Alain Thiéry

Centre National de la Recherche Scientifique

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Mélanie Auffan

Centre National de la Recherche Scientifique

Jean‐Yves Bottero

Centre de Recherche et d’Enseignement de Géosciences de l’Environnement

Jérôme Rose

Centre de Recherche et d’Enseignement de Géosciences de l’Environnement

Catherine Santaella

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Antoine Thill

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Armand Masion

Centre de Recherche et d’Enseignement de Géosciences de l’Environnement

Wafa Achouak

Aix-Marseille Université

Stephan Roche

Institut Català de Nanociència i Nanotecnologia

Florence Mouchet

Centre de Recherche sur la Biodiversité et l'Environnement

Ilya V. Pobelov

University of Bern

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Centre National de la Recherche Scientifique

179

Aix-Marseille Université

Institut de Recherche pour le Développement

Institut Méditerranéen de Biodiversité et d'Ecologie Marine et Continentale

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Centre de Recherche et d’Enseignement de Géosciences de l’Environnement

Université d'Avignon et des Pays de Vaucluse

Sorbonne Université

Université de Montpellier

Inserm

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Electron-Beam-Induced Chemical Vapor Deposition

Springer eBooks (2012)

Mélanie Auffan Catherine Santaella Alain Thiéry Christine Paillès Jérôme Rose

Deposition

10.1007/978-90-481-9751-4_100216

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Amphiphilic Copolymer for Delivery of Xenobiotics: In Vivo Studies in a Freshwater Invertebrate, a Mesostominae Flatworm

Bioconjugate Chemistry (2008)

Laetitia De Jong Xavier Moreau Alain Thiéry Guilhem Godeau Mark W. Grinstaff

The synthesis of an amphiphilic polymethacrylate copolymer containing cholesterol hydrophobic moieties and rhodamine as a fluorescent probe, the formation of microspheres, and the uptake of these microspheres in an invertebrate are reported. The cholesterol-derived methacryloyl monomer, which was prepared via a one-step synthesis, was copolymerized with methacrylic acid and methacryloxyethyl thiocarbamoyl rhodamine B in the presence of AIBN as initiator. The obtained dye-labeled copolymer was characterized by (1)H NMR and UV-vis spectroscopy. Fluorescence and TEM microscopies studies show that this amphiphilic copolymer aggregates to give microspheres with diameters ranging from approximately 3 to 11 microm. The in vivo study in a freshwater invertebrate, a Mesostominae flatworm (Rhabdocoela, Thyphloplanidae), indicates that the microspheres enter the cells by endocytosis. The data collected demonstrate that the rhodamine B covalently attached to the amphiphilic copolymers is bioaccumulated without being translocated out of the cell by the multixenobiotic resistance (MXR) transporters. As the MXR system is similar to the multidrug resistance (MDR) first observed in tumor cell lines resistant to anticancer drugs, the present data confirm the significant role that amphiphilic copolymers can play in the ongoing development of drug delivery strategies to overcome multidrug resistance. These investigations illustrate a promising approach for the development of new medical and ecotoxicological tools that can deliver specific molecules within cells.

Flatworm

Xenobiotic

10.1021/bc700425x

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Role of molting on the biodistribution of CeO2 nanoparticles within Daphnia pulex

Water Research (2013)

Mélanie Auffan Delphine Bertin Perrine Chaurand Christine Paillès Christian Dominici

Daphnia pulex

Pulex

Gammarus pulex

10.1016/j.watres.2012.11.063

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Citations (41)

Exposure to Cerium Dioxide Nanoparticles Differently Affect Swimming Performance and Survival in Two Daphnid Species

PLoS ONE (2013)

Ester Artells Julien Issartel Mélanie Auffan Daniel Borschneck Antoine Thill

The CeO2 NPs are increasingly used in industry but the environmental release of these NPs and their subsequent behavior and biological effects are currently unclear. This study evaluates for the first time the effects of CeO2 NPs on the survival and the swimming performance of two cladoceran species, Daphnia similis and Daphnia pulex after 1, 10 and 100 mg.L−1 CeO2 exposures for 48 h. Acute toxicity bioassays were performed to determine EC50 of exposed daphnids. Video-recorded swimming behavior of both daphnids was used to measure swimming speeds after various exposures to aggregated CeO2 NPs. The acute ecotoxicity showed that D. similis is 350 times more sensitive to CeO2 NPs than D. pulex, showing 48-h EC50 of 0.26 mg.L−1 and 91.79 mg.L−1, respectively. Both species interacted with CeO2 NPs (adsorption), but much more strongly in the case of D. similis. Swimming velocities (SV) were differently and significantly affected by CeO2 NPs for both species. A 48-h exposure to 1 mg.L−1 induced a decrease of 30% and 40% of the SV in D. pulex and D. similis, respectively. However at higher concentrations, the SV of D. similis was more impacted (60% off for 10 mg.L−1 and 100 mg.L−1) than the one of D. pulex. These interspecific toxic effects of CeO2 NPs are explained by morphological variations such as the presence of reliefs on the cuticle and a longer distal spine in D. similis acting as traps for the CeO2 aggregates. In addition, D. similis has a mean SV double that of D. pulex and thus initially collides with twice more NPs aggregates. The ecotoxicological consequences on the behavior and physiology of a CeO2 NPs exposure in daphnids are discussed.

Daphnia pulex

Pulex

Ecotoxicity

10.1371/journal.pone.0071260

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Citations (81)

Introduction

Alain Thiéry

10.4000/books.eua.6724

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Organic Pollution and Genotoxicity of Sediments of the Palun Marshes (Berre Lagoon, France)

Journal of Environmental Quality (2010)

Carole Di Giorgio Wei Liu Luc Sarrazin Emmanuel Wafo Xavier Moreau

The impact of industrial, rural, and urban activities on two runnels (B1, B2, and B3 from Beausset runnel and V1 and V2 from Vallat du Ceinturon runnel) located in the Palun marshes (Berre lagoon, France) was evaluated by analyzing 16 polycyclic aromatic hydrocarbons (PAHs), 1-nitropyrene (1-NP), 1-aminopyrene (1-AP), and six pesticides in sediment samples. The mutagenicity was assessed with the Salmonella mutagenicity test using tester strains TA98+S9 Mix and YG1041 +/- S9 Mix. The clastogenicity was evaluated with the micronucleus assay on Chinese Ovarian cells +/- S9 Mix. A gradient of PAHs concentrations was observed from B1 (3359 microg kg(-1) dry weight [dw]), close to industrial zones, to V2 (497 microg kg(-1) dw), away from the source of pollution. Similar gradient was noted for 1-AP (from B1: 11.8 microg kg(-1) dw to V2: 0.6 microg kg(-1) dw). However, this trend was not observed in 1-NP concentrations (concentrations ranged from 1.2 microg kg(-1) dw [V1] to 0.4 microg kg(-1) dw [B1]). Pesticides were detected in all samples. Diazinon and dieldrin were found in high concentrations in B1 extracts (74.5 and 39.9 microg.kg(-1) dw, respectively). All the sediments except V2 were mutagenic with strain TA98+S9 Mix. The mutagenicity was linked to the presence of PAHs (V1), nitroarenes (B1 and B3) and aromatic amines (B2). All sediments were clastogenic with and without S9 Mix except V1 extract, which was negative without S9 Mix. Overall, the two runnels in the Palun marshes were found to be polluted by many organic compounds that originate from direct human activities and pose a significant genotoxic risk.

Dry weight

10.2134/jeq2009.0178

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The neotropical genusDendrocephalus(Crustacea: Anostraca: Thamnocephalidae) in Brazil (South America), with a description of two new species

Journal of Natural History (1996)

Nicolas Rabet Alain Thiéry

Two new species in the neotropical genus Dendrocephalus (Anostraca, Thamnocephalidae) are described from Brazil. Dendrocephalus orientalis n. sp., occurs in temporary rainpools in the eastern part of Brazil in the States of Paraíba and Bahia (Nordeste region). Dendrocephalus goiasensis n. sp. inhabits a temporary rainpool in the 'cerrados' in the State of Goias (Centro-Oeste region). The descriptions are based principally on male morphology, with a detailed study of the frontal appendage (basal part of the arms, branch 1V, 2A, and 2D), and of the endopodites of the first four thoracopods. Cyst morphology is also described using scanning electron microscopy. Differential diagnoses of these two species are presented. New records of Dendrocephalus brasiliensis Pesta, provide a better idea of its distribution range in Brazil. A dichotomous key to Brazilian dendrocephalids is included.

Anostraca

Appendage

10.1080/00222939600770261

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Citations (28)

Long term dynamics of a Mediterranean alkaline vernal pool (Rhone delta, Southern France)

HAL (Le Centre pour la Communication Scientifique Directe) (2008)

Tony Rey Serge Müller Hélène Bruneton Ingeborg Soulié‐Märsche Alain Thiéry

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Actualisation de l'inventaire des grands branchiopodes des eaux temporaires stagnantes de la région Paca (Provence-Alpes-Côte-d'Azur), sud-est de la France