Hu Da

Northwest Normal University

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Zhuo Xiong

Tsinghua University

Zhikang Ge

University of Rochester

Changpan Zhou

Computational Physics (United States)

Jian Liu

Southwest Medical University

Yuying Wang

Sichuan University

Ze Qiao

Westlake University

Shibin Gao General

University of Rochester

J Alan

University of Rochester

Claudia Melania

University of Rochester

Wentao Wang

Zhongshan Hospital

Cooperative Institutions

University of Rochester

185

Computational Physics (United States)

178

North Carolina State University

176

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Sichuan University

Air Force Medical University

Zhejiang University

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

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Joint design of routing selection and user association in multi-hop mmWave IABN: a multi-agent and double DQN framework

Telecommunication Systems (2025)

Hu Da Fei Xiao Zhongyu Ma Z. S. Zhang Qun Guo

Association (psychology)

10.1007/s11235-024-01256-w

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Recent Report on Cardiovascular Safety of Cox-2 Inhibitor Celebrex

Hu Da

Food and Drug Administration (FDA) has suspended the use of both celecoxib (Celebrex, Pfizer) and naproxen (Aleve, Bayer) in prevention large clinical trials after discovering that celecoxib and naproxen appeared to increase the risk of cardiovascular events with patients on placebo. FDA also advises patients who are currently taking over the counter naproxen products to carefully follow the instructions on the label. Pfizer suggested that alternatives to celecoxib should be considered based on individual patient needs and risk. The cardiovascular community responds differently.

Celecoxib

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CuS@YF_3:Euコア-シェルナノ粒子の合成と増強ルミネセンス特性【JST・京大機械翻訳】

Applied Physics A (2020)

Hu Da Peng Hongxia Yangxi Peng Guo Jun

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Secondary SCNT doubles the pre-implantation development rate of reconstructed interspecies embryos by using cytoplasts of Sannen dairy goat ova.

PubMed (2007)

Ai Min Zhang Jian Quan Chen Hong Sha Juan Chen Xu Jun Xu

The aim of this study was to investigate whether ova of Sannen goat could support the pre-implantation development of interspecies embryos constructed through somatic cell nucleus transfer (SCNT) embryos and whether secondary SCNT (SSCNT) could improve the pre-implantation development of those embryos. The primary SCNT (PSCNT) embryos were produced by using Sannen goat ovum cytoplasts as recipients and fibroblast cells, derived from human, rabbit and Boer goat skins, as nucleus donors. The blastomeres of 8 to 16 cells stage of PSCNT embryos were subsequently used as nucleus donor cells and Sannen goat ovum cytoplasts as recipients to evaluate the effect of SSCNT on the pre-implantation development rate of these reconstructed interspecies embryos. Our results indicate that the pre-implantation development rates of SSCNT embryos reconstructed using these three different blastomeres are almost twice of that of corresponding PSCNT embryos (human, 15.8% vs. 7.8%; rabbit, 27.9% vs. 12.5%; Boer goat 55.3% vs. 24.5%; P < 0.05 in all three cases). The time durations that embryos need for the serial events of remodeling and reprogramming to take place vary, depending on the animal species of nucleus donors. These data suggest that remodeling and reprogramming of donor nucleus may be enhanced by prolonged exposure of donor nucleus to maternal cytoplast. We conclude that Sannen goat cytoplast can support the pre-implantation development of embryos constructed with nuclei from various donors, including fibroblasts of human, rabbit and Boer goat; and the somatic nucleus derived from different species requires more time to achieve its reprogramming necessary for pre-implantation development.

Cytoplast

Reprogramming

Blastomere

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Gene therapy with IL-2 and IL-12 for murine hepatocellular carcinoma

Hu Da

Objective To explore the anti tumor efficacy of intratumor administration of plasmid DNA expres sing both mIL12 and hIL2 in mice H22 hepatocellular carcinoma grafted subcutaneously. Methods Eukaryotic expression plasmid vectors of hIL2 mIL12, mIL12, and hIL2 were constructed. The expressions of the plasmid in the the eukaryotic cells in different groups were examined by enzyme linked immunosorbent assay (ELISA). Cytokine expression in serum was detected at different time after intratumor administration of plasmid DNA. The mean diameter of the tumor mass and the livability of mice were measured in each mouse model group. Lactic dehydrogenase (LDH) assay was used to examine whether or not the treatment with different plasmid DNA could induce systemic cytolytic activity of lymphocytes against parental H22 cells. Histopathological changes were observed after administration of plasmid DNA vectors in each mouse model group. Results Plasmid vectors were constructed successfully and could efficiently express cytokines. After the intratumor administration, the expression levels of hIL2 and mIL12 in the pDC511hIL2 mIL12 group were statistically different as compared with that in group pDC511hIL2 ( F =71.11, P 0.01) or group pDC511mIL12 ( F =30.70, P 0.05) at different time, respectively. Growth of tumor in combined gene therapy group was significantly inhibited as compared with that in other groups ( P 0.05). Enhanced activity of CTL was observed in the pDC511hIL2 mIL12 group. In the group treated with pDC511hIL2 mIL12 plasmid DNA, inflammatory cell infiltration was more extensive and necrosis was more definite than those in other groups. Conclusion Both IL 2 and IL 12 are able to inhibit the growth of mice H22 hepatocellular carcinoma grafted subcutaneously and induce the host anti tumor immune response efficiently. Combination of IL 2 and IL 12 may have synergistic effect in anti tumor.

CTL*

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The Evaluation of Value before Radiotherapy Hemoglobin Concentration Sensitive Degree of Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma and Prognosis

Medical Innovation of China (2014)

Hu Da

Intensity

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Effects of Pinacidil and Nifedipine on Transmural Dispersion of Repolarization in Canine Left Ventricle in Long QT2 Model.

The Chinese Journal of Cardiac Pacing and Electrophysiology (2002)

Hu Da

.To observe the effects of d sotalol (Ikr blocker)on APD 90 and transmural dispersion of repolarization(TDR) in endocardium,epicardium,and M cells and the reversal effects of potassium channel opener (pinacidil),cacium channel blocker (nifedipine) by using standard glass microelectrode method.The results:①Superfusion with d sotalol(100 μmol/L),APD 90 were prolonged in all three type cells,but significantly in M cells.TDR was markedly increased.Early afterdepolarizations (EADs),APD alternans induced by d sotalol in M cells but not in endocardinm and epicardium.②In the presence with d sotalol,pinacidil(2 to 6 μmol/L) and nifedipine(2 to 10 μmol/L) dose dependently reversed the effects of d sotalol on APD and TDR,and effectively abolished EADs,APD alternans induced by d sotalol.

Pinacidil

Sotalol

Endocardium

Afterdepolarization

Torsades de pointes

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Biological effects of pcDNA 3 hbFGF modified human keratinocytes on the proliferation of human dermal fibroblastes

Hu Da

AIM: To observe the effects produced by pcDNA 3 hbFGF modified human keratinocytes (HKs) on the proliferation of human dermal fibroblasts (HDFibs). METHODS: The supernatant, collected from pcDNA 3 hbFGF modified HKs culture, was added to the cultivated HKFibs. The MTT method, 3H TdR incorporation and flow cytometry were employed to measure the cell proliferation, DNA synthesis rate and division cycle. RESULTS: 72 h after the supernatant from pcDNA 3 hbFGF modified HKs culture was added to HDFibs, the HDFibs proliferated by 1.5, 1.0 and 3 0 times more than the other cells, to which only ordinary culture medium, the supernatant from normal HKs or pcDNA 3 neo modified HKs cultures was added respectively ( P 0 01). Correspondingly, the DNA of HDFibs synthesized faster by 2.3, 1.6 and 3.4 times compared with that of other cells ( P 0.01). Although by 24 h, the proportion of HDFibs in the stage S of cell cycle was much higher, the change disappeared by 72 h. CONCLUSION: The HKs transfected with pcDNA 3 hbFGF could secrete active products to enhance the DNA synthesis and the proliferation of HDFibs, the mechanism of which might be that the HDFibs were stimulated into the stage S of cell generation cycle and this stimulating effect is of time dependent manner.

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Application and research of GIS in sewage design and management

Jisuanji gongcheng yu sheji (2004)

Hu Da

The application and development trend in sewage of GIS are demostrated including sewage design and management, urban sewage treatment plant design and management, pipelines emergency analysis, water pollution condition and trend analysis. For example, the sewage pipelines information management system in Hangzhou city is presented. It is stated that GIS can supply timely, accurate , integral needed information and even better supply rule for municipal manager.

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Introduction of fluorin into PBO polymer chains:Toward higher thermal stability and lower dielectric constant

Scientia Sinica(Technologica) (2009)

Hu Da

A series of novel fluorinated benzoxazole polymers (6FPBO’s) with high thermal stability and low dielectric constant were synthesized by copolymerization of 1,3-diamino-4, 6-dihydroxybenzene dihy-drochloride (DAR), 1,4-benzenedicarboxylic acid (PTA) and various amount of 4’4- (hexafluoroisopro-pylidene) bis (benzoic acid) (BIS-B-AF) in the medium of polyphosphoric acid (PPA). 6FPBO fibers were then obtained via dry-jet wet-spinning technique and characterized by means of Fourier transform infrared (FTIR) spectra, thermogravimetric analysis (TGA), single fiber tensile testing machine and scanning electron microscopy (SEM). FTIR spectrum of 6FPBO fibers indicated that the fluorine groups had been incorporated into PBO molecular chains successfully. TGA curves revealed that 6FPBO fibers possessed high thermal stability just as pure PBO fibers. Moreover, dielectric constant spectrum of 6FPBO exhibited that the polymers had low dielectric constant, especially in the range of high- frequency.

Thermogravimetric analysis

Thermal Stability

Benzoxazole

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