Byung Mu Lee

Sungkyunkwan University

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Hyung Sik Kim

Sungkyunkwan University

Seung Jun Kwack

Changwon National University

Kyu‐Bong Kim

Dankook University

Jaewon Lee

Pusan National University

Ji Yeon Son

Ajou University

Soon Young Han

Korea Institute of Drug Safety and Risk Management

Kyeong Seok Kim

Hanyang University

Sun Dong Yoo

Sungkyunkwan University

Mee Young Ahn

Silla University

Sam Kacew

University of Ottawa

Cooperative Institutions

Sungkyunkwan University

146

Seoul National University

Ministry of Food and Drug Safety

Pusan National University

National Institute of Food and Drug Safety Evaluation

Yonsei University

Korea University

United States Food and Drug Administration

Government of the Republic of Korea

Korea Institute of Toxicology

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Toxicological evaluation of isopropylparaben and isobutylparaben mixture in Sprague–Dawley rats following 28 days of dermal exposure

Regulatory Toxicology and Pharmacology (2015)

Min Ji Kim Seung Jun Kwack Seong Kwang Lim Yeon Joo Kim Taehyun Roh

Paraben

No-observed-adverse-effect level

Reproductive toxicity

10.1016/j.yrtph.2015.08.005

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Citations (19)

Determination of Sampling Rates of Passive Samplers for Organic Vapors Based on Estimated Diffusion Coefficients

AIHAJ (1987)

Charles E. Feigley Byung Mu Lee

Abstract If the sampling rate of a passive sampler is not known for an organic vapor of interest, it may be necessary to estimate the rate based on the diffusion coefficient of that vapor in air. Regression equations for two commercially available samplers were developed relating measured sampling rates to estimated diffusion coefficients. Two methods for estimating diffusion coefficients were evaluated. Ideal sampling rates (DA/L) averaged 27% to 61% higher than actual, measured rates. The use of these regression equations to estimate sampling rates is preferable to several other approaches using diffusion coefficient data. The Fuller-Schettler-Giddings method for estimating the diffusion coefficient is recommended because it is simpler and applicable to a greater number of compounds with no apparent loss of accuracy. This method was extended for use with organic vapors containing bromine.

10.1202/0002-8894(1987)048<0873:dosrop>2.0.co;2

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A novel histone deacetylase (HDAC) inhibitor MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells

Biomedicine & Pharmacotherapy (2013)

Nabanita Patra Umasankar De Tae Hyung Kim Young Ju Lee Mee Young Ahn

DU145

Histone deacetylase inhibitor

Vorinostat

Viability assay

10.1016/j.biopha.2013.01.006

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Citations (22)

Determination of Sampling Rates of Passive Samplers for Organic Vapors Based on Estimated Diffusion Coefficients

AIHAJ (1988)

Charles E. Feigley Byung Mu Lee

If the sampling rate of a passive sampler is not known for an organic vapor of interest, it may be necessary to estimate the rate based on the diffusion coefficient of that vapor in air. Regression equations for two commercially available samplers were developed relating measured sampling rates to estimated diffusion coefficients. Two methods for estimating diffusion coefficients were evaluated. Ideal sampling rates (DA/L) averaged 27% to 61% higher than actual, measured rates. The use of these regression equations to estimate sampling rates is preferable to several other approaches using diffusion coefficient data. The Fuller-Schettler-Giddings method for estimating the diffusion coefficient is recommended because it is simpler and applicable to a greater number of compounds with no apparent loss of accuracy. This method was extended for use with organic vapors containing bromine.

10.1202/0002-8894(1988)049<0266:dosrop>2.0.co;2

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Citations (0)

Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats

Toxicology and Applied Pharmacology (2020)

Amit Kundu Richa Sachan Prasanta Dey Kyeong Seok Kim Ji Yeon Son

Blood urea nitrogen

Glomerulosclerosis

10.1016/j.taap.2020.114899

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Citations (23)

Abstract 4370: Knockdown of PKM2 induces autophagic cell death via Akt/mTOR pathway in human prostate cancer cells

Cancer Research (2019)

Prasanta Dey Amit Kundu Byung Mu Lee Hyung Sik Kim

Abstract Pyruvate kinase M2 (PKM2) is crucial for aerobic glycolysis that is highly expressed in the various cancer tissues. Although high expression of PKM2 is observed in prostate tumor tissues, its functional role against affecting cancer metabolism is not clearly understood. Herein, we investigate its role in regulating autophagy and its associated pathways. In the current study, various PKM2-siRNA constructs were used to knockdown the PKM2 expression and observed its cellular pathways on autophagy. Cell viability was significantly reduced in PKM2-siRNA transfected prostate cancer cells, DU145. Acridine orange staining and immunoblotting analysis showed that downregulation of PKM2 markedly increased autophagy cell death. In addition, immunoblotting analysis exhibited the blocking the protein kinase B (Akt) and mTOR1 pathways, which subsequently down-regulated the expression of glycolytic enzymes lactate dehydrogenase A (LDHA) and Glucose transporter 1 (GLUT1). To the best of our knowledge, this is the first study that inhibition of PKM2 changes in cancer cell metabolism and induces autophagy, thus, providing new perspectives into the mechanism of its anticancer activity against prostate cancer, DU145. Citation Format: Prasanta Dey, Amit Kundu, Byung Mu Lee, Hyung Sik Kim. Knockdown of PKM2 induces autophagic cell death via Akt/mTOR pathway in human prostate cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4370.

DU145

PKM2

Anaerobic glycolysis

Wortmannin

10.1158/1538-7445.am2019-4370

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Risk assessment of lithium-ion battery explosion: chemical leakages

Journal of Toxicology and Environmental Health Part B (2018)

Yoo Jung Park Minkook Kim Hyung Sik Kim Byung Mu Lee

Use of lithium-ion batteries has raised safety issues owing to chemical leakages, overcharging, external heating, or explosions. A risk assessment was conducted for hydrofluoric acid (HF) and lithium hydroxide (LiOH) which potential might leak from lithium-ion batteries. The inhalation no-observed-adverse-effect-level (NOAEL) for HF was 0.75 mg/kg/d. When a lithium-ion battery explodes in a limited space, HF emissions amount to 10-100 ppm. Assuming the worst-case scenario, the conversion rate was calculated to be 81.8 mg/m3, and the average daily dose (ADD) was 19.5 mg/kg/d. Consequently, the margin of exposure (MOE = NOAEL/ADD) was 0.034, a value which constitutes an unsafe inhalation exposure for HF. Conversely, skin toxicity NOAEL for LiOH was 41.35 mg/kg/d-. This LiOH value reflects the amount of lithium in the lithium-ion battery, which is generated upon contact between water and the electrolyte. The quantity of lithium in a mobile phone is approximately 295 mg, and systemic exposure dose (SED) was 4.92 mg/kg/d. Accordingly, the MOE (NOAEL/SED) value was 8.41, and skin exposure of LiOH was deemed as safe for humans. However, it is important that Energy Storage System batteries still require safety measures and technologies for next-generation batteries, to prevent any potential explosions of lithium-ion batteries.

10.1080/10937404.2019.1601815

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Citations (41)

Inducible Nitric Oxide Synthase mRNA Is Upregulated in Skin Tumors of v-Ha-ras Transgenic TG-AC Mice Treated with 12-o-Tetradecanoylphorbol-13-acetate.

Biological and Pharmaceutical Bulletin (2000)

Byung Mu Lee Hyung Sik Kim Gwang‐Ho Jeohn

The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic α-like, ξ-globin gene. In animals treated with TPA (2.5 μg×2/week, for 2 weeks), the increase of iNOS mRNA wa locally confined only to the regions of papillomas, but not to the skin tissues surrounding the papillomas. However, the tissues surrounding the papillomas showed only a minor increase in the steady-state level of iNOS mRNA. These data suggest that iNOS gene expressions may underlie tumorigenesis during TPA promotion in TG-AC mice.

12-O-Tetradecanoylphorbol-13-acetate

Tumor promotion

Tetradecanoylphorbol Acetate

10.1248/bpb.23.826

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Citations (3)

Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, β-carotene and red ginseng)

Cancer Letters (1998)

Byung Mu Lee Seung Ki Lee Hyung Sik Kim

Carotene

Cotinine

10.1016/s0304-3835(98)00227-4

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Citations (159)

Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse

Carcinogenesis (2001)

Michael Battalora Judson W. Spalding Carl J. Szczesniak James E. Cape Rebecca Morris

Transgenic Tg.AC (v-Ha-ras ) mice develop skin tumors in response to specific carcinogens and tumor promoters. The Tg.AC mouse carries the coding sequence of v-Ha ras, linked to a ζ-globin promoter and an SV40 polyadenylation signal sequence. The transgene confers on these mice the property of genetically initiated skin. This study examines the age-dependent sensitivity of the incidence of skin papillomas in Tg.AC mice exposed to topically applied 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, full thickness skin wounding or UV radiation. Skin tumor incidence and multiplicity were strongly age-dependent, increasing with increasing age of the animal when first treated at 5, 10, 21 or 32 weeks of age. Furthermore, the temporal induction of transgene expression in keratinocytes isolated from TPA-treated mouse skin was also influenced by the age of the mice. Transgene expression was seen as early as 14 days after the start of TPA treatment in mice that were 10–32 weeks of age, but was not detected in similarly treated 5-week old mice. When isolated keratinocytes were fractionated by density gradient centrifugation the highest transgene expression was found in the denser basal keratinocytes. Transgene expression could be detected in the denser keratinocyte fraction as early as 9 days from start of TPA treatment in 32-week old mice. Using flow cytometry, a positive correlation was observed between expression of the v-Ha-ras transgene and enriched expression of the cell surface protein β1-integrin, a putative marker of epidermal stem cells. This result suggests that, in the Tg.AC mouse, an age-dependent sensitivity to tumor promotion and the correlated induction of transgene expression are related to changes in cellular development in the follicular compartment of the skin.

10.1093/carcin/22.4.651

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Citations (25)