George Omura

University of Alabama at Birmingham

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Brian C. Benton

Drury University

Alfred A. Bartolucci

University of Alabama at Birmingham

B. A. Peterson

Mount Stromlo Observatory

Charles A. Schiffer

The Barbara Ann Karmanos Cancer Institute

Ronald D. Alvarez

Vanderbilt University Medical Center

William T. Creasman

Medical University of South Carolina

Robert Y. Kim

University of Alabama at Birmingham

Mark F. Brady

Brown University

Edgardo Yordan

Rush University Medical Center

David Gordon

Princeton Public Schools

Cooperative Institutions

University of Alabama at Birmingham

Gynecologic Oncology Group

Duke Medical Center

Roswell Park Comprehensive Cancer Center

Memorial Sloan Kettering Cancer Center

Wake Forest University

The University of Texas MD Anderson Cancer Center

Cornell University

Dana-Farber Cancer Institute

Duke University

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Using Advanced 3D Features

George Omura Brian C. Benton

The Autodesk® AutoCAD® 2019 software has an extended set of tools for working with 3D drawings that lets users to create 3D objects with few limitations on shape and orientation. This chapter focuses on the use of these tools, which help users easily generate 3D forms and view them in both perspective and orthogonal modes. In some 3D modeling operations, the user coordinate system (UCS); helps to have several different views of the model through the Viewports feature. The chapter helps users to learn how to: master the UCS; understand the UCS options; use viewports to aid in 3D drawing; use the array tools; create complex 3D surfaces; create spiral forms; create surface models; and move objects in 3D space. It shows how one can use a surface created from the Loft command to slice a solid into two pieces, imprinting the solid with the surface shape.

3D modeling

3d model

Feature (linguistics)

10.1002/9781119495048.ch21

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Citations (2)

Phase III Trial of Paclitaxel at Two Dose Levels, the Higher Dose Accompanied by Filgrastim at Two Dose Levels in Platinum-Pretreated Epithelial Ovarian Cancer: An Intergroup Study

Journal of Clinical Oncology (2003)

George Omura Mark F. Brady Katherine Y. Look Hervy E. Averette James E. Delmore

To determine if increasing the dose of paclitaxel increases the probability of clinical response, progression-free survival, or overall survival in women who have persistent or recurrent ovarian cancer, and whether doubling the dose of prophylactic filgrastim accompanying the higher paclitaxel dose decreases the frequency of neutropenic fever.Consenting patients with persistent, recurrent, or progressing ovarian cancer, despite first-line platinum therapy (but no prior taxane), were randomly assigned to paclitaxel 135 mg/m2, 175 mg/m2, or 250 mg/m2 over 24 hours every 3 weeks. Patients receiving paclitaxel 250 mg/m2 were also randomly assigned to 5 or 10 microg/kg of filgrastim per day subcutaneously.Accession to the paclitaxel 135-mg/m2 arm was closed early. Among the 271 patients on the other regimens with measurable disease, partial and complete response on paclitaxel 250 mg/m2 (36%) was significantly higher than on 175 mg/m2 (27%, P =.027). This difference was more evident among patients who never responded to prior platinum. However, progression-free and overall survival results were similar. The median durations of overall survival were 13.1 and 12.3 months for paclitaxel 175 mg/m2 and 250 mg/m2, respectively. Thrombocytopenia, neuropathy, and myalgia were greater with paclitaxel 250 mg/m2 (P <.05). The incidence of neutropenic fever after the first cycle of paclitaxel 250 mg/m2 was 19% and 18% on the 5-microg/kg and 10-microg/kg filgrastim dose, respectively (22% for paclitaxel 175 mg/m2 without filgrastim).Paclitaxel exhibits a dose effect with regard to response rate, but there is more toxicity and no survival benefit to justify paclitaxel 250 mg/m2 plus filgrastim. Doubling the filgrastim dose from 5 to 10 microg/kg did not reduce the probability of neutropenic fever after high-dose paclitaxel.

Taxane

10.1200/jco.2003.10.082

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Citations (93)

Late Intensification Therapy in Adult Acute Lymphoid Leukemia: Long-Term Follow-Up of the Southeastern Cancer Study Group Experience

Leukemia & lymphoma/Leukemia and lymphoma (1994)

George Omura William R. Vogler Orlando J. Martelo David Gordon Alfred A. Bartolucci

One hundred and ninety-two evaluable patients were treated on a multicenter protocol for adult acute lymphoid leukemia to determine in a prospective randomized fashion if late intensification chemotherapy beginning after about six months of treatment would improve remission duration and survival. The complete remission rate was 60%. The median remission duration from beginning of maintenance was 18.7 versus 25.9 months (P = 0.36) for standard maintenance therapy and late intensification, respectively, and the median survival from randomization was 25.8 versus 28.5 months (P = 0.94) respectively. There was a suggestion that the late intensification strategy was helpful with respect to remission duration, and this trend was sustained in long-term follow-up. However, relapse proved to be common during the earlier phases of treatment; thus, insufficient numbers of patients were available at the randomization point to conclusively address the possible value of late intensification. Intensive therapy earlier in the course of treatment should be evaluated, including transplantation in selected patients.

Maintenance therapy

10.3109/10428199409051680

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Citations (3)

Front Matter

George Omura Brian C. Benton

The prelims comprise: Title Copyright Dedication Acknowledgements About the Authors Contents at a Glance Contents Introduction

10.1002/9781119414179.fmatter

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Creating 3D Drawings

George Omura Brian C. Benton

This chapter discusses how AutoCAD users can learn to understand the 3D Modeling workspace, draw in 3D using solids, create 3D forms from 2D shapes, isolate coordinates with point filters, move around their model, and get a visual effect. The AutoCAD 2018 program offers the 3D Modeling and 3D Basics workspaces, which give users a set of tools to help ease their way into 3D modeling. The 3D Modeling workspace gives AutoCAD a different set of Ribbon panels. AutoCAD behaves in the same basic way, and the AutoCAD files produced are the same regardless of whether they are 2D or 3D drawings. The Ribbon along the top of the AutoCAD window offers all the tools that they will need to create 3D models. The 3D Modeling workspace Ribbon offers a few of the tabs and panels with which users are already familiar. AutoCAD offers a method for 3D point selection that can help users isolate the x-, y-, or z coordinate of a location in 3D. Users can enter an X, Y, or Z value by picking a point on the screen and telling AutoCAD to use only the X, Y, or Z value of that point or any combination of those values using point filters. AutoCAD offers a number of tools to help users view their 3D model.

Work space

3d model

3D modeling

Ribbon

10.1002/9781119414179.ch20

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Randomized Phase II Evaluation of Iproplatin (CHIP) and Carboplatin (CBDCA) in Lung Cancer

American Journal of Clinical Oncology (1988)

Barnett S. Kramer Robert Birch Anthony Greco Karen Prestridge Paolo De Simone

Cisplatin-containing regimens have shown activity in both small and non-small cell lung cancer. We therefore conducted a randomized Phase II trial of the new platinum congeners iproplatin and carboplatin in bronchogenic carcinoma. The overall response rate in chemotherapy-naive non-small cell patients with iproplatin was 3/48 (6%; 95% confidence interval 2–18%) and with carboplatin 6/50 (12%; 95% confidence interval 5–25%). The response rates in previously treated small cell patients were 0/16 and 1/18, respectively. Overall, neither agent has pronounced activity in bronchogenic carcinoma.

Carboplatin

Bronchogenic carcinoma

10.1097/00000421-198812000-00010

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Citations (22)

Introducing AutoCAD 2008

George Omura

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Mastering AutoCAD 2012 and AutoCAD LT 2012

George Omura

Learn to master the AutoCAD softwareThis Autodesk Official Training guide is a comprehensive reference and tutorial that will help you quickly master AutoCAD software. Featuring concise explanations, step-by-step instructions, and hands-on projects based on real-world designs, this Autodesk Official Training Guide covers everything from interface best practices to hatches, fields, dynamic blocks, attributes, linking drawings to databases, rendering realistic views, and presenting designs. This Mastering book is recommended as a Certification Preparation study guide resource for the AutoCAD Associate and Professional exams.Serves as an in-depth resource on the fundamentals, functions, and features of AutoCAD, the popular 2D and 3D drawing software, and its less expensive version AutoCAD LTDescribes how to effectively use hatches, fields, and tables; execute 3D modeling, imaging, and customizing; work with dynamic blocks, drawing curves, and solid fills; and moreFeatures a DVD with more than a dozen video tutorials, before and after tutorial files, a trial version of AutoCAD, and additional tools and utilitiesShares helpful examples, step-by-step instructions, and hands-on projects from award-winning author and CAD specialist George OmuraThis detailed tutorial is mandatory reading if you're eager to become proficient with AutoCAD or AutoCAD LT.

Study guide

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Setting Up and Using the Drafting Tools

George Omura Brian C. Benton

This chapter helps readers to learn how to set up a work area and how to use the AutoCAD modes as drafting tools. It explores the drawing process, and shows how to plan and lay out a drawing. In the process of drawing an apartment's bathroom fixtures, the reader will learn how to use the basic AutoCAD tools. The drawing process often involves many cycles of adding objects and then editing them. The chapter also shows how to use AutoCAD commands and provides a solid understanding of the basic AutoCAD package. It presents some common AutoCAD commands and also shows how to use them to complete a simple drawing. It briefly describes the trim options such as fence, crossing, project, edge, erase, and undo. The chapter also describes how planning ahead will make the use of AutoCAD more efficient. The chapter also helps the reader to learn how to control the grid's appearance.

Undo

Fence (mathematics)

10.1002/9781119495048.ch3

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Drawing Curves

George Omura Brian C. Benton

This chapter describes how to create and edit polylines, create a polyline spline curve, create and edit true spline curves, and mark divisions on curves. User can create a curve in AutoCAD in many ways. If user does not need the representation of a curve to be accurate, user can use a polyline curve. Next, the chapter explains how to use the polyline curve to experiment with some of the editing options unique to the Pedit command. It lists a few of the Pedit options, such as Spline/Decurve, and Edit Vertex. The Pedit command's Spline option offers a way to draw smoother and more controllable curves than those produced by the Fit option. A polyline spline does not pass through the vertex points as does a fitted curve. Instead, the vertex points act as weights pulling the curve in their direction. These "weighted" vertex points are called control vertices.

Spline (mechanical)

Curve fitting

Representation

10.1002/9781119415510.ch18

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