Tamaki Ohta

Komagino Hospital

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Toshio Murayama

University of Niigata Prefecture

Kazuhiro Funakoshi

Niigata Prefectural Central Hospital

Yasumasa Takii

Niigata Cancer Center Hospital

Toshiyuki Kato

Kariya Toyota General Hospital

Futoshi Arai

Niigata Cancer Center Hospital

Atsushi Nashimoto

Niigata Cancer Center Hospital

Hirotaka Motoyama

Niigata Cancer Center Hospital

Yoshiaki Tsuchiya

Aisin (Japan)

Hiroshi Yabusaki

Niigata Cancer Center Hospital

Yusuke Oyama

Toin University of Yokohama

Cooperative Institutions

Niigata University

Niigata Cancer Center Hospital

Niigata University Medical and Dental Hospital

Kyoto Prefectural University of Medicine

Kyoto University

Tokyo Medical and Dental University

University of Tsukuba

Teikyo University

National Cancer Center Hospital East

Kyoto first Red Cross hospital

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Intramural and Mesorectal Distal Spread Detected by Whole-Mount Sections in the Determination of Optimal Distal Resection Margin in Patients Undergoing Surgery for Rectosigmoid or Rectal Cancer Without Preoperative Therapy

Diseases of the Colon & Rectum (2011)

Yoshifumi Shimada Yasumasa Takii Satoshi Maruyama Tamaki Ohta

The current Japanese general rules for clinical and pathologic studies on cancer of the colon, rectum, and anus state that a 3-cm distal resection margin is needed in resecting rectosigmoid cancer and rectal cancer with a distal edge above the peritoneal reflection, and 2 cm is needed for rectal cancer with a distal edge below the peritoneal reflection. The appropriateness of these rules has not been proved.Our aim was to evaluate the appropriateness of the Japanese rules.We retrospectively analyzed surgical and pathology records of patients who underwent surgery at a tertiary care cancer center in Japan.The study included 381 consecutive patients with stage I to IV rectosigmoid or rectal cancer without preoperative chemotherapy or radiotherapy.We investigated both intramural and mesorectal distal spread, using whole-mount sections to measure the maximum length of distal spread. Long distal spread was defined as distal spread longer than the distal resection margin stated in the Japanese general rules. Risk factors for both distal spread and long distal spread were evaluated.Of 381 patients, 325 (85.3%) had no distal spread and a total of 56 (14.7%) had distal spread. Distal spread was within the limits specified by the Japanese general rules in 48 of the 381 patients (12.6%) and beyond the Japanese limits (long distal spread) in 8 patients (2.1%). The prevalence of distal spread increased with TNM stage (stage I, 2.7%; stage II, 5.3%; stage III, 17.4%; stage IV, 46.2%). Long distal spread was not observed in stage I or II, was found in only 1.4% of patients with stage III disease and in 11.5% of patients with stage IV. The maximum extent of distal spread in patients with rectosigmoid cancer or rectal cancer with the distal edge above the peritoneal reflection was 38 mm; in patients with rectal cancer with the distal edge below the peritoneal reflection, 35 mm. Multivariable analyses showed that nodal involvement and distant metastasis were independent risk factors for distal spread; distant metastasis was the only independent risk factor for long distal spread.The Japanese general rules specifying the distal resection margin are appropriate for most patients who undergo surgery for rectosigmoid and rectal cancer without preoperative chemotherapy or radiotherapy. A further increase of 1 to 2 cm beyond the recommended distal resection margin may contribute to improved local control for patients with distant metastasis.

Resection margin

Anus

10.1097/dcr.0b013e318233fc4a

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Citations (58)

Mucosal Prolapse Syndrome of the Rectum : Correlation between Macroscopic Type and Location in a Discussion on Its Natural History

Acta Medica et Biologica (1993)

Tamaki Ohta

Source

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Reliability of Evaluation Parameters of Ground Reaction Force in Stepping Motion

International journal of human movement and sports sciences (2022)

Yusuke Oyama Maki Kameoka Yusuke Sakaguchi Toshio Murayama Tamaki Ohta

The purpose of this study was to 1) examine the reliability of the evaluation parameters of the ground reaction force (GRF) in the stepping motion among middle-aged and elderly people, and 2) calculate the number of steps required for the analysis of the stepping motion.Participants were 128 middle-aged and elderly individuals regularly exercising at a health promotion facility.Participants performed 3 trials of the stepping motion for 10 seconds at the optimum speed on the same spot.We used a force plate to measure the vertical GRF during the stepping motion.The number of cycles and spatiotemporal parameters (8 mechanical parameters, 6 temporal parameters) were evaluated from the waveform of the GRF.Results showed that the number of cycles in the stepping motion was higher in the 2 nd and 3 rd trials than in the 1 st trial, and the intraclass correlation coefficients (ICC) were as high as .837for men and .840for women.When comparing the two consecutive steps of 10 steps after the start of the stepping motion, the stepping motion was in a steady state from the 3 rd step because the difference between the two steps became smaller after the 3 rd step.Furthermore, when the number of steps required to ensure reliability was calculated using the ICC (1, 1) of each parameter, it was shown that 15 or more steps were required.Our results suggested that stepping motion may be able to secure high reliability with a smaller number of steps than gait.

Ground reaction force

10.13189/saj.2022.100317

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Prognostic significance of peritoneal washing cytology for gastric cancer

The Journal of the Japanese Society of Clinical Cytology (2003)

H. Ochiai Tomoko SAKURAI Kouichi USAMI Yumiko Kobayashi Kaori IZUMIDA

目的:胃癌の術中腹腔洗浄細胞診 (以下細胞診) について県立がんセンター新潟病院 (以下当院) における成績をまとめ, その意義と問題点について検討する.方法:過去10年間の当院胃癌手術例のうち, 術中細胞診が提出された698例を対象として, パパニコロウ染色細胞診の予後因子としての有用性を検証するとともに, 臨床病理学的諸因子との関連性について検討した. 最近の症例では, CEA, MOC-31の免疫染色を加え同様の検討を行った.成績:細胞診陽性例は癌深達度と無関係に予後不良であった (P<0.0001). 低分化型腺癌は深く深達する例が多く細胞診では単離性に出現する傾向があったが, ときに異型性軽度の場合があり, 細胞診では陽性と判定し, むずかしい症例も存在した. CEAまたはMOC-31免疫染色陽性例は陰性例に比べ有意に再発した. また, CEAまたはMOC-31陽性を腫瘍細胞陽性とした場合, 陽性率が約11%向上した.結論:当院材料の検討から細胞診の予後因子としての有用性が確認されたが, 細胞診のさらなる精度向上のためには, 免疫染色等の補助的診断法も考慮すべきである.

Clinical Significance

10.5795/jjscc.42.444

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A new histological classification for intra‐operative histological examination of the ductal resection margin in cholangiocarcinoma

Cancer Science (2008)

Masaru Konishi Atsushi Ochiai Hidenori Ojima Takahiro Hasebe Masayuki Mano

The purpose of this study was to establish a standard histological classification for intra-operative histological examination of ductal resection margins in cholangiocarcinoma to distinguish between epithelial and intramural lesions and to clarify correlations between the new classification and clinical outcomes. Intra-operative diagnosis of ductal margins was performed for 357 stumps from 216 patients undergoing surgical resection of cholangiocarcinoma at the National Cancer Center, Japan. Three expert pathologists reviewed the materials and established a histological classification defined by grade of atypia. The new classification comprised four categories: 'insufficient', insufficient for diagnosis due to distortion of specimen; 'negative for malignancy', no atypia suggestive of neoplasia; 'undetermined lesion', specimen showing either cellular or structural atypia; and 'positive for malignancy', specimen showing both cellular and structural atypia. Each category was defined to distinguish between epithelial and intramural lesions. Validity and reproducibility of the proposed classification were found to be moderate to substantial. Multivariate analyses using the clinicopathological factors identified to be associated with overall survival by univariate analyses indicated that patients diagnosed with 'positive for malignancy' in intramural lesions of the proximal margin displayed significant poor prognosis. Meanwhile, in patients diagnosed with 'positive for malignancy' or 'undetermined lesion' in epithelial lesions of the proximal margin, no difference in overall survival was apparent compared to patients diagnosed with 'negative for malignancy'. We propose new histological classification for intra-operative histological examination of ductal resection margins in cholangiocarcinoma that shows a correlation with patients' prognosis and should facilitate the determination of ductal resection margin status for cholangiocarcinoma.

Atypia

Resection margin

Nuclear atypia

Surgical margin

10.1111/j.1349-7006.2008.01043.x

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Relationship between the recognition error of dynamic postural control ability and the extent of exercise in middle-aged older women

Sport Sciences for Health (2022)

Yusuke Oyama Toshio Murayama Tamaki Ohta

Sports medicine

Exercise intensity

Human physiology

Intensity

10.1007/s11332-022-00900-9

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Citations (1)

A CASE OF ENDOCRINE CARCINOMA OF THE PANCREAS WITH PANCREATIC DUCT OCCLUSION

Hirotaka Motoyama Takashi Yamamoto Nobuhiro Akiyama Jun Inayoshi Futoshi Arai

Pancreatic carcinoma

10.11280/gee1973b.48.334

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Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis

International Journal of Rheumatic Diseases (2013)

Wataru Fukuda Atsushi Omoto Tamaki Ohta Saori Majima Toshihiro Kimura

Abstract Aim To investigate the relationship between quality of life ( QOL ) and rheumatoid chachesia, malnutrition in patients with rheumatoid arthritis ( RA ). Methods Euro Q ol G roup 5‐ D imension S elf‐ R eport Q uestionnaire ( EQ 5 D ) and J apanese H ealth A ssessment Q uestionnaire ( JHAQ ) scores, body mass index ( BMI ), arm muscle area ( AMA ) and clinical indicators were measured in 385 RA patients. One‐way analysis of variance for obtained data was conducted among three groups: 131 with low BMI (< 20), 163 with moderate (20–25) and 91 with high BMI (≥25). Then multiple regression analyses for JHAQ and EQ 5 D scores with nutritional and clinical indicators as independent variables were performed. Results EQ 5 D and JHAQ scores were significantly lower and higher, respectively, in the low BMI group than those in the moderate BMI group. Clinical indicators including doses of corticosteroid were similar among the three groups except for disease duration. Disease activity score ( DAS ) 28, disease duration, C ‐reactive protein and AMA were significant variables in the regression model for EQ 5 D . Conclusion Low BMI deteriorates the QOL of RA patients. Muscle protein loss apparently leads to a reduction in BMI and QOL .

10.1111/1756-185x.12079

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Citations (24)

Musculoskeletal system

The Journal of Physical Fitness and Sports Medicine (2020)

Yusuke Oyama Toshio Murayama Maki Kameoka Yusuke Sakaguchi Koki Hara

We considered a sex differences and reliability from the viewpoint of ground reaction force in the stepping.[method] The subjects were 50 middle-aged and older people, consisting of 49 men (63.7±10.3years) and 71 women (60.5±8.9 years).They performed stepping for 10 seconds on the force plate, and we calculated the ground reaction force of vertical direction in the left and right.They performed the stepping at the optimum speed, and the swing of the fist and the upper extremity of the leg was arbitrary.We evaluated the number of steps, ground reaction force (M shaped, symmetry) and takeoff time.[result] There was no sex differences in all evaluation variable of the stepping.The reliability of the 2nd and 3rd trials was high for both males and females (male: ICC = 0.82, female: ICC = 0.76).The reliability of M shaped was very high (ICC = 0.93-0.97),but the reliability of symmetry was low (ICC = 0.29-0.59).The reliability of takeoff time was stable between the 2nd and 3rd steps (ICC = 0.65-0.72).[conclusion] There was no sex differences and reliability was maintained by using the average variable of the 2nd and 3rd trials and the ground reaction force from the 2nd step of each trial.

10.7600/jpfsm.9.278

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Successful endoscopic therapy of superficial esophageal cancer on varices in a patient with alcoholic liver cirrhosis

Digestive Endoscopy (2001)

Kazuhiro Funakoshi Nobuhiro Akiyama Ikuo Kozakai Futoshi Arai Hirotaka Motoyama

10.1046/j.1443-1661.2001.d01-4.x

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