Amelia Lissia

University of Sassari

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Antonio Cossu

Azienda Ospedaliero Universitaria di Sassari

Giuseppe Palmieri

University of Sassari

Maria Colombino

National Research Council

Paolo A. Ascierto

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Panagiotis Paliogiannis

University of Sassari

Maria Cristina Sini

National Research Council

Antonella Manca

National Research Council

Gerardo Botti

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Milena Casula

National Research Council

Grazia Palomba

National Research Council

Cooperative Institutions

University of Sassari

Istituti di Ricovero e Cura a Carattere Scientifico

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Istituto di Chimica Biomolecolare

Azienda Ospedaliero Universitaria di Sassari

National Research Council

University of Naples Federico II

John Wiley & Sons (United States)

University of Siena

University of Cagliari

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Identification of Mycobacterium avium subsp. paratuberculosis in Biopsy Specimens from Patients with Crohn's Disease Identified by In Situ Hybridization

Journal of Clinical Microbiology (2001)

Leonardo A. Sechi Mura Manuela Tanda Francesco Amelia Lissia Antonio Solinas

ABSTRACT Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract of unknown etiology. We report on the presence of cell wall-deficient Mycobacterium avium subsp. paratuberculosis in 35 of 48 paraffin-embedded tissue specimens from 33 patients with Crohn's disease by in situ hybridization with IS 900 as a probe.

Etiology

10.1128/jcm.39.12.4514-4517.2001

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Citations (149)

Synchronous Interdigitating Dendritic Cell Sarcoma and B-Cell Small Lymphocytic Lymphoma in a Lymph Node

Archives of Pathology & Laboratory Medicine (2006)

Antonio Cossu Angelo Deiana Amelia Lissia Maria Filomena Dedola Lucia Cocco

Abstract A gradually enlarging axillary mass in a 79-year-old man was excised. The specimen was processed for light microscopy, immunohistochemical studies, and electron microscopy; gene rearrangement studies were also performed. A diagnosis of an interdigitating dendritic cell tumor of the lymph node and a B-cell small lymphocytic lymphoma occurring in the same anatomic location was made. We found that although rare cases of interdigitating dendritic cell tumor with an associated secondary malignancy have been described in the literature, to our knowledge, this is the first report of interdigitating dendritic cell tumor and synchronous neoplasm diagnosed at the same site. A possible relationship between the 2 disorders is also discussed.

Follicular dendritic cells

10.5858/2006-130-544-sidcsa

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Citations (33)

Extragenital human papillomavirus 16-associated bowen's disease

Indian Journal of Dermatology (2017)

MariaAntonietta Montesu G L Onnis Amelia Lissia Rosanna Satta BiancaMaria Are

Bowen's disease

10.4103/0019-5154.198035

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Citations (2)

Palmoplantar keratoderma in keratosis follicularis spinulosa decalvans.

PubMed (2010)

Maria Antonietta Montesu Marco Castori Maria Vittoria Masala Amelia Lissia Francesca Cottoni

Auteur(s) : Maria Antonietta Montesu1, Marco Castori2, Maria Vittoria Masala3, Amelia Lissia4, Francesca Cottoni1 1Institute of Dermatology, University of Sassari, Viale San Pietro, 43/b, 07100 Sassari, Italy 2Medical Genetics, Department of Experimental Medicine, Sapienza University, San Camillo – Forlanini Hospital, Rome, Italy 3Dermatology Surgery, ASL 3, Nuoro, Italy 4Department of Histology and Pathology, University of Sassari, Sassari, Italy Keratosis [...]

Keratoderma

Dyskeratosis

Actinic keratosis

10.1684/ejd.2010.1113

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Citations (4)

FOLLICULAR MUCINOSIS PLUS MYCOSIS FUNGOIDES AND ACANTHOSIS NIGRICANS PLUS ALVEOLAR BRONCHIOLAR CARCINOMA

International Journal of Dermatology (1995)

Francesca Cottoni Giovannino Massarelli GIUSEPPINA TEDDE Amelia Lissia

10.1111/j.1365-4362.1995.tb04427.x

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Primary Dermal Melanoma in a Patient with a History of Multiple Malignancies: A Case Report with Molecular Characterization

Case Reports in Dermatology (2013)

Germana Sini Maria Colombino Amelia Lissia Sara Maxia Marcello Gulino

Primary dermal melanoma (PDM) is a recently described clinical entity accounting for less than 1% of all melanomas. Histologically, it is located in the dermis or subcutaneous tissue, and it shows no connections with the overlying epidermis. The differential diagnosis is principally made along with that of metastatic cutaneous melanoma.A 72-year-old Caucasian woman with a history of multiple cancers (metachronous bilateral breast cancer, meningioma, clear cell renal cell carcinoma, uterine fibromatosis and intestinal adenomatous polyposis), came to our attention with a nodular lesion on her back. After removal of the lesion, the histology report indicated malignant PDM or metastatic malignant melanoma. The clinical and instrumental evaluation of the patient did not reveal any other primary tumour, suggesting the primitive nature of the lesion. The absence of an epithelial component argued for a histological diagnosis of PDM. Subsequently, the patient underwent a wide surgical excision with sentinel node biopsy, which was positive for metastatic melanoma. Finally, the mutational status was studied in the main genes that regulate proliferation, apoptosis and cellular senescence. No pathogenetic mutations in CDKN2A, BRAF, NRAS, KRAS, cKIT, TP53 and PTEN genes were observed. This suggests that alternative pathways and low-frequency alterations may be involved.The differential diagnosis between PDM and isolated metastatic melanoma depends on the negativity of imaging studies and clinical findings for other primary lesions. This distinction is important because 5-year survival rates in such cases are higher than in metastatic cases (80-100 vs. 5-20%, respectively).

10.1159/000354032

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Citations (8)

Graham‐Little‐Piccardi‐Lassueur syndrome in siblings

International Journal of Dermatology (2021)

Gabriele Biondi Rosanna Satta Amelia Lissia Antonella Maria Fara Maria Antonietta Montesu

Histopathology

10.1111/ijd.15534

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Citations (4)

Targeted Therapies in Melanoma: Successes and Pitfalls

InTech eBooks (2013)

Giuseppe Palmieri Maria Colombino María Cristina Paolo Antonio Amelia Lissia

Incidence of melanoma is steadily rising worldwide [1]. Lifetime risk of developing melano‐ ma in Caucasians is estimated as 1 in 50 individuals [2-3]. The incidence of melanoma varies according to the geographical origins of the population and the extent of sun exposure. In Australia and United States, an incidence of melanoma higher than observed in the Europe‐ an countries (with the notable exception of Sweden) has been reported [4-5]. There is a gra‐ dient of melanoma incidence from north to south in Europe, with highest frequencies in the northern counties. This suggests that initiation and development of melanoma is due to a combination of the damaging effects of UV and a predisposing genetic background [5].

10.5772/53624

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Citations (2)

Different prevalence of BRAF and NRAS somatic mutations in melanomas according to the patients’ origin.

Journal of Clinical Oncology (2013)

Giuseppe Palmieri Amelia Lissia Antonio Cossu Paolo A. Ascierto Gerardo Botti

e20013 Background: Genetic factors predisposing to melanoma at germline level have been demonstrated to be geographically heterogeneous. We here evaluated the spectrum of NRAS and BRAF mutations at somatic level, in a large subset of melanoma tissues from patients originating from different Italian geographical areas: Sardinia, whose population is genetically homogeneous, and Middle-South Italy, with a genetically heterogeneous population. Methods: Patients were enrolled consecutively between June 2008 and December 2012. Genomic DNA was isolated from tumor tissues [primary melanomas (N=439) and melanoma metastases (N=269)] or melanoma cell lines (N=32). Paired samples of primary melanomas (n=140) and synchronous or asynchronous metastases from the same patients (n=203) were included. The full coding sequences and splice junctions of NRAS (exons 2-3) and BRAF (exon 15) genes were screened for mutations through automated sequencing. Results: BRAF/NRAS mutations were identified in 63% of primary melanomas (48% BRAF; 15% NRAS), 67% melanoma metastases (51% BRAF; 16% NRAS), and 68% melanoma cell lines (56% BRAF; 12% NRAS). A non-significant increase in mutation frequency after progression from primary melanoma was observed. However, distribution of BRAF/NRAS mutations varied between in vivo tumors and melanoma cell lines, suggesting a preponderant role for BRAF activation in highly proliferating cultured melanoma cells. Among paired samples, consistency of BRAF/NRAS mutation patterns between metastatic and primary melanomas ranged from 71% (skin metastases) to about 90% (lymph node and visceral metastases). A significant inverse distribution of BRAF/NRAS mutation rates was observed in our series on the basis of the geographical origin of patients: for BRAF, 58% Sardinian vs. 42% non-Sardinian cases (p=0.045); for NRAS, 2% Sardinian vs. 21% non-Sardinian cases (p<0.001). Conclusions: Our findings provide additional insights into the spectrum and distribution of BRAF/NRAS mutations in melanoma; moreover, they support the hypothesis that differences in patients’ origins and related genetic backgrounds may contribute to even determine the incidence rate of somatic mutations in such cancer genes.

10.1200/jco.2013.31.15_suppl.e20013

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PharmaNews / Pharma/Ticker

Kompass Dermatologie (2014)

Árpád Farkas Lajos Kemény M. Lemper Sarah Snykers Tamara Vanhaecke

10.1159/000360665

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