatment. The diagnosis and treatment must be precise and swift to improve the clinical outcome and minimize the complications. This article presents a rare case of odontogenic keratocyst involving a linguoverted impacted third molar presenting as orocutaneous fistula. The patient was initially treated with empirical antibiotic therapy with no resolution of the cutaneous fistula and thickening of the skin around the sinus opening resulting in cosmetic deformity. Once the fistula was attributed to the underlying odontogenic cyst, treatment was done by cyst enucleation along with the extraction of tooth and fistula excision. The purpose of the paper is to emphasize the importance of early and accurate diagnosis and prompt management of the orocutaneous fistula due to the odontogenic origin.
lingual and sublingual hematoma is a rare complication following heparin therapy which may result in serious life-threatening airway obstruction. A 75-year-old female with ischemic heart disease was heparinized for percutaneous transluminal coronary angioplasty of the left anterior descending artery leading to sublingual hematoma with difficulty in swallowing and breathing. This paper presents a case report and management of sublingual hematoma following heparin therapy.
Most fractures of the mandible are contralateral owing to its unique shape and types of forces applied during fracture. Triple unilateral fracture of mandible is extremely uncommon and rarely reported in literature. Dentition free segment adds to the challenges of accurate reduction. This case report talks about a case of right parasymphysis, right angle and right subcondylar fracture of mandible in a 21 year old male and the methods employed for reduction. Non dentate segment is reduced first to maintain vertical ramus height followed by reduction of angle and parasymphysis. The difficulty inherent in treating these fractures can be alleviated with the use of proper sequencing and techniques of open reduction and internal fixation.
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