Kunio Mizuguchi

Teikyo University

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Kaname Maruno

Teikyo University

Tatsuo Yamakawa

The Japanese Society of Gastroenterological Surgery

Kyoji Nakamura

Fuchu Hospital

Mitsugu Ishizawa

Tokyo Metropolitan Tama Medical Center

Akihiko Tachibana

Kanto Central Hospital

Naoto Fukuda

Kawasaki Hospital

Akihiko Yamamura

Centro Universitário Lusíada

Yoshinori Ui

Teikyo University Hospital

Masataka Tanno

Nippon Medical School

Yasuyuki Sugiyama

Japan Proton Accelerator Research Complex

Cooperative Institutions

Teikyo University

The University of Tokyo

Teikyo University Hospital

Juntendo University

Fuchu Hospital

Tohoku University

Chiba University

University of Tsukuba

Teikyo University Hospital, Mizonokuchi

Kyoto University

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A case of xanthogranulomatous endometritis.

The Journal of the Japanese Society of Clinical Cytology (1997)

Mitsugu Ishizawa Hanako Matsushima Sawako TAKAHASHI Kunio Mizuguchi Kyoji Nakamura

Endometritis

10.5795/jjscc.36.98

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A Case of Testicular tumor Associated with Lumbago

Juntendō Igaku/Juntendo igaku (1981)

J Igari Yoshio Kawachi Yoshihisa Wakabayashi Kunio Mizuguchi

Testicular tumor

10.14789/pjmj.27.8

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Adrenal Myelolipoma Associated with Congenital Adrenal 21-Hydroxylase Deficiency.

Internal Medicine (1992)

Chika Murakami Miyuki Ishibashi Masahiro Kondo Sumako OHSHIRO Mutsumi Fujita

The occurrence of adrenal myelolipomas is reported in an untreated patient with congenital adrenal 21-hydroxylase deficiency. Laparotomy demonstrated the presence of two lesions, a large tumor which arose from an ectopic adrenal cortex and a smaller tumor in the left adrenal gland. Six cases of adrenal myelolipomas and congenital adrenal hyperplasia have been reported in the literature. All patients were associated with excessive ACTH secretion for a long period of time. The relative frequency of this association, coupled with the observation by Selye and Stone (Am J Pathol 26 : 211, 1950) that anterior pituitary extracts cause myelolipomatous changes in rats, may indicate a possible role for ACTH in the development of myelolipomas.(Internal Medicine 31 : 803-806, 1992)

Myelolipoma

21-Hydroxylase

10.2169/internalmedicine.31.803

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Citations (43)

A case of neuroendocrine carcinoma of the prostate.

The Journal of the Japanese Society of Clinical Cytology (2001)

Yuji Mori Toshihito Shinagawa Fumikazu Kimura Ayako Suzuki M Minamide

背景:前立腺のまれな腫瘍である神経内分泌癌: Neuroendocrine carcinoma (以下NEC) を経験したので報告する.症例:患者は78歳, 男性, 頻尿を主訴に来院した. 前立腺針穿刺組織検査で高分化腺癌が認められた. 尿細胞診においても腺癌を疑う異型細胞がみられた. 治療を開始し経過観察を行った. その後尿細胞診では異型細胞の出現は認められなかったが, 3年5ヵ月後に排尿困難を訴えTURを施行, 組織学的に一部腺癌を含むNECが認められた. ほぼ同時に施行された尿細胞診では腺癌由来の細胞は認められなかったが, 小型でN/C比が高く, クロマチンの増量した裸核状異型細胞が小集塊, 孤立散在性, また一部ではインディアンファイル状配列を呈して認められ, NEC由来の腫瘍細胞と診断した. 免疫組織化学的にNECはneuron specific enolase (NSE), synaptophysin, chromogranin Aが陽性であり, 腺癌部分ではprostatic specific antigen (PSA), prostaticacid phosphatase (PAP) が陽性であった.結論:尿細胞診スクリーニングにあたっては腺癌の既往歴を有してもNEC細胞が出現する可能性のあることを考慮することが重要と思われた.

Enolase

Chromogranin A

Synaptophysin

Neuroendocrine carcinoma

Prostatic acid phosphatase

Prostate carcinoma

Neuroendocrine differentiation

10.5795/jjscc.40.58

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A uterine leiomyosarcoma with multiple pulmonary metastases.

日本胸部臨床 (1988)

Ritsu Kohiyama Nakano Hiroyasu Katsuhiko Kamei Hikaru Suzuki Kunio Mizuguchi

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A case report of immature teratoma of the ovary with glial implants on the peritoneum.

The Journal of the Japanese Society of Clinical Cytology (1987)

Yuko Aizawa Thizuko KUWAE Hiroshi AIZAWA Fumiko KUGA Nobuyuki Fukudome

卵巣未熟奇形腫は, 多彩な組織学的所見を示し, 臨床経過も種々であるが, 腹水細胞診が予後推定に有用であった症例を経験したので報告する.患者は29歳主婦.右卵巣未熟奇形腫, stage Ic, grade 3の診断で, 右付属器摘出術+左卵巣模状切除術を行った. 奇形腫の未熟組織は神経成分のみであった. 手術後VAQ療法を4クール行ったが, 終了4ヵ月後リンパ節転移とLDH上昇をきたし, PVP療法を6クール行った。LDH下降, リンパ節やや縮小したものの, 再度LDH上昇, 急激な腹水貯留, イレウスを呈し, 手術より1年5ヵ月後消化管出血にて死亡した.腹水細胞診では, 原発巣の捺印細胞診と同様の神経芽細胞腫に似た細胞像であり, また腹水のcell block中の腫瘍細胞では, PAP法によるs100タンパクが染色されたことから, 未熟神経成分の腹膜への播種と診断した. 剖見所見でも, 腹腔内への播種は未熟神経組織でほかの成分はなかった. そして今回の症例では, LDHがAFPより腫瘍マーカーとして有用であった.

10.5795/jjscc.26.482

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A Case of Invasive Lobular Carcinoma of the Breast Mixed with Suquamous Cell Carcinoma

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2013)

Kaname Maruno Shozo Fujino Masasi Kawamoto Kunio Mizuguchi

症例は50歳の女性で，2カ月前に拇指頭大の右乳房腫瘤に気付き，その後，腫瘤が急速に増大したので，平成23年9月当科外来を受診した．右乳房のACE領域に8.5×7.0cmの弾性硬で表面整，境界明瞭な腫瘤を，右腋窩に径1.0cm大のリンパ節を2～3個触知した．針生検にて浸潤性小葉癌，ER，PgR，HER2はすべて陰性と診断した．NAC（FECとnanoparticle albumin bound paclitaxel）施行後，右乳房腫瘤も右腋窩リンパ節もほとんど触知出来ない程度まで縮小した．平成24年7月に右胸筋温存乳房切除術・右腋窩リンパ節郭清を施行した．摘出標本では主にACとA領域に腫瘤を認め，病理組織検査所見ではAC領域の腫瘍に浸潤性小葉癌と扁平上皮癌の混在を認めた．本症例は2007年のSentaniらの報告以来，乳腺の浸潤性小葉癌と扁平上皮癌が混在した症例としては2例目である．

Invasive lobular carcinoma

Lobular carcinoma

Breast carcinoma

10.3919/jjsa.74.2718

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Two cases of cecal volvulus.

The Japanese Journal of Gastroenterological Surgery (1986)

Jun Matsumoto Tomohito MINAMI Tokio Onodera C Yazawa Kunio Mizuguchi

10.5833/jjgs.19.993

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Citations (1)

[A case of Goodpasture's syndrome with IgA antibasement membrane antibody].

PubMed (1990)

Hiroyasu Nakano Akira Suzuki Hirokazu Tojima Akira Watanabe Kunio Mizuguchi

This is a very rare case report of Goodpasture's syndrome with IgA antibasement membrane antibody. A 43-year old male was admitted because of severe dyspnea with slight hemoptysis. Chest X-ray demonstrated extensive bilateral infiltrates with air bronchogram, predominantly in the right lung. Laboratory data on admission showed severe anemia and moderate renal impairment. The pulmonary infiltrates resolved spontaneously within 10 days. Goodpasture's syndrome or collagen vascular disease was suspected and he underwent a percutaneous renal and transbronchial lung biopsy. The renal biopsy showed crescent formation affecting 70-80% of glomeruli. Linear IgA deposits, but not IgG, were demonstrated along the glomerular basement membrane by the direct immunofluorescence procedure. The lung biopsy contained many hemosiderin-laden macrophages in the lumen of the alveoli and showed mild thickening of alveolar walls. However, linear immunoglobulin deposits on the alveolar capillary basement membrane were not demonstrated by direct immunofluorescence. The diagnosis of Goodpasture's syndrome with IgA antibasement membrane antibody was made. His serum was negative for antibasement antibody by indirect immunofluorescence. He was treated with prednisone, 30 mg daily. His pulmonary symptoms and anemia improved markedly, but his renal function did not change. Thirteen months after his first admission, he suffered from severe bacterial pneumonia, which was complicated by disseminated intravascular coagulation. He died of respiratory failure. Autopsy was rejected.

Goodpasture's syndrome

Hemosiderin

Goodpasture syndrome

Lung biopsy

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Citations (9)

Contents

Acta Cytologica (1998)

Gláucia Maria Machado‐Santelli Masuzo Kamiya Kunio Mizuguchi Makoto Yoshimoto Miyuki Tanaka

10.1159/000331813

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