Alexandra Bialonski

Bernhard Nocht Institute for Tropical Medicine

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Co-Authors

Jonas Schmidt‐Chanasit

Bernhard Nocht Institute for Tropical Medicine

Stephan Günther

Bernhard Nocht Institute for Tropical Medicine

Peter F. Zipfel

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

Hanna Jöst

Bernhard Nocht Institute for Tropical Medicine

Dániel Cadar

Bernhard Nocht Institute for Tropical Medicine

Patrick Heinemann

Charité - Universitätsmedizin Berlin

Hans Wilhelm Doerr

Goethe University Frankfurt

Rainer G. Ulrich

Friedrich-Loeffler-Institut

Christine Skerka

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

Heike von Baum

Institute of Medical Microbiology and Hygiene

Cooperative Institutions

Bernhard Nocht Institute for Tropical Medicine

German Center for Infection Research

Universität Hamburg

Heidelberg University

University of Antananarivo

World Health Organization - Pakistan

Association Vahatra

Charité - Universitätsmedizin Berlin

University of Pecs

University Medical Center Hamburg-Eppendorf

Author Statistics

Papers

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Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains.

Proceedings of the National Academy of Sciences (1991)

Hj. Müller Christine Skerka Alexandra Bialonski Peter F. Zipfel

We report the structure and regulation of a gene represented by clone pAT 133, which is induced upon transition from a resting state (G0) through the early phase of the cell cycle (G1). The pAT 133 gene is immediately induced, with FOS-like kinetics, in human T cells and in fibroblasts. Primary structure analysis showed that the encoded protein contains three tandem zinc-finger sequences of the type Cys2-Xaa12-His2. This zinc-finger region, which is thought to bind DNA in a sequence-specific manner, is similar (greater than 80% on the amino acid level) to two previously described transcription factors pAT 225/EGR1 and pAT 591/EGR2. Except for the conserved zinc-finger domains, the amino acid sequences of the three proteins are distinct. This structural similarity suggests that the pAT 133 gene encodes a transcription factor with a specific biological function. Comparing the regulation of these related zinc-finger-encoding genes showed coordinate induction upon mitogenic stimulation of resting T lymphocytes and of resting fibroblasts. However, upon transition from a proliferating (G1) to a resting state of the cell cycle the three genes were differently regulated. In human histiocytic U937 cells mRNA of clone pAT 133 was constitutively expressed, whereas mRNA of pAT 225/EGR1 was induced upon induction of terminal differentiation. In contrast mRNA representing pAT 591/EGR2 was not expressed in these cells. This difference in gene regulation suggests distinct biological roles in the control of cell proliferation for the respective proteins.

Sp1 transcription factor

10.1073/pnas.88.22.10079

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Citations (41)

Blood donor screening for West Nile virus (WNV) revealed acute Usutu virus (USUV) infection, Germany, September 2016

Eurosurveillance (2017)

Dániel Cadar Philipp Maier Susanne Müller Julia Kreß Michael Chudy

Between 1 June and 31 December 2016, 13,023 blood donations from the University Hospital Aachen in Germany were routinely screened for West Nile virus (WNV) RNA using the cobas TaqScreen WNV Test. On 28 September 2016, one blood donor was tested positive. Subsequent analysis revealed an acute Usutu virus (USUV) infection. During the ongoing USUV epizootics in Germany, blood transfusion services, public health authorities and clinicians should be aware of increased human USUV infections.

West Nile virus

Flavivirus

10.2807/1560-7917.es.2017.22.14.30501

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Citations (80)

The peroxidoxin 2 protein of the human parasite Onchocerca volvulus : recombinant expression, immunolocalization, and demonstration of homologous molecules in other species

Parasitology Research (1998)

Peter F. Zipfel Silke Schrum Alexandra Bialonski Dietrich W. Büttner

Onchocerca

Molecular mass

10.1007/s004360050461

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Citations (18)

Onchocerca volvulus-microfilariae avoid complement attack by direct binding of factor H

Immunopharmacology (2000)

Taru Meri T. Sakari Jokiranta Jens Hellwage Alexandra Bialonski Seppo Meri

Complement

10.1016/s0162-3109(00)80161-7

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Citations (1)

A 12-year molecular survey of clinical herpes simplex virus type 2 isolates demonstrates the circulation of clade A and B strains in Germany

Journal of Clinical Virology (2010)

Jonas Schmidt‐Chanasit Alexandra Bialonski Patrick Heinemann Rainer G. Ulrich Stephan Günther

Intergenic region

Molecular Epidemiology

Coding region

10.1016/j.jcv.2010.04.009

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Citations (8)

First Detection of the Invasive Mosquito Vector Aedes albopictus (Diptera: Culicidae) in Benin, West Africa, 2021

Journal of Medical Entomology (2022)

Anges Yadouleton Gildas Hounkanrin Carine Tchibozo Alexandra Bialonski Jonas Schmidt‐Chanasit

Abstract Aedes albopictus (Skuse) is native to Southeast Asia and has colonized tropical and temperate regions worldwide in the last three to four decades. In Africa, data on its distribution is incomplete. Most studies having focused on the abundance, competition to other species, and phylogenetics of this vector are from the central African region. Here, we report the first detection of Ae. albopictus in Benin, West Africa. A total of 13 specimens were collected during the study period in 2021. The phylogenetic analysis of a cytochrome oxidase c subunit I gene fragment revealed a close relationship to populations from tropical India. Because of its close geographical proximity to areas where it has been found, it is assumed that the species was introduced several years before and is currently widely distributed in Benin. Additional studies are needed to explore its distribution, expansion range, and competitive effects on native species.

Aedes albopictus

10.1093/jme/tjac039

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Citations (6)

Identification of a peroxidoxin protein (OvPXN-2) of the human parasitic nematode Onchocerca volvulus by sequential protein fractionation

Molecular and Biochemical Parasitology (1998)

Silke Schrum Alexandra Bialonski Thomas M. Marti Peter F. Zipfel

Identification

10.1016/s0166-6851(98)00034-6

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Citations (8)

Cell type specific expression of members of the IL-8/NAP-1 gene family

Cytokine (1993)

Christine Skerka Steven G. Irving Alexandra Bialonski Peter F. Zipfel

Cell type

10.1016/1043-4666(93)90049-b

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Citations (17)

Surveillance of arthropod-borne viruses in Benin, West Africa 2020–2021: detection of dengue virus 3 in Aedes aegypti (Diptera: Culicidae)

Military Medical Research (2022)

Carine Tchibozo Gildas Hounkanrin Anges Yadouléton Alexandra Bialonski Eric Agboli

Arthropod

10.1186/s40779-022-00425-9

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Citations (8)

Isolation of Usutu Virus in Germany

American Journal of Tropical Medicine and Hygiene (2011)

Hanna Jöst Alexandra Bialonski Deborah Maus Vittorio Sambri Martin Eiden

Usutu virus (USUV) is a mosquito-borne flavivirus that emerged 2001 in Austria and caused deaths in wild birds. In Germany, 70,378 female mosquitoes were captured in 2009 and 2010 and assayed for USUV. Virus was isolated in cell culture from one pool of Culex pipiens pipiens mosquitoes trapped exclusively in August 2010 in Weinheim, Germany. Subsequent phylogenetic analysis demonstrated a close relationship between the isolated USUV strain from Germany and a USUV strain from Austria, which was detected in a dead blackbird in 2004.

Flavivirus

Culex pipiens

Isolation

Strain (injury)

10.4269/ajtmh.2011.11-0248

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Citations (174)