Yonggang Zou

Aerospace Information Research Institute

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Xiaohui Ma

Heilongjiang Bayi Agricultural University

He Zhang

Changchun University of Science and Technology

Xiaohui Ma

University of Science and Technology Beijing

Li Xu

Shandong Eye Hospital

Yingtian Xu

Changchun University of Science and Technology

Jie Fan

Changchun University of Science and Technology

Liang Jin

Florey Institute of Neuroscience and Mental Health

Linbao Hou

China Aerospace Science and Technology Corporation

Pengfei Zhao

Chinese Academy of Sciences

Yina Hai

Changchun University of Science and Technology

Cooperative Institutions

Chinese Academy of Sciences

Changchun University of Science and Technology

University of Chinese Academy of Sciences

Zhejiang University

Aerospace Information Research Institute

Tsinghua University

Chongqing University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Jilin University

Sichuan University

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Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells

Cells (2022)

Qi Zheng Yonggang Zou Peng Teng Zhenghua Chen Yuefeng Wu

Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted by laminar flow to maintain endothelial homeostasis. However, how the expression of KLF2/4 is regulated by shear stress is poorly understood. Here, we showed that the activation of PIEZO1 upregulates the expression of KLF2/4 in endothelial cells. Mice with endothelial-specific deletion of Piezo1 exhibit reduced KLF2/4 expression in thoracic aorta and pulmonary vascular endothelial cells. Mechanistically, shear stress activates PIEZO1, which results in a calcium influx and subsequently activation of CaMKII. CaMKII interacts with and activates MEKK3 to promote MEKK3/MEK5/ERK5 signaling and ultimately induce the transcription of KLF2/4. Our data provide the molecular insight into how endothelial cells sense and convert mechanical stimuli into a biological response to promote KLF2/4 expression for the maintenance of endothelial function and homeostasis.

KLF2

Piezo1

Endothelial Dysfunction

Homeostasis

10.3390/cells11142191

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Citations (26)

The progress of grating coupled surface emitting distributed feedback semiconductor lasers

Kun Tian Yonggang Zou Li Xu Xiaohui Ma Junming Zhang

At present, grating coupled surface emitting distributed feedback semiconductor lasers has been the focus of the laser field due to a number of excellent performance, such as high brightness, high power, low divergence, easy packaging etc, compared with the conventional edge-emitting semiconductor lasers. In this paper, the progress of research at home and abroad were summed and reviewed. And then, the further research and development trend has been discussed based on all of these progress.

10.1109/icoom.2015.7398786

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Study on heat sink and solder of C-Mount packaged semiconductor laser

International Conference on Optoelectronics and Microelectronics (2012)

Daoming Xi Yonggang Zou Xiaohui Ma Yang Li Zibin Yang

The selection of semiconductor laser package materials including heat sink and solder has an important impact to the cooling and life of the laser, and thus performing related studies is very important. A C-Mount package semiconductor laser model was established in this paper, and thermal characteristic of different kinds of heat sink materials was simulated by the finite element software ANSYS. The temperature distribution of semiconductor laser was subsequently simulated. Then Cu was selected as heat sink, and In or AuSn was used as a solder, and the thermal stress distribution and thermal deformation of different solder materials were analyzed. The distribution of thermal stress of the semiconductor laser has also been investigated.

Electronic Packaging

10.1109/icoom.2012.6316218

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Citations (2)

A Method with Time-sensitive Features for the Automated Prognosis Prediction of Cardiac Arrest Patients Based on EEG

Computing in cardiology (2023)

Siying Li Yonggang Zou Xianya Yu Xiuying Mou Yueqi Li

10.22489/cinc.2023.088

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Design and Research of High Tuning Efficiency V-cavity Tunable Semiconductor Laser

Chinese Journal of Luminescence (2020)

Ao Wang Yonggang Zou Mingyu Li Tuo Chen Kai Chang

10.37188/fgxb20204108.0977

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Design of 6 kw fiber-coupled system for semiconductor laser

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2016)

Yulong Wu Zhiyong Dong Yongqi Chen Yunfei Qi Lushuang Ding

In this paper, we present the design of a 6 kW fiber-coupled laser diode system by using ZEMAX, and power scaling and fiber coupling techniques for high-power laser diode stacks were introduced in detail. Beams emitted from eight laser diode stacks comprised of four 960 W stacks with center wavelength of 938 nm and four 960 W stacks with center wavelength of 976 nm are combined and coupled into a standard fiber with a core diameter of 800 μm and numerical aperture of 0.22. Simulative result shows that the final power came out of the fiber could reach 6283.9 W, the fiber-coupling efficiency is 87%, and the brightness is 8.2 MW/ (cm²·sr).

Zemax

Numerical aperture

Laser diode

10.1117/12.2246776

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A survey of the high power high brightness fiber coupled laser diode

International Conference on Optoelectronics and Microelectronics (2012)

Zaijin Li Te Li Peng Lu Yong Wang Yonggang Zou

The high power laser diode bars have many advantages over conventional lasers of similar power levels. However, the poor beam quality of its output beam hinders its direct applications. The technologies for beam shaping of the high power laser diode bars have become a hot topic. In this paper the applications and the progress of high power high brightness fiber coupled laser diode are discussed.

Laser diode

10.1109/icoom.2012.6316214

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Citations (3)

Design of 150W, 105-μm, 0.22NA, fiber coupled laser diode module by ZEMAX

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2016)

Yunfei Qi Pengfei Zhao Qing Chen Yulong Wu Yongqi Chen

We represent a design of a high brightness, fiber coupled diode laser module based on 16 single emitters at 915nm. The module can produce more than 150 Watts output power from a standard fiber with core diameter of 105μm and numerical aperture (NA) of 0.22. To achieve a high power and high brightness laser beam, the spatial beam combination and polarization beam combination are used to combine output of 16 single emitters into a single beam, and then an aspheric lens is used to couple the combined beam into an optical fiber. The simulation show that the total coupling efficiency is more than 95% and the highest brightness is estimated to be 11MW/ (cm²*sr).

Zemax

Numerical aperture

Laser diode

10.1117/12.2247657

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Citations (2)

Optical design and optimization of panoramic objective lens system

International Conference on Optoelectronics and Microelectronics (2012)

Haodong Shi Yonggang Zou Jie Li Henan Chen Xiaohui Ma

Panoramic camera's characteristics are large field of view, large field of depth, small volume, light weight and good seismic performance. It is widely used in aerial reconnaissance, topographic mapping and other fields. The ZEMAX software is used to research the panoramic camera lens. The lens system of the ordinary optical materials are discussed and analyzed. To explore the system structure with better image quality, the modulation transfer function of the lens system is adjusted, the radius of the surface, the thickness of lens and the air gap are optimized. The pros and cons of image quality are analyzed by the aberration curve.

Zemax

Optical transfer function

Field of view

Depth of field

Optical engineering

10.1109/icoom.2012.6316283

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D‐Unet: A symmetric architecture of convolutional neural network with two auxiliary outputs for dementia recognition

International Journal of Imaging Systems and Technology (2024)

Siying Li Pan Xia Yonggang Zou Lidong Du Zhenfeng Li

Abstract Dementia‐associated disorders cause damage to the brains of patients and bring huge burdens to individuals and families. Electroencephalogram (EEG) monitoring is friendly to patients on account of low cost, non‐invasion, and objective. Event‐related potential (ERP) is a component of EEG that has huge potential to evaluate the cognitive function of the brain. In this study, we recorded the ERP from patients with dementia and healthy people, then proposed an ERP‐based deep learning method to realize dementia recognition via the model Dementia‐Unet (D‐Unet). To improve the performance of the model, on the base of the decoder and the primary classifier, we added new structures including a symmetric decoder and two auxiliary outputs. One of the auxiliary outputs was input reconstruction, and the other one was aimed at working like the primary classifier with the same task. The results of the experiment of four‐fold cross‐validation demonstrated the two auxiliary outputs improved the performance of the model effectively. When compared with some other machine learning methods and deep learning methods, our model obtained the best performance with an accuracy of 0.815, a precision of 0.829, a recall of 0.797, and an f1‐score of 0.812. Besides, we put up a complex training strategy with all outputs involved, but a simple testing strategy with only a primary classifier working to keep high performance but cut down the complexity burden during testing.

10.1002/ima.23047

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