Two surgical procedures were required to make experimental model of liver metastasis (SC42-DS). In this paper, the protective effects of OK432 against liver metastasis were examined experimentally, as a immunotherapeutic agent under perioperative condition. In 5 combinations of administration, OK432 showed some different effects on liver metastasis, however, in general, simultaneous intrasplenic injection of OK432 reduced liver metastasis. From this result, the efficacy of intraoperative OK432 via portal vein was speculated.
Presented is the case of a 58-year-old female who had been found to have a submucosal tumor of the stomach during a group medical examination 7 years earlier. Since that time, the proliferative course of the tumor has been regularly observed and the diagnosis of a gastric smooth muscle sarcoma was finally determined after an endoscopic examination performed this year. On the basis of X-ray photographs taken periodically, the mass gradually proliferated from 1.3 to 3.5 cm in diameter during the observation period of 2392 days. According to the doubling time (DT) calculation of Horai et al, the DT was 0.69. The proliferation in this case was very slow and this seems to be a characteristic of a highly differentiated smooth muscle sarcoma of the stomach.
Helical computed tomography was performed with intravenous contrast material administration in ten patients with hepatic tumors (metastatic tumor, n = 6; hepatocellular carcinoma, n = 4). Maximum intensity projection (MIP) images of intrahepatic portal venous branches and hepatic veins, and shaded surface display (SSD) images of the hepatic tumors were reconstructed for each patient. The MIP image and SSD image were fitted to overlap on a single display to obtain three-dimensional (3-D) images showing both the hepatic vessels and hepatic tumors. Subsegmental localization of the tumors determined from the 3-D images proved to be correct in all of the six patients who received hepatic resection after examination. 3-D images seem to be useful for preoperative assessment of hepatic tumors.
An unusual case of peritumoral hemorrhage after radiosurgery for the treatment of metastatic brain tumor is reported. This 64-year-old woman had a history of breast cancer and underwent right mastectomy in 1989. She remained well until January 1993, when she started to have headache, nausea and speech disturbance, and was hospitalized on February 25, 1993. Neurological examination disclosed right hemiparesis and bilateral papilledema. CT scan and MR imaging showed a solitary round mass lesion in the left basal ganglia region. It was a well-demarcated, highly enhanced mass, 37mm in diameter. Cerebral angiography confirmed a highly vascular mass lesion in the same location. She was treated with radiosurgery on March 8 (maximum dose was 20Gy in the center and 10Gy in the peripheral part of the tumor). After radiosurgery, she had an uneventful course and clinical and radiosurgical improvement could be detected. Her neurological symptoms and signs gradually improved and reduction of the tumor size and perifocal edema could be seen one month after radiosurgery. However, 6 weeks after radiosurgery, she suddenly developed semicoma and right hemiplegia. CT scan disclosed a massive peritumoral hemorrhage. Then, emergency craniotomy, evacuation of the hematoma and total removal of the tumor were performed on April 24. Histopathological diagnosis was adenocarcinoma. It was the same finding as that of the previous breast cancer. Histopathological examination revealed necrosis without tumor cells in the center and residual tumor cells in the peripheral part of the tumor.(ABSTRACT TRUNCATED AT 250 WORDS)
