Christos K. Koutinas

Aristotle University of Thessaloniki

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Mathios E. Mylonakis

Aristotle University of Thessaloniki

Zoe S. Polizopοulou

Aristotle University of Thessaloniki

ΚΘ

Κωνσταντίνα Θεοδώρου

Aristotle University of Thessaloniki

Alexander F. Koutinas

Aristotle University of Thessaloniki

ΑD

Αnastasia Diakou

Aristotle University of Thessaloniki

Manolis N. Saridomichelakis

University of Thessaly

Leonidas Leontides

University of Thessaly

Victoria I. Siarkou

Aristotle University of Thessaloniki

A. F. Koutinas

Aristotle University of Thessaloniki

Edward B. Breitschwerdt

North Carolina State University

Cooperative Institutions

Aristotle University of Thessaloniki

University of Thessaly

University of Veterinary Medicine

University of Veterinary Medicine Vienna

North Carolina State University

University of Zurich

National School of Public Health

University of Life Sciences in Lublin

University of Copenhagen

Institute of Parasitology

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D-dimer concentrations in dogs with kidney disease with or without protein-losing nephropathy

Comparative Clinical Pathology (2016)

Efstathios Roumpeas Polychronis Kostoulas Zoe S. Polizopοulou Christos K. Koutinas Mathios E. Mylonakis

D-dimer

10.1007/s00580-016-2297-y

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Citations (2)

Seroprevalence and risk factors associated with Ehrlichia canis in a hospital canine population

Veterinary Clinical Pathology (2019)

Tryfon A. Chochlios Elisavet Angelidou Maria Kritsepi‐Konstantinou Christos K. Koutinas Mathios E. Mylonakis

Ehrlichia canis (E canis) infection has been documented in a few small canine case series in Greece. However, there is limited information on the prevalence of exposure to, or the potential risk factors associated with E canis seroreactivity in a large native canine population.The objectives of this study were to evaluate E canis seroprevalence in dogs admitted to a veterinary teaching hospital, and to investigate the potential association between seropositivity and signalment, health status, the serologic assays used, and selected clinical and clinicopathologic abnormalities.The medical records of 850 client-owned dogs, tested using three in-office serologic assays, were retrospectively reviewed.The E canis seroprevalence was significantly higher in sick (54.9%) compared with healthy (33.9%) dogs. Seropositivity differed significantly between the serologic assays used in this study (ImmunoComb vs SNAP 3Dx/SNAP 4Dx). Dogs presenting with bleeding tendencies, anemia, thrombocytopenia, leukopenia, pancytopenia, and hyperproteinemia were more likely to be E canis seropositive, and the median hematocrit (HCT), white blood cell (WBC), neutrophil, and platelet values were significantly lower in seropositive compared with seronegative dogs.A high E canis seroprevalence was documented in a canine population living in an endemic area. Selected clinicopathologic variables might be useful indicators of E canis exposure and could allow the prioritization of serologic testing in the clinical setting.

Ehrlichia canis

Seroprevalence

Ehrlichiosis

10.1111/vcp.12736

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Citations (7)

Efficacy of rifampicin in the treatment of experimental acute canine monocytic ehrlichiosis

Journal of Antimicrobial Chemotherapy (2013)

Κωνσταντίνα Θεοδώρου Mathios E. Mylonakis Victoria I. Siarkou Leonidas Leontides A. F. Koutinas

To assess the efficacy of rifampicin in achieving clinical and haematological recovery and clearing infection in dogs with experimentally induced acute monocytic ehrlichiosis.Five Ehrlichia canis-infected Beagle dogs were treated with rifampicin (10 mg/kg/24 h orally for 3 weeks), nine E. canis-infected dogs received no treatment (infected untreated dogs) and two dogs served as uninfected controls. Clinical score, platelet counts, immunofluorescent antibody titres and PCR detection of E. canis-specific DNA in blood, bone marrow and spleen aspirates were evaluated on post-inoculation days 21 (start of rifampicin), 42 (end of rifampicin) and 98 (end of the study).By day 21 post-inoculation, all infected dogs became clinically ill and thrombocytopenic, seroconverted and were PCR positive in at least one tissue. Clinical scores and antibody titres did not differ between the treated and infected untreated dogs throughout the study. The rifampicin-treated dogs experienced an earlier resolution of their thrombocytopenia (Kaplan-Meier survival plot, P=0.048), and the median platelet counts were significantly higher in the treated compared with the infected untreated dogs on post-inoculation days 42 (P=0.0233) and 98 (P=0.0195). At the end of the study, three treated and six untreated infected dogs remained PCR positive in one tissue each.The rifampicin treatment regimen applied in this study hastened haematological recovery, but was inconsistent in eliminating the acute E. canis infection.

Ehrlichiosis

Ehrlichia canis

Beagle

10.1093/jac/dkt053

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Citations (19)

Primary Gastric Choriocarcinoma in a Dog

Journal of Comparative Pathology (2008)

Theofilos Poutahidis Michael Doulberis E. Karamanavi Katerina Angelopoulou Christos K. Koutinas

Submucosa

10.1016/j.jcpa.2008.06.003

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Citations (10)

Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat

Journal of the American Animal Hospital Association (2015)

Christos K. Koutinas Nektarios Soubasis S.C. Djajadiningrat‐Laanen Elissavet Kolia Κωνσταντίνα Θεοδώρου

A 9 yr old cat was presented with clinical signs and laboratory abnormalities attributed to arterial hypertension (mean systolic arterial pressure, 290 mm Hg). Plasma aldosterone concentration was increased at the time of admission (651 pmol/L), but serum creatinine and potassium concentrations were within the reference range. A second increased aldosterone (879 pmol/L) and normal plasma renin activity (1.85 ng/mL/hr) resulted in an increased aldosterone/renin ratio, which was suggestive of primary hyperaldosteronism (PHA). To further support the diagnosis of PHA, the urinary aldosterone/creatinine ratio was calculated both before and after oral administration of fludrocortisone acetate (0.05 mg/kg q 12 hr for 4 consecutive days). The urinary aldosterone/creatinine ratio was 92.6 × 10(-9) before fludrocortisone administration and 155.8 × 10(-9) 4 days later. Absence of suppression was typical of PHA. The cat had a limited response to antihypertensive medication and died before treatment for PHA could be instituted. A necropsy was not permitted by the owner.

Fludrocortisone

Plasma renin activity

Hypoaldosteronism

Hyperaldosteronism

10.5326/jaaha-ms-6201

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Citations (5)

Correlation of serum cardiac troponin I and acute phase protein concentrations with clinical staging in dogs with degenerative mitral valve disease

Veterinary Clinical Pathology (2015)

Zoe S. Polizopοulou Christos K. Koutinas J. M. Castro Cerón Asta Tvarijonaviciute Silvia Martínez‐Subiela

Cardiac troponin I (cTnI) correlates with severity of myocardial injury. Nonspecific inflammation in congestive heart failure (CHF) could be assessed by C-reactive protein (CRP), haptoglobin (Hp), and ceruloplasmin (Cp) measurements.The aim of the study was to determine whether serum cTnI, CRP, Hp, and Cp concentrations differ among various stages of mitral valve disease (MVD) in dogs.Dogs with MVD were allocated to 3 groups (I - asymptomatic; II - mild to moderate CHF; III advanced CHF) according to the scheme of the International Small Animal Cardiac Healthy Council (ISACHC). Concentrations of cTnI, CRP, Cp, and Hp were measured in all dogs upon admission, and cTnI and CRP were measured bimonthly during a 4-month follow-up period.In total 46 dogs with MVD were enrolled for the cross-sectional part (21 Group I, 11 Group II, 14 Group III), and 35 dogs were included in the longitudinal study. Initial mean Cp concentrations were similar among all groups. There was a statistically significant difference in Hp and CRP concentrations between group I (n = 21, P = .019) and III (n = 14, P < .001). There was a statistically significant decrease in CRP (P = .033) and cTnI (P = .009) concentrations over the longitudinal study (all groups). CRP concentrations were significantly higher in group I than III (P = .004). During the 6-month monitoring period of 35 dogs, there was a statistically significant positive correlation between cTnI and CRP (P < .001).Differences in CRP concentrations between clinical stages of MVD suggest a clinically and therapeutically relevant inflammatory component.

Haptoglobin

10.1111/vcp.12278

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Citations (24)

Occurrence and characterization of extended-spectrum cephalosporin-resistant Enterobacteriaceae in healthy household dogs in Greece

Journal of Medical Microbiology (2018)

Apostolos Liakopoulos Jonathan W. Betts Roberto M. La Ragione Alieda van Essen-Zandbergen Daniela Ceccarelli

Extended-spectrum cephalosporin- and/or carbapenem-resistant (ESCR and/or CarbR) Enterobacteriaceae constitute a public health hazard because of limited treatment options and are endemic among humans in Greece. Recently, ESCR and CarbREnterobacteriaceae have been increasingly isolated from companion animals, stressing their potential role as a reservoir for humans. However, the presence of ESCR bacteria in companion animals within Greek households has not been determined yet. Genes conferring the ESCR and CarbR phenotype were detected among canine isolates and their chromosomal or plasmid location was determined. Standard methods were applied for plasmid characterization. The clonal relatedness of the recovered isolates was examined by multilocus sequence typing (MLST). Here, we report the first findings on the presence of ESCREnterobacteriaceae in healthy Greek dogs. ESCREscherichia coli isolates were associated with different sequence types (STs), including the human pandemic ST131 clone. The occurrence of human-related ESBL/pAmpC genes, plasmid types and/or strain STS in this animal reservoir suggests possible bilateral transmission.

10.1099/jmm.0.000768

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Citations (22)

A Case of Bacteremia Due to Peptostreptococcus anaerobius in a Westphalian Stallion

Journal of Equine Veterinary Science (2016)

Nikolaos Diakakis Panagiota Tyrnenopoulou Fotini Dimitrakopoulou Christos K. Koutinas Michail Patsikas

Bacteremia

Leukocytosis

10.1016/j.jevs.2016.10.008

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Citations (1)

Fifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016

Parasites & Vectors (2017)

Fernando Simón Vladimir Kartashev Javier González‐Miguel Alicia E Arrona Rivera Alicia Diosdado

Angiostrongylus chabaudi (arrows) on the endothelium of the right ventricle of a wildcat in Northern Greece

Parasitology

Dirofilaria

Dirofilariasis

Entomology

10.1186/s13071-016-1902-x

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Citations (85)

A comparison of cytologic quality in fine‐needle specimens obtained with and without aspiration from superficial lymph nodes in the dog

Journal of Small Animal Practice (2021)

Vicky Karakitsou Mary M. Christopher Emmanouel Meletis Polychronis Kostoulas Dimitra Pardali

To assess the impact of aspiration on cytologic quality of fine-needle specimens obtained from lymph nodes of dogs and to compare the level of agreement of the cytologic diagnosis between the two sampling techniques.Fifty-three client-owned dogs were prospectively enrolled. Client-owned dogs were prospectively enrolled in the study if cytologic examination of lymph nodes was indicated in the course of their clinical diagnostic work-up. In each dog, two superficial, palpably accessible lymph nodes were sampled: one by fine-needle aspiration and the other by fine-needle non-aspiration, using a 21-Gauge needle with or without a 5-mL syringe. Cytologic quality was assessed in duplicate smears assessed by two observers who rated cellularity, blood contamination, thickness, cell preservation and cytoplasmic fragmentation using a predefined scoring system.Fifty-three client-owned dogs were included in the study. No significant difference was found in rating scores between the two sampling techniques for any of the cytologic quality parameters assessed. Cohen's kappa coefficient was 0.84 (95% confidence interval 0.68-1.00), indicating diagnostic agreement between the sampling techniques.In this study, both fine-needle aspiration and fine-needle non-aspiration techniques yielded lymph node specimens of comparable cytologic quality and with acceptable agreement in cytologic diagnosis.

10.1111/jsap.13429

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Citations (7)