Qijuan Yuan

Xihua University

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Zhipeng Gu

Sichuan University

Zhenqiang Dong

Quzhou University

Bang‐Jing Li

Chengdu Institute of Biology

Sheng Zhang

Beijing University of Chemical Technology

Jun Wu

Wuhan University

Guiting Liu

Sichuan University

Shanbai Xiong

Huazhong Agricultural University

Yi‐Fu Wang

National Cheng Kung University

Juan You

Huazhong Agricultural University

Jian‐Hu Li

Zhejiang University

Cooperative Institutions

Sichuan University

Sun Yat-sen University

West China Hospital of Sichuan University

State Key Laboratory of Biotherapy

Huazhong Agricultural University

Chinese Academy of Sciences

Chengdu University

Ministry of Education of the People's Republic of China

Shanghai Jiao Tong University

Peking University

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Double-Layer Microsphere Incorporated with Strontium Doped Calcium Polyphosphate Scaffold for Bone Regeneration

Journal of Biomedical Nanotechnology (2019)

Zhangfan Ding Qijuan Yuan Keqing Huang Zhipeng Gu Ming Xuan

To design and prepare a novel controlled release system for sustained release of two drugs. In this study, a double-layer microsphere was incorporated with strontium-doped calcium polyphosphate (SCPP) scaffold to facilitate bone regeneration and achieve skull repair. The double-layer microsphere combining tetracycline loaded sodium alginate and matrix metalloproteinase-2 (MMP-2) loaded chitosan was manufactured by electrospinning, which were further adhered to SCPP scaffold. The characteristics of microstructure were observed through scanning electron microscope. Loading efficiencies and the optimal ratio of microsphere of the obtained controlled release system were investigated. In addition, the cytotoxicity and the effects on osteoblast proliferation and expressions of osteogenesis-related factors were examined in vitro. Thereafter, the compound material with the controlled release system was implanted in the skull defect of rabbit to evaluate its properties of promoting bone regeneration. The results indicated that this novel controlled release system with SCPP scaffold and the double-layer microspheres loaded with tetracycline and MMP-2 could be a promising material for bones repair.

Polyphosphate

10.1166/jbn.2019.2728

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Citations (9)

Advances of nanotechnology for intracerebral hemorrhage therapy

Frontiers in Bioengineering and Biotechnology (2023)

Jiayan Wang Tianyou Wang Mei Fang Zexu Wang Wei Xu

Intracerebral hemorrhage (ICH), the most devastating subtype of stoke, is of high mortality at 5 years and even those survivors usually would suffer permanent disabilities. Fortunately, various preclinical active drugs have been approached in ICH, meanwhile, the therapeutic effects of these pharmaceutical ingredients could be fully boosted with the assistance of nanotechnology. In this review, besides the pathology of ICH, some ICH therapeutically available active drugs and their employed nanotechnologies, material functions, and therapeutic principles were comprehensively discussed hoping to provide novel and efficient strategies for ICH therapy in the future.

10.3389/fbioe.2023.1265153

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A Tri-Stimuli-Responsive Shape-Memory Material Using Host-Guest Interactions as Molecular Switches

Macromolecular Rapid Communications (2016)

Min Pan Qijuan Yuan Xiaolei Gong Sheng Zhang Bang‐Jing Li

A thermo-, photo- and chemoresponsive shape-memory material is successfully prepared by introducing α-cyclodextrin (αCD) and azobenzene (Azo) into a poly(acrylate acid)/alginate (PAA/Alg) network. The tri-stimuli-responsive formation/dissociation of αCD-Azo acts as molecular switches freezing or increasing the molecular mobility. The resulting film herein can be processed into temporary shapes as needed and recovers its initial shape upon the application of light irradiation, heating, or chemical agent independently. Furthermore, the agar diffusion test suggests that the α-CD-Alg/Azo-PAA has good biocompatibility for L929 fibroblast-like cells.

Azobenzene

Biocompatibility

Molecular switch

Shape-memory polymer

10.1002/marc.201500602

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Citations (40)

Macromol. Rapid Commun. 10/2013

Macromolecular Rapid Communications (2013)

Zhenqiang Dong Ya Cao Qijuan Yuan Yi‐Fu Wang Jian‐Hu Li

Front Cover: A redox-induced shape-memory polymer is prepared by cross-linking β-cyclodextrin modified chitosan and ferrocene modified poly(ethylene imine). The reversible redox-sensitive β-CD/Fc inclusion complexes and covalent cross-links serve as reversible phases and fi xing phases, respectively. This material can be processed into a desired temporary shape upon reduction and recovers to its initial shape after oxidation. The shape memory behavior also occurs when glucose is introduced with glucose oxidase entrapped in the system. Further details can be found in the article by Z.-Q. Dong, Y. Cao, Q.-J. Yuan, Y.-F. Wang, J.-H. Li, B.-J. Li,* and S. Zhang- on page 867.

Imine

Glucose oxidase

10.1002/marc.201370032

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H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin

Frontiers in Pharmacology (2018)

Zhenqiang Dong Yang Kang Qijuan Yuan Man‐Li Luo Zhipeng Gu

Designing stimuli responsive, controllable and biocompatible multifunctional nanoparticles is an important progress in the current quest for drug delivery systems. Herein, we devoted to developing a β-cyclodextrin (β-CD) based drug delivery nanoparticles (NPs) that release BSA via glucose-responsive gate. The design involves synthesis of sodium alginate with β-CD modified (Alg-β-CD) and methoxypolyethylene glycol (mPEG-Fc) containing Fc uncharged end-capping. When α-cyclodextrin (α-CD) was added with these two segments, the stable noncovalent supramolecular structure of Alg-β-CD/mPEG-Fc/α-CD can be self-assembled into NPs in aqueous solution. Bovine serum albumin (BSA) loaded Alg-β-CD/mPEG-Fc/α-CD also has been prepared. Interestingly, these supramolecular Alg-β-CD/mPEG-Fc/α-CD/BSA NPs showed uniform sphere structure and constant BSA loading content. Also, this new kind of NPs can disassemble in the present of hydrogen peroxide (H2O2). Since glucose oxidase (GOD) can oxidize glucose and produce H2O2, so this kind of polymeric NPs can also have glucose responsive behavior in the GOD containing environment. Developed functional Alg-β-CD/mPEG-Fc/α-CD might be a promising drug delivery strategy for diabetes or immunotherapy with more efficiency.

Glucose oxidase

Bovine serum albumin

10.3389/fphar.2018.00552

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Enhanced Osteoconductivity and Osseointegration in Calcium Polyphosphate Bioceramic Scaffold via Lithium Doping for Bone Regeneration

ACS Biomaterials Science & Engineering (2019)

Yihang Yuan Qijuan Yuan Chenzhou Wu Zhangfan Ding Xu Wang

Calcium polyphosphate (CPP) is a novel bioceramic bone substitute, which is favored because its composition is highly similar to natural bone. According to previous studies, doping ions into CPP is an effective and convenient method for overcoming the shortcomings, such as poor osteoconductivity of CPP. Lithium (Li) is a fairly new additive to bone substitutes that brought attention due to its role in osteogenesis. The present study was conducted to assess whether doping Li into CPP could influence the microstructure, degradation, and osteoinductivity of CPP. The results found that both CPP and Li-doped CPP (LiCPP) had a single beta-CPP phase, indicating that Li did not affect the crystallized phase. SEM images revealed that both scaffolds were porous, while the surface of LiCPP was rougher and more uneven compared to CPP. Also, a better degradation property of LiCPP was observed via weight loss and ion release tests. In vitro study found that LiCPP extracts had advantages of promoting osteoblasts' proliferation and differentiation over CPP extracts. In vivo study on rabbit's cranial defects was also conducted. Microcomputed tomography and histological staining showed that LiCPP had better osteoconductivity than CPP. This study proved that doping Li into CPP is a feasible modification method, and LiCPP might be a suitable bioceramic for bone tissue engineering.

Bioceramic

Polyphosphate

10.1021/acsbiomaterials.9b00950

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Citations (27)

Development of Biocompatible and Antibacterial Collagen Hydrogels via Dialdehyde Polysaccharide Modification and Tetracycline Hydrochloride Loading

Macromolecular Materials and Engineering (2019)

Xiaoyue Yu Qijuan Yuan Mingtao Yang Ru Liu Shichen Zhu

Abstract Nowadays, collagen hydrogels with both good physicochemical and antibacterial properties for tissue engineering have drawn broad attention. Herein, a biocompatible and antibacterial collagen hydrogel is developed via alginate dialdehyde (ADA) modification and tetracycline hydrochloride (TC) loading based on Schiff's base formation. Fourier transform infrared spectroscopy and X‐ray diffraction spectra suggest the maintenance of collagen structure integrity after ADA modification. The modification significantly contributes to the improved swelling property, resistance against type I collagenase, and strengthens storage modulus of hydrogels with an increase of ADA concentrations. Meanwhile, dynamic release curves of tetracycline hydrochloride (TC)‐loaded hydrogels describe the burst release at the first 15 min then a gradual release, hydrogels act ideally as carriers in antibacterial activity. Furthermore, in vitro biocompatibility and antibacterial properties are successfully confirmed from the fabricated collagen hydrogels. This physicochemical‐ and antibacterial‐property–improved collagen hydrogel would be a potential candidate for wound healing as a scaffold.

Tetracycline Hydrochloride

Biocompatibility

10.1002/mame.201800755

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Citations (23)

pH‐Switchable Macroscopic Assembly through Host–Guest Inclusion

Macromolecular Rapid Communications (2013)

Qijuan Yuan Yifu Wang Jian‐Hu Li Bang‐Jing Li Sheng Zhang

Abstract A novel pH‐switchable macroscopic assembly is reported using alginate‐based hydrogels functionalized with host (α‐cyclodextrin, αCD) and guest (diethylenetriamine, DETA) moieties. Since the interaction of αCD and DETA is pH sensitive, the host hydrogel and guest hydrogel could adhere together when the pH is 11.5 and separate when the pH is 7.0. Furthermore, this pH‐controlled adhesion and dissociation shows a good reversibility. The host and guest polymers have good biocompatibility; therefore, this pH‐sensitive macroscopic assembly shows great potential in biotechnological and biomedical applications. magnified image

Diethylenetriamine

Biocompatibility

10.1002/marc.201300289

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Citations (11)

Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery

Chinese Chemical Letters (2019)

Caihong Xian Qijuan Yuan Ziting Bao Guiting Liu Jun Wu

Raft

10.1016/j.cclet.2019.03.052

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Citations (55)

Amino Acid- and Growth Factor-Based Multifunctional Nanocapsules for the Modulation of the Local Microenvironment in Tissue Engineering

ACS Applied Materials & Interfaces (2021)

Qijuan Yuan Jun Huang Caihong Xian Jun Wu

Oxidative damage to cells from metabolites at a wound site is one of the trickiest factors inhibiting tissue regeneration, especially with bulk damage. In addition, an excessive inflammatory reaction by the body at the wound site can make it even worse. How to scavenge the reactive oxygen species (ROS) produced from metabolism and inflammatory reactions has become a critical issue in tissue engineering. Here, we utilize the natural bioactive small molecules l-arginine and l-phenylalanine and the growth factor inositol to synthesize a branched poly(ester amide) (BPEA) to fabricate BPEA nanocapsules for vitamin E delivery at wound sites. BPEA nanocapsules loaded with vitamin E (BPEA@VE NCs) could protect cells from both extracellular and intracellular damage by scavenging ROS. Simultaneously, the inflammatory reaction could also be downregulated, benefiting from the introduction of l-arginine. Furthermore, the biodegradation products of BPEA are natural metabolites of the body, such as amino acids and growth factors, guaranteeing the biocompatibility of the BPEA@VE NCs. The protective ability of the BPEA@VE NCs was also investigated in vivo for accelerated wound healing. All the results indicate that the BPEA@VE NCs have promising potential for the modulation of the local microenvironment in tissue engineering for excellent antioxidative and anti-inflammatory properties.

Nanocapsules

Biocompatibility

10.1021/acsami.0c15133

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Citations (32)